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Protein
Submitted name:

Transforming growth factor-beta type III receptor

Gene

TGFBR3

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • coreceptor activity Source: Ensembl
  • glycosaminoglycan binding Source: BHF-UCL
  • transforming growth factor beta binding Source: BHF-UCL
  • transforming growth factor beta receptor activity, type III Source: BHF-UCL

GO - Biological processi

  • cardiac epithelial to mesenchymal transition Source: BHF-UCL
  • cell migration Source: BHF-UCL
  • embryonic digestive tract development Source: AgBase
  • embryonic organ development Source: AgBase
  • endothelial cell activation Source: AgBase
  • epithelial to mesenchymal transition Source: BHF-UCL
  • eye development Source: AgBase
  • heart development Source: AgBase
  • heart morphogenesis Source: BHF-UCL
  • immune response Source: Ensembl
  • intracellular signal transduction Source: Ensembl
  • kidney development Source: AgBase
  • liver development Source: AgBase
  • lung development Source: AgBase
  • mesenchymal cell differentiation Source: AgBase
  • negative regulation of cell adhesion Source: AgBase
  • negative regulation of cell-cell adhesion Source: AgBase
  • negative regulation of cellular component movement Source: Ensembl
  • nervous system development Source: AgBase
  • pathway-restricted SMAD protein phosphorylation Source: Ensembl
  • positive regulation of cell migration Source: AgBase
  • positive regulation of gene expression Source: AgBase
  • response to follicle-stimulating hormone Source: Ensembl
  • response to luteinizing hormone Source: Ensembl
  • response to prostaglandin E Source: Ensembl
  • transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Transforming growth factor-beta type III receptorImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:TGFBR3Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 8

Subcellular locationi

  • Secreted SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei775 – 79925HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 841821Sequence analysisPRO_5007715456Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

  • transforming growth factor beta binding Source: BHF-UCL

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032713.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini446 – 723278ZPInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains ZP domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IK7K. Eukaryota.
ENOG410XSMK. LUCA.
GeneTreeiENSGT00530000063861.
HOGENOMiHOG000090193.
HOVERGENiHBG057515.
KOiK05843.
OMAiFAIQTCF.
OrthoDBiEOG72ZCDK.
TreeFamiTF337375.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSCVTPVF ALMILCFADA GPVPRSECVL SPVNSSHPVH ALLESFTVLS
60 70 80 90 100
GCASRGTTGL PQEVHVLNLR NPDEGLDHHE REVTLHLTPI SSVHIHQKPL
110 120 130 140 150
VFLLNSPLPL VWKLKTERLA PGIRRVFFVS SGSIVWFEKG NFSLSAETEE
160 170 180 190 200
KNFPERNEHL LQWAQKEYGA VTSFTELKIS RNIYIKVGED QVFPPTCNIE
210 220 230 240 250
KNFLSLNYLA GYLQPKRAEG CLMSNLVQER EVHIIELITP NSNPYSAFQV
260 270 280 290 300
DIIVDIKPSQ PGAKLERNVV LILKCKKSVN WVIKSHDVQG KLEVITSNSI
310 320 330 340 350
GFGKETERSM TMSKSVIPDI PSSHESLIKW AYEHKYSPVT SYTKAPVANR
360 370 380 390 400
FHLQLEHTEE MNDEEDHSLP PELTELLHGA KNPALSDGLT FPFHINRGGH
410 420 430 440 450
ETGGEGIFPS RDSVDTLINH DFEHSLSKHK EPEEVQGSAD VALSIKCDDK
460 470 480 490 500
VMTVAVEKDS LQASGYTRTE LSLLDHSCKA RMNGTHFILE SLPNKCGTRT
510 520 530 540 550
SYILDKIVYF NSIVIQLSSP AEGSSFDDDD MESGDNGFPG DADEGDVTFS
560 570 580 590 600
NWPEIAFNCT LHQPEKDFFN PAMFWPPEPH ITNVTFNMEL YKTDLFLAPS
610 620 630 640 650
QGLFSVAENG PIYVEVSVTK ADISLGFAIQ TCFVSPFSNP DRMSDYTIIE
660 670 680 690 700
NICPKDESVK FYSTEKLNFP IAHAQKDKKR FSFVFKPIFN ISLLFLHCEL
710 720 730 740 750
TLCTNIDKDT QRLPKCVPPD EACTSLNVDM ILAMMHNKKT FTKPLVITHE
760 770 780 790 800
GKPEDSSLPK SNVRQPSVFY GLDTLTVVGI AFAAFVIGAL LTGALWFIYS
810 820 830 840
HTGEAAGRRQ VPTSPPASEN SSAAHSIGST QSTPCSSSSA T
Length:841
Mass (Da):93,313
Last modified:November 1, 1996 - v1
Checksum:iBFDEA3FCCBFFFB72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03005659 Genomic DNA. No translation available.
L01121 mRNA. Translation: AAA49090.1.
PIRiI50428.
RefSeqiNP_989670.1. NM_204339.1.
UniGeneiGga.804.

Genome annotation databases

EnsembliENSGALT00000033354; ENSGALP00000032713; ENSGALG00000006038.
GeneIDi374251.
KEGGigga:374251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03005659 Genomic DNA. No translation available.
L01121 mRNA. Translation: AAA49090.1.
PIRiI50428.
RefSeqiNP_989670.1. NM_204339.1.
UniGeneiGga.804.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032713.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000033354; ENSGALP00000032713; ENSGALG00000006038.
GeneIDi374251.
KEGGigga:374251.

Organism-specific databases

CTDi7049.

Phylogenomic databases

eggNOGiENOG410IK7K. Eukaryota.
ENOG410XSMK. LUCA.
GeneTreeiENSGT00530000063861.
HOGENOMiHOG000090193.
HOVERGENiHBG057515.
KOiK05843.
OMAiFAIQTCF.
OrthoDBiEOG72ZCDK.
TreeFamiTF337375.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and developmental expression of the chick type II and type III TGF beta receptors."
    Barnett J.V., Moustakas A., Lin W., Wang X.-F., Lin H.Y., Galper J.B., Maas R.L.
    Dev. Dyn. 199:12-27(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  2. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiQ90998_CHICK
AccessioniPrimary (citable) accession number: Q90998
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.