Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytoplasmic dynein 1 light intermediate chain 1

Gene

DYNC1LI1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 1 light intermediate chain 1
Alternative name(s):
Dynein light chain A
Short name:
DLC-A
Dynein light intermediate chain 1, cytosolic
LIC57/59
Gene namesi
Name:DYNC1LI1
Synonyms:DNCLI1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Cytoplasmic dynein 1 light intermediate chain 1PRO_0000114669Add
BLAST

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ90828.
PRIDEiQ90828.

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs) (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000018705.

Structurei

3D structure databases

ProteinModelPortaliQ90828.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3905. Eukaryota.
ENOG410XQS4. LUCA.
GeneTreeiENSGT00390000008295.
HOGENOMiHOG000236263.
HOVERGENiHBG005546.
InParanoidiQ90828.
KOiK10416.
OMAiILYENMH.
OrthoDBiEOG7V7668.
PhylomeDBiQ90828.
TreeFamiTF352602.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR008467. Dynein1_light_intermed_chain.
IPR022780. Dynein_light_int_chain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12688. PTHR12688. 1 hit.
PfamiPF05783. DLIC. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q90828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVGRAGSF GSSSASGAAN NASAELRAGG EEDDGQNLWS CILSEVSTRS
60 70 80 90 100
RSKLPSGKSV LLLGEDGAGK TSLIGKIQGI EEYKKGRGME YLYLNVHDED
110 120 130 140 150
RDDQTRCNVR ILDGDLYHKG LLKFAMEANS LKDTLIMLVV DMSRPWTAMD
160 170 180 190 200
SLQKWASVVR EHIDKLKIPP EEMKEMEQKL VRDFQEYVEP GEDFPASPQR
210 220 230 240 250
RNTSLQEDKD DSVILPLGAD TLTCNLGIPV VVVCTKCDAI SVLEKEHDYR
260 270 280 290 300
DEHFDFIQSH IRRFCLQYGA ALIYTSVKEN KNIDLVYKYI VQKLYGFPFN
310 320 330 340 350
VPAVVVEKDA VFIPAGWDND KKIGILHENF QTLKAEDSFE DSIRKPPVRK
360 370 380 390 400
FVHEKEIVAE DDQVFLMKQQ SQLAKQPPTA AGRPVDASPR VPGGSPRTPN
410 420 430 440 450
RSVTSNVASV TPIPAGSKKI DPNMKAGATS EGVLANFFNS LLSKKTGSPG
460 470 480 490 500
GPGGVGGSPG GGSAGGTGSN LPPSAKKSGQ KPVLTDVQAE LDRISRKPEM
510
VSPTSPTSPT EGEAS
Length:515
Mass (Da):55,893
Last modified:November 1, 1997 - v1
Checksum:iF163848CCDC7854E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79088 mRNA. Translation: CAA55698.1.
PIRiI50637.
RefSeqiNP_001161209.1. NM_001167737.1.
UniGeneiGga.25866.

Genome annotation databases

EnsembliENSGALT00000018728; ENSGALP00000018705; ENSGALG00000011491.
GeneIDi420668.
KEGGigga:420668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79088 mRNA. Translation: CAA55698.1.
PIRiI50637.
RefSeqiNP_001161209.1. NM_001167737.1.
UniGeneiGga.25866.

3D structure databases

ProteinModelPortaliQ90828.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000018705.

Proteomic databases

PaxDbiQ90828.
PRIDEiQ90828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000018728; ENSGALP00000018705; ENSGALG00000011491.
GeneIDi420668.
KEGGigga:420668.

Organism-specific databases

CTDi51143.

Phylogenomic databases

eggNOGiKOG3905. Eukaryota.
ENOG410XQS4. LUCA.
GeneTreeiENSGT00390000008295.
HOGENOMiHOG000236263.
HOVERGENiHBG005546.
InParanoidiQ90828.
KOiK10416.
OMAiILYENMH.
OrthoDBiEOG7V7668.
PhylomeDBiQ90828.
TreeFamiTF352602.

Miscellaneous databases

NextBioi20823550.
PROiQ90828.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR008467. Dynein1_light_intermed_chain.
IPR022780. Dynein_light_int_chain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12688. PTHR12688. 1 hit.
PfamiPF05783. DLIC. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Characterization of DLC-A and DLC-B, two families of cytoplasmic dynein light chain subunits."
    Gill S.R., Cleveland D.W., Schroer T.A.
    Mol. Biol. Cell 5:645-654(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 90-98.
    Tissue: Embryonic brain.

Entry informationi

Entry nameiDC1L1_CHICK
AccessioniPrimary (citable) accession number: Q90828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.