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Protein

Protein NEL

Gene

NEL

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NEL
Alternative name(s):
93 kDa protein
Gene namesi
Name:NEL
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000766322 – 816Protein NELAdd BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi401 ↔ 413PROSITE-ProRule annotation
Disulfide bondi407 ↔ 422PROSITE-ProRule annotation
Disulfide bondi424 ↔ 438PROSITE-ProRule annotation
Disulfide bondi444 ↔ 457PROSITE-ProRule annotation
Disulfide bondi451 ↔ 466PROSITE-ProRule annotation
Disulfide bondi468 ↔ 480PROSITE-ProRule annotation
Disulfide bondi486 ↔ 499PROSITE-ProRule annotation
Disulfide bondi493 ↔ 508PROSITE-ProRule annotation
Disulfide bondi510 ↔ 521PROSITE-ProRule annotation
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi525 ↔ 535PROSITE-ProRule annotation
Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
Disulfide bondi543 ↔ 552PROSITE-ProRule annotation
Disulfide bondi559 ↔ 572PROSITE-ProRule annotation
Disulfide bondi566 ↔ 581PROSITE-ProRule annotation
Disulfide bondi583 ↔ 600PROSITE-ProRule annotation
Disulfide bondi606 ↔ 619PROSITE-ProRule annotation
Disulfide bondi613 ↔ 628PROSITE-ProRule annotation
Glycosylationi615N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi630 ↔ 636PROSITE-ProRule annotation
Glycosylationi635N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90827

Expressioni

Tissue specificityi

Strongly expressed in early embryonic neural tissues (brain, spinal cord, dorsal root ganglia); less in other tissues such as cells around cartilage, myocardium, lung mesenchymal cells, and liver. After hatching expression is restricted to neural tissues including retina.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037995

Structurei

3D structure databases

ProteinModelPortaliQ90827
SMRiQ90827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 228Laminin G-likeAdd BLAST164
Domaini272 – 331VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini397 – 439EGF-like 1PROSITE-ProRule annotationAdd BLAST43
Domaini440 – 481EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini482 – 522EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini523 – 553EGF-like 4PROSITE-ProRule annotationAdd BLAST31
Domaini555 – 601EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST47
Domaini602 – 637EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini638 – 693VWFC 2PROSITE-ProRule annotationAdd BLAST56
Domaini698 – 756VWFC 3PROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
HOGENOMiHOG000217920
HOVERGENiHBG004805
InParanoidiQ90827
PhylomeDBiQ90827

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001007 VWF_dom
PfamiView protein in Pfam
PF07645 EGF_CA, 4 hits
PF02210 Laminin_G_2, 1 hit
PF00093 VWC, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit
SM00214 VWC, 3 hits
SM00215 VWC_out, 2 hits
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 6 hits
PS01187 EGF_CA, 3 hits
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGCGLGTL CLLLCLGPVV GFGVDPSLQI DVLSELGLPG YAAGVRQVPG
60 70 80 90 100
LHNGSKAFLF PDTSRSVKAS PETAEIFFQK LRNKYEFTIL VTLKQAHLNS
110 120 130 140 150
GVIFSIHHLD HRYLELESSG HRNEIRLHYR TGSHRSHTEV FPYILADDKW
160 170 180 190 200
HRLSLAISAS HLILHVDCNK IYERVVEKPF MDLPVGTTFW LGQRNNAHGY
210 220 230 240 250
FKGIMQDVQL LVMPQGFISQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK
260 270 280 290 300
TSAKLSQAEQ RMNKLDQCYC ERTCTMKGMT YREFESWTDG CKNCTCMNGT
310 320 330 340 350
VQCEALICSL SDCPPNSALS YVDGKCCKEC QSVCIFEGRT YFEGQRETVY
360 370 380 390 400
SSSGDCVLFE CKDHKMQRIP KDSCATLNCP ESQQIPLSHS CCKICKGHDF
410 420 430 440 450
CTEGHNCMEH SVCRNLDDRA VCSCRDGFRA LREDNAYCED VDECAEGQHY
460 470 480 490 500
CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECVTNQ HNCDENALCF
510 520 530 540 550
NTVGGHNCVC KLGYTGNGTV CKAFCKDGCR NGGACIASNV CACPQGFTGP
560 570 580 590 600
SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC
610 620 630 640 650
EDIDECATGR HSCANDTVCF NLDGGYDCRC PHGKNCTGDC IHEDKIKHNG
660 670 680 690 700
QIWVLENDRC SVCSCQSGYV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC
710 720 730 740 750
LHQSGELSYN SGDSWIQNCQ QCRCLQGEVD CWPLPCPEVD CEFSVLPENE
760 770 780 790 800
CCPRCVTDPC QADTIRNDIT KTCLDETNVV RFTGSSWIKH GTECTLCQCK
810
NGHVCCSVDP QCLQEL
Length:816
Mass (Da):90,969
Last modified:November 1, 1996 - v1
Checksum:iBFCDBC983C02F831
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86747 mRNA Translation: BAA13167.1
RefSeqiNP_001025911.1, NM_001030740.1
UniGeneiGga.595

Genome annotation databases

GeneIDi417799
KEGGigga:417799

Similar proteinsi

Entry informationi

Entry nameiNEL_CHICK
AccessioniPrimary (citable) accession number: Q90827
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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