Reviewed, UniProtKB/Swiss-Prot Q90875 (ACOC_CHICK)

Names and origin

Protein names

Recommended name:
    Cytoplasmic aconitate hydratase
      Short name=Aconitase
    EC=4.2.1.3
Alternative name(s):
    Citrate hydro-lyase
    Iron-responsive element-binding protein 1
      Short name=IRE-BP 1

Gene names

Name:	ACO1
Synonyms:	IREB1

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	889 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA By similarity. This protein also expresses aconitase activity By similarity.
Catalytic activity	Citrate = isocitrate.
Cofactor	Binds 1 4Fe-4S cluster per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the aconitase/IPM isomerase family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Cytoplasm
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding RNA-binding
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: UniProtKB-KW aconitate hydratase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 889	889	Cytoplasmic aconitate hydratase		PRO_0000076679
Sites
	Metal binding	437	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	503	1	Iron-sulfur (4Fe-4S) By similarity
	Metal binding	506	1	Iron-sulfur (4Fe-4S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q90875-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 527314F6AE08C842	FASTA	889	98,074
	10 20 30 40 50 60 MSNPFVQIVE PLDAKEPVKK FFNLSKLEDV RYARLPFSIR VLLEAAIRNC DEFLVKKQDV 70 80 90 100 110 120 ENILNWKVMQ HKNVEVPFKP ARVILQDFTG VPAVVDFAAM RDAVKKLGGD PEKINPICPA 130 140 150 160 170 180 DLVIDHSIQV DFNRRSDSLQ KNQDLEFERN KERFEFLKWG SQAFKNMRII PPGSGIIHQV 190 200 210 220 230 240 NLEYLARVVM DQDGYYYPDS VVGTDSHTTM VDGLGVLGWG VGGIEAEAVM LGQPISMVLP 250 260 270 280 290 300 EVVGYKLLGN PQPLVTSTDI VLTITKHLRQ VGVVGKFVEF FGPGVAQLSI ADRATIANMC 310 320 330 340 350 360 PEYGATAAYF PVDDISIGYL VQTGRDKEKV LCTKKYLEAV GMLRDFKNSS QDPDFTQVVE 370 380 390 400 410 420 LDLHTVVPCC SGPKRPQDKV AVSDMKKDFE TCLGAKQGFK GFQIAPDRHN SVIKFNFEGC 430 440 450 460 470 480 DFELAHGSVV IAAITSCTNT SNPSVMLGAG LLAKKAVEAG LTVKPYIKTS LSPGSGVVTY 490 500 510 520 530 540 YLRESGVMSY LSQLGFDVVG YGCMTCIGNS GPLPDSVVEA ITQGDLVAVG VLSGNRNFEG 550 560 570 580 590 600 RVHPNTRANY LASPPLVIAY AIAGTVRIDF EKEPLGISAS GKKIFLKDIW PTRNEIQAVE 610 620 630 640 650 660 RQYVIPGMFK EVYQKIETVN EAWNALDAPS DKLYTWNPKS TYIKSPPFFD GLTLALQTPK 670 680 690 700 710 720 TIEDAYVLLN FGDSVTTDHI SPAGNIARNS PAARYLTSRG LTPREFNSYG SRRGNDAVMA 730 740 750 760 770 780 RGTFANIRLV NKFIDKQGPQ TIHFPSGETL DVFDAAERYK QAGHPLIVLA GKEYGAGSSR 790 800 810 820 830 840 DWAAKGPFLL GVKAVLAESY ERIHRSNLVG MGVIPLQYLP GEDARTLGLT GRERYTIIIP 850 860 870 880 ENLKPQMNIQ IKLDTGKTFH AIMRFDTDVE LTYFHNGGIL NYMIRKMAS

References

[1]

"Identification and localization of two genes on the chicken Z chromosome: implication of evolutionary conservation of the Z chromosome among avian species." Saitoh Y., Ogawa A., Hori T., Kunita R., Mizuno S. Chromosome Res. 1:239-251(1993) [PubMed: 8156162] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D16150 mRNA. Translation: BAA03715.1.
IPI	IPI00573699.
RefSeq	NP_001025707.1.
UniGene	Gga.4139
3D structure databases
SMR	Q90875. Positions 2-888.
ModBase	Search...
Protein-protein interaction databases
STRING	Q90875.
Proteomic databases
PRIDE	Q90875.
Genome annotation databases
Ensembl	ENSGALT00000003386; ENSGALP00000003381; ENSGALG00000002162; Gallus gallus. [Genome view]
GeneID	373916.
KEGG	gga:373916.
Organism-specific databases
CTD	373916.
Phylogenomic databases
HOVERGEN	Q90875.
Enzyme and pathway databases
BRENDA	4.2.1.3. 4.
Family and domain databases
InterPro	IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3. IPR001030. Acoase/IPM_deHydtase_lsu_aba. IPR015937. Aconitase-like_core. IPR015928. Aconitase/3IPM_dehydase_swvl. IPR006249. Aconitase/Fe_reg_prot_2. IPR015934. Aconitase/Fe_reg_prot_2/AcnD. IPR015932. Aconitase/IPMdHydase_lsu_aba_2. IPR018136. Aconitase_4Fe-4S_BS. IPR000573. AconitaseA/IPMdHydase_ssu_swvl. [Graphical view]
Gene3D	G3DSA:3.30.499.10. Acnase/IPM_dHydase_lsu_aba_1/3. 2 hits. G3DSA:3.20.19.10. Aconitase/3IPM_dehydase_swvl. 1 hit. G3DSA:3.40.1060.10. Aconitase/IPMdHydase_lsu_aba_2. 1 hit.
PANTHER	PTHR11670. Aconitase-like_core. 1 hit. PTHR11670:SF1. Aconitase/Fe_reg_prot_2/AcnD. 1 hit.
Pfam	PF00330. Aconitase. 1 hit. PF00694. Aconitase_C. 1 hit. [Graphical view]
PRINTS	PR00415. ACONITASE.
ProDom	PD000511. Aconitase_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01341. aconitase_1. 1 hit.
PROSITE	PS00450. ACONITASE_1. 1 hit. PS01244. ACONITASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACOC_CHICK

Accession

Primary (citable) accession number: Q90875

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	September 1, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)