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Q90826

- CCL4_CHICK

UniProt

Q90826 - CCL4_CHICK

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Protein

C-C motif chemokine 4 homolog

Gene

CCL4

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Monokine with inflammatory and chemokinetic properties.By similarity

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 4 homolog
Alternative name(s):
Macrophage inflammatory protein 1-beta homolog
Short name:
MIP-1-beta
Small-inducible cytokine A4 homolog
Gene namesi
Name:CCL4
Synonyms:SCYA4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 9069C-C motif chemokine 4 homologPRO_0000005169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 56By similarity
Disulfide bondi33 ↔ 72By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

ExpressionAtlasiQ90826. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ90826.
SMRiQ90826. Positions 22-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38896.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ90826.
KOiK12964.
OMAiLCAMALC.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90826 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVSVAALAV LLIAICYQTS AAPVGSDPPT SCCFTYISRQ LPFSFVADYY
60 70 80 90
ETNSQCPHAG VVFITRKGRE VCANPENDWV QDYMNKLELN
Length:90
Mass (Da):9,969
Last modified:August 30, 2005 - v4
Checksum:i50AF96781267408F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871L → M in AAA48747. (PubMed:10582310)Curated
Sequence conflicti87 – 871L → M in CAB45103. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34553 mRNA. Translation: AAA48747.1.
AJ243034 mRNA. Translation: CAB45103.1.
AY895166 Genomic DNA. Translation: AAX83390.1.
RefSeqiNP_001025531.2. NM_001030360.2.
UniGeneiGga.4409.

Genome annotation databases

EnsembliENSGALT00000001404; ENSGALP00000001402; ENSGALG00000000951.
GeneIDi395551.
KEGGigga:395551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34553 mRNA. Translation: AAA48747.1 .
AJ243034 mRNA. Translation: CAB45103.1 .
AY895166 Genomic DNA. Translation: AAX83390.1 .
RefSeqi NP_001025531.2. NM_001030360.2.
UniGenei Gga.4409.

3D structure databases

ProteinModelPortali Q90826.
SMRi Q90826. Positions 22-90.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000001404 ; ENSGALP00000001402 ; ENSGALG00000000951 .
GeneIDi 395551.
KEGGi gga:395551.

Organism-specific databases

CTDi 6351.

Phylogenomic databases

eggNOGi NOG38896.
GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q90826.
KOi K12964.
OMAi LCAMALC.

Miscellaneous databases

NextBioi 20815626.
PROi Q90826.

Gene expression databases

ExpressionAtlasi Q90826. baseline.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a cDNA encoding a novel chicken chemokine homologous to mammalian macrophage inflammatory protein-1 beta."
    Petrenko O., Ischenko I., Enrietto P.J.
    Gene 160:305-306(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow.
  2. "Mapping of the gene encoding a chicken homologue of the mammalian chemokine SCYA4."
    Hughes S.M., Bumstead N.
    Anim. Genet. 30:404-404(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The chicken MIP-like chemokine cluster has a reduced repertoire compared to that of mammals."
    Hughes S.M.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCCL4_CHICK
AccessioniPrimary (citable) accession number: Q90826
Secondary accession number(s): Q4KS31, Q910C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 30, 2005
Last modified: October 29, 2014
This is version 90 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3