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Protein
Submitted name:

Insulin-like growth factor 1

Gene

igf1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • dorsal/ventral pattern formation Source: ZFIN

Enzyme and pathway databases

ReactomeiR-DRE-114608 Platelet degranulation
R-DRE-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-DRE-2428928 IRS-related events triggered by IGF1R
R-DRE-2428933 SHC-related events triggered by IGF1R
R-DRE-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor 1Imported
Submitted name:
Insulin-like growth factor 1bImported
Submitted name:
Insulin-like growth factor ILImported
Gene namesi
Name:igf1Imported
Synonyms:IGF-1Imported, IGF-1LImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-010607-2 igf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_501410767845 – 161Sequence analysisAdd BLAST117

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000094132

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017449

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 105IlGFInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T Eukaryota
ENOG4111MIV LUCA
GeneTreeiENSGT00530000063856
HOGENOMiHOG000233362
HOVERGENiHBG006137
KOiK05459
OMAiCFQSCDL
OrthoDBiEOG091G0H56
TreeFamiTF332820

Family and domain databases

InterProiView protein in InterPro
IPR022341 IGF-I
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 2 hits
PRINTSiPR02002 INSLNLIKEGF
PR02005 INSLNLIKEGF1
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q90VV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGHFFQGH WCDVFKCTMR CLPSTHTLSL VLCVLALTPA TLEAGPETLC
60 70 80 90 100
GAELVDTLQF VCGDRGFYFS KPTGYGPSSR RSHNRGIVDE CCFQSCELRR
110 120 130 140 150
LEMYCAPVKT GKSPRSLRAQ RHTDIPRTPK KPISGHSHSS CKEVHQKNSS
160
RGNTGGRNYR M
Length:161
Mass (Da):17,926
Last modified:December 1, 2001 - v1
Checksum:iC97DE0B1FF24E0CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX510924 Genomic DNA No translation available.
BC114262 mRNA Translation: AAI14263.1
AF268051 mRNA Translation: AAK58584.1
AH010825, AF270703 Genomic DNA Translation: AAK58609.1
AF314545 mRNA Translation: AAL26846.1
RefSeqiNP_571900.1, NM_131825.2
UniGeneiDr.82556

Genome annotation databases

EnsembliENSDART00000004717; ENSDARP00000017449; ENSDARG00000094132
GeneIDi114433
KEGGidre:114433

Similar proteinsi

Entry informationi

Entry nameiQ90VV9_DANRE
AccessioniPrimary (citable) accession number: Q90VV9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported