ID   CCL4_CHICK              Reviewed;          90 AA.
AC   Q90826; Q4KS31; Q910C9;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 4.
DT   27-MAR-2024, entry version 141.
DE   RecName: Full=C-C motif chemokine 4 homolog;
DE   AltName: Full=Macrophage inflammatory protein 1-beta homolog;
DE            Short=MIP-1-beta;
DE   AltName: Full=Small-inducible cytokine A4 homolog;
DE   Flags: Precursor;
GN   Name=CCL4; Synonyms=SCYA4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7642115; DOI=10.1016/0378-1119(95)00210-w;
RA   Petrenko O., Ischenko I., Enrietto P.J.;
RT   "Isolation of a cDNA encoding a novel chicken chemokine homologous to
RT   mammalian macrophage inflammatory protein-1 beta.";
RL   Gene 160:305-306(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10582310; DOI=10.1046/j.1365-2052.1999.00526-27.x;
RA   Hughes S.M., Bumstead N.;
RT   "Mapping of the gene encoding a chicken homologue of the mammalian
RT   chemokine SCYA4.";
RL   Anim. Genet. 30:404-404(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hughes S.M.;
RT   "The chicken MIP-like chemokine cluster has a reduced repertoire compared
RT   to that of mammals.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Monokine with inflammatory and chemokinetic properties.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; L34553; AAA48747.1; -; mRNA.
DR   EMBL; AJ243034; CAB45103.1; -; mRNA.
DR   EMBL; AY895166; AAX83390.1; -; Genomic_DNA.
DR   RefSeq; NP_001025531.2; NM_001030360.2.
DR   AlphaFoldDB; Q90826; -.
DR   SMR; Q90826; -.
DR   STRING; 9031.ENSGALP00000067768; -.
DR   Ensembl; ENSGALT00000093905; ENSGALP00000065186; ENSGALG00000032717.
DR   Ensembl; ENSGALT00010071450.1; ENSGALP00010044140.1; ENSGALG00010029562.1.
DR   Ensembl; ENSGALT00015059902; ENSGALP00015036384; ENSGALG00015024533.
DR   GeneID; 395551; -.
DR   KEGG; gga:395551; -.
DR   VEuPathDB; HostDB:LOC395551; -.
DR   GeneTree; ENSGT01100000263482; -.
DR   HOGENOM; CLU_141716_4_2_1; -.
DR   InParanoid; Q90826; -.
DR   OMA; TACCFRY; -.
DR   OrthoDB; 4265193at2759; -.
DR   Reactome; R-GGA-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-GGA-416476; G alpha (q) signalling events.
DR   Reactome; R-GGA-418594; G alpha (i) signalling events.
DR   Reactome; R-GGA-444473; Formyl peptide receptors bind formyl peptides and many other ligands.
DR   PRO; PR:Q90826; -.
DR   Proteomes; UP000000539; Chromosome 19.
DR   Bgee; ENSGALG00000032717; Expressed in granulocyte and 10 other cell types or tissues.
DR   ExpressionAtlas; Q90826; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   CDD; cd00272; Chemokine_CC; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF183; C-C MOTIF CHEMOKINE 3; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..90
FT                   /note="C-C motif chemokine 4 homolog"
FT                   /id="PRO_0000005169"
FT   DISULFID        32..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..72
FT                   /evidence="ECO:0000250"
FT   CONFLICT        87
FT                   /note="L -> M (in Ref. 2; AAA48747 and 3; CAB45103)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   90 AA;  9969 MW;  50AF96781267408F CRC64;
     MKVSVAALAV LLIAICYQTS AAPVGSDPPT SCCFTYISRQ LPFSFVADYY ETNSQCPHAG
     VVFITRKGRE VCANPENDWV QDYMNKLELN
//