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Protein

C-C motif chemokine 4 homolog

Gene

CCL4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_297287. Chemokine receptors bind chemokines.
REACT_338065. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4 homolog
Alternative name(s):
Macrophage inflammatory protein 1-beta homolog
Short name:
MIP-1-beta
Small-inducible cytokine A4 homolog
Gene namesi
Name:CCL4
Synonyms:SCYA4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 9069C-C motif chemokine 4 homologPRO_0000005169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 56By similarity
Disulfide bondi33 ↔ 72By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

ExpressionAtlasiQ90826. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ90826.
SMRiQ90826. Positions 22-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ90826.
KOiK12964.
OMAiSAPFGAD.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSVAALAV LLIAICYQTS AAPVGSDPPT SCCFTYISRQ LPFSFVADYY
60 70 80 90
ETNSQCPHAG VVFITRKGRE VCANPENDWV QDYMNKLELN
Length:90
Mass (Da):9,969
Last modified:August 30, 2005 - v4
Checksum:i50AF96781267408F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871L → M in AAA48747 (PubMed:10582310).Curated
Sequence conflicti87 – 871L → M in CAB45103 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34553 mRNA. Translation: AAA48747.1.
AJ243034 mRNA. Translation: CAB45103.1.
AY895166 Genomic DNA. Translation: AAX83390.1.
RefSeqiNP_001025531.2. NM_001030360.2.
UniGeneiGga.4409.

Genome annotation databases

EnsembliENSGALT00000001404; ENSGALP00000001402; ENSGALG00000000951.
GeneIDi395551.
KEGGigga:395551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34553 mRNA. Translation: AAA48747.1.
AJ243034 mRNA. Translation: CAB45103.1.
AY895166 Genomic DNA. Translation: AAX83390.1.
RefSeqiNP_001025531.2. NM_001030360.2.
UniGeneiGga.4409.

3D structure databases

ProteinModelPortaliQ90826.
SMRiQ90826. Positions 22-90.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000001404; ENSGALP00000001402; ENSGALG00000000951.
GeneIDi395551.
KEGGigga:395551.

Organism-specific databases

CTDi6351.

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ90826.
KOiK12964.
OMAiSAPFGAD.

Enzyme and pathway databases

ReactomeiREACT_297287. Chemokine receptors bind chemokines.
REACT_338065. G alpha (i) signalling events.

Miscellaneous databases

NextBioi20815626.
PROiQ90826.

Gene expression databases

ExpressionAtlasiQ90826. baseline.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of a cDNA encoding a novel chicken chemokine homologous to mammalian macrophage inflammatory protein-1 beta."
    Petrenko O., Ischenko I., Enrietto P.J.
    Gene 160:305-306(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow.
  2. "Mapping of the gene encoding a chicken homologue of the mammalian chemokine SCYA4."
    Hughes S.M., Bumstead N.
    Anim. Genet. 30:404-404(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The chicken MIP-like chemokine cluster has a reduced repertoire compared to that of mammals."
    Hughes S.M.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCCL4_CHICK
AccessioniPrimary (citable) accession number: Q90826
Secondary accession number(s): Q4KS31, Q910C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 30, 2005
Last modified: May 27, 2015
This is version 95 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.