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Q90805 (CNG1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclic nucleotide-gated channel cone photoreceptor subunit alpha
Alternative name(s):
CNG channel 1
Short name=CNG-1
Short name=CNG1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length735 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. [View classification]

Contains 1 cyclic nucleotide-binding domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 735735Cyclic nucleotide-gated channel cone photoreceptor subunit alpha
PRO_0000219324

Regions

Topological domain1 – 210210Cytoplasmic Potential
Transmembrane211 – 23020Helical; Name=H1; Potential
Topological domain231 – 24313Extracellular Potential
Transmembrane244 – 26219Helical; Name=H2; Potential
Topological domain263 – 28624Cytoplasmic Potential
Transmembrane287 – 30620Helical; Name=H3; Potential
Topological domain307 – 34438Extracellular Potential
Transmembrane345 – 36723Helical; Name=H4; Potential
Topological domain368 – 41952Cytoplasmic Potential
Transmembrane420 – 43920Helical; Name=H5; Potential
Topological domain440 – 52384Extracellular Potential
Transmembrane524 – 54421Helical; Name=H6; Potential
Topological domain545 – 735191Cytoplasmic Potential
Nucleotide binding532 – 654123cAMP By similarity

Sites

Binding site5911cAMP Potential
Binding site6061cAMP Potential

Amino acid modifications

Glycosylation4491N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q90805 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: A67ADFDD942CEFCE

FASTA73585,032
        10         20         30         40         50         60 
MAKINTQHSY PGMHGLSVRT TDEDIERIEN GFIRTHSLCE DTSSELQRVI SMEGRHLSGS 

        70         80         90        100        110        120 
QTSPFTGRGA MARLSRFVVS LRSWATRHLH HEDQRPDSFL ERIRGPELVE VSSRQSNIRS 

       130        140        150        160        170        180 
FLGIREQPGG VNGPWPLARF NVNFSNNTNE DKKEEKKEVK EEKKEEKKEE KKEEKKDDKK 

       190        200        210        220        230        240 
DDKKDDKKDD KKKEEQKKEV FVIDPSSNMY YNWLTIIAAP VFYNWCMLIC RACFDELQID 

       250        260        270        280        290        300 
HIKLWLFLDY CSDIIYVFDM FVRFRTGFLE QGLLVKDEKK LRDHYTQTVQ FKLDVLSLLP 

       310        320        330        340        350        360 
TDLAYLKLGL NYPELRFNRL LRIARLFEFF DRTETRTNYP NMFRIGNLVL YILIIIHWNA 

       370        380        390        400        410        420 
CIYFAISKVI GFGTDSWVYP NVSIPEYGRL SRKYIYSLYW STLTLTTIGE TPPPVKDEEY 

       430        440        450        460        470        480 
LFVVIDFLVG VLIFATIVGN VGSMISNMNA SRAEFQAKVD SIKQYMHFRK VTKDLEARVI 

       490        500        510        520        530        540 
KWFDYLWTNK KTVDEKEVLK NLPDKLKAEI AINVHLDTLK KVRIFQDCEA GLLIELVLKL 

       550        560        570        580        590        600 
KPTVFSPGDY ICKKGDIGRE MYIIKEGKLA VVADDGITQF VVLSDGSYFG EISILNIKGS 

       610        620        630        640        650        660 
KSGNRRTANI RSIGYSDLFC LSKDDLMEAL TEYPEAKKAL EEKGRQILMK DNLIDEEAAK 

       670        680        690        700        710        720 
AGADPKDLEE KIDRLETALD TLQTRFARLL AEYSSSQQKV KQRLARVETR VKKYGSGSLS 

       730 
VGEPEPEKPE EQKKD 

« Hide

References

[1]"Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels."
Boenigk W., Altenhofen W., Mueller F., Dose A., Illing M., Molday R.S., Kaupp U.B.
Neuron 10:865-877(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89598 mRNA. Translation: CAA61757.1.
PIRI50630.
RefSeqNP_990552.1. NM_205221.1.
UniGeneGga.672.

3D structure databases

ProteinModelPortalQ90805.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000026992.

Proteomic databases

PaxDbQ90805.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396144.
KEGGgga:396144.

Organism-specific databases

CTD1261.

Phylogenomic databases

eggNOGNOG300025.
HOGENOMHOG000007898.
HOVERGENHBG000281.
InParanoidQ90805.
KOK04950.
PhylomeDBQ90805.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816201.
PROQ90805.

Entry information

Entry nameCNG1_CHICK
AccessionPrimary (citable) accession number: Q90805
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families