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Q90826 (CCL4_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 4 homolog
Alternative name(s):
Macrophage inflammatory protein 1-beta homolog
Short name=MIP-1-beta
Small-inducible cytokine A4 homolog
Gene names
Name:CCL4
Synonyms:SCYA4
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length90 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Monokine with inflammatory and chemokinetic properties By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 9069C-C motif chemokine 4 homolog
PRO_0000005169

Amino acid modifications

Disulfide bond32 ↔ 56 By similarity
Disulfide bond33 ↔ 72 By similarity

Experimental info

Sequence conflict871L → M in AAA48747. Ref.2
Sequence conflict871L → M in CAB45103. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q90826 [UniParc].

Last modified August 30, 2005. Version 4.
Checksum: 50AF96781267408F

FASTA909,969
        10         20         30         40         50         60 
MKVSVAALAV LLIAICYQTS AAPVGSDPPT SCCFTYISRQ LPFSFVADYY ETNSQCPHAG 

        70         80         90 
VVFITRKGRE VCANPENDWV QDYMNKLELN 

« Hide

References

[1]"Isolation of a cDNA encoding a novel chicken chemokine homologous to mammalian macrophage inflammatory protein-1 beta."
Petrenko O., Ischenko I., Enrietto P.J.
Gene 160:305-306(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Bone marrow.
[2]"Mapping of the gene encoding a chicken homologue of the mammalian chemokine SCYA4."
Hughes S.M., Bumstead N.
Anim. Genet. 30:404-404(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The chicken MIP-like chemokine cluster has a reduced repertoire compared to that of mammals."
Hughes S.M.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L34553 mRNA. Translation: AAA48747.1.
AJ243034 mRNA. Translation: CAB45103.1.
AY895166 Genomic DNA. Translation: AAX83390.1.
RefSeqNP_001025531.2. NM_001030360.2.
UniGeneGga.4409.

3D structure databases

ProteinModelPortalQ90826.
SMRQ90826. Positions 22-90.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000001404; ENSGALP00000001402; ENSGALG00000000951.
GeneID395551.
KEGGgga:395551.

Organism-specific databases

CTD6351.

Phylogenomic databases

eggNOGNOG38896.
GeneTreeENSGT00730000110278.
HOGENOMHOG000036685.
HOVERGENHBG017871.
KOK12964.
OMASAPFGAD.

Gene expression databases

ArrayExpressQ90826.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815626.
PROQ90826.

Entry information

Entry nameCCL4_CHICK
AccessionPrimary (citable) accession number: Q90826
Secondary accession number(s): Q4KS31, Q910C9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 30, 2005
Last modified: March 19, 2014
This is version 86 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families