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Q90827

- NEL_CHICK

UniProt

Q90827 - NEL_CHICK

Protein

Protein NEL

Gene

NEL

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein NEL
    Alternative name(s):
    93 kDa protein
    Gene namesi
    Name:NEL
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 816795Protein NELPRO_0000007663Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi401 ↔ 413PROSITE-ProRule annotation
    Disulfide bondi407 ↔ 422PROSITE-ProRule annotation
    Disulfide bondi424 ↔ 438PROSITE-ProRule annotation
    Disulfide bondi444 ↔ 457PROSITE-ProRule annotation
    Disulfide bondi451 ↔ 466PROSITE-ProRule annotation
    Disulfide bondi468 ↔ 480PROSITE-ProRule annotation
    Disulfide bondi486 ↔ 499PROSITE-ProRule annotation
    Disulfide bondi493 ↔ 508PROSITE-ProRule annotation
    Disulfide bondi510 ↔ 521PROSITE-ProRule annotation
    Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi525 ↔ 535PROSITE-ProRule annotation
    Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
    Disulfide bondi543 ↔ 552PROSITE-ProRule annotation
    Disulfide bondi559 ↔ 572PROSITE-ProRule annotation
    Disulfide bondi566 ↔ 581PROSITE-ProRule annotation
    Disulfide bondi583 ↔ 600PROSITE-ProRule annotation
    Disulfide bondi606 ↔ 619PROSITE-ProRule annotation
    Disulfide bondi613 ↔ 628PROSITE-ProRule annotation
    Glycosylationi615 – 6151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi630 ↔ 636PROSITE-ProRule annotation
    Glycosylationi635 – 6351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ90827.
    PRIDEiQ90827.

    Expressioni

    Tissue specificityi

    Strongly expressed in early embryonic neural tissues (brain, spinal cord, dorsal root ganglia); less in other tissues such as cells around cartilage, myocardium, lung mesenchymal cells, and liver. After hatching expression is restricted to neural tissues including retina.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000037995.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90827.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 228164Laminin G-likeAdd
    BLAST
    Domaini272 – 33160VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini397 – 43943EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini440 – 48142EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 52241EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini523 – 55331EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini555 – 60147EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini602 – 63736EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini638 – 69356VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini698 – 75659VWFC 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 3 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG253557.
    HOGENOMiHOG000217920.
    HOVERGENiHBG004805.
    PhylomeDBiQ90827.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF07645. EGF_CA. 4 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 4 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90827-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESGCGLGTL CLLLCLGPVV GFGVDPSLQI DVLSELGLPG YAAGVRQVPG    50
    LHNGSKAFLF PDTSRSVKAS PETAEIFFQK LRNKYEFTIL VTLKQAHLNS 100
    GVIFSIHHLD HRYLELESSG HRNEIRLHYR TGSHRSHTEV FPYILADDKW 150
    HRLSLAISAS HLILHVDCNK IYERVVEKPF MDLPVGTTFW LGQRNNAHGY 200
    FKGIMQDVQL LVMPQGFISQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK 250
    TSAKLSQAEQ RMNKLDQCYC ERTCTMKGMT YREFESWTDG CKNCTCMNGT 300
    VQCEALICSL SDCPPNSALS YVDGKCCKEC QSVCIFEGRT YFEGQRETVY 350
    SSSGDCVLFE CKDHKMQRIP KDSCATLNCP ESQQIPLSHS CCKICKGHDF 400
    CTEGHNCMEH SVCRNLDDRA VCSCRDGFRA LREDNAYCED VDECAEGQHY 450
    CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECVTNQ HNCDENALCF 500
    NTVGGHNCVC KLGYTGNGTV CKAFCKDGCR NGGACIASNV CACPQGFTGP 550
    SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC 600
    EDIDECATGR HSCANDTVCF NLDGGYDCRC PHGKNCTGDC IHEDKIKHNG 650
    QIWVLENDRC SVCSCQSGYV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC 700
    LHQSGELSYN SGDSWIQNCQ QCRCLQGEVD CWPLPCPEVD CEFSVLPENE 750
    CCPRCVTDPC QADTIRNDIT KTCLDETNVV RFTGSSWIKH GTECTLCQCK 800
    NGHVCCSVDP QCLQEL 816
    Length:816
    Mass (Da):90,969
    Last modified:November 1, 1996 - v1
    Checksum:iBFCDBC983C02F831
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86747 mRNA. Translation: BAA13167.1.
    RefSeqiNP_001025911.1. NM_001030740.1.
    UniGeneiGga.595.

    Genome annotation databases

    GeneIDi417799.
    KEGGigga:417799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86747 mRNA. Translation: BAA13167.1 .
    RefSeqi NP_001025911.1. NM_001030740.1.
    UniGenei Gga.595.

    3D structure databases

    ProteinModelPortali Q90827.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000037995.

    Proteomic databases

    PaxDbi Q90827.
    PRIDEi Q90827.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 417799.
    KEGGi gga:417799.

    Organism-specific databases

    CTDi 4753.

    Phylogenomic databases

    eggNOGi NOG253557.
    HOGENOMi HOG000217920.
    HOVERGENi HBG004805.
    PhylomeDBi Q90827.

    Miscellaneous databases

    NextBioi 20821047.
    PROi Q90827.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 4 hits.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 4 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 6 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "New gene, nel, encoding a M(r) 93 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos."
      Matsuhashi S., Noji S., Koyama E., Myokai F., Ohuchi H., Taniguchi S., Hori K.
      Dev. Dyn. 203:212-222(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiNEL_CHICK
    AccessioniPrimary (citable) accession number: Q90827
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3