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Protein
Submitted name:

Ryanodine receptor type 3

Gene

RyR3

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ryanodine receptor type 3Imported
Gene namesi
Name:RyR3Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4187 – 420822HelicalSequence analysisAdd
BLAST
Transmembranei4411 – 443121HelicalSequence analysisAdd
BLAST
Transmembranei4475 – 449723HelicalSequence analysisAdd
BLAST
Transmembranei4621 – 464626HelicalSequence analysisAdd
BLAST
Transmembranei4669 – 469123HelicalSequence analysisAdd
BLAST
Transmembranei4750 – 477324HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ90985.
PRIDEiQ90985.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005342.

Structurei

3D structure databases

ProteinModelPortaliQ90985.
SMRiQ90985. Positions 3472-3498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 15456MIRInterPro annotationAdd
BLAST
Domaini161 – 20646MIRInterPro annotationAdd
BLAST
Domaini214 – 26855MIRInterPro annotationAdd
BLAST
Domaini274 – 33158MIRInterPro annotationAdd
BLAST
Domaini342 – 39958MIRInterPro annotationAdd
BLAST
Domaini584 – 795212B30.2/SPRYInterPro annotationAdd
BLAST
Domaini1011 – 1207197B30.2/SPRYInterPro annotationAdd
BLAST
Domaini1253 – 1467215B30.2/SPRYInterPro annotationAdd
BLAST
Domaini3929 – 395729EF-handInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3589 – 361628Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.
HOGENOMiHOG000231428.
HOVERGENiHBG006699.
PhylomeDBiQ90985.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 5 hits.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 1 hit.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50222. EF_HAND_2. 1 hit.
PS50919. MIR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGGEGGED EIQFLRTDDE VVLQCVSSIH KEQRKFCLAA EGLGNRLCFL
60 70 80 90 100
EPTSEAKYVP PDLCICNFVL EQSLSVRALQ EMLTNTGDNA SEGAAQGGHR
110 120 130 140 150
TLLYGHAILL RHSFSEMYLT CLTSSRSQTD KLAFDVGLRE NAAGEACWWT
160 170 180 190 200
IHPASKQRSE GEKVRIGDDL ILVSVSSERY LHLSMSNGSI QVDASFMQTL
210 220 230 240 250
WNVHPTCSGS NITEGYLLGG HVVRLFHGHD EYLTIPSTDQ NDSQQKKVLY
260 270 280 290 300
ETGGAGVRAR SLWRVEPLRI SWSGSNIRWG QPFRLRHITT GMYLALNDDE
310 320 330 340 350
GLVMLDREKS DTTSSAFCFR ASKELKEKQD STLKRDIDGM GVPEIKYGDS
360 370 380 390 400
VCFIQHVASA LWLTYKAPDA KSARLGLLKR KVILHQEGHM DDGLTLQRCQ
410 420 430 440 450
HEESQAARII RNTTSLFSQF ISGNNRTLSP IALPVEEMAQ TLQDLIKYFQ
460 470 480 490 500
PPGEDLEHED KQNKLRSLKN RQNLFKDEGM LALVLNCIDR LNDYNSAAHF
510 520 530 540 550
AEISRVENGT AWKEILNLLY ELLAALIRGN RNNCTQFSSN LDWLISKLDR
560 570 580 590 600
LESSSGILEV LHCILIESPE ALNIIAEEHI KSIISLLDKH GRNYKVLDVL
610 620 630 640 650
CSLCVCNGVA VRANQNLICD NLLPRRDLLL QTRLINDVTS IRPNIFLGVA
660 670 680 690 700
EGSAQYKKWY FELIIDQVDP FLTAEPTHLR VGWASTSGYA PYPGGGEGWG
710 720 730 740 750
GNGVGDDLYS FGFDGLHLWS GRVPRAVASV NQHLLSSDDV VSCCLDLGVP
760 770 780 790 800
SISFRINGQP VQGMFENFCT EGFFFPVVSL SAGVKARFLL GGRHGEFKFL
810 820 830 840 850
PPTGYAPCYE ALLPKEKMKL EPVKEYKRDS DGVRDLLGTT QFLSQASFIP
860 870 880 890 900
CPIDTSQIAL PFHLEKIRDK LAENIHELWG MNKIELGWTY GKIRDDNKRH
910 920 930 940 950
HPCLVEFSKL PETEKNYNLQ MSTETLKTLL ALGCHIVHAN PAAEEDLKXV
960 970 980 990 1000
KLPKNYIMSN GYKPAPLDLS EVKLLPSQEF LVNKLAENAH NVWAKDRIKQ
1010 1020 1030 1040 1050
GWTYGIQQDL KNKRNPRLVP YDLLDERTKK SNRDSLREAV RTFAGYGYNV
1060 1070 1080 1090 1100
EPPDQEIADQ TVEKVSIDKI RFYRVEQSYA VKSGKWYFEF EAVTGGDMRV
1110 1120 1130 1140 1150
GWARPGCRPD IELGADDQAF VFEGSKGQRW HQGSGFFGRS WQPGDVVGCM
1160 1170 1180 1190 1200
INLDDKSIIF TLNGELLITS KGSELAFADF GIESGFVPIC SLGLSQIGRM
1210 1220 1230 1240 1250
NLGMDASTFK YYTMCGLQEG FEPFAVNMNR DVAMWFSKRL PTFVNVPKNH
1260 1270 1280 1290 1300
PHIEIWRIDG TIESPPRLKV THKTLGTQNS NSDMIYCRLS MPIEFRSSFN
1310 1320 1330 1340 1350
FGVGVENASS DALQKRKHSQ EFPASSTTCF YSLRIFAGQD PSSVWVGWVT
1360 1370 1380 1390 1400
PDYHFYSENF DINKNCTVTV TLGDERGRVH ESVKRSNCYM VWGGDIAANS
1410 1420 1430 1440 1450
QRSGRSNVDL EIGCFVDLAT GMLSFTANGK ELGTCYQVEP NTKLFPAAFV
1460 1470 1480 1490 1500
QPTSTNLIQF ELGKLKNTMP LSAAIFKSEE RNPVPQCPPR LDVQTITPVL
1510 1520 1530 1540 1550
WSRMPNSFLK VETERVSERH GWVVQCLEPL QMMALHIPEE NRCVDILELC
1560 1570 1580 1590 1600
EQEDLMKFHY HTLKLYSSVC ALGNTRVAYA LCSHVDISQL FYTIDNQYLP
1610 1620 1630 1640 1650
GLLRSGFYDL LISIHLDHAK QAKLMMNNEF IIPVTEETRT IKLYPDETKK
1660 1670 1680 1690 1700
HGLPGVGLST CLKPSFNFST PCFIVTSEEH QTSSPDIPLD TLKSKAISML
1710 1720 1730 1740 1750
TEAVQCSGSH IRDPVGGHIA FQFVPVLKLI ATLLVMGVFD DDDVKQVLIL
1760 1770 1780 1790 1800
IDPNVFGDHK EEAEEKTEKE EVTQVEEKAV EAGEKAVKET KAPTKGLLQT
1810 1820 1830 1840 1850
RLPESVKLQM CHLLNYFCDC ELQHRVEAIV SFADHYVSKL QYNQKYRYNE
1860 1870 1880 1890 1900
LMQALNMSAA LTAKKTKEFR SPPQEQINML LNFQLGEDCP CPEEIRDELY
1910 1920 1930 1940 1950
DFHDDLLIHC GIPLEEEEEE EEDSSLTGKL RSLIYKIKGP PKPEKIEPRE
1960 1970 1980 1990 2000
EEDKSPTTLK ELISQTMVRW SQEDQIQDPE LVRIMYTLLR RQYDSIGELL
2010 2020 2030 2040 2050
QALRKAYTIS AASVKDTINL LAALGQIRSL LSVRMGKEEE LLMINGLGDI
2060 2070 2080 2090 2100
MNNKVFYQHP NLMRVLGMHE TVMDVMVNVL GGDKSQIAFP KMVASCCRFL
2110 2120 2130 2140 2150
CYFCRISRQN QKAMFEHLSY LLENSSVGLA FPSMRGSTPL DVAAASVMDN
2160 2170 2180 2190 2200
NELALALEEP DLDKVVTYLA GCGLQSCPVL LAKGYPDIGW NPIEGERYLS
2210 2220 2230 2240 2250
FLRFAVFVNS ESVEENASVV VKLLIRRPEC FGPELRGEGG NGLLAAMQEA
2260 2270 2280 2290 2300
IRISENPTRD LPSQGYKREG DEEEEEEEEI VHMGNAIMSF YSALIDLLGR
2310 2320 2330 2340 2350
CAPEMHLIQS GKGEAIRIRS ILRSLVPTED LVGIISIPLK LSTVNKDGTV
2360 2370 2380 2390 2400
NEPDMSANFC PDHKAPMVLF LDRVYGIKDQ SFLLHLLEVG FLPDLRASAS
2410 2420 2430 2440 2450
LDTVSLSTTE AALALNRYIC SAVFPLLKRC APLFSGTEHH ASLVDSMLHT
2460 2470 2480 2490 2500
IYRLSKGRSL TKAQRDTIEE CLLAICHHLR PSMLQQLLRR LVFDVPLLNE
2510 2520 2530 2540 2550
YCKMPLKLLT NHYEQCWKYY CLPSGMGSYG IAAEDELHLT EKLFWGIFDS
2560 2570 2580 2590 2600
LSHKKYDPEL FRMALPCLSA IAGALPPDYL DTRIRSTLEK QTSVDPEGNF
2610 2620 2630 2640 2650
DPKPVNTANL VLPEKLEYIV SKYAEHSHDK WAFDKTNNGW KYGVSLDENT
2660 2670 2680 2690 2700
KTHPLIRPFK TLTEKEKEIY RWPVRESLKT MLAMGWSLER TKEGGEGMLH
2710 2720 2730 2740 2750
QRENEKLRSI SQSSQGNGYS PAPLDLTNVV LSRELQGMVE VMAENYHNIW
2760 2770 2780 2790 2800
AKKKKMELES KGGGSHPLLV PYDTLTAKEK SRDREKAQEL FKFLQVNGII
2810 2820 2830 2840 2850
ISRGLNDMDL DASSMEKRFA FKFLKKILKY VDSAQEFIAH LEAIVTSGKT
2860 2870 2880 2890 2900
EKSPHDQEIK FFAKVLLPLV DQYFTNHCLY FLSSPTKTLS SSGYASNKEK
2910 2920 2930 2940 2950
EMVASLFCKL AALVRHRISI FGSDSTTMVS CLHILAQSLD TRTVMKSGSE
2960 2970 2980 2990 3000
LVKAGLRAFF ENAAEDLEKT SENLKLGKFT HSRTQIKGVS QNINYTTVAL
3010 3020 3030 3040 3050
LPVLTSIFEH ISQYHFGVDL LLGDVQVSCY RILCSLYSLG TGKNIYVERQ
3060 3070 3080 3090 3100
RPALGECLAS LAAAIPVAFL EPSLNHYNPL SVFNTKSARE RAILGMPDTV
3110 3120 3130 3140 3150
EEMCPEIPQL DGLIKEINNL AESGARYTEM PHVIEVILPM LCNYLSYWWE
3160 3170 3180 3190 3200
RGSESVPESA GPCCTMITSE HLSIILGNIL KIINNNLGID EASWMKRIAV
3210 3220 3230 3240 3250
YAQPIISKAR PDLLKTHFIP TLEKLKKKAI KIVMEEEQLR ADSKSDTQEA
3260 3270 3280 3290 3300
ELLILDEFAV LCRDLYAFYP MLIRYVDNNR ANWLKKPDAD SDELFRMVAE
3310 3320 3330 3340 3350
VFILWCKSHN FKREEQNFVI QNEINNLAFL TGDTKSKMSK AMQVKSGGQD
3360 3370 3380 3390 3400
QERKKSKRRG DLYSIQTSLI VAALKKMLPI GLNMCTPGDQ ELISLAKTRY
3410 3420 3430 3440 3450
SHRDTDEEVK EHIRNNLHLQ EKSDDPAVKW QLNLYKDILK SDEPPDPEKN
3460 3470 3480 3490 3500
VERVQRISAA LYHLDQVEQP LRSKKAVWHK LLSKQRKRAV VACFRMAPLY
3510 3520 3530 3540 3550
NLPRHRSINL FLHGYQNYWI ETEEYSFEEK LVQDLATSPK KEEEEEEDTE
3560 3570 3580 3590 3600
KEQPDPLHQI ILYFSRNALT ERSKLEDDPL YIAYAAMMAK SCQEEEEEEE
3610 3620 3630 3640 3650
EDKEKTFEEK EMEKQRTLYQ QARLHDRGAA EMVLQMISAS KGHTGPMVVE
3660 3670 3680 3690 3700
TLKLGIAILN GGNTIVQQKM LDYLKEKKDA GFFQSLSGLM QSCSVLDLNA
3710 3720 3730 3740 3750
FERQSKAEGL GMVTEEETLI VRERGEKVLQ HDEFTRDLFR FLQLLCEGHN
3760 3770 3780 3790 3800
NDFQNYLRTQ MGNTTTVNII ISTVDYLLRL QESISDFYWY YSGKDVIDES
3810 3820 3830 3840 3850
GQRNFSKALA VTKQIFNSLT EYIQGPCIGN QQSLAHSRLW DAVVGFLHVF
3860 3870 3880 3890 3900
ANMQMKLSQD SAQIELLKEL LDLLKDMVVM LLSLLEGNVV NGTIGKQMVD
3910 3920 3930 3940 3950
TLVESPSNVE LILKFFDMFL KLKDLTNSDA FKEHDPDGKG IISKKDFQKS
3960 3970 3980 3990 4000
MEAQKQYIQS EIEFLLSCAE ADENDMFNYI DFVERFHEPA KDIGFNVAVL
4010 4020 4030 4040 4050
LTNLSEHMPN DSRLQSLLEP AEESVLNYFE PYLGRIEIMG GAKKIERVYF
4060 4070 4080 4090 4100
EISESSRMQW EKPQVKESKR QFIFGIVNEG GEEEKMELFV NFCEDTIFET
4110 4120 4130 4140 4150
QLASQISESD SRERLRKIEE PCYVVDIGDD EEEKKSLESP SAFALACAAV
4160 4170 4180 4190 4200
KKNVANFFKM VTVKNLRKQY RKVRKMTVKE MVKCFSLFFW ILFVGVFQLF
4210 4220 4230 4240 4250
FTIVWGIFQI LWSTVFGGGL VEGAKNIKVT KILGDMPDPT QFGIHDDVTE
4260 4270 4280 4290 4300
AEKTEGAEHG IRDELVQFVK GEKGETDIIS DIFGIPSKKE GGSKHGHDAG
4310 4320 4330 4340 4350
LGDIAEILGS DIQSSLENNA RKKKGLQIPE TAKEAEAERK VEAEKADMED
4360 4370 4380 4390 4400
GEKQDKAKEE QSEQPEEGKM KKKKRRHGQK IEKPEAVMAN FFKALEIYQT
4410 4420 4430 4440 4450
KILHYLARNF YNLRFLALFV AFAINFILLF YKVTEEPLDE VEEDSNLWNS
4460 4470 4480 4490 4500
FEEEEEEEGM VFFVLEESTG YMAPALRALA LFIPIISFVC VIGYYCLKVP
4510 4520 4530 4540 4550
LVVFKREKEV ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN TPSFPNNYWD
4560 4570 4580 4590 4600
KFVKRKVINK YGDLYGAERI AELLGLDKNA RHFCPVEESE PEAASLVSWL
4610 4620 4630 4640 4650
SSIDTKYHIW KLGVVFTDNS FLYLAWYTTM SILGHYNNFF FAAHLLDIAM
4660 4670 4680 4690 4700
GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF FRKFYNKSED
4710 4720 4730 4740 4750
EDEPDMKCDD MMMCYLFHMY VGVRAGGGIG DEIEDPAGDP YEMYRIVFDI
4760 4770 4780 4790 4800
TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVREDMETKC FICGIGNDYF
4810 4820 4830 4840 4850
DTIPHGFETH TLQEHNLANY LFFLMYLINK DETEHTGQES FVWKMYQERC
4860
WDFFPAGDCF RKQYEDQLG
Length:4,869
Mass (Da):552,782
Last modified:November 1, 1996 - v1
Checksum:iE04D6260F20FFA21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95267 mRNA. Translation: CAA64563.1.
PIRiS66572.
UniGeneiGga.658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95267 mRNA. Translation: CAA64563.1.
PIRiS66572.
UniGeneiGga.658.

3D structure databases

ProteinModelPortaliQ90985.
SMRiQ90985. Positions 3472-3498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005342.

Proteomic databases

PaxDbiQ90985.
PRIDEiQ90985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.
HOGENOMiHOG000231428.
HOVERGENiHBG006699.
PhylomeDBiQ90985.

Miscellaneous databases

NextBioi20816169.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 5 hits.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 1 hit.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50222. EF_HAND_2. 1 hit.
PS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "alpha and beta isoforms of ryanodine receptor from chicken skeletal muscle are the homologues of mammalian RyR1 and RyR3."
    Ottini L., Marziali G., Conti A., Charlesworth A., Sorrentino V.
    Biochem. J. 315:207-216(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ90985_CHICK
AccessioniPrimary (citable) accession number: Q90985
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.