Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q90826

- CCL4_CHICK

UniProt

Q90826 - CCL4_CHICK

Protein

C-C motif chemokine 4 homolog

Gene

CCL4

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Monokine with inflammatory and chemokinetic properties.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 4 homolog
    Alternative name(s):
    Macrophage inflammatory protein 1-beta homolog
    Short name:
    MIP-1-beta
    Small-inducible cytokine A4 homolog
    Gene namesi
    Name:CCL4
    Synonyms:SCYA4
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 19

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 9069C-C motif chemokine 4 homologPRO_0000005169Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 56By similarity
    Disulfide bondi33 ↔ 72By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ90826.
    SMRiQ90826. Positions 22-90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38896.
    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    KOiK12964.
    OMAiLCAMALC.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90826-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSVAALAV LLIAICYQTS AAPVGSDPPT SCCFTYISRQ LPFSFVADYY   50
    ETNSQCPHAG VVFITRKGRE VCANPENDWV QDYMNKLELN 90
    Length:90
    Mass (Da):9,969
    Last modified:August 30, 2005 - v4
    Checksum:i50AF96781267408F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti87 – 871L → M in AAA48747. (PubMed:10582310)Curated
    Sequence conflicti87 – 871L → M in CAB45103. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34553 mRNA. Translation: AAA48747.1.
    AJ243034 mRNA. Translation: CAB45103.1.
    AY895166 Genomic DNA. Translation: AAX83390.1.
    RefSeqiNP_001025531.2. NM_001030360.2.
    UniGeneiGga.4409.

    Genome annotation databases

    EnsembliENSGALT00000001404; ENSGALP00000001402; ENSGALG00000000951.
    GeneIDi395551.
    KEGGigga:395551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34553 mRNA. Translation: AAA48747.1 .
    AJ243034 mRNA. Translation: CAB45103.1 .
    AY895166 Genomic DNA. Translation: AAX83390.1 .
    RefSeqi NP_001025531.2. NM_001030360.2.
    UniGenei Gga.4409.

    3D structure databases

    ProteinModelPortali Q90826.
    SMRi Q90826. Positions 22-90.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000001404 ; ENSGALP00000001402 ; ENSGALG00000000951 .
    GeneIDi 395551.
    KEGGi gga:395551.

    Organism-specific databases

    CTDi 6351.

    Phylogenomic databases

    eggNOGi NOG38896.
    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    KOi K12964.
    OMAi LCAMALC.

    Miscellaneous databases

    NextBioi 20815626.
    PROi Q90826.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a cDNA encoding a novel chicken chemokine homologous to mammalian macrophage inflammatory protein-1 beta."
      Petrenko O., Ischenko I., Enrietto P.J.
      Gene 160:305-306(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone marrow.
    2. "Mapping of the gene encoding a chicken homologue of the mammalian chemokine SCYA4."
      Hughes S.M., Bumstead N.
      Anim. Genet. 30:404-404(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The chicken MIP-like chemokine cluster has a reduced repertoire compared to that of mammals."
      Hughes S.M.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCCL4_CHICK
    AccessioniPrimary (citable) accession number: Q90826
    Secondary accession number(s): Q4KS31, Q910C9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 89 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3