Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytoplasmic dynein 1 light intermediate chain 1

Gene

DYNC1LI1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi64 – 71ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-GGA-2467813 Separation of Sister Chromatids
R-GGA-2500257 Resolution of Sister Chromatid Cohesion
R-GGA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-GGA-5663220 RHO GTPases Activate Formins
R-GGA-6798695 Neutrophil degranulation
R-GGA-6807878 COPI-mediated anterograde transport
R-GGA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-GGA-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 1 light intermediate chain 1
Alternative name(s):
Dynein light chain A
Short name:
DLC-A
Dynein light intermediate chain 1, cytosolic
LIC57/59
Gene namesi
Name:DYNC1LI1
Synonyms:DNCLI1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001146691 – 515Cytoplasmic dynein 1 light intermediate chain 1Add BLAST515

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ90828
PRIDEiQ90828

PTM databases

iPTMnetiQ90828

Expressioni

Gene expression databases

BgeeiENSGALG00000011491

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000018705

Structurei

3D structure databases

ProteinModelPortaliQ90828
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3905 Eukaryota
ENOG410XQS4 LUCA
GeneTreeiENSGT00390000008295
HOGENOMiHOG000236263
HOVERGENiHBG005546
InParanoidiQ90828
KOiK10416
OMAiLCVVCQN
OrthoDBiEOG091G0B3J
PhylomeDBiQ90828
TreeFamiTF352602

Family and domain databases

InterProiView protein in InterPro
IPR008467 Dynein1_light_intermed_chain
IPR022780 Dynein_light_int_chain
IPR027417 P-loop_NTPase
PANTHERiPTHR12688 PTHR12688, 1 hit
PfamiView protein in Pfam
PF05783 DLIC, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

Q90828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVGRAGSF GSSSASGAAN NASAELRAGG EEDDGQNLWS CILSEVSTRS
60 70 80 90 100
RSKLPSGKSV LLLGEDGAGK TSLIGKIQGI EEYKKGRGME YLYLNVHDED
110 120 130 140 150
RDDQTRCNVR ILDGDLYHKG LLKFAMEANS LKDTLIMLVV DMSRPWTAMD
160 170 180 190 200
SLQKWASVVR EHIDKLKIPP EEMKEMEQKL VRDFQEYVEP GEDFPASPQR
210 220 230 240 250
RNTSLQEDKD DSVILPLGAD TLTCNLGIPV VVVCTKCDAI SVLEKEHDYR
260 270 280 290 300
DEHFDFIQSH IRRFCLQYGA ALIYTSVKEN KNIDLVYKYI VQKLYGFPFN
310 320 330 340 350
VPAVVVEKDA VFIPAGWDND KKIGILHENF QTLKAEDSFE DSIRKPPVRK
360 370 380 390 400
FVHEKEIVAE DDQVFLMKQQ SQLAKQPPTA AGRPVDASPR VPGGSPRTPN
410 420 430 440 450
RSVTSNVASV TPIPAGSKKI DPNMKAGATS EGVLANFFNS LLSKKTGSPG
460 470 480 490 500
GPGGVGGSPG GGSAGGTGSN LPPSAKKSGQ KPVLTDVQAE LDRISRKPEM
510
VSPTSPTSPT EGEAS
Length:515
Mass (Da):55,893
Last modified:November 1, 1997 - v1
Checksum:iF163848CCDC7854E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79088 mRNA Translation: CAA55698.1
PIRiI50637
RefSeqiNP_001161209.1, NM_001167737.1
UniGeneiGga.25866

Genome annotation databases

EnsembliENSGALT00000018728; ENSGALP00000018705; ENSGALG00000011491
GeneIDi420668
KEGGigga:420668

Similar proteinsi

Entry informationi

Entry nameiDC1L1_CHICK
AccessioniPrimary (citable) accession number: Q90828
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health