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Q90WY4

- ADA2A_DANRE

UniProt

Q90WY4 - ADA2A_DANRE

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Protein
Alpha-2A adrenergic receptor
Gene
adra2a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > oxymetazoline = epinephrine > norepinephrine.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei102 – 1021Implicated in ligand binding By similarity
Sitei181 – 1811Implicated in catechol agonist binding and receptor activation By similarity
Sitei185 – 1851Implicated in catechol agonist binding and receptor activation By similarity

GO - Molecular functioni

  1. alpha2-adrenergic receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ZFIN
  2. adrenergic receptor signaling pathway Source: GOC
  3. negative regulation of adenylate cyclase activity Source: UniProtKB
  4. platelet activation Source: InterPro
  5. regulation of smooth muscle contraction Source: InterPro
  6. regulation of vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
Gene namesi
Name:adra2a
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-021010-1. adra2a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Extracellular By similarity
Add
BLAST
Transmembranei23 – 4826Helical; Name=1; By similarity
Add
BLAST
Topological domaini49 – 5911Cytoplasmic By similarity
Add
BLAST
Transmembranei60 – 8526Helical; Name=2; By similarity
Add
BLAST
Topological domaini86 – 9510Extracellular By similarity
Transmembranei96 – 11823Helical; Name=3; By similarity
Add
BLAST
Topological domaini119 – 13820Cytoplasmic By similarity
Add
BLAST
Transmembranei139 – 16224Helical; Name=4; By similarity
Add
BLAST
Topological domaini163 – 17311Extracellular By similarity
Add
BLAST
Transmembranei174 – 19825Helical; Name=5; By similarity
Add
BLAST
Topological domaini199 – 311113Cytoplasmic By similarity
Add
BLAST
Transmembranei312 – 33726Helical; Name=6; By similarity
Add
BLAST
Topological domaini338 – 3447Extracellular By similarity
Transmembranei345 – 36824Helical; Name=7; By similarity
Add
BLAST
Topological domaini369 – 38820Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Alpha-2A adrenergic receptor
PRO_0000069084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12 – 121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 169 By similarity
Lipidationi380 – 3801S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Structurei

3D structure databases

ProteinModelPortaliQ90WY4.
SMRiQ90WY4. Positions 107-138.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi309 – 35244Phe-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ90WY4.
PhylomeDBiQ90WY4.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF24. PTHR24248:SF24. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90WY4-1 [UniParc]FASTAAdd to Basket

« Hide

MICGANATNG TNATKEYTLL VALPLSIAVG LLILLIIFGN VLVIIAVFTS    50
RALRAPQNLF LVSLASADIL VATLVMPFSL ANELMGMWTF GGVWCEIYLA 100
LDVLFCTASI THLCAISLDR YWSITQAIEY NLKRTPQRIK RIIFIVWIIA 150
AVISCPPLIT MKKSEGDICD INKEKWYIVS SCIGSFFLPC IIMVLVYIRI 200
YQIAKKRTRA PPGDHRKNEV GKKENDPHEK LNGIQNAEPD DKDEINGVDM 250
EESSSSDHKV SNPCSLKKKS SKGKTKLSQI KPGDGDKTEA CQTTKASRWK 300
GRQNREKRFT FVLAVVIGVF VICWFPFFFT YTFTAFCDCC VPETLFKFFF 350
WFGYCNSSLN PIIYTIFNND FRRSFKKILC RRDKRRVV 388
Length:388
Mass (Da):43,997
Last modified:December 1, 2001 - v1
Checksum:i431965A04E1986DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY048971 Genomic DNA. Translation: AAL07510.1.
UniGeneiDr.30878.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY048971 Genomic DNA. Translation: AAL07510.1 .
UniGenei Dr.30878.

3D structure databases

ProteinModelPortali Q90WY4.
SMRi Q90WY4. Positions 107-138.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ZFINi ZDB-GENE-021010-1. adra2a.

Phylogenomic databases

eggNOGi NOG249628.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi Q90WY4.
PhylomeDBi Q90WY4.

Miscellaneous databases

PROi Q90WY4.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR002233. ADR_fam.
IPR001946. ADRA2A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF24. PTHR24248:SF24. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish."
    Ruuskanen J.O., Xhaard H., Marjamaki A., Salaneck E., Salminen T., Yan Y.-L., Postlethwait J.H., Johnson M.S., Larhammar D., Scheinin M.
    Mol. Biol. Evol. 21:14-28(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha2-adrenoceptors."
    Ruuskanen J.O., Laurila J., Xhaard H., Rantanen V.-V., Vuoriluoto K., Wurster S., Marjamaki A., Vainio M., Johnson M.S., Scheinin M.
    Br. J. Pharmacol. 144:165-177(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiADA2A_DANRE
AccessioniPrimary (citable) accession number: Q90WY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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