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Protein

Netrin-1

Gene

NTN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-418885. DCC mediated attractive signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-1
Gene namesi
Name:NTN1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: Ensembl
  • cell periphery Source: MGI
  • cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001708426 – 606Netrin-1Add BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi121 ↔ 154By similarity
Glycosylationi133N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi287 ↔ 296By similarity
Disulfide bondi289 ↔ 306By similarity
Disulfide bondi308 ↔ 317By similarity
Disulfide bondi320 ↔ 340By similarity
Disulfide bondi343 ↔ 352By similarity
Disulfide bondi345 ↔ 370By similarity
Disulfide bondi373 ↔ 382By similarity
Disulfide bondi385 ↔ 403By similarity
Disulfide bondi406 ↔ 418By similarity
Disulfide bondi408 ↔ 425By similarity
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi427 ↔ 436By similarity
Disulfide bondi439 ↔ 453By similarity
Disulfide bondi474 ↔ 546By similarity
Disulfide bondi493 ↔ 603By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiENSGALG00000023626.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DscamQ9ERC87EBI-1798593,EBI-1798601From a different organism.

Protein-protein interaction databases

IntActiQ90922. 3 interactors.

Structurei

Secondary structure

1606
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 48Combined sources3
Beta strandi57 – 59Combined sources3
Turni60 – 63Combined sources4
Beta strandi67 – 69Combined sources3
Beta strandi77 – 85Combined sources9
Beta strandi88 – 96Combined sources9
Beta strandi98 – 100Combined sources3
Helixi101 – 103Combined sources3
Helixi107 – 109Combined sources3
Beta strandi110 – 112Combined sources3
Beta strandi116 – 118Combined sources3
Beta strandi134 – 155Combined sources22
Beta strandi159 – 171Combined sources13
Beta strandi174 – 182Combined sources9
Helixi183 – 187Combined sources5
Beta strandi199 – 201Combined sources3
Beta strandi205 – 207Combined sources3
Beta strandi215 – 223Combined sources9
Turni224 – 227Combined sources4
Helixi231 – 236Combined sources6
Helixi238 – 243Combined sources6
Beta strandi245 – 253Combined sources9
Helixi268 – 272Combined sources5
Beta strandi277 – 287Combined sources11
Beta strandi296 – 298Combined sources3
Beta strandi304 – 306Combined sources3
Beta strandi312 – 314Combined sources3
Beta strandi350 – 354Combined sources5
Helixi356 – 361Combined sources6
Beta strandi368 – 372Combined sources5
Beta strandi377 – 379Combined sources3
Beta strandi389 – 391Combined sources3
Beta strandi393 – 395Combined sources3
Beta strandi397 – 399Combined sources3
Beta strandi403 – 405Combined sources3
Turni410 – 412Combined sources3
Beta strandi413 – 416Combined sources4
Turni420 – 422Combined sources3
Beta strandi431 – 436Combined sources6
Beta strandi443 – 445Combined sources3
Beta strandi449 – 451Combined sources3
Beta strandi453 – 455Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PLMX-ray2.80A26-457[»]
4PLNX-ray3.20A/B26-457[»]
4PLOX-ray2.90A26-457[»]
ProteinModelPortaliQ90922.
SMRiQ90922.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 286Laminin N-terminalPROSITE-ProRule annotationAdd BLAST238
Domaini287 – 342Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini343 – 405Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini406 – 455Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST50
Domaini474 – 603NTRPROSITE-ProRule annotationAdd BLAST130

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi532 – 534Cell attachment siteSequence analysis3

Sequence similaritiesi

Contains 3 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin N-terminal domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG006464.
InParanoidiQ90922.
KOiK06843.
OMAiQVHILKA.
OrthoDBiEOG091G005L.
PhylomeDBiQ90922.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR002049. Laminin_EGF.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRGAEGPL ALLLAAAWLA QPLRGGYPGL NMFAVQTAQP DPCYDEHGLP
60 70 80 90 100
RRCIPDFVNS AFGKEVKVSS TCGKPPSRYC VVTEKGEEQV RSCHLCNASD
110 120 130 140 150
PKRAHPPSFL TDLNNPHNLT CWQSDSYVQY PHNVTLTLSL GKKFEVTYVS
160 170 180 190 200
LQFCSPRPES MAIYKSMDYG KTWVPFQFYS TQCRKMYNKP SRAAITKQNE
210 220 230 240 250
QEAICTDSHT DVRPLSGGLI AFSTLDGRPT AHDFDNSPVL QDWVTATDIK
260 270 280 290 300
VTFSRLHTFG DENEDDSELA RDSYFYAVSD LQVGGRCKCN GHASRCVRDR
310 320 330 340 350
DDNLVCDCKH NTAGPECDRC KPFHYDRPWQ RATAREANEC VACNCNLHAR
360 370 380 390 400
RCRFNMELYK LSGRKSGGVC LNCRHNTAGR HCHYCKEGFY RDLSKPISHR
410 420 430 440 450
KACKECDCHP VGAAGQTCNQ TTGQCPCKDG VTGITCNRCA KGYQQSRSPI
460 470 480 490 500
APCIKIPAAP PPTAASSTEE PADCDSYCKA SKGKLKINMK KYCKKDYAVQ
510 520 530 540 550
IHILKAEKNA DWWKFTVNII SVYKQGSNRL RRGDQTLWVH AKDIACKCPK
560 570 580 590 600
VKPMKKYLLL GSTEDSPDQS GIIADKSSLV IQWRDTWARR LRKFQQREKK

GKCRKA
Length:606
Mass (Da):68,127
Last modified:November 1, 1996 - v1
Checksum:i9BFF0E3B07A71AE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34549 mRNA. Translation: AAA60369.1.
PIRiA54665.
RefSeqiNP_990750.1. NM_205419.1.
UniGeneiGga.794.

Genome annotation databases

GeneIDi396389.
KEGGigga:396389.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34549 mRNA. Translation: AAA60369.1.
PIRiA54665.
RefSeqiNP_990750.1. NM_205419.1.
UniGeneiGga.794.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PLMX-ray2.80A26-457[»]
4PLNX-ray3.20A/B26-457[»]
4PLOX-ray2.90A26-457[»]
ProteinModelPortaliQ90922.
SMRiQ90922.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ90922. 3 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396389.
KEGGigga:396389.

Organism-specific databases

CTDi9423.

Phylogenomic databases

HOVERGENiHBG006464.
InParanoidiQ90922.
KOiK06843.
OMAiQVHILKA.
OrthoDBiEOG091G005L.
PhylomeDBiQ90922.

Enzyme and pathway databases

ReactomeiR-GGA-418885. DCC mediated attractive signaling.

Miscellaneous databases

PROiQ90922.

Gene expression databases

BgeeiENSGALG00000023626.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR002049. Laminin_EGF.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 3 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNET1_CHICK
AccessioniPrimary (citable) accession number: Q90922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.