Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dual specificity mitogen-activated protein kinase kinase 2

Gene

MAP2K2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991ATPPROSITE-ProRule annotation
Active sitei192 – 1921Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi76 – 849ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.2. 1306.
ReactomeiR-GGA-451533. ERK2 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)
Short name:
MAP kinase kinase 2
Short name:
MAPKK 2
Alternative name(s):
ERK activator kinase 2
MAPK/ERK kinase 2
Short name:
MEK2
Gene namesi
Name:MAP2K2
Synonyms:MEK2, MKK2, PRKMK2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Dual specificity mitogen-activated protein kinase kinase 2PRO_0000086375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201Phosphoserine; by RAFBy similarity
Modified residuei224 – 2241Phosphoserine; by RAFBy similarity

Post-translational modificationi

Activated by phosphorylation on Ser/Thr catalyzed by MAP kinase kinase kinases (RAF).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ90891.
PRIDEiQ90891.

PTM databases

iPTMnetiQ90891.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001932.

Structurei

3D structure databases

ProteinModelPortaliQ90891.
SMRiQ90891. Positions 58-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 367298Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi264 – 31350Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0581. Eukaryota.
ENOG410XQ5A. LUCA.
HOGENOMiHOG000234206.
HOVERGENiHBG108518.
InParanoidiQ90891.
KOiK04369.
PhylomeDBiQ90891.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAKRKPVLP ALTITPSPAE GPGPGGSAEA NLVDLQKKLE ELELDEQQKK
60 70 80 90 100
RLEAFLTQKA KVGELKDDDF ERISELGAGN GGVVTKVQHK PSGLIMARKL
110 120 130 140 150
IHLEIKPAIR NQIIRELQVL HECNSPYIVG FYGAFYSDGE ISICMEHMDG
160 170 180 190 200
GSLDQVLKEA KRIPEEILGK VSIAVLRGLA YLREKHQIMH RDVKPSNILV
210 220 230 240 250
NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS
260 270 280 290 300
MGLSLVELSI GRYPIPPPDS KELEAIFGRP VVDGAEGESH SVSPWARPPG
310 320 330 340 350
RPISGHGMDS RPAMAIFELL DYIVNEPPPK LPNGVFTQDF QEFVNKCLIK
360 370 380 390
NPAERADLKM LMNHTFIKRS EVEEVDFAGW LCKTLRLNQP STPTRAAV
Length:398
Mass (Da):44,078
Last modified:November 1, 1996 - v1
Checksum:i84BDD4C9797D62D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28703 mRNA. Translation: AAA75576.1.
RefSeqiNP_990719.1. NM_205388.1.
UniGeneiGga.2391.
Gga.46258.

Genome annotation databases

GeneIDi396349.
KEGGigga:396349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28703 mRNA. Translation: AAA75576.1.
RefSeqiNP_990719.1. NM_205388.1.
UniGeneiGga.2391.
Gga.46258.

3D structure databases

ProteinModelPortaliQ90891.
SMRiQ90891. Positions 58-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001932.

PTM databases

iPTMnetiQ90891.

Proteomic databases

PaxDbiQ90891.
PRIDEiQ90891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396349.
KEGGigga:396349.

Organism-specific databases

CTDi5605.

Phylogenomic databases

eggNOGiKOG0581. Eukaryota.
ENOG410XQ5A. LUCA.
HOGENOMiHOG000234206.
HOVERGENiHBG108518.
InParanoidiQ90891.
KOiK04369.
PhylomeDBiQ90891.

Enzyme and pathway databases

BRENDAi2.7.12.2. 1306.
ReactomeiR-GGA-451533. ERK2 activation.

Miscellaneous databases

NextBioi20816397.
PROiQ90891.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of cDNAs encoding chicken mitogen-activated protein kinase kinase type 2, MEK2: downregulation of MEK2 in response to inhibition of mitochondrial DNA expression."
    Wang H., Meury L., Morais R.
    Biochemistry 36:15371-15380(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: White leghorn.
    Tissue: Liver.

Entry informationi

Entry nameiMP2K2_CHICK
AccessioniPrimary (citable) accession number: Q90891
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.