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Q90805

- CNG1_CHICK

UniProt

Q90805 - CNG1_CHICK

Protein

Cyclic nucleotide-gated channel cone photoreceptor subunit alpha

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei591 – 5911cAMPSequence Analysis
    Binding sitei606 – 6061cAMPSequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi532 – 654123cAMPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. cAMP binding Source: UniProtKB-KW
    2. ion channel activity Source: InterPro

    GO - Biological processi

    1. response to stimulus Source: UniProtKB-KW
    2. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel

    Keywords - Biological processi

    Ion transport, Sensory transduction, Transport, Vision

    Keywords - Ligandi

    cAMP, cAMP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic nucleotide-gated channel cone photoreceptor subunit alpha
    Alternative name(s):
    CNG channel 1
    Short name:
    CNG-1
    Short name:
    CNG1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 735735Cyclic nucleotide-gated channel cone photoreceptor subunit alphaPRO_0000219324Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ90805.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000026992.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90805.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 210210CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini231 – 24313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini263 – 28624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini307 – 34438ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini368 – 41952CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini440 – 52384ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini545 – 735191CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei211 – 23020Helical; Name=H1Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26219Helical; Name=H2Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30620Helical; Name=H3Sequence AnalysisAdd
    BLAST
    Transmembranei345 – 36723Helical; Name=H4Sequence AnalysisAdd
    BLAST
    Transmembranei420 – 43920Helical; Name=H5Sequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421Helical; Name=H6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300025.
    HOGENOMiHOG000007898.
    HOVERGENiHBG000281.
    InParanoidiQ90805.
    KOiK04950.
    PhylomeDBiQ90805.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
    PS00889. CNMP_BINDING_2. 1 hit.
    PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90805-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKINTQHSY PGMHGLSVRT TDEDIERIEN GFIRTHSLCE DTSSELQRVI    50
    SMEGRHLSGS QTSPFTGRGA MARLSRFVVS LRSWATRHLH HEDQRPDSFL 100
    ERIRGPELVE VSSRQSNIRS FLGIREQPGG VNGPWPLARF NVNFSNNTNE 150
    DKKEEKKEVK EEKKEEKKEE KKEEKKDDKK DDKKDDKKDD KKKEEQKKEV 200
    FVIDPSSNMY YNWLTIIAAP VFYNWCMLIC RACFDELQID HIKLWLFLDY 250
    CSDIIYVFDM FVRFRTGFLE QGLLVKDEKK LRDHYTQTVQ FKLDVLSLLP 300
    TDLAYLKLGL NYPELRFNRL LRIARLFEFF DRTETRTNYP NMFRIGNLVL 350
    YILIIIHWNA CIYFAISKVI GFGTDSWVYP NVSIPEYGRL SRKYIYSLYW 400
    STLTLTTIGE TPPPVKDEEY LFVVIDFLVG VLIFATIVGN VGSMISNMNA 450
    SRAEFQAKVD SIKQYMHFRK VTKDLEARVI KWFDYLWTNK KTVDEKEVLK 500
    NLPDKLKAEI AINVHLDTLK KVRIFQDCEA GLLIELVLKL KPTVFSPGDY 550
    ICKKGDIGRE MYIIKEGKLA VVADDGITQF VVLSDGSYFG EISILNIKGS 600
    KSGNRRTANI RSIGYSDLFC LSKDDLMEAL TEYPEAKKAL EEKGRQILMK 650
    DNLIDEEAAK AGADPKDLEE KIDRLETALD TLQTRFARLL AEYSSSQQKV 700
    KQRLARVETR VKKYGSGSLS VGEPEPEKPE EQKKD 735
    Length:735
    Mass (Da):85,032
    Last modified:November 1, 1997 - v1
    Checksum:iA67ADFDD942CEFCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89598 mRNA. Translation: CAA61757.1.
    PIRiI50630.
    RefSeqiNP_990552.1. NM_205221.1.
    UniGeneiGga.672.

    Genome annotation databases

    GeneIDi396144.
    KEGGigga:396144.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89598 mRNA. Translation: CAA61757.1 .
    PIRi I50630.
    RefSeqi NP_990552.1. NM_205221.1.
    UniGenei Gga.672.

    3D structure databases

    ProteinModelPortali Q90805.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000026992.

    Proteomic databases

    PaxDbi Q90805.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396144.
    KEGGi gga:396144.

    Organism-specific databases

    CTDi 1261.

    Phylogenomic databases

    eggNOGi NOG300025.
    HOGENOMi HOG000007898.
    HOVERGENi HBG000281.
    InParanoidi Q90805.
    KOi K04950.
    PhylomeDBi Q90805.

    Miscellaneous databases

    NextBioi 20816201.
    PROi Q90805.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
    PS00889. CNMP_BINDING_2. 1 hit.
    PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rod and cone photoreceptor cells express distinct genes for cGMP-gated channels."
      Boenigk W., Altenhofen W., Mueller F., Dose A., Illing M., Molday R.S., Kaupp U.B.
      Neuron 10:865-877(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCNG1_CHICK
    AccessioniPrimary (citable) accession number: Q90805
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3