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Q90W58 (DUS1B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 1-B

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
XCL100-beta
Gene names
Name:dusp1-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-188' and 'Tyr-190', regulating its activity during the meiotic cell cycle By similarity. UniProtKB Q91790

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. UniProtKB Q91790

Subcellular location

Nucleus By similarity UniProtKB Q91790.

Post-translational modification

Phosphorylated by MAPK1/ERK2 at Thr-168 and at one or more serine residues in a progesterone-dependent manner. Phosphorylation reduces its rate of degradation but does not seem to affect phosphatase activity By similarity. UniProtKB Q91790

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 rhodanese domain.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Dual specificity protein phosphatase 1-B
PRO_0000421474

Regions

Domain21 – 138118Rhodanese
Domain175 – 369195Tyrosine-protein phosphatase

Sites

Active site2601Phosphocysteine intermediate By similarity UniProtKB Q91790

Amino acid modifications

Modified residue1681Phosphothreonine; by MAPK1 By similarity UniProtKB Q91790

Sequences

Sequence LengthMass (Da)Tools
Q90W58 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5E280CA6EF633CC6

FASTA36940,363
        10         20         30         40         50         60 
MVNMEICAMD CCVFKGLLAE RAHKCLILDC RSFFAFSSSS IIGSSNVRLS TIVKRRAKGS 

        70         80         90        100        110        120 
MGLEHIIPNE EQRGRLVAGM YEAVVLLDER TSELDMLRKD STMMLAVNAL SRDPRGSRIY 

       130        140        150        160        170        180 
FLKGGYETFS SQCPEFCNKN SPPVALSLPL SPNNVPGSAD SNCTPCGTPL YDQGGPVEIL 

       190        200        210        220        230        240 
PFLYLGSAYH ASRKDMLEAL GITALINVSA NCPNHFEGHF QYKSIPVEDS HKADISSWFN 

       250        260        270        280        290        300 
EAIDFIDSIK TCGGRVFVHC QAGISRSATI CLAYLMRTNR VKLDEAFEFV KQRRSIISPN 

       310        320        330        340        350        360 
FSFMGQLLQF ESQVLAPSCS AEAGSPTISV LDRGTSTTTV FNFPVSIPVH SGANSLSYLQ 


NPITTSPSC 

« Hide

References

[1]"Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes."
Sohaskey M.L., Ferrell J.E. Jr.
Mol. Biol. Cell 13:454-468(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ320159 mRNA. Translation: CAC44127.1.
RefSeqNP_001082153.1. NM_001088684.1.
UniGeneXl.2803.

3D structure databases

ProteinModelPortalQ90W58.
SMRQ90W58. Positions 173-315.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID398254.
KEGGxla:398254.

Organism-specific databases

CTD398254.

Phylogenomic databases

HOVERGENHBG007347.
KOK04459.

Family and domain databases

Gene3D3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PIRSFPIRSF000939. MAPK_Ptase. 1 hit.
PRINTSPR01908. ADSPHPHTASE.
PR01764. MAPKPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUS1B_XENLA
AccessionPrimary (citable) accession number: Q90W58
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families