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Q90W88

- BRK1C_BOMMX

UniProt

Q90W88 - BRK1C_BOMMX

Protein

Kininogen-1c

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Potent vasodilator. Binds B1 (BDKRB1) and B2 (BDKRB2) bradykinin receptors.

    GO - Biological processi

    1. defense response Source: UniProtKB-KW
    2. vasodilation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Amphibian defense peptide, Bradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kininogen-1c
    Alternative name(s):
    BMK-1
    Cleaved into the following 2 chains:
    Alternative name(s):
    Bombinakinin M
    OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
    Taxonomic identifieri161274 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 152129Kininogen-1cPRO_0000003416Add
    BLAST
    Peptidei41 – 5919Maximakinin1 PublicationPRO_0000003417Add
    BLAST
    Peptidei51 – 599Bradykinin1 PublicationPRO_0000003418
    Peptidei69 – 8719Maximakinin1 PublicationPRO_0000003419Add
    BLAST
    Peptidei79 – 879Bradykinin1 PublicationPRO_0000003420
    Peptidei97 – 11519Maximakinin1 PublicationPRO_0000003421Add
    BLAST
    Peptidei107 – 1159Bradykinin1 PublicationPRO_0000003422
    Peptidei125 – 14319Maximakinin1 PublicationPRO_0000003423Add
    BLAST
    Peptidei135 – 1439Bradykinin1 PublicationPRO_0000003424

    Expressioni

    Tissue specificityi

    Expressed by the skin glands.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bradykinin-related peptide family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG031664.

    Family and domain databases

    InterProiIPR009608. Bradykinin.
    [Graphical view]
    PfamiPF06753. Bradykinin. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90W88-1 [UniParc]FASTAAdd to Basket

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    MRLWFCLSLF IVLCLEHFPG TLADERNVPE SEEKTEQFLR DLPKINRKGP    50
    RPPGFSPFRG KFHSQTLRDL PKINRKGPRP PGFSPFRGKF HSQTLRDLPK 100
    INRKGPRPPG FSPFRGKFHS QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS 150
    HV 152
    Length:152
    Mass (Da):17,604
    Last modified:November 21, 2003 - v2
    Checksum:iB58B31389D837686
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315488 mRNA. Translation: CAC48026.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315488 mRNA. Translation: CAC48026.2 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG031664.

    Family and domain databases

    InterProi IPR009608. Bradykinin.
    [Graphical view ]
    Pfami PF06753. Bradykinin. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of maximakinin precursor cDNAs from Chinese toad, Bombina maxima, venom."
      Chen T., Bjourson A.J., McClean S., Orr D.F., O'Kane E.J., Rao P., Shaw C.
      Peptides 24:853-861(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF MAXIMAKININ, SYNTHESIS OF MAXIMAKININ.
      Tissue: Skin secretion.

    Entry informationi

    Entry nameiBRK1C_BOMMX
    AccessioniPrimary (citable) accession number: Q90W88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: November 21, 2003
    Last modified: October 1, 2014
    This is version 42 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3