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Protein

Alpha-2A adrenergic receptor

Gene

adra2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > oxymetazoline = epinephrine > norepinephrine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei102Implicated in ligand bindingBy similarity1
Sitei181Implicated in catechol agonist binding and receptor activationBy similarity1
Sitei185Implicated in catechol agonist binding and receptor activationBy similarity1

GO - Molecular functioni

  • alpha2-adrenergic receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Gene namesi
Name:adra2a
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-021010-1. adra2a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularBy similarityAdd BLAST22
Transmembranei23 – 48Helical; Name=1By similarityAdd BLAST26
Topological domaini49 – 59CytoplasmicBy similarityAdd BLAST11
Transmembranei60 – 85Helical; Name=2By similarityAdd BLAST26
Topological domaini86 – 95ExtracellularBy similarity10
Transmembranei96 – 118Helical; Name=3By similarityAdd BLAST23
Topological domaini119 – 138CytoplasmicBy similarityAdd BLAST20
Transmembranei139 – 162Helical; Name=4By similarityAdd BLAST24
Topological domaini163 – 173ExtracellularBy similarityAdd BLAST11
Transmembranei174 – 198Helical; Name=5By similarityAdd BLAST25
Topological domaini199 – 311CytoplasmicBy similarityAdd BLAST113
Transmembranei312 – 337Helical; Name=6By similarityAdd BLAST26
Topological domaini338 – 344ExtracellularBy similarity7
Transmembranei345 – 368Helical; Name=7By similarityAdd BLAST24
Topological domaini369 – 388CytoplasmicBy similarityAdd BLAST20

GO - Cellular componenti

  • integral component of plasma membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690841 – 388Alpha-2A adrenergic receptorAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 169PROSITE-ProRule annotation
Lipidationi380S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ90WY4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000059868.

Structurei

3D structure databases

ProteinModelPortaliQ90WY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi309 – 352Phe-richAdd BLAST44

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ90WY4.
PhylomeDBiQ90WY4.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90WY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICGANATNG TNATKEYTLL VALPLSIAVG LLILLIIFGN VLVIIAVFTS
60 70 80 90 100
RALRAPQNLF LVSLASADIL VATLVMPFSL ANELMGMWTF GGVWCEIYLA
110 120 130 140 150
LDVLFCTASI THLCAISLDR YWSITQAIEY NLKRTPQRIK RIIFIVWIIA
160 170 180 190 200
AVISCPPLIT MKKSEGDICD INKEKWYIVS SCIGSFFLPC IIMVLVYIRI
210 220 230 240 250
YQIAKKRTRA PPGDHRKNEV GKKENDPHEK LNGIQNAEPD DKDEINGVDM
260 270 280 290 300
EESSSSDHKV SNPCSLKKKS SKGKTKLSQI KPGDGDKTEA CQTTKASRWK
310 320 330 340 350
GRQNREKRFT FVLAVVIGVF VICWFPFFFT YTFTAFCDCC VPETLFKFFF
360 370 380
WFGYCNSSLN PIIYTIFNND FRRSFKKILC RRDKRRVV
Length:388
Mass (Da):43,997
Last modified:December 1, 2001 - v1
Checksum:i431965A04E1986DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048971 Genomic DNA. Translation: AAL07510.1.
UniGeneiDr.30878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY048971 Genomic DNA. Translation: AAL07510.1.
UniGeneiDr.30878.

3D structure databases

ProteinModelPortaliQ90WY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000059868.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ90WY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-021010-1. adra2a.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ90WY4.
PhylomeDBiQ90WY4.

Miscellaneous databases

PROiQ90WY4.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA2A_DANRE
AccessioniPrimary (citable) accession number: Q90WY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: October 5, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.