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Protein

Insulin-like growth factor II-A

Gene

igf2-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development.Curated1 Publication

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • head morphogenesis Source: UniProtKB
  • nervous system development Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, Growth factor
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II-A
Short name:
IGF-II-A
Alternative name(s):
Insulin-like growth factor 2-A
Short name:
xIGF-2
Gene namesi
Name:igf2-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6251806. igf2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: InterPro

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 56Sequence analysisAdd BLAST56
ChainiPRO_000022463957 – 123Insulin-like growth factor II-ASequence analysisAdd BLAST67
PropeptideiPRO_0000224640124 – 217E peptideSequence analysisAdd BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 103By similarity
Disulfide bondi76 ↔ 116By similarity
Disulfide bondi102 ↔ 107By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Expressed in the dorsal midline during gastrulation and neurulation.1 Publication

Interactioni

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliQ90WW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 83BSequence analysisAdd BLAST27
Regioni84 – 96CSequence analysisAdd BLAST13
Regioni97 – 117ASequence analysisAdd BLAST21
Regioni118 – 123DSequence analysis6

Sequence similaritiesi

Belongs to the insulin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.
KOiK13769.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
PfamiView protein in Pfam
PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005188. IGF2_C. 1 hit.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90WW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLSCKHRS SSVEAEAQLC RQTESRSTQL PRMSVMRHLF LLSITFLVYT
60 70 80 90 100
LDSAKAYRAT ETLCGGELVD TLQFVCGDRG FYFSTNNGRS NRRPNRGIVD
110 120 130 140 150
VCCFKSCDLE LLETYCAKPT KNERDVSTAP ATAIPPLSKQ DLYHKHHHTK
160 170 180 190 200
SSKYDIWQRK SIHRLRRGVP AIVRARQYRL LMEKAEEAEQ ALSHRPLTTL
210
PITRPLRLQQ ASEPSHN
Length:217
Mass (Da):24,874
Last modified:December 1, 2001 - v1
Checksum:iE1D290F8458BBA7A
GO

Sequence cautioni

The sequence AAH70545 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050645 mRNA. Translation: AAL11445.1.
BC070545 mRNA. Translation: AAH70545.1. Different initiation.
RefSeqiNP_001082128.1. NM_001088659.1.
XP_018114956.1. XM_018259467.1.
UniGeneiXl.12101.

Genome annotation databases

GeneIDi398240.
KEGGixla:398240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050645 mRNA. Translation: AAL11445.1.
BC070545 mRNA. Translation: AAH70545.1. Different initiation.
RefSeqiNP_001082128.1. NM_001088659.1.
XP_018114956.1. XM_018259467.1.
UniGeneiXl.12101.

3D structure databases

ProteinModelPortaliQ90WW4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398240.
KEGGixla:398240.

Organism-specific databases

CTDi398240.
XenbaseiXB-GENE-6251806. igf2.

Phylogenomic databases

HOVERGENiHBG006137.
KOiK13769.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
PfamiView protein in Pfam
PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005188. IGF2_C. 1 hit.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIGF2A_XENLA
AccessioniPrimary (citable) accession number: Q90WW4
Secondary accession number(s): Q6NS08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: February 15, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.