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Protein

Dual specificity mitogen-activated protein kinase kinase 2

Gene

MAP2K2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ATPPROSITE-ProRule annotation1
Active sitei192Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi76 – 84ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.2. 1306.
ReactomeiR-GGA-451533. ERK2 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
Short name:
MAP kinase kinase 2
Short name:
MAPKK 2
Alternative name(s):
ERK activator kinase 2
MAPK/ERK kinase 2
Short name:
MEK2
Gene namesi
Name:MAP2K2
Synonyms:MEK2, MKK2, PRKMK2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863751 – 398Dual specificity mitogen-activated protein kinase kinase 2Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220Phosphoserine; by RAFBy similarity1
Modified residuei224Phosphoserine; by RAFBy similarity1

Post-translational modificationi

Activated by phosphorylation on Ser/Thr catalyzed by MAP kinase kinase kinases (RAF).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ90891.
PRIDEiQ90891.

PTM databases

iPTMnetiQ90891.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001932.

Structurei

3D structure databases

ProteinModelPortaliQ90891.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 367Protein kinasePROSITE-ProRule annotationAdd BLAST298

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi264 – 313Pro-richAdd BLAST50

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0581. Eukaryota.
ENOG410XQ5A. LUCA.
HOGENOMiHOG000234206.
HOVERGENiHBG108518.
InParanoidiQ90891.
KOiK04369.
PhylomeDBiQ90891.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAKRKPVLP ALTITPSPAE GPGPGGSAEA NLVDLQKKLE ELELDEQQKK
60 70 80 90 100
RLEAFLTQKA KVGELKDDDF ERISELGAGN GGVVTKVQHK PSGLIMARKL
110 120 130 140 150
IHLEIKPAIR NQIIRELQVL HECNSPYIVG FYGAFYSDGE ISICMEHMDG
160 170 180 190 200
GSLDQVLKEA KRIPEEILGK VSIAVLRGLA YLREKHQIMH RDVKPSNILV
210 220 230 240 250
NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS
260 270 280 290 300
MGLSLVELSI GRYPIPPPDS KELEAIFGRP VVDGAEGESH SVSPWARPPG
310 320 330 340 350
RPISGHGMDS RPAMAIFELL DYIVNEPPPK LPNGVFTQDF QEFVNKCLIK
360 370 380 390
NPAERADLKM LMNHTFIKRS EVEEVDFAGW LCKTLRLNQP STPTRAAV
Length:398
Mass (Da):44,078
Last modified:November 1, 1996 - v1
Checksum:i84BDD4C9797D62D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28703 mRNA. Translation: AAA75576.1.
RefSeqiNP_990719.1. NM_205388.1.
UniGeneiGga.2391.
Gga.46258.

Genome annotation databases

GeneIDi396349.
KEGGigga:396349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28703 mRNA. Translation: AAA75576.1.
RefSeqiNP_990719.1. NM_205388.1.
UniGeneiGga.2391.
Gga.46258.

3D structure databases

ProteinModelPortaliQ90891.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001932.

PTM databases

iPTMnetiQ90891.

Proteomic databases

PaxDbiQ90891.
PRIDEiQ90891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396349.
KEGGigga:396349.

Organism-specific databases

CTDi5605.

Phylogenomic databases

eggNOGiKOG0581. Eukaryota.
ENOG410XQ5A. LUCA.
HOGENOMiHOG000234206.
HOVERGENiHBG108518.
InParanoidiQ90891.
KOiK04369.
PhylomeDBiQ90891.

Enzyme and pathway databases

BRENDAi2.7.12.2. 1306.
ReactomeiR-GGA-451533. ERK2 activation.

Miscellaneous databases

PROiQ90891.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMP2K2_CHICK
AccessioniPrimary (citable) accession number: Q90891
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.