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Protein

Transcriptional regulator Erg

Gene

ERG

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi310 – 39081ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator Erg
Gene namesi
Name:ERG
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Transcriptional regulator ErgPRO_0000204105Add
BLAST

Proteomic databases

PaxDbiQ90837.

Expressioni

Tissue specificityi

Expressed in mesoderm- and, to a lesser extent, in ectoderm-derived tissues.

Gene expression databases

ExpressionAtlasiQ90837. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029713.

Structurei

3D structure databases

ProteinModelPortaliQ90837.
SMRiQ90837. Positions 105-201, 305-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 19987PNTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000290658.
HOVERGENiHBG001553.
InParanoidiQ90837.
KOiK09435.
OMAiNSNCITW.
OrthoDBiEOG73V6K8.
PhylomeDBiQ90837.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTIKEALS VVSEDQSLFE CAYGSPHLAK TEMTASSSSE YGQTSKMSPR
60 70 80 90 100
VPQQDWLSQP PARVTIKMEC NPNQVNGSRN SPDDCSVAKG GKMVSSSDNV
110 120 130 140 150
GMNYGSYMEE KHIPPPNMTT NERRVIVPAD PTLWSTDHVR QWLEWAVKEY
160 170 180 190 200
GLPDVDILLF QNIDGKELCK MTKDDFQRLT PSYNADILLS HLHYLRETPL
210 220 230 240 250
PHLTSDDVDK ALQNSPRLMH ARNTGGATFI FPNTSVYPEA TQRITTRPDL
260 270 280 290 300
PYEQARRSAW TSHSHPTQSK ATQPSSSTVP KTEDQRPQLD PYQILGPTSS
310 320 330 340 350
RLANPGSGQI QLWQFLLELL SDSSNSNCIT WEGTNGEFKM TDPDEVARRW
360 370 380 390 400
GERKSKPNMN YDKLSRALRY YYDKNIMTKV HGKRYAYKFD FHGIAQALQP
410 420 430 440 450
HPPESSMYKY PSDLPYMSSY HAHPQKMNFV APHPPALPVT SSSFFAAPNP
460 470
YWNSPTGGIY PNTRLPAAHM PSHLGTYY
Length:478
Mass (Da):53,913
Last modified:November 1, 1996 - v1
Checksum:i8DFDB243ED8623A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77159 mRNA. Translation: CAA54404.1.
PIRiS60754.
RefSeqiNP_989611.1. NM_204280.1.
UniGeneiGga.2064.

Genome annotation databases

EnsembliENSGALT00000030350; ENSGALP00000029713; ENSGALG00000016058.
GeneIDi374146.
KEGGigga:374146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77159 mRNA. Translation: CAA54404.1.
PIRiS60754.
RefSeqiNP_989611.1. NM_204280.1.
UniGeneiGga.2064.

3D structure databases

ProteinModelPortaliQ90837.
SMRiQ90837. Positions 105-201, 305-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029713.

Proteomic databases

PaxDbiQ90837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000030350; ENSGALP00000029713; ENSGALG00000016058.
GeneIDi374146.
KEGGigga:374146.

Organism-specific databases

CTDi2078.

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000290658.
HOVERGENiHBG001553.
InParanoidiQ90837.
KOiK09435.
OMAiNSNCITW.
OrthoDBiEOG73V6K8.
PhylomeDBiQ90837.
TreeFamiTF350537.

Miscellaneous databases

NextBioi20813660.
PROiQ90837.

Gene expression databases

ExpressionAtlasiQ90837. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mesodermal expression of the chicken erg gene associated with precartilaginous condensation and cartilage differentiation."
    Dhordain P., Dewitte F., Desbiens X., Stehelin D., Duterque-Coquillaud M.
    Mech. Dev. 50:17-28(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiERG_CHICK
AccessioniPrimary (citable) accession number: Q90837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.