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Protein

LIM/homeobox protein Lhx9

Gene

LHX9

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in gonadal development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi267 – 326HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • dorsal spinal cord interneuron anterior axon guidance Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • spinal cord motor neuron differentiation Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx9
Short name:
LIM homeobox protein 9
Gene namesi
Name:LHX9
Synonyms:LH-2A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003642291 – 397LIM/homeobox protein Lhx9Add BLAST397

Proteomic databases

PaxDbiQ90881

Expressioni

Developmental stagei

Expressed in the limb mesenchyme throughout stages 16 to 32. Expressed in the prospective wing bud at stage 16. Expressed in the leg bud at stage 17. Expressed in the forebrain throughout stages 14 to 21.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003475

Structurei

3D structure databases

SMRiQ90881
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 130LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini131 – 193LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
HOGENOMiHOG000034022
HOVERGENiHBG006262
InParanoidiQ90881
KOiK09373
PhylomeDBiQ90881

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q90881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIVGCRAEE NTCPFRPPAM LFHGISGGHI QGIMEEMERR SKTESRLAKG
60 70 80 90 100
GQMNGRETNM PPMSPEKPAL CAGCGGKISD RYYLLAVDKQ WHLRCLKCCE
110 120 130 140 150
CKLALESELT CFAKDGSIYC KEDYYRRFSV QRCARCHLGI SASEMVMRAR
160 170 180 190 200
ESVYHLSCFT CTTCNKTLTT GDHFGMKDNL VYCRAHFESL LQGEYPPQLS
210 220 230 240 250
YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV NYNSGCNENE
260 270 280 290 300
ADHMDRDQQP YPPSQKTKRM ATSFKHHQLR TMKSYFAINH NPDAKDLKQL
310 320 330 340 350
AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS
360 370 380 390
GALTPPGTAT TLTDLTNPTI TVVTSVTSNL DSHEPGSPSQ TTLTNLF
Length:397
Mass (Da):44,109
Last modified:March 3, 2009 - v2
Checksum:i8C124654B394C43B
GO

Sequence cautioni

The sequence AAA50258 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35566 mRNA Translation: AAA50258.1 Different initiation.
PIRiJC5658
RefSeqiNP_990757.1, NM_205426.1
UniGeneiGga.2348

Genome annotation databases

GeneIDi396397
KEGGigga:396397

Similar proteinsi

Entry informationi

Entry nameiLHX9_CHICK
AccessioniPrimary (citable) accession number: Q90881
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome