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Q90WY4

- ADA2A_DANRE

UniProt

Q90WY4 - ADA2A_DANRE

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Protein

Alpha-2A adrenergic receptor

Gene

adra2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > oxymetazoline = epinephrine > norepinephrine.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei102 – 1021Implicated in ligand bindingBy similarity
Sitei181 – 1811Implicated in catechol agonist binding and receptor activationBy similarity
Sitei185 – 1851Implicated in catechol agonist binding and receptor activationBy similarity

GO - Molecular functioni

  1. alpha2-adrenergic receptor activity Source: UniProtKB

GO - Biological processi

  1. adrenergic receptor signaling pathway Source: GOC
  2. G-protein coupled receptor signaling pathway Source: ZFIN
  3. negative regulation of adenylate cyclase activity Source: UniProtKB
  4. platelet activation Source: InterPro
  5. regulation of smooth muscle contraction Source: InterPro
  6. regulation of vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Gene namesi
Name:adra2a
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-021010-1. adra2a.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Alpha-2A adrenergic receptorPRO_0000069084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 169PROSITE-ProRule annotation
Lipidationi380 – 3801S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Structurei

3D structure databases

ProteinModelPortaliQ90WY4.
SMRiQ90WY4. Positions 107-138.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222ExtracellularBy similarityAdd
BLAST
Topological domaini49 – 5911CytoplasmicBy similarityAdd
BLAST
Topological domaini86 – 9510ExtracellularBy similarity
Topological domaini119 – 13820CytoplasmicBy similarityAdd
BLAST
Topological domaini163 – 17311ExtracellularBy similarityAdd
BLAST
Topological domaini199 – 311113CytoplasmicBy similarityAdd
BLAST
Topological domaini338 – 3447ExtracellularBy similarity
Topological domaini369 – 38820CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4826Helical; Name=1By similarityAdd
BLAST
Transmembranei60 – 8526Helical; Name=2By similarityAdd
BLAST
Transmembranei96 – 11823Helical; Name=3By similarityAdd
BLAST
Transmembranei139 – 16224Helical; Name=4By similarityAdd
BLAST
Transmembranei174 – 19825Helical; Name=5By similarityAdd
BLAST
Transmembranei312 – 33726Helical; Name=6By similarityAdd
BLAST
Transmembranei345 – 36824Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi309 – 35244Phe-richAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ90WY4.
PhylomeDBiQ90WY4.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90WY4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MICGANATNG TNATKEYTLL VALPLSIAVG LLILLIIFGN VLVIIAVFTS
60 70 80 90 100
RALRAPQNLF LVSLASADIL VATLVMPFSL ANELMGMWTF GGVWCEIYLA
110 120 130 140 150
LDVLFCTASI THLCAISLDR YWSITQAIEY NLKRTPQRIK RIIFIVWIIA
160 170 180 190 200
AVISCPPLIT MKKSEGDICD INKEKWYIVS SCIGSFFLPC IIMVLVYIRI
210 220 230 240 250
YQIAKKRTRA PPGDHRKNEV GKKENDPHEK LNGIQNAEPD DKDEINGVDM
260 270 280 290 300
EESSSSDHKV SNPCSLKKKS SKGKTKLSQI KPGDGDKTEA CQTTKASRWK
310 320 330 340 350
GRQNREKRFT FVLAVVIGVF VICWFPFFFT YTFTAFCDCC VPETLFKFFF
360 370 380
WFGYCNSSLN PIIYTIFNND FRRSFKKILC RRDKRRVV
Length:388
Mass (Da):43,997
Last modified:December 1, 2001 - v1
Checksum:i431965A04E1986DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY048971 Genomic DNA. Translation: AAL07510.1.
UniGeneiDr.30878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY048971 Genomic DNA. Translation: AAL07510.1 .
UniGenei Dr.30878.

3D structure databases

ProteinModelPortali Q90WY4.
SMRi Q90WY4. Positions 107-138.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ZFINi ZDB-GENE-021010-1. adra2a.

Phylogenomic databases

eggNOGi NOG249628.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi Q90WY4.
PhylomeDBi Q90WY4.

Miscellaneous databases

PROi Q90WY4.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF24. PTHR24248:SF24. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish."
    Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.
    Mol. Biol. Evol. 21:14-28(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha2-adrenoceptors."
    Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.
    Br. J. Pharmacol. 144:165-177(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiADA2A_DANRE
AccessioniPrimary (citable) accession number: Q90WY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3