Q90830 (CRTAP_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cartilage-associated protein

Alternative name(s):
Dualin

Gene names

Name:	CRTAP
Synonyms:	CASP

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Found in articular chondrocytes. Expressed in a variety of tissues.
Sequence similarities	Belongs to the leprecan family.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LEPRE1	Q6JHU8	3	EBI-1169253,EBI-1169258

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 271	256	Cartilage-associated protein		PRO_0000006321
Amino acid modifications
	Glycosylation	76	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q90830 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A56343DBF604914C	FASTA	271	31,494
	10 20 30 40 50 60 MWRTLLAALL ATAGAQYERY SFRSFPRDEL MPLESAYRYG LDQYSTENWP ESVSYLEVSM 70 80 90 100 110 120 RLYRLLRDTE AFCHHNCSSA GPLTAPPPAD GELAELRLLA GVLRRAQCLR RCKQGLPAFR 130 140 150 160 170 180 QAQPGRELLE EFQRREPYKY LQFAYFKANN LPKAIAAAHT FLLKHPDDEM MQRNMAYYKS 190 200 210 220 230 240 IPDAEEHIKD LETKPYENLF VRAVRAYNGD NWRTSISDME LALPDFFKTY DDCIAACEGS 250 260 270 REIKDFKDFY LSIADHYIEV LACKVQFDIT T

References

[1]	"Cartilage associated protein (CASP) is a novel developmentally regulated chick embryo protein." Castagnola P., Gennari M., Morello R., Tonachini L., Marin O., Gaggero A., Cancedda R. J. Cell Sci. 110:1351-1359(1997) [PubMed: 9217321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97607 mRNA. Translation: CAA66206.1.
IPI	IPI00580675.
RefSeq	NP_990431.1. NM_205100.1.
UniGene	Gga.4211.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q90830. 2 interactions.
STRING	Q90830.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395992.
KEGG	gga:395992.
Organism-specific databases
CTD	10491.
Phylogenomic databases
GeneTree	ENSGT00550000074573.
HOVERGEN	HBG005540.
InParanoid	Q90830.
Family and domain databases
InterPro	IPR011990. TPR-like_helical. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CRTAP_CHICK

Accession

Primary (citable) accession number: Q90830

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	September 21, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program