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Protein

Insulin-like growth factor-binding protein 5

Gene

igfbp5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes anterior neural development by stimulating insulin growth factor (IGF) signaling via IGF receptors.Curated1 Publication

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: UniProtKB
  • insulin-like growth factor receptor signaling pathway Source: UniProtKB
  • nervous system development Source: UniProtKB
  • regulation of cell growth Source: InterPro

Keywordsi

Molecular functionDevelopmental protein, Growth factor binding

Protein family/group databases

MEROPSiI31.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Short name:
xIGFBP-5
Gene namesi
Name:igfbp5Imported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-485077. igfbp5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000022389422 – 265Insulin-like growth factor-binding protein 5Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 60PROSITE-ProRule annotation
Disulfide bondi68 ↔ 81PROSITE-ProRule annotation
Disulfide bondi185 ↔ 212PROSITE-ProRule annotationBy similarity
Disulfide bondi223 ↔ 234PROSITE-ProRule annotationBy similarity
Disulfide bondi236 ↔ 256PROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Expressed on the dorsal side during gastrulation. Becomes confined to the floor plate, notochord and dorsal endoderm during neurulation. Expressed in additional domains at the tailbud stage in cranial nerves, ear vesicle, dorsal fin and somites. Dorsal midline expression becomes restricted to the floor plate and hypochord.1 Publication

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ90WV8.
SMRiQ90WV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 104IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini182 – 256Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002631.

Family and domain databases

CDDicd00191. TY. 1 hit.
Gene3Di4.10.800.10. 1 hit.
InterProiView protein in InterPro
IPR009030. Growth_fac_rcpt_cys_sf.
IPR012213. IGFBP-5.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
IPR036857. Thyroglobulin_1_sf.
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF4. PTHR11551:SF4. 1 hit.
PfamiView protein in Pfam
PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
PRINTSiPR01976. IGFBPFAMILY.
PR01981. IGFBPFAMILY5.
SMARTiView protein in SMART
SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiView protein in PROSITE
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90WV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLLPMCLL LVSLCLGQCQ ALGSFVHCEP CDDKAMSMCP PTPVGCELVK
60 70 80 90 100
EPGCGCCMTC ALAEGHRCGV YTEHCAKGLR CLPEQGEEKP LHALLHGRGV
110 120 130 140 150
CLNLKNHRDQ SKIDRESREE DPTTSETEDI YQSKHRGKMR LSDQKAIALN
160 170 180 190 200
TFRQKKHSQS RIVSVEKVQS PSTPEHSIEI DMGPCRRQVE TLMQEMKLSH
210 220 230 240 250
RVYPRAFYLP NCDRKGFYKR KQCKPSRGRK RGLCWCVDKY GLKLPGIDYV
260
NGDLQCHSFD SSNTE
Length:265
Mass (Da):29,995
Last modified:December 1, 2001 - v1
Checksum:iE0B943382778A8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052629 mRNA. Translation: AAL12250.1.
RefSeqiNP_001083938.1. NM_001090469.1.
XP_018089692.1. XM_018234203.1.
UniGeneiXl.5266.

Genome annotation databases

GeneIDi399201.
KEGGixla:399201.

Similar proteinsi

Entry informationi

Entry nameiIBP5_XENLA
AccessioniPrimary (citable) accession number: Q90WV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 1, 2001
Last modified: December 20, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program