Reviewed, UniProtKB/Swiss-Prot Q90VZ9 (HXA7_CHICK)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A7

Gene names

Name:	HOXA7
Synonyms:	HOXA-7

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Homeobox protein Hox-A7		PRO_0000200075
Regions
	DNA binding	129 – 188	60	Homeobox
	Motif	118 – 123	6	Antp-type hexapeptide
	Compositional bias	212 – 219	8	Asp/Glu-rich (highly acidic)

Sequences

	Sequence		Length	Mass (Da)
	Q90VZ9-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 4BAE9046D52C0705	FASTA	219	24,953
	10 20 30 40 50 60 MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FASNSQRSGY GPGAGAFASS MPGLYNVNST 70 80 90 100 110 120 IYQSPFSSGY SLGSDAYNLH CSSFDQNIPV LCNDLTKPSC EKAEESNLHN QAEANFRIYP 130 140 150 160 170 180 WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF NRYLTRRRRI EIAHALCLTE RQIKIWFQNR 190 200 210 RMKWKKEHKE ESSSTPAPNE PTSAAASVEK VEEDEEEED

References

[1]	"Gradients and forward spreading of vertebrate Hox gene expression detected using a Hox/lacZ transgene." Gaunt S.J. Dev. Dyn. 221:26-36(2001) [PubMed: 11357191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Expression and regulation of HOXA5, HOXA6 and HOXA7 during chick wing development." Oberg K.C., Pira C.U., Creamer D.H., Revelli J.-P., Eichele G. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ291729 Genomic DNA. Translation: CAC37629.1. AF408695 mRNA. Translation: AAL01899.1.
IPI	IPI00573429.
RefSeq	NP_989926.1.
UniGene	Gga.5122
3D structure databases
SMR	Q90VZ9. Positions 129-189.
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALT00000018013; ENSGALP00000017991; ENSGALG00000011061; Gallus gallus. [Genome view]
GeneID	395290.
KEGG	gga:395290.
Organism-specific databases
CTD	395290.
Phylogenomic databases
HOGENOM	HBG715745.
HOVERGEN	Q90VZ9.
InParanoid	Q90VZ9.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA7_CHICK

Accession

Primary (citable) accession number: Q90VZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	December 1, 2001
Last modified:	December 15, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)