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Protein

Actin-related protein 3

Gene

ACTR3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-GGA-3928662. EPHB-mediated forward signaling.
R-GGA-5663213. RHO GTPases Activate WASPs and WAVEs.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 3
Alternative name(s):
Actin-like protein 3
Gene namesi
Name:ACTR3
Synonyms:ARP3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell projection By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 418417Actin-related protein 3PRO_0000342357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ90WD0.
PRIDEiQ90WD0.

Expressioni

Tissue specificityi

Detected in fibroblasts.1 Publication

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019832.

Structurei

3D structure databases

ProteinModelPortaliQ90WD0.
SMRiQ90WD0. Positions 3-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP3 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0678. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00550000074695.
HOGENOMiHOG000233339.
HOVERGENiHBG003771.
InParanoidiQ90WD0.
KOiK18584.
OMAiKMQRYAV.
OrthoDBiEOG7TMZRM.
PhylomeDBiQ90WD0.
TreeFamiTF300644.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR015623. Arp3_met.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF253. PTHR11937:SF253. 1 hit.
PfamiPF00022. Actin. 2 hits.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90WD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRLPACVV DCGTGYTKLG YAGNTEPQFI IPSCIAIKES AKVVDQAQRR
60 70 80 90 100
VLKGVDDLDF FIGDEAIEKP TYATKWPIRH GIVEDWDLME RFMEQVIFKY
110 120 130 140 150
LRAEPEDHYF LLTEPPLNTP ENREYTAEIM FESFNVPGLY IAVQAVLALA
160 170 180 190 200
ASWTSRQVGE RTLTGTVIDS GDGVTHVIPV AEGYVIGSCI KHIPIAGRDI
210 220 230 240 250
TYFIQQLLRE REVGIPPEQS LETAKAVKER FSYVCPDLVK EFNKYDTDGT
260 270 280 290 300
KWIKQYTGIN AISKKEFTID VGYERFLGPE IFFHPEFANP DFTQPISEVV
310 320 330 340 350
DEVIQNCPID VRRPLYKNIV LSGGSTMFRD FGRRLQRDLK RTVDARLKLS
360 370 380 390 400
EELSGGRLKP KPIDVQVITH HMQRYAVWFG GSMLASTPEF YQVCHTKKDY
410
EEIGPSICRH NPVFGVMS
Length:418
Mass (Da):47,421
Last modified:December 1, 2001 - v1
Checksum:i832BDBB14FCAFED7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288600 mRNA. Translation: AAK83060.1.
RefSeqiNP_989638.1. NM_204307.1.
UniGeneiGga.4076.

Genome annotation databases

EnsembliENSGALT00000019859; ENSGALP00000019832; ENSGALG00000012159.
GeneIDi374197.
KEGGigga:374197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288600 mRNA. Translation: AAK83060.1.
RefSeqiNP_989638.1. NM_204307.1.
UniGeneiGga.4076.

3D structure databases

ProteinModelPortaliQ90WD0.
SMRiQ90WD0. Positions 3-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019832.

Proteomic databases

PaxDbiQ90WD0.
PRIDEiQ90WD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000019859; ENSGALP00000019832; ENSGALG00000012159.
GeneIDi374197.
KEGGigga:374197.

Organism-specific databases

CTDi10096.

Phylogenomic databases

eggNOGiKOG0678. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00550000074695.
HOGENOMiHOG000233339.
HOVERGENiHBG003771.
InParanoidiQ90WD0.
KOiK18584.
OMAiKMQRYAV.
OrthoDBiEOG7TMZRM.
PhylomeDBiQ90WD0.
TreeFamiTF300644.

Enzyme and pathway databases

ReactomeiR-GGA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-GGA-3928662. EPHB-mediated forward signaling.
R-GGA-5663213. RHO GTPases Activate WASPs and WAVEs.

Miscellaneous databases

PROiQ90WD0.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR015623. Arp3_met.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF253. PTHR11937:SF253. 1 hit.
PfamiPF00022. Actin. 2 hits.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2/3 complex in the protrusions of fibroblasts."
    Mingle L.A., Okuhama N.N., Shi J., Singer R.H., Condeelis J., Liu G.
    J. Cell Sci. 118:2425-2433(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiARP3_CHICK
AccessioniPrimary (citable) accession number: Q90WD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.