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Protein
Submitted name:

Protein-tyrosine phosphatase CRYPalpha1 isoform

Gene

CRYPalpha1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein-tyrosine phosphatase CRYPalpha1 isoformImported
Gene namesi
Name:CRYPalpha1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei851 – 874HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500431847629 – 1499Sequence analysisAdd BLAST1471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 106Combined sources
Disulfide bondi155 ↔ 206Combined sources

Proteomic databases

PRIDEiQ90815.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YD4X-ray1.65A29-226[»]
4PBVX-ray2.50C/D/E29-316[»]
4PBWX-ray3.05D/E/F29-316[»]
ProteinModelPortaliQ90815.
SMRiQ90815.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ90815.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 122Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST91
Domaini134 – 223Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST90
Domaini231 – 313Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST83
Domaini320 – 410Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini415 – 509Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini513 – 602Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini604 – 688Fibronectin type-IIIInterPro annotationAdd BLAST85
Domaini945 – 1200Tyrosine-protein phosphataseInterPro annotationAdd BLAST256
Domaini1120 – 1191TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini1232 – 1490Tyrosine-protein phosphataseInterPro annotationAdd BLAST259
Domaini1409 – 1481TYR_PHOSPHATASE_2InterPro annotationAdd BLAST73

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000010250.
HOVERGENiHBG053758.
KOiK06778.
PhylomeDBiQ90815.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 7 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90815-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILPSPGMP ALLSLVSLLS VLLMGCVAES PPVFIKKPVD QIGVSGGVAS
60 70 80 90 100
FVCQATGDPK PRVTWNKKGK KVNSQRFETI EFDESAGAVL RIQPLRTPRD
110 120 130 140 150
ENIYECVAQN PHGEVTVHAK LTVLREDQLP PGFPNIDMGP QLKVVERTRT
160 170 180 190 200
ATMLCAASGN PDPEITWFKD FLPVDPSTSN GRIKQLRSGG LQIESSEETD
210 220 230 240 250
QGKYECVASN SAGVRYSSPA NLYVRVRRVA PRFSILPVSH EIMPGGNVNI
260 270 280 290 300
TCVAVGSPMP YVKWMQGAED LTPEDDMPVG RNVLELTDVK DSANYTCVAM
310 320 330 340 350
SSLGVIEAVA QITVKSLPKA PGTPVVTETT ATSITITWDS GNPDPVSYYV
360 370 380 390 400
IEYKSKSQDG PYQIKEDITT TRYSIGGLSP NSEYEIWVSA VNSIGQGPPS
410 420 430 440 450
ESVVTRTGEQ APASAPRNVQ GRMLSSTTMI IQWEEPVEPN GQIRGYRVYY
460 470 480 490 500
TMEPDQPVSN WQKHNVDDSL LTTVGSLLED ETYTVRVLAF TSVGDGPLSD
510 520 530 540 550
PIQVKTQQGV PGQPMNFRAE AKTETSIVLS WSPPRQEIIV KYELLFKEGD
560 570 580 590 600
HGREVPRNFE PTTSFTVEGL KPNTEYVFRL AARSALGLGA FTPEVRERTL
610 620 630 640 650
QSILPKNFKV KMVTKTSVLL SWEFPENYNS PTPYKIQYNG LNVDVDGRTT
660 670 680 690 700
KKLITNLKPH TFYNFVLMNR GNSMGGLQQN VAAWTAANML SRKPEVTHKP
710 720 730 740 750
DADGNVVVIL PDVKSSVAVQ AYYIVVVPLR KSRGGQFLNP LGSPEEMDLE
760 770 780 790 800
ELIQDIARLR RRSLRHSRQL DFPKPYIAAR FRSLPNHFVL GDMKHYDNFE
810 820 830 840 850
NRALEPGQRY VIFILAVLQE PEATFAASPF SDPIQLDNPD PQPIIDGEEG
860 870 880 890 900
LIWVIGPVLA VVFIICIVIA ILLYKNKPDS KRKDSEPRTK CLLNNAEITP
910 920 930 940 950
HHPKDPVEMR RINFQTPGML SHPPIPVSEL AEHTEHLKAN DNLKLSQEYE
960 970 980 990 1000
SIDPGQQFTW EHSNLEVNKP KNRYANVIAY DHSRVILLPI EGIVGSDYIN
1010 1020 1030 1040 1050
ANYIDGYRKQ NAYIATQGPL PETFGDFWRM VWEQRSATIV MMTKLEEKSR
1060 1070 1080 1090 1100
IKCDQYWPGR GTDTYGMIQV TLLDTIELAT FCVRTFSLHK NGSSEKREVR
1110 1120 1130 1140 1150
QFQFTAWPDH GVPEYPTPFL AFLRRVKTCN PPDAGPIVVH CSAGVGRTGC
1160 1170 1180 1190 1200
FIVIDAMLER IKHEKTVDIY GHVTLMRSQR NYMVQTEDQY SFIHDALLEA
1210 1220 1230 1240 1250
VACGNTEVPA RNLYTYIQKL AQIEVGEHVT GMELEFKRLA NSKAHTSRFI
1260 1270 1280 1290 1300
SANLPCNKFK NRLVNIMPYE TTRVCLQPIR GVEGSDYINA SFIDGYRQQK
1310 1320 1330 1340 1350
AYIATQGPLA ETTEDFWRML WENNSTIVVM LTKLREMGRE KCHQYWPAER
1360 1370 1380 1390 1400
SARYQYFVVD PMAEYNMPQY ILREFKVTDA RDGQSRTVRQ FQFTDWPEQG
1410 1420 1430 1440 1450
VPKSGEGFID FIGQVHKTKE QFGQDGPISV HCSAGVGRTG VFITLSIVLE
1460 1470 1480 1490
RMRYEGVVDI FQTVKMLRTQ PAMVQTEDEY QFCYQAALEY LGSFDHYAT
Length:1,499
Mass (Da):168,571
Last modified:November 1, 1996 - v1
Checksum:iA1FBD6E3C2453F82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32780 mRNA. Translation: AAA64460.1.
PIRiI50212.
RefSeqiNP_990738.1. NM_205407.1.
UniGeneiGga.2657.
Gga.42907.

Genome annotation databases

GeneIDi396375.
KEGGigga:396375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32780 mRNA. Translation: AAA64460.1.
PIRiI50212.
RefSeqiNP_990738.1. NM_205407.1.
UniGeneiGga.2657.
Gga.42907.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YD4X-ray1.65A29-226[»]
4PBVX-ray2.50C/D/E29-316[»]
4PBWX-ray3.05D/E/F29-316[»]
ProteinModelPortaliQ90815.
SMRiQ90815.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ90815.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396375.
KEGGigga:396375.

Organism-specific databases

CTDi5802.

Phylogenomic databases

HOGENOMiHOG000010250.
HOVERGENiHBG053758.
KOiK06778.
PhylomeDBiQ90815.

Miscellaneous databases

EvolutionaryTraceiQ90815.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 7 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ90815_CHICK
AccessioniPrimary (citable) accession number: Q90815
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.