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Protein
Submitted name:

Insulin-like growth factor 1

Gene

igf1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • insulin-like growth factor receptor binding Source: ZFIN

GO - Biological processi

  • dorsal/ventral pattern formation Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-DRE-2428928. IRS-related events triggered by IGF1R.
R-DRE-2428933. SHC-related events triggered by IGF1R.
R-DRE-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor 1Imported
Submitted name:
Insulin-like growth factor 1bImported
Submitted name:
Insulin-like growth factor ILImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:igf1Imported
Synonyms:IGF-1Imported, IGF-1LImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-010607-2. igf1.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

  • extracellular region Source: ZFIN
  • extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_500878521645 – 161Sequence analysisAdd BLAST117

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000094132.

Interactioni

GO - Molecular functioni

  • insulin-like growth factor receptor binding Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017449.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 105IlGFInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
KOiK05459.
OMAiCFQSCEL.
OrthoDBiEOG091G0H56.
TreeFamiTF332820.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90VV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGHFFQGH WCDVFKCTMR CLPSTHTLSL VLCVLALTPA TLEAGPETLC
60 70 80 90 100
GAELVDTLQF VCGDRGFYFS KPTGYGPSSR RSHNRGIVDE CCFQSCELRR
110 120 130 140 150
LEMYCAPVKT GKSPRSLRAQ RHTDIPRTPK KPISGHSHSS CKEVHQKNSS
160
RGNTGGRNYR M
Length:161
Mass (Da):17,926
Last modified:December 1, 2001 - v1
Checksum:iC97DE0B1FF24E0CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510924 Genomic DNA. No translation available.
BC114262 mRNA. Translation: AAI14263.1.
AF268051 mRNA. Translation: AAK58584.1.
AH010825, AF270703 Genomic DNA. Translation: AAK58609.1.
AF314545 mRNA. Translation: AAL26846.1.
RefSeqiNP_571900.1. NM_131825.2.
UniGeneiDr.82556.

Genome annotation databases

EnsembliENSDART00000004717; ENSDARP00000017449; ENSDARG00000094132.
GeneIDi114433.
KEGGidre:114433.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510924 Genomic DNA. No translation available.
BC114262 mRNA. Translation: AAI14263.1.
AF268051 mRNA. Translation: AAK58584.1.
AH010825, AF270703 Genomic DNA. Translation: AAK58609.1.
AF314545 mRNA. Translation: AAL26846.1.
RefSeqiNP_571900.1. NM_131825.2.
UniGeneiDr.82556.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017449.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000004717; ENSDARP00000017449; ENSDARG00000094132.
GeneIDi114433.
KEGGidre:114433.

Organism-specific databases

CTDi3479.
ZFINiZDB-GENE-010607-2. igf1.

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
KOiK05459.
OMAiCFQSCEL.
OrthoDBiEOG091G0H56.
TreeFamiTF332820.

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-DRE-2428928. IRS-related events triggered by IGF1R.
R-DRE-2428933. SHC-related events triggered by IGF1R.
R-DRE-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Gene expression databases

BgeeiENSDARG00000094132.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ90VV9_DANRE
AccessioniPrimary (citable) accession number: Q90VV9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.