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Protein

Netrin-1

Gene

NTN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-418885. DCC mediated attractive signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-1
Gene namesi
Name:NTN1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: Ensembl
  • cell periphery Source: MGI
  • cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 606581Netrin-1PRO_0000017084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi121 ↔ 154By similarity
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi287 ↔ 296By similarity
Disulfide bondi289 ↔ 306By similarity
Disulfide bondi308 ↔ 317By similarity
Disulfide bondi320 ↔ 340By similarity
Disulfide bondi343 ↔ 352By similarity
Disulfide bondi345 ↔ 370By similarity
Disulfide bondi373 ↔ 382By similarity
Disulfide bondi385 ↔ 403By similarity
Disulfide bondi406 ↔ 418By similarity
Disulfide bondi408 ↔ 425By similarity
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi427 ↔ 436By similarity
Disulfide bondi439 ↔ 453By similarity
Disulfide bondi474 ↔ 546By similarity
Disulfide bondi493 ↔ 603By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DscamQ9ERC87EBI-1798593,EBI-1798601From a different organism.

Protein-protein interaction databases

IntActiQ90922. 3 interactions.

Structurei

Secondary structure

1
606
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi46 – 483Combined sources
Beta strandi57 – 593Combined sources
Turni60 – 634Combined sources
Beta strandi67 – 693Combined sources
Beta strandi77 – 859Combined sources
Beta strandi88 – 969Combined sources
Beta strandi98 – 1003Combined sources
Helixi101 – 1033Combined sources
Helixi107 – 1093Combined sources
Beta strandi110 – 1123Combined sources
Beta strandi116 – 1183Combined sources
Beta strandi134 – 15522Combined sources
Beta strandi159 – 17113Combined sources
Beta strandi174 – 1829Combined sources
Helixi183 – 1875Combined sources
Beta strandi199 – 2013Combined sources
Beta strandi205 – 2073Combined sources
Beta strandi215 – 2239Combined sources
Turni224 – 2274Combined sources
Helixi231 – 2366Combined sources
Helixi238 – 2436Combined sources
Beta strandi245 – 2539Combined sources
Helixi268 – 2725Combined sources
Beta strandi277 – 28711Combined sources
Beta strandi296 – 2983Combined sources
Beta strandi304 – 3063Combined sources
Beta strandi312 – 3143Combined sources
Beta strandi350 – 3545Combined sources
Helixi356 – 3616Combined sources
Beta strandi368 – 3725Combined sources
Beta strandi377 – 3793Combined sources
Beta strandi389 – 3913Combined sources
Beta strandi393 – 3953Combined sources
Beta strandi397 – 3993Combined sources
Beta strandi403 – 4053Combined sources
Turni410 – 4123Combined sources
Beta strandi413 – 4164Combined sources
Turni420 – 4223Combined sources
Beta strandi431 – 4366Combined sources
Beta strandi443 – 4453Combined sources
Beta strandi449 – 4513Combined sources
Beta strandi453 – 4553Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4PLMX-ray2.80A26-457[»]
4PLNX-ray3.20A/B26-457[»]
4PLOX-ray2.90A26-457[»]
ProteinModelPortaliQ90922.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 286238Laminin N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini287 – 34256Laminin EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini343 – 40563Laminin EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini406 – 45550Laminin EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini474 – 603130NTRPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi532 – 5343Cell attachment siteSequence analysis

Sequence similaritiesi

Contains 3 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin N-terminal domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00840000129717.
HOVERGENiHBG006464.
InParanoidiQ90922.
KOiK06843.
OMAiQVHILKA.
PhylomeDBiQ90922.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR002049. Laminin_EGF.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRGAEGPL ALLLAAAWLA QPLRGGYPGL NMFAVQTAQP DPCYDEHGLP
60 70 80 90 100
RRCIPDFVNS AFGKEVKVSS TCGKPPSRYC VVTEKGEEQV RSCHLCNASD
110 120 130 140 150
PKRAHPPSFL TDLNNPHNLT CWQSDSYVQY PHNVTLTLSL GKKFEVTYVS
160 170 180 190 200
LQFCSPRPES MAIYKSMDYG KTWVPFQFYS TQCRKMYNKP SRAAITKQNE
210 220 230 240 250
QEAICTDSHT DVRPLSGGLI AFSTLDGRPT AHDFDNSPVL QDWVTATDIK
260 270 280 290 300
VTFSRLHTFG DENEDDSELA RDSYFYAVSD LQVGGRCKCN GHASRCVRDR
310 320 330 340 350
DDNLVCDCKH NTAGPECDRC KPFHYDRPWQ RATAREANEC VACNCNLHAR
360 370 380 390 400
RCRFNMELYK LSGRKSGGVC LNCRHNTAGR HCHYCKEGFY RDLSKPISHR
410 420 430 440 450
KACKECDCHP VGAAGQTCNQ TTGQCPCKDG VTGITCNRCA KGYQQSRSPI
460 470 480 490 500
APCIKIPAAP PPTAASSTEE PADCDSYCKA SKGKLKINMK KYCKKDYAVQ
510 520 530 540 550
IHILKAEKNA DWWKFTVNII SVYKQGSNRL RRGDQTLWVH AKDIACKCPK
560 570 580 590 600
VKPMKKYLLL GSTEDSPDQS GIIADKSSLV IQWRDTWARR LRKFQQREKK

GKCRKA
Length:606
Mass (Da):68,127
Last modified:November 1, 1996 - v1
Checksum:i9BFF0E3B07A71AE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34549 mRNA. Translation: AAA60369.1.
PIRiA54665.
RefSeqiNP_990750.1. NM_205419.1.
UniGeneiGga.794.

Genome annotation databases

EnsembliENSGALT00000039331; ENSGALP00000038541; ENSGALG00000023626.
GeneIDi396389.
KEGGigga:396389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34549 mRNA. Translation: AAA60369.1.
PIRiA54665.
RefSeqiNP_990750.1. NM_205419.1.
UniGeneiGga.794.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4PLMX-ray2.80A26-457[»]
4PLNX-ray3.20A/B26-457[»]
4PLOX-ray2.90A26-457[»]
ProteinModelPortaliQ90922.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ90922. 3 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000039331; ENSGALP00000038541; ENSGALG00000023626.
GeneIDi396389.
KEGGigga:396389.

Organism-specific databases

CTDi9423.

Phylogenomic databases

GeneTreeiENSGT00840000129717.
HOVERGENiHBG006464.
InParanoidiQ90922.
KOiK06843.
OMAiQVHILKA.
PhylomeDBiQ90922.

Enzyme and pathway databases

ReactomeiR-GGA-418885. DCC mediated attractive signaling.

Miscellaneous databases

PROiQ90922.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR002049. Laminin_EGF.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6."
    Serafini T., Kennedy T.E., Galko M.J., Mirzayan C., Jessell T.M., Tessier-Lavigne M.
    Cell 78:409-424(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: White leghorn.
    Tissue: Embryonic brain.

Entry informationi

Entry nameiNET1_CHICK
AccessioniPrimary (citable) accession number: Q90922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.