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Protein

Protein polybromo-1

Gene

PBRM1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1378 – 1446HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein polybromo-1
Gene namesi
Name:PBRM1
Synonyms:PB1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002231861 – 1633Protein polybromo-1Add BLAST1633

Proteomic databases

PaxDbiQ90941.
PRIDEiQ90941.

Interactioni

Subunit structurei

Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002412.

Structurei

Secondary structure

11633
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi961 – 964Combined sources4
Beta strandi974 – 983Combined sources10
Beta strandi989 – 997Combined sources9
Helixi999 – 1001Combined sources3
Beta strandi1009 – 1011Combined sources3
Beta strandi1014 – 1025Combined sources12
Helixi1026 – 1028Combined sources3
Beta strandi1029 – 1037Combined sources9
Helixi1038 – 1041Combined sources4
Beta strandi1044 – 1046Combined sources3
Helixi1051 – 1053Combined sources3
Beta strandi1054 – 1062Combined sources9
Turni1063 – 1066Combined sources4
Beta strandi1067 – 1070Combined sources4
Beta strandi1083 – 1085Combined sources3
Beta strandi1094 – 1096Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W4SX-ray1.55A932-1103[»]
ProteinModelPortaliQ90941.
SMRiQ90941.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ90941.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 135Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini197 – 267Bromo 2PROSITE-ProRule annotationAdd BLAST71
Domaini398 – 468Bromo 3PROSITE-ProRule annotationAdd BLAST71
Domaini536 – 606Bromo 4PROSITE-ProRule annotationAdd BLAST71
Domaini674 – 744Bromo 5PROSITE-ProRule annotationAdd BLAST71
Domaini790 – 860Bromo 6PROSITE-ProRule annotationAdd BLAST71
Domaini954 – 1072BAH 1PROSITE-ProRule annotationAdd BLAST119
Domaini1155 – 1271BAH 2PROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi357 – 363Poly-Ala7
Compositional biasi629 – 631Poly-Asp3
Compositional biasi1435 – 1543Pro-richAdd BLAST109

Sequence similaritiesi

Contains 2 BAH domains.PROSITE-ProRule annotation
Contains 6 bromo domains.PROSITE-ProRule annotation
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiKOG1827. Eukaryota.
COG5076. LUCA.
HOGENOMiHOG000045795.
HOVERGENiHBG079860.
InParanoidiQ90941.
KOiK11757.
PhylomeDBiQ90941.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
1.20.920.10. 6 hits.
InterProiIPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF00439. Bromodomain. 6 hits.
PF00505. HMG_box. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00439. BAH. 2 hits.
SM00297. BROMO. 6 hits.
SM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF47370. SSF47370. 6 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00633. BROMODOMAIN_1. 5 hits.
PS50014. BROMODOMAIN_2. 6 hits.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKRRRATS PSSSVSGGDF DDGHHSTNIP GPSRKRRRLS NLPTVDPIAV
60 70 80 90 100
CHELYNTIRD YKDEQGRLLC ELFIRAPKRR NQPDYYEVVS QPIDLMKIQQ
110 120 130 140 150
KLKMEEYDDV NVLTADFQLL FNNAKAYYKP DSPEYKAACK LWELYLRTKN
160 170 180 190 200
EFVQKGDAEE EDEDEEGHDS QELSSPGYLK EILEQLLEAV AVATNPSGRL
210 220 230 240 250
ISELFQKLPS KVQYPDYYAI IKEPIDLKTI AQRIQNGTYK SIHAMAKDID
260 270 280 290 300
LLAKNAKTYN EPGSQVFKDA NAIKKIFNMK KAEIEHSELA KSSLRLRTPS
310 320 330 340 350
NLTASKLTGP SSQGKGSVGD ERNSSNKYFR NKRSAQGDRL SAITMALQYG
360 370 380 390 400
SESDEDAALA AAARYEGESE AESITSFMDT SNPLYQLYDT VRSCRNNQGQ
410 420 430 440 450
LISEPFFQLP SKKKYPDYYQ QIKTPISLQQ IRAKLKNHEY ETLDQLEADL
460 470 480 490 500
NLMFENAKRY NVPNSAIYKR VLKMQQVMQA KKKELARRDD IEDGDSMISS
510 520 530 540 550
ATSDTGSSKR KSKKNMRKQR MKILYNAVLE ARESGTGRRL CDLFMVKPSK
560 570 580 590 600
KDYPDYYKII LEPMDLKMIE HNIRNDKYVG EEAMIDDMKL MFRNARHYNE
610 620 630 640 650
EGSQVYNDAH MLEKILKEKR KELGPLPEDD DVASPKLKLS RKSGISPKKS
660 670 680 690 700
KYMTPMQQKL NEVYEAVKNY TDKRGRRLSA IFLRLPSRSE LPDYYITIKK
710 720 730 740 750
PVDMEKIRSH MMANKYQDID SMVEDFVMMF NNACTYNEPE SLIYKDALVL
760 770 780 790 800
HKVLLETRRE IEGDEDSHVP NVTLLIQELI HNLFVSVMSH QDDEGRCYSD
810 820 830 840 850
SLAEIPAVDP NFPNKPPLTF DIIRKNVENN RYRRLDLFQE NMFEVLERAR
860 870 880 890 900
RMNRTDSEIY EDAVELQQFF IKIRDELCKN GEILLSPALS YTTKHLHNDV
910 920 930 940 950
EKEKKEKLPK EIEEDKLKRE EEKREAEKSE DSSGSAGLSS LHRTYSQDCS
960 970 980 990 1000
FKNSMYHVGD YVYVEPAEAN LQPHIVCIER LWEDSAGEKW LYGCWFYRPN
1010 1020 1030 1040 1050
ETFHLATRKF LEKEVFKSDY YNKVPVSKIL GKCVVMFVKE YFKLCPENFR
1060 1070 1080 1090 1100
DEDVYVCESR YSAKTKSFKK IKLWTMPVSS VRFVPRDVPL PVVRVASVFA
1110 1120 1130 1140 1150
NTDKAEEEKH SDTLDDSKVG ESILHLEKDK EDVPVEMSNG EPGCHYFEQL
1160 1170 1180 1190 1200
CYNDMWLKVG DCVFIKSHGL VRPRVGRIEK MWVRDGAAYF FGPIFIHPEE
1210 1220 1230 1240 1250
TEHEPTKMFY KKEVFLSNLE ETCPMSCILG KCAVLSFKDF LCCRPTEISE
1260 1270 1280 1290 1300
NDVFLCESRY NESDKQMKKF KGLKRFSLSA KVVDDEIYYF RKPIVPQKEP
1310 1320 1330 1340 1350
SPLLEKKIQQ LEAKFAELGG GDEDMEEMGE EEGDITETPS MPQLQTPLTS
1360 1370 1380 1390 1400
ELDIMPYTPP QSTPKSVKGS TKKEGSKRKI NMSGYILFSS EMRPVIKAQH
1410 1420 1430 1440 1450
PDYSFGELSR LVGTEWRNLE ATKKAEYEGM ISGYPPVLPP LQGPVDGIVS
1460 1470 1480 1490 1500
MGSMQPLHPG VPPPHQLPPG MPGIPGIPPP GVIGQNVSPM VGTPAPGAGP
1510 1520 1530 1540 1550
FGQQIGILGP PGQQAPPPYP GQSPATQPVM QQPSTPMFVS PPPKTQRLLH
1560 1570 1580 1590 1600
SEAYLKYIEG LSAESNSISK WDQTLAARRR DVHLSKEQES RLPSHWLKSK
1610 1620 1630
GAHTTMADAL WRLRDLMLRD TLNIRQAYNI ENV
Length:1,633
Mass (Da):187,055
Last modified:November 1, 1996 - v1
Checksum:iE4CA350E1087F888
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90849 mRNA. Translation: CAA62353.1.
PIRiJC5056.
RefSeqiNP_990496.1. NM_205165.1.
UniGeneiGga.3045.

Genome annotation databases

GeneIDi396074.
KEGGigga:396074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90849 mRNA. Translation: CAA62353.1.
PIRiJC5056.
RefSeqiNP_990496.1. NM_205165.1.
UniGeneiGga.3045.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W4SX-ray1.55A932-1103[»]
ProteinModelPortaliQ90941.
SMRiQ90941.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002412.

Proteomic databases

PaxDbiQ90941.
PRIDEiQ90941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396074.
KEGGigga:396074.

Organism-specific databases

CTDi55193.

Phylogenomic databases

eggNOGiKOG1827. Eukaryota.
COG5076. LUCA.
HOGENOMiHOG000045795.
HOVERGENiHBG079860.
InParanoidiQ90941.
KOiK11757.
PhylomeDBiQ90941.

Miscellaneous databases

EvolutionaryTraceiQ90941.
PROiQ90941.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
1.20.920.10. 6 hits.
InterProiIPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR009071. HMG_box_dom.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF00439. Bromodomain. 6 hits.
PF00505. HMG_box. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00439. BAH. 2 hits.
SM00297. BROMO. 6 hits.
SM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF47370. SSF47370. 6 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00633. BROMODOMAIN_1. 5 hits.
PS50014. BROMODOMAIN_2. 6 hits.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPB1_CHICK
AccessioniPrimary (citable) accession number: Q90941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.