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Protein

Hypermethylated in cancer 1 protein

Gene

HIC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds specifically to the gamma F-1-binding motif of the gamma F-crystallin promoter. May have a regulatory role in sclerotome specification and/or differentiation. Isoform 2 functions as a transcriptional repressor in lens cells.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 447C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri474 – 501C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri502 – 529C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri530 – 557C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri558 – 585C2H2-type 5PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hypermethylated in cancer 1 protein
Short name:
Hic-1
Alternative name(s):
GammaFBP
Gene namesi
Name:HIC1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000046944‹1 – 676Hypermethylated in cancer 1 proteinAdd BLAST›676

Proteomic databases

PRIDEiQ90850

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in kidney and lung. Expression of isoform 2 is higher in the lens, retina and stomach, and extremely low in heart, muscle, kidney and lung. Isoform 3 is weakly expressed in heart, kidney and lens.

Developmental stagei

In the embryo of stage 11, expressed predominantly in the head mesenchyme surrounding the brain and in the paraxial mesoderm. Highly expressed in presomitic mesoderm and then over the entire epithelial somite. During somitic differentiation, expression becomes restricted to the sclerotome. In the developing lens, expression is most active at the beginning of lens fiber cell differentiation.

Gene expression databases

BgeeiENSGALG00000026718

Interactioni

Subunit structurei

Interacts with CtBP.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ90850
SMRiQ90850
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 126BTBPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni241 – 245Binding to CtBP5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 447C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri474 – 501C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri502 – 529C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri530 – 557C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri558 – 585C2H2-type 5PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG031606
InParanoidiQ90850
OrthoDBiEOG091G051O
PhylomeDBiQ90850

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR028424 HIC1
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44802 PTHR44802, 1 hit
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (3)i

Sequence statusi: Fragment.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 3 (identifier: Q90850-1) [UniParc]FASTAAdd to basket
Also known as: GammaFBP-C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
APGARPAASR ERGHKSREER CGERGAAAGR RARGAMLEAM EVPSHSRQLL
60 70 80 90 100
LQLNTQRTKG FLCDVIIVVQ NALFRAHKNI LAASSAYLKS LVVHDNLLNL
110 120 130 140 150
DHEMVSPGIF RLILDFIYTG RLGECEPGGE QSLGAVLAAA SYLQIPGLVA
160 170 180 190 200
LCKKKLKRSG KYCHLRGGYA PYKLGRGLRA TTPVIQACYS GTPRPVDLQP
210 220 230 240 250
VEPAAPLNTQ CGELYASASQ GTPLHPHGLC PPERHCSPPC GLDLSKKSPT
260 270 280 290 300
GPSAQLLPTD RLLPAEPREP SLPPRHDSPP VSGGLLAGHP AAYKDSPPGG
310 320 330 340 350
EPGGHPHATD PFRSTPPCAE PPLPRGDGRE LMYRWMKHEP LGPYLDEGEA
360 370 380 390 400
EKELEREEKA ESPPAAPQPR YPSVESNDLE PDNSTSEETG SSEGPSPGDA
410 420 430 440 450
LDRYCNHLGY EPESLGDNLY VCIPCGKGFP SSEQLNAHVE AHNEEELYHK
460 470 480 490 500
AAAEQAVPFL DKGGAGLGDI LRPYRCSSCD KSYKDPATLR QHEKTHWLTR
510 520 530 540 550
PYPCTICGKK FTQRGTMTRH MRSHLGLKPF ACDACGMRFT RQYRLTEHMR
560 570 580 590 600
IHSGEKPYEC QVCGGKFAQQ RNLISHMKMH AAGPDGKAKL DFPDSVYAMA
610 620 630 640 650
RLTADQLGLK QEKAAELLSH TSHFLSDPKA MESLYPLAKF TAEHLGLSQD
660 670
KAAEVLAQAP HLHADAARTI ERYSPP
Length:676
Mass (Da):73,759
Last modified:May 2, 2002 - v2
Checksum:i3D3C7FD3302F32EC
GO
Isoform 1 (identifier: Q90850-2) [UniParc]FASTAAdd to basket
Also known as: GammaFBP-A

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: APGARPAASRERGHKSREERCGERGAAAGRRARGA → MRVHRELGWLAEGSGRAGRRARGA

Show »
Length:665
Mass (Da):72,750
Checksum:iFEA5BAB7D989FC43
GO
Isoform 2 (identifier: Q90850-3) [UniParc]FASTAAdd to basket
Also known as: GammaFBP-B

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:641
Mass (Da):70,118
Checksum:i4A41AD03A461987C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0068271 – 35APGAR…RARGA → MRVHRELGWLAEGSGRAGRR ARGA in isoform 1. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0068281 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79011 mRNA Translation: CAA55644.1
X79050 mRNA Translation: CAA55652.1
X79051 mRNA Translation: CAA55653.1
PIRiI50643
RefSeqiNP_990567.1, NM_205236.1 [Q90850-2]
UniGeneiGga.3731

Genome annotation databases

GeneIDi396164
KEGGigga:396164

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHIC1_CHICK
AccessioniPrimary (citable) accession number: Q90850
Secondary accession number(s): Q90851, Q90852
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: March 28, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health