Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q90W88 (BRK1C_BOMMX) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kininogen-1c
Alternative name(s):
BMK-1

Cleaved into the following 2 chains:

  1. Maximakinin
    Alternative name(s):
    Bombinakinin M
  2. Bradykinin
OrganismBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifier161274 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Protein attributes

Sequence length152 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potent vasodilator. Binds B1 (BDKRB1) and B2 (BDKRB2) bradykinin receptors.

Subcellular location

Secreted.

Tissue specificity

Expressed by the skin glands.

Sequence similarities

Belongs to the bradykinin-related peptide family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 152129Kininogen-1c
PRO_0000003416
Peptide41 – 5919Maximakinin
PRO_0000003417
Peptide51 – 599Bradykinin
PRO_0000003418
Peptide69 – 8719Maximakinin
PRO_0000003419
Peptide79 – 879Bradykinin
PRO_0000003420
Peptide97 – 11519Maximakinin
PRO_0000003421
Peptide107 – 1159Bradykinin
PRO_0000003422
Peptide125 – 14319Maximakinin
PRO_0000003423
Peptide135 – 1439Bradykinin
PRO_0000003424

Sequences

Sequence LengthMass (Da)Tools
Q90W88 [UniParc].

Last modified November 21, 2003. Version 2.
Checksum: B58B31389D837686

FASTA15217,604
        10         20         30         40         50         60 
MRLWFCLSLF IVLCLEHFPG TLADERNVPE SEEKTEQFLR DLPKINRKGP RPPGFSPFRG 

        70         80         90        100        110        120 
KFHSQTLRDL PKINRKGPRP PGFSPFRGKF HSQTLRDLPK INRKGPRPPG FSPFRGKFHS 

       130        140        150 
QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS HV 

« Hide

References

[1]"Cloning of maximakinin precursor cDNAs from Chinese toad, Bombina maxima, venom."
Chen T., Bjourson A.J., McClean S., Orr D.F., O'Kane E.J., Rao P., Shaw C.
Peptides 24:853-861(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF MAXIMAKININ, SYNTHESIS OF MAXIMAKININ.
Tissue: Skin secretion.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ315488 mRNA. Translation: CAC48026.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG031664.

Family and domain databases

InterProIPR009608. Bradykinin.
[Graphical view]
PfamPF06753. Bradykinin. 4 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBRK1C_BOMMX
AccessionPrimary (citable) accession number: Q90W88
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 21, 2003
Last modified: November 13, 2013
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families