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Protein

Interferon regulatory factor 1

Gene

IRF1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 113IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST109

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-GGA-933541. TRAF6 mediated IRF7 activation.
R-GGA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 1
Short name:
IRF-1
Gene namesi
Name:IRF1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545481 – 313Interferon regulatory factor 1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-271. Sumoylation is enhanced by PIAS3. Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites (By similarity).By similarity
Ubiquitinated. Appears to compete with sumoylation on C-terminal sites (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ90876.

Expressioni

Gene expression databases

BgeeiENSGALG00000006785.
ExpressionAtlasiQ90876. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002242.

Structurei

3D structure databases

ProteinModelPortaliQ90876.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IER3. Eukaryota.
ENOG4111HM7. LUCA.
GeneTreeiENSGT00760000119093.
HOGENOMiHOG000037937.
HOVERGENiHBG003455.
InParanoidiQ90876.
KOiK09444.
OMAiCKEEPEV.
OrthoDBiEOG091G0CB8.
PhylomeDBiQ90876.

Family and domain databases

CDDicd00103. IRF. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR031215. IRF1.
IPR017431. IRF1/IRF2.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PANTHERiPTHR11949. PTHR11949. 1 hit.
PTHR11949:SF3. PTHR11949:SF3. 1 hit.
PfamiView protein in Pfam
PF00605. IRF. 1 hit.
PIRSFiPIRSF038196. IFN_RF1/2. 1 hit.
PRINTSiPR00267. INTFRNREGFCT.
SMARTiView protein in SMART
SM00348. IRF. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q90876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSRMRMRP WLEMQINSNQ IPGLIWINKD KMIFQIPWKH AAKHGWDMEK
60 70 80 90 100
DACLFRSWAI HTGRYKVGEK DPDPKTWKAN FRCAMNSLPD IEEVKDKSIN
110 120 130 140 150
KGSSAVRVYR MLPPLTKDQK KERKSKSSRE ARNKSKRKLY EDMRMEESAE
160 170 180 190 200
RLTSTPLPDD HSSYTAHDYT GQEVEVENTS ITLDLSSCEV SGSLTDWRMP
210 220 230 240 250
MEIAMADSTN DIYQLQVSPL GSSSEDEDEM KSNIIKLLEP TQDWHTTSVE
260 270 280 290 300
GKGFFTNEPG TQTMCSTFGY KEQDGEIDTS SAELEFRMMD QKSSLDFSWL
310
DTVRPMQAIS CSL
Length:313
Mass (Da):36,010
Last modified:November 1, 1997 - v1
Checksum:i0895FA3736FA7463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39766 mRNA. Translation: AAA62160.1.
AJ621385 Genomic DNA. Translation: CAF18545.1.
RefSeqiNP_990746.1. NM_205415.1.
UniGeneiGga.791.

Genome annotation databases

EnsembliENSGALT00000002244; ENSGALP00000002242; ENSGALG00000006785.
GeneIDi396384.
KEGGigga:396384.

Similar proteinsi

Entry informationi

Entry nameiIRF1_CHICK
AccessioniPrimary (citable) accession number: Q90876
Secondary accession number(s): Q5W4T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 25, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families