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Q90W58

- DUS1B_XENLA

UniProt

Q90W58 - DUS1B_XENLA

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Protein

Dual specificity protein phosphatase 1-B

Gene

dusp1-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-188' and 'Tyr-190', regulating its activity during the meiotic cell cycle.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarityPROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei260 – 2601Phosphocysteine intermediateBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: UniProtKB
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. inactivation of MAPK activity Source: UniProtKB
  2. meiotic nuclear division Source: UniProtKB-KW
  3. mitotic cell cycle arrest Source: UniProtKB
  4. negative regulation of MAPK cascade Source: UniProtKB
  5. negative regulation of meiotic cell cycle Source: UniProtKB
  6. peptidyl-threonine dephosphorylation Source: UniProtKB
  7. peptidyl-tyrosine dephosphorylation Source: UniProtKB
  8. regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 1-BBy similarity (EC:3.1.3.16By similarity, EC:3.1.3.48By similarity)
Alternative name(s):
XCL100-beta1 Publication
Gene namesi
Name:dusp1-bBy similarity
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Dual specificity protein phosphatase 1-BPRO_0000421474Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei168 – 1681Phosphothreonine; by MAPK1By similarity

Post-translational modificationi

Phosphorylated by MAPK1/ERK2 at Thr-168 and at one or more serine residues in a progesterone-dependent manner. Phosphorylation reduces its rate of degradation but does not seem to affect phosphatase activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ90W58.
SMRiQ90W58. Positions 173-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 138118RhodanesePROSITE-ProRule annotationAdd
BLAST
Domaini175 – 369195Tyrosine-protein phosphataseCuratedSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.Sequence Analysis

Phylogenomic databases

HOVERGENiHBG007347.
KOiK04459.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSiPR01908. ADSPHPHTASE.
PR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90W58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNMEICAMD CCVFKGLLAE RAHKCLILDC RSFFAFSSSS IIGSSNVRLS
60 70 80 90 100
TIVKRRAKGS MGLEHIIPNE EQRGRLVAGM YEAVVLLDER TSELDMLRKD
110 120 130 140 150
STMMLAVNAL SRDPRGSRIY FLKGGYETFS SQCPEFCNKN SPPVALSLPL
160 170 180 190 200
SPNNVPGSAD SNCTPCGTPL YDQGGPVEIL PFLYLGSAYH ASRKDMLEAL
210 220 230 240 250
GITALINVSA NCPNHFEGHF QYKSIPVEDS HKADISSWFN EAIDFIDSIK
260 270 280 290 300
TCGGRVFVHC QAGISRSATI CLAYLMRTNR VKLDEAFEFV KQRRSIISPN
310 320 330 340 350
FSFMGQLLQF ESQVLAPSCS AEAGSPTISV LDRGTSTTTV FNFPVSIPVH
360
SGANSLSYLQ NPITTSPSC
Length:369
Mass (Da):40,363
Last modified:December 1, 2001 - v1
Checksum:i5E280CA6EF633CC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320159 mRNA. Translation: CAC44127.1.
RefSeqiNP_001082153.1. NM_001088684.1.
UniGeneiXl.2803.

Genome annotation databases

GeneIDi398254.
KEGGixla:398254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320159 mRNA. Translation: CAC44127.1 .
RefSeqi NP_001082153.1. NM_001088684.1.
UniGenei Xl.2803.

3D structure databases

ProteinModelPortali Q90W58.
SMRi Q90W58. Positions 173-315.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 398254.
KEGGi xla:398254.

Organism-specific databases

CTDi 398254.

Phylogenomic databases

HOVERGENi HBG007347.
KOi K04459.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
PRINTSi PR01908. ADSPHPHTASE.
PR01764. MAPKPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes."
    Sohaskey M.L., Ferrell J.E. Jr.
    Mol. Biol. Cell 13:454-468(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: OvaryImported.

Entry informationi

Entry nameiDUS1B_XENLA
AccessioniPrimary (citable) accession number: Q90W58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: December 1, 2001
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3