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Protein

Structural maintenance of chromosomes protein 2

Gene

SMC2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 2
Short name:
SMC protein 2
Short name:
SMC-2
Alternative name(s):
Chromosome scaffold protein ScII
Gene namesi
Name:SMC2
Synonyms:SCII, SMC2L1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus
  • Cytoplasm
  • Chromosome

  • Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11891189Structural maintenance of chromosomes protein 2PRO_0000118997Add
BLAST

Proteomic databases

PRIDEiQ90988.

Interactioni

Subunit structurei

Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and probably some non SMC subunits that regulate the complex.

Structurei

3D structure databases

ProteinModelPortaliQ90988.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni504 – 673170Flexible hingeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili211 – 503293Sequence analysisAdd
BLAST
Coiled coili674 – 1030357Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1085 – 112036Ala/Asp-rich (DA-box)Add
BLAST

Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC2 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG106605.
InParanoidiQ90988.
KOiK06674.
PhylomeDBiQ90988.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR027120. Smc2.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF9. PTHR18937:SF9. 1 hit.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.

Sequencei

Sequence statusi: Complete.

Q90988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIKSIVLEG FKSYAQRTEI RDFDPLFNAI TGLNGSGKSN ILDSICFLLG
60 70 80 90 100
ISNLSQVRAS SLQDLVYKNG QAGVNKATVS ITFDNSDKKN SPLGFENNDE
110 120 130 140 150
ITITRQVIVG GRNKYLINGM NASNNRVQDL FGSVGLNVNN PHFLIMQGQI
160 170 180 190 200
TKVLNMKPTE ILAMIEEAAG TRMYECKKIT AHKTIEKKES KLDEIRRIIT
210 220 230 240 250
EEISPTLEKL KEARASYLEY QKMTREVENL RRIYVAFQYV RAEEIKDRST
260 270 280 290 300
NALKEAQANK KKIFESMAEN EKKVKELAQQ IEETEKKNNE EFGAKLHSLE
310 320 330 340 350
AAFSELQRVD AKVRSDLDHR KQNLNSEENR LKELIKIMQE EFKAFTSKEK
360 370 380 390 400
EIKKIKEGLN GLQEESKKDA EALASAQQHF NAVSAGLSSN DSGQGTSLAD
410 420 430 440 450
QMMTCKNEIS KAATEAKQAQ MKLKYAQQEL KTKQAEVKKM DGSYKEDQEA
460 470 480 490 500
FEAIRKTKEK LQDEMKKLKY EEAEQEAHLA KKKQLSSEIS SLRELCESIE
510 520 530 540 550
AKHPYLRFEY KNPEKNWNPN CVKGLVVTLI TVKDISTSKA LEAVAGGKLY
560 570 580 590 600
NIVVDTEATG KKILEKGQLK HRYTIIPLSK ISANSIGHEI ISLAKNLIGH
610 620 630 640 650
REVHIAISLI DYNSELQKAM EYVFGTTLVC SSMDNAKKVT FDKRIMRKTV
660 670 680 690 700
TLQGDIFDPQ GTLSGGASSH VTPILSKLKT MRDAEDELKI KTSQLEATEK
710 720 730 740 750
ELANLKNMAE KYQHLKQQWE MKSEEAELLQ TKIQQSAYHK QQEDLLALKK
760 770 780 790 800
TIAECEETLK KTEESQRKAE EEYKALENKM KNAEAERGKE IKNAQQKLNS
810 820 830 840 850
AKKKADDSSR KMKEKQQEVE ALVLELEQLK QEQASYKQQS EAAQQAIASL
860 870 880 890 900
KEQVSALEAE AVKTRESLKN AENELSSEKG LMEERTKDIK AKSAKIEKYR
910 920 930 940 950
EQNNELQLSI NALEHDINKY QQETADASST LDKLLKEYKW IASEKELFGQ
960 970 980 990 1000
ADTTYDFEAN NPKETGQKLQ KLLTKKEKLE KSLNMRAMNL LSEAEERYND
1010 1020 1030 1040 1050
LMKKKRMVEN DKIKILATIE ELDRKKNKAL HIAWEKVNKD FGSIFSMLLP
1060 1070 1080 1090 1100
GAKAMLVPSK KQNILDGLEF RVGLGDIWKE NLTELSGGQR SLAALSLILA
1110 1120 1130 1140 1150
ILLFKPAPIY ILDEVDAALD LSHTQNIGQM LHAHFKQSQF LVVSLKDGMF
1160 1170 1180
NNANVLYRTK FVDGISTVSR HCQLKKKQPL SEASNNKDE
Length:1,189
Mass (Da):134,941
Last modified:November 1, 1996 - v1
Checksum:i905EBC89EC45AD5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80792 mRNA. Translation: CAA56767.1.
PIRiA54817.
RefSeqiNP_990561.1. NM_205230.1.
UniGeneiGga.4066.

Genome annotation databases

GeneIDi396156.
KEGGigga:396156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80792 mRNA. Translation: CAA56767.1.
PIRiA54817.
RefSeqiNP_990561.1. NM_205230.1.
UniGeneiGga.4066.

3D structure databases

ProteinModelPortaliQ90988.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ90988.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396156.
KEGGigga:396156.

Organism-specific databases

CTDi10592.

Phylogenomic databases

HOVERGENiHBG106605.
InParanoidiQ90988.
KOiK06674.
PhylomeDBiQ90988.

Miscellaneous databases

PROiQ90988.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR027120. Smc2.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF9. PTHR18937:SF9. 1 hit.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSMC2_CHICK
AccessioniPrimary (citable) accession number: Q90988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.