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Q90827 (NEL_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein NEL
Alternative name(s):
93 kDa protein
Gene names
Name:NEL
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length816 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Strongly expressed in early embryonic neural tissues (brain, spinal cord, dorsal root ganglia); less in other tissues such as cells around cartilage, myocardium, lung mesenchymal cells, and liver. After hatching expression is restricted to neural tissues including retina.

Sequence similarities

Contains 6 EGF-like domains.

Contains 1 laminin G-like domain.

Contains 3 VWFC domains.

Ontologies

Keywords
   DomainEGF-like domain
Repeat
Signal
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 816795Protein NEL
PRO_0000007663

Regions

Domain65 – 228164Laminin G-like
Domain272 – 33160VWFC 1
Domain397 – 43943EGF-like 1
Domain440 – 48142EGF-like 2; calcium-binding Potential
Domain482 – 52241EGF-like 3; calcium-binding Potential
Domain523 – 55331EGF-like 4
Domain555 – 60147EGF-like 5; calcium-binding Potential
Domain602 – 63736EGF-like 6; calcium-binding Potential
Domain638 – 69356VWFC 2
Domain698 – 75659VWFC 3

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation5171N-linked (GlcNAc...) Potential
Glycosylation6151N-linked (GlcNAc...) Potential
Glycosylation6351N-linked (GlcNAc...) Potential
Disulfide bond401 ↔ 413 By similarity
Disulfide bond407 ↔ 422 By similarity
Disulfide bond424 ↔ 438 By similarity
Disulfide bond444 ↔ 457 By similarity
Disulfide bond451 ↔ 466 By similarity
Disulfide bond468 ↔ 480 By similarity
Disulfide bond486 ↔ 499 By similarity
Disulfide bond493 ↔ 508 By similarity
Disulfide bond510 ↔ 521 By similarity
Disulfide bond525 ↔ 535 By similarity
Disulfide bond529 ↔ 541 By similarity
Disulfide bond543 ↔ 552 By similarity
Disulfide bond559 ↔ 572 By similarity
Disulfide bond566 ↔ 581 By similarity
Disulfide bond583 ↔ 600 By similarity
Disulfide bond606 ↔ 619 By similarity
Disulfide bond613 ↔ 628 By similarity
Disulfide bond630 ↔ 636 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90827 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BFCDBC983C02F831

FASTA81690,969
        10         20         30         40         50         60 
MESGCGLGTL CLLLCLGPVV GFGVDPSLQI DVLSELGLPG YAAGVRQVPG LHNGSKAFLF 

        70         80         90        100        110        120 
PDTSRSVKAS PETAEIFFQK LRNKYEFTIL VTLKQAHLNS GVIFSIHHLD HRYLELESSG 

       130        140        150        160        170        180 
HRNEIRLHYR TGSHRSHTEV FPYILADDKW HRLSLAISAS HLILHVDCNK IYERVVEKPF 

       190        200        210        220        230        240 
MDLPVGTTFW LGQRNNAHGY FKGIMQDVQL LVMPQGFISQ CPDLNRTCPT CNDFHGLVQK 

       250        260        270        280        290        300 
IMELQDILAK TSAKLSQAEQ RMNKLDQCYC ERTCTMKGMT YREFESWTDG CKNCTCMNGT 

       310        320        330        340        350        360 
VQCEALICSL SDCPPNSALS YVDGKCCKEC QSVCIFEGRT YFEGQRETVY SSSGDCVLFE 

       370        380        390        400        410        420 
CKDHKMQRIP KDSCATLNCP ESQQIPLSHS CCKICKGHDF CTEGHNCMEH SVCRNLDDRA 

       430        440        450        460        470        480 
VCSCRDGFRA LREDNAYCED VDECAEGQHY CRENTMCVNT PGSFMCICKT GYIRIDDYSC 

       490        500        510        520        530        540 
TEHDECVTNQ HNCDENALCF NTVGGHNCVC KLGYTGNGTV CKAFCKDGCR NGGACIASNV 

       550        560        570        580        590        600 
CACPQGFTGP SCETDIDECS DGFVQCDSRA NCINLPGWYH CECRDGYHDN GMFSPSGESC 

       610        620        630        640        650        660 
EDIDECATGR HSCANDTVCF NLDGGYDCRC PHGKNCTGDC IHEDKIKHNG QIWVLENDRC 

       670        680        690        700        710        720 
SVCSCQSGYV MCRRMVCDCE NPTVDLFCCP ECDPRLSSQC LHQSGELSYN SGDSWIQNCQ 

       730        740        750        760        770        780 
QCRCLQGEVD CWPLPCPEVD CEFSVLPENE CCPRCVTDPC QADTIRNDIT KTCLDETNVV 

       790        800        810 
RFTGSSWIKH GTECTLCQCK NGHVCCSVDP QCLQEL 

« Hide

References

[1]"New gene, nel, encoding a M(r) 93 K protein with EGF-like repeats is strongly expressed in neural tissues of early stage chick embryos."
Matsuhashi S., Noji S., Koyama E., Myokai F., Ohuchi H., Taniguchi S., Hori K.
Dev. Dyn. 203:212-222(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86747 mRNA. Translation: BAA13167.1.
RefSeqNP_001025911.1. NM_001030740.1.
UniGeneGga.595.

3D structure databases

ProteinModelPortalQ90827.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000037995.

Proteomic databases

PaxDbQ90827.
PRIDEQ90827.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID417799.
KEGGgga:417799.

Organism-specific databases

CTD4753.

Phylogenomic databases

eggNOGNOG253557.
HOGENOMHOG000217920.
HOVERGENHBG004805.
PhylomeDBQ90827.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamPF07645. EGF_CA. 4 hits.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 2 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20821047.
PROQ90827.

Entry information

Entry nameNEL_CHICK
AccessionPrimary (citable) accession number: Q90827
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families