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Protein

Cyclic nucleotide-gated channel cone photoreceptor subunit alpha

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei591cAMPSequence analysis1
Binding sitei606cAMPSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi532 – 654cAMPBy similarityAdd BLAST123

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Sensory transduction, Transport, Vision

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated channel cone photoreceptor subunit alpha
Alternative name(s):
CNG channel 1
Short name:
CNG-1
Short name:
CNG1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 210CytoplasmicSequence analysisAdd BLAST210
Transmembranei211 – 230Helical; Name=H1Sequence analysisAdd BLAST20
Topological domaini231 – 243ExtracellularSequence analysisAdd BLAST13
Transmembranei244 – 262Helical; Name=H2Sequence analysisAdd BLAST19
Topological domaini263 – 286CytoplasmicSequence analysisAdd BLAST24
Transmembranei287 – 306Helical; Name=H3Sequence analysisAdd BLAST20
Topological domaini307 – 344ExtracellularSequence analysisAdd BLAST38
Transmembranei345 – 367Helical; Name=H4Sequence analysisAdd BLAST23
Topological domaini368 – 419CytoplasmicSequence analysisAdd BLAST52
Transmembranei420 – 439Helical; Name=H5Sequence analysisAdd BLAST20
Topological domaini440 – 523ExtracellularSequence analysisAdd BLAST84
Transmembranei524 – 544Helical; Name=H6Sequence analysisAdd BLAST21
Topological domaini545 – 735CytoplasmicSequence analysisAdd BLAST191

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193241 – 735Cyclic nucleotide-gated channel cone photoreceptor subunit alphaAdd BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90805.

Expressioni

Gene expression databases

BgeeiENSGALG00000016749.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026992.

Structurei

3D structure databases

ProteinModelPortaliQ90805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
KOiK04950.
OrthoDBiEOG091G03EW.
PhylomeDBiQ90805.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKINTQHSY PGMHGLSVRT TDEDIERIEN GFIRTHSLCE DTSSELQRVI
60 70 80 90 100
SMEGRHLSGS QTSPFTGRGA MARLSRFVVS LRSWATRHLH HEDQRPDSFL
110 120 130 140 150
ERIRGPELVE VSSRQSNIRS FLGIREQPGG VNGPWPLARF NVNFSNNTNE
160 170 180 190 200
DKKEEKKEVK EEKKEEKKEE KKEEKKDDKK DDKKDDKKDD KKKEEQKKEV
210 220 230 240 250
FVIDPSSNMY YNWLTIIAAP VFYNWCMLIC RACFDELQID HIKLWLFLDY
260 270 280 290 300
CSDIIYVFDM FVRFRTGFLE QGLLVKDEKK LRDHYTQTVQ FKLDVLSLLP
310 320 330 340 350
TDLAYLKLGL NYPELRFNRL LRIARLFEFF DRTETRTNYP NMFRIGNLVL
360 370 380 390 400
YILIIIHWNA CIYFAISKVI GFGTDSWVYP NVSIPEYGRL SRKYIYSLYW
410 420 430 440 450
STLTLTTIGE TPPPVKDEEY LFVVIDFLVG VLIFATIVGN VGSMISNMNA
460 470 480 490 500
SRAEFQAKVD SIKQYMHFRK VTKDLEARVI KWFDYLWTNK KTVDEKEVLK
510 520 530 540 550
NLPDKLKAEI AINVHLDTLK KVRIFQDCEA GLLIELVLKL KPTVFSPGDY
560 570 580 590 600
ICKKGDIGRE MYIIKEGKLA VVADDGITQF VVLSDGSYFG EISILNIKGS
610 620 630 640 650
KSGNRRTANI RSIGYSDLFC LSKDDLMEAL TEYPEAKKAL EEKGRQILMK
660 670 680 690 700
DNLIDEEAAK AGADPKDLEE KIDRLETALD TLQTRFARLL AEYSSSQQKV
710 720 730
KQRLARVETR VKKYGSGSLS VGEPEPEKPE EQKKD
Length:735
Mass (Da):85,032
Last modified:November 1, 1997 - v1
Checksum:iA67ADFDD942CEFCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89598 mRNA. Translation: CAA61757.1.
PIRiI50630.
RefSeqiNP_990552.1. NM_205221.1.
UniGeneiGga.672.

Genome annotation databases

GeneIDi396144.
KEGGigga:396144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89598 mRNA. Translation: CAA61757.1.
PIRiI50630.
RefSeqiNP_990552.1. NM_205221.1.
UniGeneiGga.672.

3D structure databases

ProteinModelPortaliQ90805.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026992.

Proteomic databases

PaxDbiQ90805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396144.
KEGGigga:396144.

Organism-specific databases

CTDi1261.

Phylogenomic databases

eggNOGiKOG0500. Eukaryota.
ENOG410YWWI. LUCA.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
KOiK04950.
OrthoDBiEOG091G03EW.
PhylomeDBiQ90805.

Miscellaneous databases

PROiQ90805.

Gene expression databases

BgeeiENSGALG00000016749.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR032406. CLZ_dom.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF16526. CLZ. 1 hit.
PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNG1_CHICK
AccessioniPrimary (citable) accession number: Q90805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.