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Protein

Hypermethylated in cancer 1 protein

Gene

HIC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds specifically to the gamma F-1-binding motif of the gamma F-crystallin promoter. May have a regulatory role in sclerotome specification and/or differentiation. Isoform 2 functions as a transcriptional repressor in lens cells.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 447C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri474 – 501C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri502 – 529C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri530 – 557C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri558 – 585C2H2-type 5PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hypermethylated in cancer 1 protein
Short name:
Hic-1
Alternative name(s):
GammaFBP
Gene namesi
Name:HIC1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000046944‹1 – 676Hypermethylated in cancer 1 proteinAdd BLAST›676

Proteomic databases

PRIDEiQ90850.

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in kidney and lung. Expression of isoform 2 is higher in the lens, retina and stomach, and extremely low in heart, muscle, kidney and lung. Isoform 3 is weakly expressed in heart, kidney and lens.

Developmental stagei

In the embryo of stage 11, expressed predominantly in the head mesenchyme surrounding the brain and in the paraxial mesoderm. Highly expressed in presomitic mesoderm and then over the entire epithelial somite. During somitic differentiation, expression becomes restricted to the sclerotome. In the developing lens, expression is most active at the beginning of lens fiber cell differentiation.

Gene expression databases

BgeeiENSGALG00000026718.

Interactioni

Subunit structurei

Interacts with CtBP.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ90850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 126BTBPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni241 – 245Binding to CtBP5

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 447C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri474 – 501C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri502 – 529C2H2-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri530 – 557C2H2-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri558 – 585C2H2-type 5PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG031606.
InParanoidiQ90850.
OrthoDBiEOG091G051O.
PhylomeDBiQ90850.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR028424. HIC1.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24409:SF69. PTHR24409:SF69. 1 hit.
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Fragment.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 3 (identifier: Q90850-1) [UniParc]FASTAAdd to basket
Also known as: GammaFBP-C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
APGARPAASR ERGHKSREER CGERGAAAGR RARGAMLEAM EVPSHSRQLL
60 70 80 90 100
LQLNTQRTKG FLCDVIIVVQ NALFRAHKNI LAASSAYLKS LVVHDNLLNL
110 120 130 140 150
DHEMVSPGIF RLILDFIYTG RLGECEPGGE QSLGAVLAAA SYLQIPGLVA
160 170 180 190 200
LCKKKLKRSG KYCHLRGGYA PYKLGRGLRA TTPVIQACYS GTPRPVDLQP
210 220 230 240 250
VEPAAPLNTQ CGELYASASQ GTPLHPHGLC PPERHCSPPC GLDLSKKSPT
260 270 280 290 300
GPSAQLLPTD RLLPAEPREP SLPPRHDSPP VSGGLLAGHP AAYKDSPPGG
310 320 330 340 350
EPGGHPHATD PFRSTPPCAE PPLPRGDGRE LMYRWMKHEP LGPYLDEGEA
360 370 380 390 400
EKELEREEKA ESPPAAPQPR YPSVESNDLE PDNSTSEETG SSEGPSPGDA
410 420 430 440 450
LDRYCNHLGY EPESLGDNLY VCIPCGKGFP SSEQLNAHVE AHNEEELYHK
460 470 480 490 500
AAAEQAVPFL DKGGAGLGDI LRPYRCSSCD KSYKDPATLR QHEKTHWLTR
510 520 530 540 550
PYPCTICGKK FTQRGTMTRH MRSHLGLKPF ACDACGMRFT RQYRLTEHMR
560 570 580 590 600
IHSGEKPYEC QVCGGKFAQQ RNLISHMKMH AAGPDGKAKL DFPDSVYAMA
610 620 630 640 650
RLTADQLGLK QEKAAELLSH TSHFLSDPKA MESLYPLAKF TAEHLGLSQD
660 670
KAAEVLAQAP HLHADAARTI ERYSPP
Length:676
Mass (Da):73,759
Last modified:May 2, 2002 - v2
Checksum:i3D3C7FD3302F32EC
GO
Isoform 1 (identifier: Q90850-2) [UniParc]FASTAAdd to basket
Also known as: GammaFBP-A

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: APGARPAASRERGHKSREERCGERGAAAGRRARGA → MRVHRELGWLAEGSGRAGRRARGA

Show »
Length:665
Mass (Da):72,750
Checksum:iFEA5BAB7D989FC43
GO
Isoform 2 (identifier: Q90850-3) [UniParc]FASTAAdd to basket
Also known as: GammaFBP-B

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:641
Mass (Da):70,118
Checksum:i4A41AD03A461987C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0068271 – 35APGAR…RARGA → MRVHRELGWLAEGSGRAGRR ARGA in isoform 1. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0068281 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79011 mRNA. Translation: CAA55644.1.
X79050 mRNA. Translation: CAA55652.1.
X79051 mRNA. Translation: CAA55653.1.
PIRiI50643.
RefSeqiNP_990567.1. NM_205236.1. [Q90850-2]
UniGeneiGga.3731.

Genome annotation databases

GeneIDi396164.
KEGGigga:396164.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79011 mRNA. Translation: CAA55644.1.
X79050 mRNA. Translation: CAA55652.1.
X79051 mRNA. Translation: CAA55653.1.
PIRiI50643.
RefSeqiNP_990567.1. NM_205236.1. [Q90850-2]
UniGeneiGga.3731.

3D structure databases

ProteinModelPortaliQ90850.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ90850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396164.
KEGGigga:396164.

Organism-specific databases

CTDi3090.

Phylogenomic databases

HOVERGENiHBG031606.
InParanoidiQ90850.
OrthoDBiEOG091G051O.
PhylomeDBiQ90850.

Gene expression databases

BgeeiENSGALG00000026718.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR028424. HIC1.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24409:SF69. PTHR24409:SF69. 1 hit.
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIC1_CHICK
AccessioniPrimary (citable) accession number: Q90850
Secondary accession number(s): Q90851, Q90852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.