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Q90WY4

- ADA2A_DANRE

UniProt

Q90WY4 - ADA2A_DANRE

Protein

Alpha-2A adrenergic receptor

Gene

adra2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > oxymetazoline = epinephrine > norepinephrine.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei102 – 1021Implicated in ligand bindingBy similarity
    Sitei181 – 1811Implicated in catechol agonist binding and receptor activationBy similarity
    Sitei185 – 1851Implicated in catechol agonist binding and receptor activationBy similarity

    GO - Molecular functioni

    1. alpha2-adrenergic receptor activity Source: UniProtKB

    GO - Biological processi

    1. adrenergic receptor signaling pathway Source: GOC
    2. G-protein coupled receptor signaling pathway Source: ZFIN
    3. negative regulation of adenylate cyclase activity Source: UniProtKB
    4. platelet activation Source: InterPro
    5. regulation of smooth muscle contraction Source: InterPro
    6. regulation of vasoconstriction Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2A adrenergic receptor
    Alternative name(s):
    Alpha-2A adrenoreceptor
    Short name:
    Alpha-2A adrenoceptor
    Short name:
    Alpha-2AAR
    Gene namesi
    Name:adra2a
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-021010-1. adra2a.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ZFIN

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Alpha-2A adrenergic receptorPRO_0000069084Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 169PROSITE-ProRule annotation
    Lipidationi380 – 3801S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Structurei

    3D structure databases

    ProteinModelPortaliQ90WY4.
    SMRiQ90WY4. Positions 107-138.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222ExtracellularBy similarityAdd
    BLAST
    Topological domaini49 – 5911CytoplasmicBy similarityAdd
    BLAST
    Topological domaini86 – 9510ExtracellularBy similarity
    Topological domaini119 – 13820CytoplasmicBy similarityAdd
    BLAST
    Topological domaini163 – 17311ExtracellularBy similarityAdd
    BLAST
    Topological domaini199 – 311113CytoplasmicBy similarityAdd
    BLAST
    Topological domaini338 – 3447ExtracellularBy similarity
    Topological domaini369 – 38820CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4826Helical; Name=1By similarityAdd
    BLAST
    Transmembranei60 – 8526Helical; Name=2By similarityAdd
    BLAST
    Transmembranei96 – 11823Helical; Name=3By similarityAdd
    BLAST
    Transmembranei139 – 16224Helical; Name=4By similarityAdd
    BLAST
    Transmembranei174 – 19825Helical; Name=5By similarityAdd
    BLAST
    Transmembranei312 – 33726Helical; Name=6By similarityAdd
    BLAST
    Transmembranei345 – 36824Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi309 – 35244Phe-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiQ90WY4.
    PhylomeDBiQ90WY4.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR002233. ADR_fam.
    IPR001946. ADRA2A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90WY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MICGANATNG TNATKEYTLL VALPLSIAVG LLILLIIFGN VLVIIAVFTS    50
    RALRAPQNLF LVSLASADIL VATLVMPFSL ANELMGMWTF GGVWCEIYLA 100
    LDVLFCTASI THLCAISLDR YWSITQAIEY NLKRTPQRIK RIIFIVWIIA 150
    AVISCPPLIT MKKSEGDICD INKEKWYIVS SCIGSFFLPC IIMVLVYIRI 200
    YQIAKKRTRA PPGDHRKNEV GKKENDPHEK LNGIQNAEPD DKDEINGVDM 250
    EESSSSDHKV SNPCSLKKKS SKGKTKLSQI KPGDGDKTEA CQTTKASRWK 300
    GRQNREKRFT FVLAVVIGVF VICWFPFFFT YTFTAFCDCC VPETLFKFFF 350
    WFGYCNSSLN PIIYTIFNND FRRSFKKILC RRDKRRVV 388
    Length:388
    Mass (Da):43,997
    Last modified:December 1, 2001 - v1
    Checksum:i431965A04E1986DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY048971 Genomic DNA. Translation: AAL07510.1.
    UniGeneiDr.30878.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY048971 Genomic DNA. Translation: AAL07510.1 .
    UniGenei Dr.30878.

    3D structure databases

    ProteinModelPortali Q90WY4.
    SMRi Q90WY4. Positions 107-138.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ZFINi ZDB-GENE-021010-1. adra2a.

    Phylogenomic databases

    eggNOGi NOG249628.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi Q90WY4.
    PhylomeDBi Q90WY4.

    Miscellaneous databases

    PROi Q90WY4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR002233. ADR_fam.
    IPR001946. ADRA2A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF24. PTHR24248:SF24. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish."
      Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.
      Mol. Biol. Evol. 21:14-28(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha2-adrenoceptors."
      Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.
      Br. J. Pharmacol. 144:165-177(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiADA2A_DANRE
    AccessioniPrimary (citable) accession number: Q90WY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3