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Protein

LIM/homeobox protein Lhx9

Gene

LHX9

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in gonadal development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi267 – 32660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • motor neuron axon guidance Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • spinal cord motor neuron differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx9
Short name:
LIM homeobox protein 9
Gene namesi
Name:LHX9
Synonyms:LH-2A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397LIM/homeobox protein Lhx9PRO_0000364229Add
BLAST

Proteomic databases

PaxDbiQ90881.

Expressioni

Developmental stagei

Expressed in the limb mesenchyme throughout stages 16 to 32. Expressed in the prospective wing bud at stage 16. Expressed in the leg bud at stage 17. Expressed in the forebrain throughout stages 14 to 21.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003475.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 13062LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini131 – 19363LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000034022.
HOVERGENiHBG006262.
InParanoidiQ90881.
KOiK09373.
PhylomeDBiQ90881.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIVGCRAEE NTCPFRPPAM LFHGISGGHI QGIMEEMERR SKTESRLAKG
60 70 80 90 100
GQMNGRETNM PPMSPEKPAL CAGCGGKISD RYYLLAVDKQ WHLRCLKCCE
110 120 130 140 150
CKLALESELT CFAKDGSIYC KEDYYRRFSV QRCARCHLGI SASEMVMRAR
160 170 180 190 200
ESVYHLSCFT CTTCNKTLTT GDHFGMKDNL VYCRAHFESL LQGEYPPQLS
210 220 230 240 250
YTELAAKSGG LALPYFNGTG TVQKGRPRKR KSPALGVDIV NYNSGCNENE
260 270 280 290 300
ADHMDRDQQP YPPSQKTKRM ATSFKHHQLR TMKSYFAINH NPDAKDLKQL
310 320 330 340 350
AQKTGLTKRV LQVWFQNARA KFRRNLLRQE NGGVDKADGT SLPAPPSADS
360 370 380 390
GALTPPGTAT TLTDLTNPTI TVVTSVTSNL DSHEPGSPSQ TTLTNLF
Length:397
Mass (Da):44,109
Last modified:March 3, 2009 - v2
Checksum:i8C124654B394C43B
GO

Sequence cautioni

The sequence AAA50258.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35566 mRNA. Translation: AAA50258.1. Different initiation.
PIRiJC5658.
RefSeqiNP_990757.1. NM_205426.1.
UniGeneiGga.2348.

Genome annotation databases

GeneIDi396397.
KEGGigga:396397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35566 mRNA. Translation: AAA50258.1. Different initiation.
PIRiJC5658.
RefSeqiNP_990757.1. NM_205426.1.
UniGeneiGga.2348.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003475.

Proteomic databases

PaxDbiQ90881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396397.
KEGGigga:396397.

Organism-specific databases

CTDi56956.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000034022.
HOVERGENiHBG006262.
InParanoidiQ90881.
KOiK09373.
PhylomeDBiQ90881.

Miscellaneous databases

PROiQ90881.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential expression of the two closely related LIM-class homeobox genes LH-2A and LH-2B during limb development."
    Nohno T., Kawakami Y., Wada N., Ishikawa T., Ohuchi H., Noji S.
    Biochem. Biophys. Res. Commun. 238:506-511(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryo.

Entry informationi

Entry nameiLHX9_CHICK
AccessioniPrimary (citable) accession number: Q90881
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 8, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.