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Reviewed, UniProtKB/Swiss-Prot Q90922 (NET1_CHICK)

Last modified September 22, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Netrin-1
Gene names
Name: NTN1
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

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Protein attributes

Sequence length606 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors.

Subcellular location

Secreted › extracellular space › extracellular matrix.

Sequence similarities

Contains 3 laminin EGF-like domains.

Contains 1 laminin N-terminal domain.

Contains 1 NTR domain.

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Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   DomainLaminin EGF-like domain
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Cellular componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

DscamQ9ERC83EBI-1798593,EBI-1798601From a different organism.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 606581Netrin-1
PRO_0000017084

Regions

Domain49 – 286238Laminin N-terminal
Domain287 – 34256Laminin EGF-like 1
Domain343 – 40563Laminin EGF-like 2
Domain406 – 45550Laminin EGF-like 3
Domain474 – 603130NTR
Motif532 – 5343Cell attachment site Potential

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation1331N-linked (GlcNAc...) Potential
Glycosylation4191N-linked (GlcNAc...) Potential
Disulfide bond121 ↔ 154 By similarity
Disulfide bond287 ↔ 296 By similarity
Disulfide bond289 ↔ 306 By similarity
Disulfide bond308 ↔ 317 By similarity
Disulfide bond320 ↔ 340 By similarity
Disulfide bond343 ↔ 352 By similarity
Disulfide bond345 ↔ 370 By similarity
Disulfide bond373 ↔ 382 By similarity
Disulfide bond385 ↔ 403 By similarity
Disulfide bond406 ↔ 418 By similarity
Disulfide bond408 ↔ 425 By similarity
Disulfide bond427 ↔ 436 By similarity
Disulfide bond439 ↔ 453 By similarity
Disulfide bond474 ↔ 546 By similarity
Disulfide bond493 ↔ 603 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q90922-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9BFF0E3B07A71AE1

FASTA60668,127
        10         20         30         40         50         60 
MPRRGAEGPL ALLLAAAWLA QPLRGGYPGL NMFAVQTAQP DPCYDEHGLP RRCIPDFVNS 

        70         80         90        100        110        120 
AFGKEVKVSS TCGKPPSRYC VVTEKGEEQV RSCHLCNASD PKRAHPPSFL TDLNNPHNLT 

       130        140        150        160        170        180 
CWQSDSYVQY PHNVTLTLSL GKKFEVTYVS LQFCSPRPES MAIYKSMDYG KTWVPFQFYS 

       190        200        210        220        230        240 
TQCRKMYNKP SRAAITKQNE QEAICTDSHT DVRPLSGGLI AFSTLDGRPT AHDFDNSPVL 

       250        260        270        280        290        300 
QDWVTATDIK VTFSRLHTFG DENEDDSELA RDSYFYAVSD LQVGGRCKCN GHASRCVRDR 

       310        320        330        340        350        360 
DDNLVCDCKH NTAGPECDRC KPFHYDRPWQ RATAREANEC VACNCNLHAR RCRFNMELYK 

       370        380        390        400        410        420 
LSGRKSGGVC LNCRHNTAGR HCHYCKEGFY RDLSKPISHR KACKECDCHP VGAAGQTCNQ 

       430        440        450        460        470        480 
TTGQCPCKDG VTGITCNRCA KGYQQSRSPI APCIKIPAAP PPTAASSTEE PADCDSYCKA 

       490        500        510        520        530        540 
SKGKLKINMK KYCKKDYAVQ IHILKAEKNA DWWKFTVNII SVYKQGSNRL RRGDQTLWVH 

       550        560        570        580        590        600 
AKDIACKCPK VKPMKKYLLL GSTEDSPDQS GIIADKSSLV IQWRDTWARR LRKFQQREKK 


GKCRKA

« Hide

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References

[1]"The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6."
Serafini T., Kennedy T.E., Galko M.J., Mirzayan C., Jessell T.M., Tessier-Lavigne M.
Cell 78:409-424(1994) [PubMed: 8062384] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: White leghorn.
Tissue: Embryonic brain.

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Cross-references

Sequence databases

L34549 mRNA. Translation: AAA60369.1.
IPIIPI00570611.
PIRA54665.
RefSeqNP_990750.1.
UniGeneGga.794

3D structure databases

HSSPHSSP built from PDB template 1NPE based on UniProtKB P02468.
ModBaseSearch...

Protein-protein interaction databases

IntActQ90922. 3 interactions.

Genome annotation databases

GeneID396389.
KEGGgga:396389.

Phylogenomic databases

HOVERGENQ90922.

Family and domain databases

InterProIPR013032. EGF-like_reg_CS.
IPR002049. EGF_laminin.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
[Graphical view]
PfamPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameNET1_CHICK
AccessionPrimary (citable) accession number: Q90922
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 22, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents