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Protein

C-C motif chemokine 4 homolog

Gene

CCL4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-GGA-380108. Chemokine receptors bind chemokines.
R-GGA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4 homolog
Alternative name(s):
Macrophage inflammatory protein 1-beta homolog
Short name:
MIP-1-beta
Small-inducible cytokine A4 homolog
Gene namesi
Name:CCL4
Synonyms:SCYA4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000000516922 – 90C-C motif chemokine 4 homologAdd BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 56By similarity
Disulfide bondi33 ↔ 72By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSGALG00000000951.
ExpressionAtlasiQ90826. baseline and differential.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ90826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ90826.
KOiK12964.
OMAiICYQTSA.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSVAALAV LLIAICYQTS AAPVGSDPPT SCCFTYISRQ LPFSFVADYY
60 70 80 90
ETNSQCPHAG VVFITRKGRE VCANPENDWV QDYMNKLELN
Length:90
Mass (Da):9,969
Last modified:August 30, 2005 - v4
Checksum:i50AF96781267408F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87L → M in AAA48747 (PubMed:10582310).Curated1
Sequence conflicti87L → M in CAB45103 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34553 mRNA. Translation: AAA48747.1.
AJ243034 mRNA. Translation: CAB45103.1.
AY895166 Genomic DNA. Translation: AAX83390.1.
RefSeqiNP_001025531.2. NM_001030360.2.
UniGeneiGga.4409.

Genome annotation databases

EnsembliENSGALT00000053996; ENSGALP00000053376; ENSGALG00000032717.
GeneIDi395551.
KEGGigga:395551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34553 mRNA. Translation: AAA48747.1.
AJ243034 mRNA. Translation: CAB45103.1.
AY895166 Genomic DNA. Translation: AAX83390.1.
RefSeqiNP_001025531.2. NM_001030360.2.
UniGeneiGga.4409.

3D structure databases

ProteinModelPortaliQ90826.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000053996; ENSGALP00000053376; ENSGALG00000032717.
GeneIDi395551.
KEGGigga:395551.

Organism-specific databases

CTDi6351.

Phylogenomic databases

GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ90826.
KOiK12964.
OMAiICYQTSA.

Enzyme and pathway databases

ReactomeiR-GGA-380108. Chemokine receptors bind chemokines.
R-GGA-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ90826.

Gene expression databases

BgeeiENSGALG00000000951.
ExpressionAtlasiQ90826. baseline and differential.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCL4_CHICK
AccessioniPrimary (citable) accession number: Q90826
Secondary accession number(s): Q4KS31, Q910C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 30, 2005
Last modified: November 30, 2016
This is version 104 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.