Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q90WW4

- IGF2A_XENLA

UniProt

Q90WW4 - IGF2A_XENLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Insulin-like growth factor II-A

Gene

igf2-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development.1 PublicationCurated

GO - Molecular functioni

  1. growth factor activity Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. head morphogenesis Source: UniProtKB
  3. nervous system development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II-A
Short name:
IGF-II-A
Alternative name(s):
Insulin-like growth factor 2-A
Short name:
xIGF-2
Gene namesi
Name:igf2-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6251806. igf2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5656Sequence AnalysisAdd
BLAST
Chaini57 – 12367Insulin-like growth factor II-ASequence AnalysisPRO_0000224639Add
BLAST
Propeptidei124 – 21794E peptideSequence AnalysisPRO_0000224640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 103By similarity
Disulfide bondi76 ↔ 116By similarity
Disulfide bondi102 ↔ 107By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Expressed in the dorsal midline during gastrulation and neurulation.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ90WW4.
SMRiQ90WW4. Positions 56-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 8327BSequence AnalysisAdd
BLAST
Regioni84 – 9613CSequence AnalysisAdd
BLAST
Regioni97 – 11721ASequence AnalysisAdd
BLAST
Regioni118 – 1236DSequence Analysis

Sequence similaritiesi

Belongs to the insulin family.Sequence Analysis

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.
KOiK13769.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90WW4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQLSCKHRS SSVEAEAQLC RQTESRSTQL PRMSVMRHLF LLSITFLVYT
60 70 80 90 100
LDSAKAYRAT ETLCGGELVD TLQFVCGDRG FYFSTNNGRS NRRPNRGIVD
110 120 130 140 150
VCCFKSCDLE LLETYCAKPT KNERDVSTAP ATAIPPLSKQ DLYHKHHHTK
160 170 180 190 200
SSKYDIWQRK SIHRLRRGVP AIVRARQYRL LMEKAEEAEQ ALSHRPLTTL
210
PITRPLRLQQ ASEPSHN
Length:217
Mass (Da):24,874
Last modified:December 1, 2001 - v1
Checksum:iE1D290F8458BBA7A
GO

Sequence cautioni

The sequence AAH70545.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050645 mRNA. Translation: AAL11445.1.
BC070545 mRNA. Translation: AAH70545.1. Different initiation.
RefSeqiNP_001082128.1. NM_001088659.1.
UniGeneiXl.12101.

Genome annotation databases

GeneIDi398240.
KEGGixla:398240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050645 mRNA. Translation: AAL11445.1 .
BC070545 mRNA. Translation: AAH70545.1 . Different initiation.
RefSeqi NP_001082128.1. NM_001088659.1.
UniGenei Xl.12101.

3D structure databases

ProteinModelPortali Q90WW4.
SMRi Q90WW4. Positions 56-123.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 398240.
KEGGi xla:398240.

Organism-specific databases

CTDi 398240.
Xenbasei XB-GENE-6251806. igf2.

Phylogenomic databases

HOVERGENi HBG006137.
KOi K13769.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomi PD005188. IGF2_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Neural and head induction by insulin-like growth factor signals."
    Pera E.M., Wessely O., Li S.-Y., De Robertis E.M.
    Dev. Cell 1:655-665(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LiverImported.

Entry informationi

Entry nameiIGF2A_XENLA
AccessioniPrimary (citable) accession number: Q90WW4
Secondary accession number(s): Q6NS08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3