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Protein

Erabutoxin b

Gene
N/A
Organism
Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda semifasciata)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Erabutoxin b
Short name:
ETXB
Alternative name(s):
Short neurotoxin 1b
OrganismiLaticauda semifasciata (Black-banded sea krait) (Pseudolaticauda semifasciata)
Taxonomic identifieri8631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeLaticaudinaeLaticauda

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.15 mg/kg by intramuscular injection.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000003544722 – 83Erabutoxin bAdd BLAST62

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 45
Disulfide bondi38 ↔ 62
Disulfide bondi64 ↔ 75
Disulfide bondi76 ↔ 81

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

Secondary structure

183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 25Combined sources3
Beta strandi29 – 31Combined sources3
Beta strandi35 – 37Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 63Combined sources9
Beta strandi73 – 76Combined sources4
Turni79 – 82Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ERANMR-A22-83[»]
1FRANMR-A22-83[»]
1NXBX-ray1.38A22-83[»]
3EBXX-ray1.40A22-83[»]
6EBXX-ray1.70A/B22-83[»]
ProteinModelPortaliQ90VW1.
SMRiQ90VW1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ90VW1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

CDDicd00206. snake_toxin. 1 hit.
InterProiIPR003571. Snake_3FTx.
IPR018354. Snake_toxin_con_site.
[Graphical view]
PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90VW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLLLTLVV VTIVCLDLGY TRICFNHQSS QPQTTKTCSP GESSCYHKQW
60 70 80
SDFRGTIIER GCGCPTVKPG IKLSCCESEV CNN
Length:83
Mass (Da):9,160
Last modified:December 1, 2001 - v1
Checksum:iBBB499DA36BE50E4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti80V → R May be a real difference between the Philippine and Japanese populations. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16950 mRNA. Translation: CAA34824.1.
AB017929 mRNA. Translation: BAA75749.1.
AB017930 mRNA. Translation: BAA75750.1.
AB017931 mRNA. Translation: BAA75751.1.
AB098528 Genomic DNA. Translation: BAC78201.1.
AB098529 Genomic DNA. Translation: BAC78202.1.
PIRiS06931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16950 mRNA. Translation: CAA34824.1.
AB017929 mRNA. Translation: BAA75749.1.
AB017930 mRNA. Translation: BAA75750.1.
AB017931 mRNA. Translation: BAA75751.1.
AB098528 Genomic DNA. Translation: BAC78201.1.
AB098529 Genomic DNA. Translation: BAC78202.1.
PIRiS06931.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ERANMR-A22-83[»]
1FRANMR-A22-83[»]
1NXBX-ray1.38A22-83[»]
3EBXX-ray1.40A22-83[»]
6EBXX-ray1.70A/B22-83[»]
ProteinModelPortaliQ90VW1.
SMRiQ90VW1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006553.

Miscellaneous databases

EvolutionaryTraceiQ90VW1.

Family and domain databases

CDDicd00206. snake_toxin. 1 hit.
InterProiIPR003571. Snake_3FTx.
IPR018354. Snake_toxin_con_site.
[Graphical view]
PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei3S1EB_LATSE
AccessioniPrimary (citable) accession number: Q90VW1
Secondary accession number(s): P01435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.