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Q90WW4

- IGF2A_XENLA

UniProt

Q90WW4 - IGF2A_XENLA

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Protein
Insulin-like growth factor II-A
Gene
igf2-a
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development.1 Publication

GO - Molecular functioni

  1. growth factor activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. head morphogenesis Source: UniProtKB
  3. nervous system development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II-A
Short name:
IGF-II-A
Alternative name(s):
Insulin-like growth factor 2-A
Short name:
xIGF-2
Gene namesi
Name:igf2-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6251806. igf2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5656 Reviewed prediction
Add
BLAST
Chaini57 – 12367Insulin-like growth factor II-A
PRO_0000224639Add
BLAST
Propeptidei124 – 21794E peptide
PRO_0000224640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 103 By similarityBy similarity
Disulfide bondi76 ↔ 116 By similarityBy similarity
Disulfide bondi102 ↔ 107 By similarityBy similarity

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Expressed in the dorsal midline during gastrulation and neurulation.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ90WW4.
SMRiQ90WW4. Positions 56-123.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 8327B
Add
BLAST
Regioni84 – 9613C
Add
BLAST
Regioni97 – 11721A
Add
BLAST
Regioni118 – 1236D

Sequence similaritiesi

Belongs to the insulin family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.
KOiK13769.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90WW4-1 [UniParc]FASTAAdd to Basket

« Hide

MEQLSCKHRS SSVEAEAQLC RQTESRSTQL PRMSVMRHLF LLSITFLVYT    50
LDSAKAYRAT ETLCGGELVD TLQFVCGDRG FYFSTNNGRS NRRPNRGIVD 100
VCCFKSCDLE LLETYCAKPT KNERDVSTAP ATAIPPLSKQ DLYHKHHHTK 150
SSKYDIWQRK SIHRLRRGVP AIVRARQYRL LMEKAEEAEQ ALSHRPLTTL 200
PITRPLRLQQ ASEPSHN 217
Length:217
Mass (Da):24,874
Last modified:December 1, 2001 - v1
Checksum:iE1D290F8458BBA7A
GO

Sequence cautioni

The sequence AAH70545.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY050645 mRNA. Translation: AAL11445.1.
BC070545 mRNA. Translation: AAH70545.1. Different initiation.
RefSeqiNP_001082128.1. NM_001088659.1.
UniGeneiXl.12101.

Genome annotation databases

GeneIDi398240.
KEGGixla:398240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY050645 mRNA. Translation: AAL11445.1 .
BC070545 mRNA. Translation: AAH70545.1 . Different initiation.
RefSeqi NP_001082128.1. NM_001088659.1.
UniGenei Xl.12101.

3D structure databases

ProteinModelPortali Q90WW4.
SMRi Q90WW4. Positions 56-123.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 398240.
KEGGi xla:398240.

Organism-specific databases

CTDi 398240.
Xenbasei XB-GENE-6251806. igf2.

Phylogenomic databases

HOVERGENi HBG006137.
KOi K13769.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomi PD005188. IGF2_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Neural and head induction by insulin-like growth factor signals."
    Pera E.M., Wessely O., Li S.-Y., De Robertis E.M.
    Dev. Cell 1:655-665(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiIGF2A_XENLA
AccessioniPrimary (citable) accession number: Q90WW4
Secondary accession number(s): Q6NS08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: October 16, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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