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Q90WW4

- IGF2A_XENLA

UniProt

Q90WW4 - IGF2A_XENLA

Protein

Insulin-like growth factor II-A

Gene

igf2-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development.1 PublicationCurated

    GO - Molecular functioni

    1. growth factor activity Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. head morphogenesis Source: UniProtKB
    3. nervous system development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Growth factor

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor II-A
    Short name:
    IGF-II-A
    Alternative name(s):
    Insulin-like growth factor 2-A
    Short name:
    xIGF-2
    Gene namesi
    Name:igf2-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6251806. igf2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5656Sequence AnalysisAdd
    BLAST
    Chaini57 – 12367Insulin-like growth factor II-ASequence AnalysisPRO_0000224639Add
    BLAST
    Propeptidei124 – 21794E peptideSequence AnalysisPRO_0000224640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 103By similarity
    Disulfide bondi76 ↔ 116By similarity
    Disulfide bondi102 ↔ 107By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Developmental stagei

    Expressed both maternally and zygotically. Expressed in the dorsal midline during gastrulation and neurulation.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ90WW4.
    SMRiQ90WW4. Positions 56-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 8327BSequence AnalysisAdd
    BLAST
    Regioni84 – 9613CSequence AnalysisAdd
    BLAST
    Regioni97 – 11721ASequence AnalysisAdd
    BLAST
    Regioni118 – 1236DSequence Analysis

    Sequence similaritiesi

    Belongs to the insulin family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006137.
    KOiK13769.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomiPD005188. IGF2_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90WW4-1 [UniParc]FASTAAdd to Basket

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    MEQLSCKHRS SSVEAEAQLC RQTESRSTQL PRMSVMRHLF LLSITFLVYT    50
    LDSAKAYRAT ETLCGGELVD TLQFVCGDRG FYFSTNNGRS NRRPNRGIVD 100
    VCCFKSCDLE LLETYCAKPT KNERDVSTAP ATAIPPLSKQ DLYHKHHHTK 150
    SSKYDIWQRK SIHRLRRGVP AIVRARQYRL LMEKAEEAEQ ALSHRPLTTL 200
    PITRPLRLQQ ASEPSHN 217
    Length:217
    Mass (Da):24,874
    Last modified:December 1, 2001 - v1
    Checksum:iE1D290F8458BBA7A
    GO

    Sequence cautioni

    The sequence AAH70545.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050645 mRNA. Translation: AAL11445.1.
    BC070545 mRNA. Translation: AAH70545.1. Different initiation.
    RefSeqiNP_001082128.1. NM_001088659.1.
    UniGeneiXl.12101.

    Genome annotation databases

    GeneIDi398240.
    KEGGixla:398240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050645 mRNA. Translation: AAL11445.1 .
    BC070545 mRNA. Translation: AAH70545.1 . Different initiation.
    RefSeqi NP_001082128.1. NM_001088659.1.
    UniGenei Xl.12101.

    3D structure databases

    ProteinModelPortali Q90WW4.
    SMRi Q90WW4. Positions 56-123.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 398240.
    KEGGi xla:398240.

    Organism-specific databases

    CTDi 398240.
    Xenbasei XB-GENE-6251806. igf2.

    Phylogenomic databases

    HOVERGENi HBG006137.
    KOi K13769.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomi PD005188. IGF2_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neural and head induction by insulin-like growth factor signals."
      Pera E.M., Wessely O., Li S.-Y., De Robertis E.M.
      Dev. Cell 1:655-665(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LiverImported.

    Entry informationi

    Entry nameiIGF2A_XENLA
    AccessioniPrimary (citable) accession number: Q90WW4
    Secondary accession number(s): Q6NS08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3