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Protein

Cyclic nucleotide-gated channel cone photoreceptor subunit alpha

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei591 – 5911cAMPSequence Analysis
Binding sitei606 – 6061cAMPSequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi532 – 654123cAMPBy similarityAdd
BLAST

GO - Molecular functioni

  1. cAMP binding Source: UniProtKB-KW
  2. ion channel activity Source: InterPro

GO - Biological processi

  1. response to stimulus Source: UniProtKB-KW
  2. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport, Vision

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated channel cone photoreceptor subunit alpha
Alternative name(s):
CNG channel 1
Short name:
CNG-1
Short name:
CNG1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 210210CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei211 – 23020Helical; Name=H1Sequence AnalysisAdd
BLAST
Topological domaini231 – 24313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei244 – 26219Helical; Name=H2Sequence AnalysisAdd
BLAST
Topological domaini263 – 28624CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei287 – 30620Helical; Name=H3Sequence AnalysisAdd
BLAST
Topological domaini307 – 34438ExtracellularSequence AnalysisAdd
BLAST
Transmembranei345 – 36723Helical; Name=H4Sequence AnalysisAdd
BLAST
Topological domaini368 – 41952CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei420 – 43920Helical; Name=H5Sequence AnalysisAdd
BLAST
Topological domaini440 – 52384ExtracellularSequence AnalysisAdd
BLAST
Transmembranei524 – 54421Helical; Name=H6Sequence AnalysisAdd
BLAST
Topological domaini545 – 735191CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Cyclic nucleotide-gated channel cone photoreceptor subunit alphaPRO_0000219324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90805.

Expressioni

Gene expression databases

ExpressionAtlasiQ90805. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026992.

Structurei

3D structure databases

ProteinModelPortaliQ90805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300025.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
KOiK04950.
PhylomeDBiQ90805.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKINTQHSY PGMHGLSVRT TDEDIERIEN GFIRTHSLCE DTSSELQRVI
60 70 80 90 100
SMEGRHLSGS QTSPFTGRGA MARLSRFVVS LRSWATRHLH HEDQRPDSFL
110 120 130 140 150
ERIRGPELVE VSSRQSNIRS FLGIREQPGG VNGPWPLARF NVNFSNNTNE
160 170 180 190 200
DKKEEKKEVK EEKKEEKKEE KKEEKKDDKK DDKKDDKKDD KKKEEQKKEV
210 220 230 240 250
FVIDPSSNMY YNWLTIIAAP VFYNWCMLIC RACFDELQID HIKLWLFLDY
260 270 280 290 300
CSDIIYVFDM FVRFRTGFLE QGLLVKDEKK LRDHYTQTVQ FKLDVLSLLP
310 320 330 340 350
TDLAYLKLGL NYPELRFNRL LRIARLFEFF DRTETRTNYP NMFRIGNLVL
360 370 380 390 400
YILIIIHWNA CIYFAISKVI GFGTDSWVYP NVSIPEYGRL SRKYIYSLYW
410 420 430 440 450
STLTLTTIGE TPPPVKDEEY LFVVIDFLVG VLIFATIVGN VGSMISNMNA
460 470 480 490 500
SRAEFQAKVD SIKQYMHFRK VTKDLEARVI KWFDYLWTNK KTVDEKEVLK
510 520 530 540 550
NLPDKLKAEI AINVHLDTLK KVRIFQDCEA GLLIELVLKL KPTVFSPGDY
560 570 580 590 600
ICKKGDIGRE MYIIKEGKLA VVADDGITQF VVLSDGSYFG EISILNIKGS
610 620 630 640 650
KSGNRRTANI RSIGYSDLFC LSKDDLMEAL TEYPEAKKAL EEKGRQILMK
660 670 680 690 700
DNLIDEEAAK AGADPKDLEE KIDRLETALD TLQTRFARLL AEYSSSQQKV
710 720 730
KQRLARVETR VKKYGSGSLS VGEPEPEKPE EQKKD
Length:735
Mass (Da):85,032
Last modified:October 31, 1997 - v1
Checksum:iA67ADFDD942CEFCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89598 mRNA. Translation: CAA61757.1.
PIRiI50630.
RefSeqiNP_990552.1. NM_205221.1.
UniGeneiGga.672.

Genome annotation databases

GeneIDi396144.
KEGGigga:396144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89598 mRNA. Translation: CAA61757.1.
PIRiI50630.
RefSeqiNP_990552.1. NM_205221.1.
UniGeneiGga.672.

3D structure databases

ProteinModelPortaliQ90805.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026992.

Proteomic databases

PaxDbiQ90805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396144.
KEGGigga:396144.

Organism-specific databases

CTDi1261.

Phylogenomic databases

eggNOGiNOG300025.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
KOiK04950.
PhylomeDBiQ90805.

Miscellaneous databases

NextBioi20816201.
PROiQ90805.

Gene expression databases

ExpressionAtlasiQ90805. baseline and differential.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels."
    Boenigk W., Altenhofen W., Mueller F., Dose A., Illing M., Molday R.S., Kaupp U.B.
    Neuron 10:865-877(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCNG1_CHICK
AccessioniPrimary (citable) accession number: Q90805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: October 31, 1997
Last modified: February 3, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.