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Protein
Submitted name:

Tyrosine kinase

Gene

c-met

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1111 – 11111ATPUniRule annotation
Active sitei1205 – 12051Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1085 – 10939ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine kinaseImported
Gene namesi
Name:c-metImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei932 – 95524HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 13821358Sequence analysisPRO_5004318278Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1235 – 12351Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1236 – 12361Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1350 – 13501Phosphotyrosine; by autocatalysisUniRule annotation
Modified residuei1357 – 13571Phosphotyrosine; by autocatalysisUniRule annotation

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ90975.
PRIDEiQ90975.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015284.

Structurei

3D structure databases

ProteinModelPortaliQ90975.
SMRiQ90975. Positions 40-563, 1047-1347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 515489SemaInterPro annotationAdd
BLAST
Domaini1079 – 1346268Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation
Contains Sema domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG006348.
KOiK05099.
PhylomeDBiQ90975.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 3 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011009. Kinase-like_dom.
IPR016201. Plexin-like_fold.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001627. Semap_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016244. Tyr_kinase_HGF/MSP_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
PIRSFiPIRSF000617. TyrPK_HGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF81296. SSF81296. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPVTAYPSG IILFLFALLQ RSHGQCKEAA KKSEMNLNVK YDLPNFITET
60 70 80 90 100
PIQNVVLYKH HVYIGAVNKI YVLNETLQNI SVYKTGPILE SPGCAPCEDC
110 120 130 140 150
KDKANLSNSV WKDNVNMALL LETYYDDQLI SCGSVSGGVC HRHIIPPDNP
160 170 180 190 200
ADIESEVHCM YSPQVDGEAD NCPDCVVSTL GTKVLVTEKD RFVNFFVGNT
210 220 230 240 250
MTSAFQPPHV LHSISVRRLK ETQDGFEFLT DQSYIDILPQ FRDSYPIKYV
260 270 280 290 300
HAFEHDHFVY FLTVQRESLD SQTFHTRIIR FCTLDSEMRS YMEMPLECIF
310 320 330 340 350
TEKRRKRSIR KEVFNILQAA YVSKPGAALA HEMGLGLIDD ILYGVFAQTN
360 370 380 390 400
QIPQEPTNRS AVCAVSVRTI NEFFNKIVDK QNMKCLQHFY GKDSKYCLNR
410 420 430 440 450
AFSRNASYCR AQDDEYRLEV TTPLQRVDLF MGQFNNILLT SISVFTKGNL
460 470 480 490 500
TIANLGTSEG RFMQIVVSRS EPTAPHVSFQ LDSHAVSPQV VVEQSAAADG
510 520 530 540 550
YTLVVTGKKI TKVPLNGPGC HHFQSCSQCL LAPAFMRCGW CGQQCLRAPE
560 570 580 590 600
CNGGTWTQET CLPRVYEILP SSAPLEGGTK LTLCGWDFGF SKNNRFELRN
610 620 630 640 650
TVVHIGGQIC ALEAKSSNKN KLECTAPAAK NASFNISSSV SVGHGKTLFN
660 670 680 690 700
TFSYVNPIIT SISPTYGPKS GGTLLTIAGK YLNSGKSRRI FVGEKPCSLK
710 720 730 740 750
STSESSVECY TPAQRIPQEY RVRVGIDGAI RDAKGYFTYR EDPVVLKIHP
760 770 780 790 800
AKSFLSGGST ITAQGINLNS VCFPRMVITV PKLGMNFSVA CSHRSSSEII
810 820 830 840 850
CCTTPSLKAF NLQPPFVTKV FFIFDGVSSL YFDFDYVNNP VFKHFEKPVL
860 870 880 890 900
ISRSNPNVLE IKGNHIDSEA VKGEVLKVGN KSCENLLLQS ETILCTVPSD
910 920 930 940 950
LLKSNSELNI EWKQEVLSTV IGKVLIRQDQ NFTGLIAGVV STSVLIYIFL
960 970 980 990 1000
VFFLWRRKKK QIKDLGSDLV RYDGRVHTPH LDRLVSARSV SPTTEMVSSE
1010 1020 1030 1040 1050
SVDYRSTFLE DQFPSMSQNG SCRPAQYPHS DLSPILSSGD SDLASPLLQT
1060 1070 1080 1090 1100
NVHIDISALN PDLVKEVQHV VIGADSLMVH FSEVIGRGHF GCVSHGTLLD
1110 1120 1130 1140 1150
NDGRKIHCAV KSLNRITDLE EVAQFLKEGI IMKDFTHPNV LSLLGICLPN
1160 1170 1180 1190 1200
EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK
1210 1220 1230 1240 1250
FVHRDLAARN CMLDEKFTVK VADFGLARDV YDKEYYSVHN KTGAKLPVKW
1260 1270 1280 1290 1300
MALESLQTQK FTTKSDVWSF GVLLWELMTR GAPPYPDVNS FDITVYLLQG
1310 1320 1330 1340 1350
RRLLQPEYCP DPLYEVMLKC WHPKPEMRPA FSELVSKIST IFSTFIGEHY
1360 1370 1380
VHVNATYVNV KCVAPYPSLL SSQDNTDMDV DT
Length:1,382
Mass (Da):154,451
Last modified:November 1, 1996 - v1
Checksum:i05E1BAEF4239A4F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84044 mRNA. Translation: CAA58863.1.
RefSeqiNP_990543.2. NM_205212.2.
UniGeneiGga.13923.
Gga.669.

Genome annotation databases

GeneIDi396134.
KEGGigga:396134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84044 mRNA. Translation: CAA58863.1.
RefSeqiNP_990543.2. NM_205212.2.
UniGeneiGga.13923.
Gga.669.

3D structure databases

ProteinModelPortaliQ90975.
SMRiQ90975. Positions 40-563, 1047-1347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015284.

Proteomic databases

PaxDbiQ90975.
PRIDEiQ90975.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396134.
KEGGigga:396134.

Organism-specific databases

CTDi4233.

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
KOG3610. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG006348.
KOiK05099.
PhylomeDBiQ90975.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 3 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR011009. Kinase-like_dom.
IPR016201. Plexin-like_fold.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001627. Semap_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016244. Tyr_kinase_HGF/MSP_rcpt.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
PIRSFiPIRSF000617. TyrPK_HGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF81296. SSF81296. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ90975_CHICK
AccessioniPrimary (citable) accession number: Q90975
Secondary accession number(s): Q90785
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.