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Q90827

- NEL_CHICK

UniProt

Q90827 - NEL_CHICK

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Protein

Protein NEL

Gene

NEL

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NEL
Alternative name(s):
93 kDa protein
Gene namesi
Name:NEL
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 816795Protein NELPRO_0000007663Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi401 ↔ 413PROSITE-ProRule annotation
Disulfide bondi407 ↔ 422PROSITE-ProRule annotation
Disulfide bondi424 ↔ 438PROSITE-ProRule annotation
Disulfide bondi444 ↔ 457PROSITE-ProRule annotation
Disulfide bondi451 ↔ 466PROSITE-ProRule annotation
Disulfide bondi468 ↔ 480PROSITE-ProRule annotation
Disulfide bondi486 ↔ 499PROSITE-ProRule annotation
Disulfide bondi493 ↔ 508PROSITE-ProRule annotation
Disulfide bondi510 ↔ 521PROSITE-ProRule annotation
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi525 ↔ 535PROSITE-ProRule annotation
Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
Disulfide bondi543 ↔ 552PROSITE-ProRule annotation
Disulfide bondi559 ↔ 572PROSITE-ProRule annotation
Disulfide bondi566 ↔ 581PROSITE-ProRule annotation
Disulfide bondi583 ↔ 600PROSITE-ProRule annotation
Disulfide bondi606 ↔ 619PROSITE-ProRule annotation
Disulfide bondi613 ↔ 628PROSITE-ProRule annotation
Glycosylationi615 – 6151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi630 ↔ 636PROSITE-ProRule annotation
Glycosylationi635 – 6351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90827.
PRIDEiQ90827.

Expressioni

Tissue specificityi

Strongly expressed in early embryonic neural tissues (brain, spinal cord, dorsal root ganglia); less in other tissues such as cells around cartilage, myocardium, lung mesenchymal cells, and liver. After hatching expression is restricted to neural tissues including retina.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037995.

Structurei

3D structure databases

ProteinModelPortaliQ90827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 228164Laminin G-likeAdd
BLAST
Domaini272 – 33160VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini397 – 43943EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini440 – 48142EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini482 – 52241EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini523 – 55331EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini555 – 60147EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini602 – 63736EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini638 – 69356VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini698 – 75659VWFC 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 3 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiQ90827.
PhylomeDBiQ90827.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90827-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESGCGLGTL CLLLCLGPVV GFGVDPSLQI DVLSELGLPG YAAGVRQVPG
60 70 80 90 100
LHNGSKAFLF PDTSRSVKAS PETAEIFFQK LRNKYEFTIL VTLKQAHLNS
110 120 130 140 150
GVIFSIHHLD HRYLELESSG HRNEIRLHYR TGSHRSHTEV FPYILADDKW
160 170 180 190 200
HRLSLAISAS HLILHVDCNK IYERVVEKPF MDLPVGTTFW LGQRNNAHGY
210 220 230 240 250
FKGIMQDVQL LVMPQGFISQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK
260 270 280 290 300
TSAKLSQAEQ RMNKLDQCYC ERTCTMKGMT YREFESWTDG CKNCTCMNGT
310 320 330 340 350
VQCEALICSL SDCPPNSALS YVDGKCCKEC QSVCIFEGRT YFEGQRETVY
360 370 380 390 400
SSSGDCVLFE CKDHKMQRIP KDSCATLNCP ESQQIPLSHS CCKICKGHDF
410 420 430 440 450
CTEGHNCMEH SVCRNLDDRA VCSCRDGFRA LREDNAYCED VDECAEGQHY
460 470 480 490 500
CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECVTNQ HNCDENALCF
510 520 530 540 550
NTVGGHNCVC KLGYTGNGTV CKAFCKDGCR NGGACIASNV CACPQGFTGP
560 570 580 590 600
SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC
610 620 630 640 650
EDIDECATGR HSCANDTVCF NLDGGYDCRC PHGKNCTGDC IHEDKIKHNG
660 670 680 690 700
QIWVLENDRC SVCSCQSGYV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC
710 720 730 740 750
LHQSGELSYN SGDSWIQNCQ QCRCLQGEVD CWPLPCPEVD CEFSVLPENE
760 770 780 790 800
CCPRCVTDPC QADTIRNDIT KTCLDETNVV RFTGSSWIKH GTECTLCQCK
810
NGHVCCSVDP QCLQEL
Length:816
Mass (Da):90,969
Last modified:November 1, 1996 - v1
Checksum:iBFCDBC983C02F831
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86747 mRNA. Translation: BAA13167.1.
RefSeqiNP_001025911.1. NM_001030740.1.
UniGeneiGga.595.

Genome annotation databases

GeneIDi417799.
KEGGigga:417799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86747 mRNA. Translation: BAA13167.1 .
RefSeqi NP_001025911.1. NM_001030740.1.
UniGenei Gga.595.

3D structure databases

ProteinModelPortali Q90827.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000037995.

Proteomic databases

PaxDbi Q90827.
PRIDEi Q90827.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 417799.
KEGGi gga:417799.

Organism-specific databases

CTDi 4753.

Phylogenomic databases

eggNOGi NOG253557.
HOGENOMi HOG000217920.
HOVERGENi HBG004805.
InParanoidi Q90827.
PhylomeDBi Q90827.

Miscellaneous databases

NextBioi 20821047.
PROi Q90827.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "New gene, nel, encoding a M(r) 93 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos."
    Matsuhashi S., Noji S., Koyama E., Myokai F., Ohuchi H., Taniguchi S., Hori K.
    Dev. Dyn. 203:212-222(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNEL_CHICK
AccessioniPrimary (citable) accession number: Q90827
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3