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Protein
Submitted name:

Insulin-like growth factor 1

Gene

igf1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • dorsal/ventral pattern formation Source: ZFIN

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-2404192. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
R-DRE-2428928. IRS-related events triggered by IGF1R.
R-DRE-2428933. SHC-related events triggered by IGF1R.
R-DRE-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor 1Imported
Submitted name:
Insulin-like growth factor 1bImported
Submitted name:
Insulin-like growth factor ILImported
Gene namesi
Name:igf1Imported
Synonyms:IGF-1Imported, IGF-1LImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-010607-2. igf1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_501121227545 – 161Sequence analysisAdd BLAST117

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000094132.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017449.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 105IlGFInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
OMAiCFQSCDL.
OrthoDBiEOG091G0H56.
TreeFamiTF332820.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR036438. Insulin-like_sf.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
PfamiView protein in Pfam
PF00049. Insulin. 2 hits.
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q90VV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGHFFQGH WCDVFKCTMR CLPSTHTLSL VLCVLALTPA TLEAGPETLC
60 70 80 90 100
GAELVDTLQF VCGDRGFYFS KPTGYGPSSR RSHNRGIVDE CCFQSCELRR
110 120 130 140 150
LEMYCAPVKT GKSPRSLRAQ RHTDIPRTPK KPISGHSHSS CKEVHQKNSS
160
RGNTGGRNYR M
Length:161
Mass (Da):17,926
Last modified:December 1, 2001 - v1
Checksum:iC97DE0B1FF24E0CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510924 Genomic DNA. No translation available.
BC114262 mRNA. Translation: AAI14263.1.
AF268051 mRNA. Translation: AAK58584.1.
AH010825, AF270703 Genomic DNA. Translation: AAK58609.1.
AF314545 mRNA. Translation: AAL26846.1.
RefSeqiNP_571900.1. NM_131825.2.
UniGeneiDr.82556.

Genome annotation databases

EnsembliENSDART00000004717; ENSDARP00000017449; ENSDARG00000094132.
GeneIDi114433.

Similar proteinsi

Entry informationi

Entry nameiQ90VV9_DANRE
AccessioniPrimary (citable) accession number: Q90VV9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported