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Q90827

- NEL_CHICK

UniProt

Q90827 - NEL_CHICK

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Protein
Protein NEL
Gene
NEL
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NEL
Alternative name(s):
93 kDa protein
Gene namesi
Name:NEL
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 816795Protein NEL
PRO_0000007663Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi401 ↔ 413 By similarity
Disulfide bondi407 ↔ 422 By similarity
Disulfide bondi424 ↔ 438 By similarity
Disulfide bondi444 ↔ 457 By similarity
Disulfide bondi451 ↔ 466 By similarity
Disulfide bondi468 ↔ 480 By similarity
Disulfide bondi486 ↔ 499 By similarity
Disulfide bondi493 ↔ 508 By similarity
Disulfide bondi510 ↔ 521 By similarity
Glycosylationi517 – 5171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi525 ↔ 535 By similarity
Disulfide bondi529 ↔ 541 By similarity
Disulfide bondi543 ↔ 552 By similarity
Disulfide bondi559 ↔ 572 By similarity
Disulfide bondi566 ↔ 581 By similarity
Disulfide bondi583 ↔ 600 By similarity
Disulfide bondi606 ↔ 619 By similarity
Disulfide bondi613 ↔ 628 By similarity
Glycosylationi615 – 6151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi630 ↔ 636 By similarity
Glycosylationi635 – 6351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90827.
PRIDEiQ90827.

Expressioni

Tissue specificityi

Strongly expressed in early embryonic neural tissues (brain, spinal cord, dorsal root ganglia); less in other tissues such as cells around cartilage, myocardium, lung mesenchymal cells, and liver. After hatching expression is restricted to neural tissues including retina.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037995.

Structurei

3D structure databases

ProteinModelPortaliQ90827.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 228164Laminin G-like
Add
BLAST
Domaini272 – 33160VWFC 1
Add
BLAST
Domaini397 – 43943EGF-like 1
Add
BLAST
Domaini440 – 48142EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini482 – 52241EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini523 – 55331EGF-like 4
Add
BLAST
Domaini555 – 60147EGF-like 5; calcium-binding Reviewed prediction
Add
BLAST
Domaini602 – 63736EGF-like 6; calcium-binding Reviewed prediction
Add
BLAST
Domaini638 – 69356VWFC 2
Add
BLAST
Domaini698 – 75659VWFC 3
Add
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.
Contains 3 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
PhylomeDBiQ90827.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90827-1 [UniParc]FASTAAdd to Basket

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MESGCGLGTL CLLLCLGPVV GFGVDPSLQI DVLSELGLPG YAAGVRQVPG    50
LHNGSKAFLF PDTSRSVKAS PETAEIFFQK LRNKYEFTIL VTLKQAHLNS 100
GVIFSIHHLD HRYLELESSG HRNEIRLHYR TGSHRSHTEV FPYILADDKW 150
HRLSLAISAS HLILHVDCNK IYERVVEKPF MDLPVGTTFW LGQRNNAHGY 200
FKGIMQDVQL LVMPQGFISQ CPDLNRTCPT CNDFHGLVQK IMELQDILAK 250
TSAKLSQAEQ RMNKLDQCYC ERTCTMKGMT YREFESWTDG CKNCTCMNGT 300
VQCEALICSL SDCPPNSALS YVDGKCCKEC QSVCIFEGRT YFEGQRETVY 350
SSSGDCVLFE CKDHKMQRIP KDSCATLNCP ESQQIPLSHS CCKICKGHDF 400
CTEGHNCMEH SVCRNLDDRA VCSCRDGFRA LREDNAYCED VDECAEGQHY 450
CRENTMCVNT PGSFMCICKT GYIRIDDYSC TEHDECVTNQ HNCDENALCF 500
NTVGGHNCVC KLGYTGNGTV CKAFCKDGCR NGGACIASNV CACPQGFTGP 550
SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC 600
EDIDECATGR HSCANDTVCF NLDGGYDCRC PHGKNCTGDC IHEDKIKHNG 650
QIWVLENDRC SVCSCQSGYV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC 700
LHQSGELSYN SGDSWIQNCQ QCRCLQGEVD CWPLPCPEVD CEFSVLPENE 750
CCPRCVTDPC QADTIRNDIT KTCLDETNVV RFTGSSWIKH GTECTLCQCK 800
NGHVCCSVDP QCLQEL 816
Length:816
Mass (Da):90,969
Last modified:November 1, 1996 - v1
Checksum:iBFCDBC983C02F831
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86747 mRNA. Translation: BAA13167.1.
RefSeqiNP_001025911.1. NM_001030740.1.
UniGeneiGga.595.

Genome annotation databases

GeneIDi417799.
KEGGigga:417799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86747 mRNA. Translation: BAA13167.1 .
RefSeqi NP_001025911.1. NM_001030740.1.
UniGenei Gga.595.

3D structure databases

ProteinModelPortali Q90827.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000037995.

Proteomic databases

PaxDbi Q90827.
PRIDEi Q90827.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 417799.
KEGGi gga:417799.

Organism-specific databases

CTDi 4753.

Phylogenomic databases

eggNOGi NOG253557.
HOGENOMi HOG000217920.
HOVERGENi HBG004805.
PhylomeDBi Q90827.

Miscellaneous databases

NextBioi 20821047.
PROi Q90827.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "New gene, nel, encoding a M(r) 93 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos."
    Matsuhashi S., Noji S., Koyama E., Myokai F., Ohuchi H., Taniguchi S., Hori K.
    Dev. Dyn. 203:212-222(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiNEL_CHICK
AccessioniPrimary (citable) accession number: Q90827
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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