Reviewed, UniProtKB/Swiss-Prot Q90952 (PON2_CHICK)

Names and origin

Protein names

Recommended name:
    Serum paraoxonase/arylesterase 2
      Short name=PON 2
    EC=3.1.1.2
    EC=3.1.8.1
Alternative name(s):
    Serum aryldialkylphosphatase 2
    Aromatic esterase 2
      Short name=A-esterase 2

Gene names

Name:

PON2

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The absence of paraoxonase activity in turkey and chicken blood and in turkey liver indicates that PON2, if expressed, does not hydrolyze paraoxon.
Catalytic activity	A phenyl acetate + H2O = a phenol + acetate. An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.
Cofactor	Binds 2 calcium ions per subunit By similarity.
Subcellular location	Membrane; Peripheral membrane protein By similarity.
Post-translational modification	Glycosylated By similarity. The signal sequence is not cleaved By similarity.
Sequence similarities	Belongs to the paraoxonase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal
Ligand	Calcium Metal-binding
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aryldialkylphosphatase activity Inferred from electronic annotation. Source: EC arylesterase activity Inferred from electronic annotation. Source: EC calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Serum paraoxonase/arylesterase 2		PRO_0000223294
	Signal peptide	1 – ?		Not cleaved Potential
Sites
	Active site	114	1	Proton acceptor By similarity
	Metal binding	53	1	Calcium 1; catalytic By similarity
	Metal binding	54	1	Calcium 2 By similarity
	Metal binding	116	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	167	1	Calcium 1; catalytic By similarity
	Metal binding	168	1	Calcium 2 By similarity
	Metal binding	223	1	Calcium 1; catalytic By similarity
	Metal binding	268	1	Calcium 1; catalytic By similarity
	Metal binding	269	1	Calcium 1; catalytic By similarity
Amino acid modifications
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Glycosylation	254	1	N-linked (GlcNAc...) Potential
	Glycosylation	269	1	N-linked (GlcNAc...) Potential
	Glycosylation	323	1	N-linked (GlcNAc...) Potential
	Disulfide bond	42 ↔ 352		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q90952-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 30C3191289BC13EB	FASTA	354	39,409
	10 20 30 40 50 60 MGKVLAAALV GIAAALAAER LLAFRNRLNA TREVDPVALP NCYLIKGIET GSEDIDILPN 70 80 90 100 110 120 GLAFISSGLK YPGLKSFAPD KPGEIFLMDL NEKKPKASEL RISRGFDVGS FNPHGISTYI 130 140 150 160 170 180 DKDDTVYLFV VNHPHQKSTV ELFKFMEDDN SLVHLKTIRH DLLTSVNDVV AVGPDSFYAT 190 200 210 220 230 240 NDHYFYDFIL MFLEMYLGLT WSNVVYYSPK EVKEVAAGFY SANGINISPD KKYIYIADIL 250 260 270 280 290 300 DHNVHVMEKH ADWNLTHVKT LQLDTLADNL SVDPDTGDIW TGCHPNGMKL FYDDPDNPPA 310 320 330 340 350 SEVLRIQNIL AEQPTVTRVY AENGSVLQGT SVATVYDGKL LIGTVFHRAL YCEL

References

[1]	"The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family." Primo-Parmo S.L., Sorenson R.C., Teiber J., La Du B.N. Genomics 33:498-507(1996) [PubMed: 8661009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L47573 mRNA. Translation: AAC42234.1.
IPI	IPI00576203.
UniGene	Gga.23753
3D structure databases
SMR	Q90952. Positions 23-354.
ModBase	Search...
Protein-protein interaction databases
STRING	Q90952.
Genome annotation databases
Ensembl	ENSGALT00000015769; ENSGALP00000015753; ENSGALG00000009689; Gallus gallus. [Genome view] ENSGALT00000038023; ENSGALP00000037229; ENSGALG00000009689; Gallus gallus. [Genome view]
Phylogenomic databases
eggNOG	veNOG12704.
HOGENOM	HBG613410.
HOVERGEN	Q90952.
InParanoid	Q90952.
Enzyme and pathway databases
BRENDA	3.1.1.2. 4. 3.1.8.1. 4.
Family and domain databases
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR002640. Arylesterase. IPR008364. Paraoxonase2. [Graphical view]
Gene3D	G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit.
Pfam	PF01731. Arylesterase. 1 hit. [Graphical view]
PRINTS	PR01785. PARAOXONASE. PR01787. PARAOXONASE2.
ProtoNet	Search...

Entry information

Entry name

PON2_CHICK

Accession

Primary (citable) accession number: Q90952

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	February 9, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)