Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q90999 (TGFR2_CHICK)

Last modified November 3, 2009. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    TGF-beta receptor type-2
    EC=2.7.11.30
Alternative name(s):
    Transforming growth factor-beta receptor type II
      Short name=TGF-beta receptor type II
    TGF-beta type II receptor
    TbetaR-II
    TGFR-2
Gene names
Name: TGFBR2
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Hide | Top

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta By similarity.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Detected at low levels in embryonic heart, brain and lung. Detected at high levels in hatchling heart and lung. Ref.1

Post-translational modification

Phosphorylated on a Ser/Thr residue in the cytoplasmic domain By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 557534TGF-beta receptor type-2
PRO_5000142219

Regions

Topological domain24 – 155132Extracellular Potential
Transmembrane156 – 17621 Potential
Topological domain177 – 557381Extracellular Potential
Domain234 – 537304Protein kinase
Nucleotide binding240 – 2489ATP By similarity

Sites

Active site3691Proton acceptor By similarity
Binding site2671ATP By similarity

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 74 Ref.2
Disulfide bond44 ↔ 61 Ref.2
Disulfide bond51 ↔ 57 Ref.2
Disulfide bond67 ↔ 91 Ref.2
Disulfide bond111 ↔ 126 Ref.2
Disulfide bond128 ↔ 133 Ref.2

Secondary structure

1 ................. 557
Helix Strand Turn

Details...

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q90999-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0C578ABFAB357DF1

FASTA55763,308
        10         20         30         40         50         60 
MPPRLRPLLL RVSLWVLVGS SSPALLHDRS KENGLQLPRL CKFCDVKATT CSNQDQCKSN 

        70         80         90        100        110        120 
CNITSICEKN NEVCAAVWRR NDENVTLETI CHDPQKRLYG HMLDDSSSEQ CVMKEKKDDG 

       130        140        150        160        170        180 
GLMFMCSCTG EECNDVLIFS AIDPHKPEEK DEISKVTIIS LVPLLVISVA VIVIFYAYRT 

       190        200        210        220        230        240 
HKKRKLNKAW EKNVKPKKHK DCSDVCAIML DDDHSDISST CANNINHNTE LLPIELDIVV 

       250        260        270        280        290        300 
GKGRFAEVYK AKLKQNTSEQ YETVAVKIFP YEEYASWKTE KDIFSDVNLK HENILQFLTA 

       310        320        330        340        350        360 
EERKTDLGKQ YWLITAFHAR GNLQEYLTRH IISWEDLWKL GGSLARGIAH LHSDHTPCGR 

       370        380        390        400        410        420 
PKTPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPSLSV DDLANSGQVG TARYMAPEVL 

       430        440        450        460        470        480 
ESRMNLENME SFKQTDVYSM ALVLWEMTSR CNGVGEVKEY EPPFGSKVRE HPCVESMKDN 

       490        500        510        520        530        540 
VLRDRGRPEI PSSWLNHQGI QMVCETLIEC WDHDPEARLT AQCVAERFSE FKHHDKLSGR 

       550 
SCSEEKIPED GSVTTAK

« Hide

Hide | Top

References

[1]"Cloning and developmental expression of the chick type II and type III TGF beta receptors."
Barnett J.V., Moustakas A., Lin W., Wang X.-F., Lin H.Y., Galper J.B., Maas R.L.
Dev. Dyn. 199:12-27(1994) [PubMed: 8167376] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TGF-BETA, TISSUE SPECIFICITY.
Tissue: Embryonic brain.
[2]"Solution structure of the chick TGFbeta type II receptor ligand-binding domain."
Marlow M.S., Brown C.B., Barnett J.V., Krezel A.M.
J. Mol. Biol. 326:989-997(2003) [PubMed: 12589747] [Abstract]
Cited for: STRUCTURE BY NMR OF 36-142, DISULFIDE BONDS.

Hide | Top

Cross-references

Sequence databases

L18784 mRNA. Translation: AAA49091.1.
IPIIPI00595267.
PIRI50429.
RefSeqNP_990759.1.
UniGeneGga.2645

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1KS6NMR-A36-142[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGQ90999.

Genome annotation databases

EnsemblENSGALT00000018657; ENSGALP00000018634; ENSGALG00000011442; Gallus gallus. [Genome view]
GeneID396399.
KEGGgga:396399.

Organism-specific databases

CTD396399.

Phylogenomic databases

HOGENOMQ90999.
HOVERGENQ90999.
OMAMVTDNNG.

Family and domain databases

InterProIPR000333. Activin_II_recpt.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR015769. TGF-beta-2_rcpt_C.
IPR017194. Transform_growth_fac-b_typ-2.
IPR015013. Transforming_GF_b_rcpt_2_ecto.
[Graphical view]
PANTHERPTHR23255:SF11. TGF-beta_II_C. 1 hit.
PfamPF08917. ecTbetaR2. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF037393. TGFRII. 1 hit.
PRINTSPR00653. ACTIVIN2R.
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameTGFR2_CHICK
AccessionPrimary (citable) accession number: Q90999
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 1, 1996
Last modified: November 3, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Hide | Top

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents