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Protein

Kininogen-1c

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potent vasodilator. Binds B1 (BDKRB1) and B2 (BDKRB2) bradykinin receptors.

GO - Biological processi

  1. defense response Source: UniProtKB-KW
  2. vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Bradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-1c
Alternative name(s):
BMK-1
Cleaved into the following 2 chains:
Alternative name(s):
Bombinakinin M
OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifieri161274 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 152129Kininogen-1cPRO_0000003416Add
BLAST
Peptidei41 – 5919Maximakinin1 PublicationPRO_0000003417Add
BLAST
Peptidei51 – 599Bradykinin1 PublicationPRO_0000003418
Peptidei69 – 8719Maximakinin1 PublicationPRO_0000003419Add
BLAST
Peptidei79 – 879Bradykinin1 PublicationPRO_0000003420
Peptidei97 – 11519Maximakinin1 PublicationPRO_0000003421Add
BLAST
Peptidei107 – 1159Bradykinin1 PublicationPRO_0000003422
Peptidei125 – 14319Maximakinin1 PublicationPRO_0000003423Add
BLAST
Peptidei135 – 1439Bradykinin1 PublicationPRO_0000003424

Expressioni

Tissue specificityi

Expressed by the skin glands.

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90W88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLWFCLSLF IVLCLEHFPG TLADERNVPE SEEKTEQFLR DLPKINRKGP
60 70 80 90 100
RPPGFSPFRG KFHSQTLRDL PKINRKGPRP PGFSPFRGKF HSQTLRDLPK
110 120 130 140 150
INRKGPRPPG FSPFRGKFHS QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS

HV
Length:152
Mass (Da):17,604
Last modified:November 21, 2003 - v2
Checksum:iB58B31389D837686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315488 mRNA. Translation: CAC48026.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315488 mRNA. Translation: CAC48026.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of maximakinin precursor cDNAs from Chinese toad, Bombina maxima, venom."
    Chen T., Bjourson A.J., McClean S., Orr D.F., O'Kane E.J., Rao P., Shaw C.
    Peptides 24:853-861(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF MAXIMAKININ, SYNTHESIS OF MAXIMAKININ.
    Tissue: Skin secretion.

Entry informationi

Entry nameiBRK1C_BOMMX
AccessioniPrimary (citable) accession number: Q90W88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 21, 2003
Last modified: January 7, 2015
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.