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Protein

TGF-beta receptor type-2

Gene

TGFBR2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).By similarity1 Publication

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei267ATPPROSITE-ProRule annotation1
Active sitei369Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi240 – 248ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Differentiation, Growth regulation

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-2173788. Downregulation of TGF-beta receptor signaling.
R-GGA-2173789. TGF-beta receptor signaling activates SMADs.
R-GGA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

Names & Taxonomyi

Protein namesi
Recommended name:
TGF-beta receptor type-2 (EC:2.7.11.30)
Short name:
TGFR-2
Alternative name(s):
TGF-beta type II receptor
Transforming growth factor-beta receptor type II
Short name:
TGF-beta receptor type II
Short name:
TbetaR-II
Gene namesi
Name:TGFBR2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity
  • Membrane raft By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 155ExtracellularSequence analysisAdd BLAST132
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 557CytoplasmicSequence analysisAdd BLAST381

GO - Cellular componenti

  • caveola Source: AgBase
  • cell Source: AgBase
  • external side of plasma membrane Source: AgBase
  • extracellular matrix Source: AgBase
  • integral component of membrane Source: AgBase
  • membrane Source: AgBase
  • membrane raft Source: AgBase
  • plasma membrane Source: AgBase
  • receptor complex Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500014221924 – 557TGF-beta receptor type-2Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 741 Publication
Disulfide bondi44 ↔ 611 Publication
Disulfide bondi51 ↔ 571 Publication
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi67 ↔ 911 Publication
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 1261 Publication
Disulfide bondi128 ↔ 1331 Publication

Post-translational modificationi

Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ90999.

Expressioni

Tissue specificityi

Detected at low levels in embryonic heart, brain and lung. Detected at high levels in hatchling heart and lung.1 Publication

Gene expression databases

BgeeiENSGALG00000011442.

Interactioni

Subunit structurei

Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ90999. 1 interactor.
STRINGi9031.ENSGALP00000018634.

Structurei

Secondary structure

1557
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi44 – 48Combined sources5
Beta strandi69 – 71Combined sources3
Beta strandi74 – 81Combined sources8
Beta strandi84 – 90Combined sources7
Beta strandi106 – 110Combined sources5
Beta strandi114 – 116Combined sources3
Beta strandi119 – 132Combined sources14
Turni133 – 135Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KS6NMR-A36-142[»]
ProteinModelPortaliQ90999.
SMRiQ90999.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ90999.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 537Protein kinasePROSITE-ProRule annotationAdd BLAST304

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG104975.
InParanoidiQ90999.
KOiK04388.
OMAiTRHIISW.
OrthoDBiEOG091G03YO.
PhylomeDBiQ90999.
TreeFamiTF314724.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
IPR017194. Transform_growth_fac-b_typ-2.
IPR015013. Transforming_GF_b_rcpt_2_ecto.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF08917. ecTbetaR2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF037393. TGFRII. 1 hit.
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRLRPLLL RVSLWVLVGS SSPALLHDRS KENGLQLPRL CKFCDVKATT
60 70 80 90 100
CSNQDQCKSN CNITSICEKN NEVCAAVWRR NDENVTLETI CHDPQKRLYG
110 120 130 140 150
HMLDDSSSEQ CVMKEKKDDG GLMFMCSCTG EECNDVLIFS AIDPHKPEEK
160 170 180 190 200
DEISKVTIIS LVPLLVISVA VIVIFYAYRT HKKRKLNKAW EKNVKPKKHK
210 220 230 240 250
DCSDVCAIML DDDHSDISST CANNINHNTE LLPIELDIVV GKGRFAEVYK
260 270 280 290 300
AKLKQNTSEQ YETVAVKIFP YEEYASWKTE KDIFSDVNLK HENILQFLTA
310 320 330 340 350
EERKTDLGKQ YWLITAFHAR GNLQEYLTRH IISWEDLWKL GGSLARGIAH
360 370 380 390 400
LHSDHTPCGR PKTPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPSLSV
410 420 430 440 450
DDLANSGQVG TARYMAPEVL ESRMNLENME SFKQTDVYSM ALVLWEMTSR
460 470 480 490 500
CNGVGEVKEY EPPFGSKVRE HPCVESMKDN VLRDRGRPEI PSSWLNHQGI
510 520 530 540 550
QMVCETLIEC WDHDPEARLT AQCVAERFSE FKHHDKLSGR SCSEEKIPED

GSVTTAK
Length:557
Mass (Da):63,308
Last modified:November 1, 1996 - v1
Checksum:i0C578ABFAB357DF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18784 mRNA. Translation: AAA49091.1.
PIRiI50429.
RefSeqiNP_990759.1. NM_205428.1.
UniGeneiGga.2645.

Genome annotation databases

EnsembliENSGALT00000037691; ENSGALP00000036896; ENSGALG00000011442.
GeneIDi396399.
KEGGigga:396399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18784 mRNA. Translation: AAA49091.1.
PIRiI50429.
RefSeqiNP_990759.1. NM_205428.1.
UniGeneiGga.2645.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KS6NMR-A36-142[»]
ProteinModelPortaliQ90999.
SMRiQ90999.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ90999. 1 interactor.
STRINGi9031.ENSGALP00000018634.

Proteomic databases

PaxDbiQ90999.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000037691; ENSGALP00000036896; ENSGALG00000011442.
GeneIDi396399.
KEGGigga:396399.

Organism-specific databases

CTDi7048.

Phylogenomic databases

eggNOGiKOG3653. Eukaryota.
ENOG410XS2Z. LUCA.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG104975.
InParanoidiQ90999.
KOiK04388.
OMAiTRHIISW.
OrthoDBiEOG091G03YO.
PhylomeDBiQ90999.
TreeFamiTF314724.

Enzyme and pathway databases

ReactomeiR-GGA-2173788. Downregulation of TGF-beta receptor signaling.
R-GGA-2173789. TGF-beta receptor signaling activates SMADs.
R-GGA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

Miscellaneous databases

EvolutionaryTraceiQ90999.
PROiQ90999.

Gene expression databases

BgeeiENSGALG00000011442.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
IPR017194. Transform_growth_fac-b_typ-2.
IPR015013. Transforming_GF_b_rcpt_2_ecto.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF08917. ecTbetaR2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF037393. TGFRII. 1 hit.
PRINTSiPR00653. ACTIVIN2R.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGFR2_CHICK
AccessioniPrimary (citable) accession number: Q90999
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.