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Protein

Ras-related protein Rab-2A

Gene

RAB2A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 219GTPBy similarity
Nucleotide bindingi61 – 655GTPBy similarity
Nucleotide bindingi119 – 1224GTPBy similarity
Nucleotide bindingi149 – 1513GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2A
Gene namesi
Name:RAB2A
Synonyms:RAB2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ras-related protein Rab-2APRO_0000260524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi211 – 2111S-geranylgeranyl cysteineBy similarity
Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiQ90965.
PRIDEiQ90965.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035947.

Structurei

3D structure databases

ProteinModelPortaliQ90965.
SMRiQ90965. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0098. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ90965.
KOiK07877.
OMAiRRDTFTH.
PhylomeDBiQ90965.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW
110 120 130 140 150
LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA
160 170 180 190 200
KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNATLAG
210
NQGGQQAGGG CC
Length:212
Mass (Da):23,522
Last modified:November 1, 1996 - v1
Checksum:iF8731E3F8FB39CB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84220 mRNA. Translation: CAA59004.1.
PIRiS52325.
RefSeqiNP_990559.1. NM_205228.1.
XP_015138187.1. XM_015282701.1.
XP_015138188.1. XM_015282702.1.
UniGeneiGga.16919.
Gga.42081.

Genome annotation databases

EnsembliENSGALT00000024914; ENSGALP00000024868; ENSGALG00000015450.
GeneIDi396153.
KEGGigga:396153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84220 mRNA. Translation: CAA59004.1.
PIRiS52325.
RefSeqiNP_990559.1. NM_205228.1.
XP_015138187.1. XM_015282701.1.
XP_015138188.1. XM_015282702.1.
UniGeneiGga.16919.
Gga.42081.

3D structure databases

ProteinModelPortaliQ90965.
SMRiQ90965. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035947.

Proteomic databases

PaxDbiQ90965.
PRIDEiQ90965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000024914; ENSGALP00000024868; ENSGALG00000015450.
GeneIDi396153.
KEGGigga:396153.

Organism-specific databases

CTDi5862.

Phylogenomic databases

eggNOGiKOG0098. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ90965.
KOiK07877.
OMAiRRDTFTH.
PhylomeDBiQ90965.

Miscellaneous databases

NextBioi20816209.
PROiQ90965.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rab2 nucleotide coding sequence in Gallus gallus and it phylogenetic position."
    Montpellier C., Kherrouche Z., Begue A., Stehelin D., Coll J.
    DNA Seq. 6:37-39(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibroblast.

Entry informationi

Entry nameiRAB2A_CHICK
AccessioniPrimary (citable) accession number: Q90965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.