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Protein
Submitted name:

C-eyk protein

Gene

c-eyk

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotationImported

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
C-eyk proteinImported
Gene namesi
Name:c-eykImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei492 – 51524HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 974951Sequence analysisPRO_5004320686Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ90777.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013423.

Structurei

3D structure databases

ProteinModelPortaliQ90777.
SMRiQ90777. Positions 356-474, 566-852.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 17593Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini187 – 26983Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini276 – 37196Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini376 – 47398Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini577 – 848272Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IG6I. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
KOiK05117.
PhylomeDBiQ90777.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGGRCALLC ALLCALPLPR CGAAEFGGAG GHGGLRSLSA GAPLARPLWA
60 70 80 90 100
KHHRPKRGLT SGRWPPQGAK PSATSVGQLK FNPTVGHVVI NELKDVTFNC
110 120 130 140 150
SIKVPQLLVR PDSPGISLWK DGRELHTLDR IATSHFEILD EEEVAMTSTF
160 170 180 190 200
SIRAAQRSDN GSYVCKLNIS GIEIASDPIL VQLEGLPHFI QQPEKLNVTR
210 220 230 240 250
NSPFNLTCQA VGPPEPVEIY WFRNNVQLNM KPYISPSVLT VPGLNETALF
260 270 280 290 300
SCEAHNSKGL TASNPGQVNV KGIPSAPKAV HVLKRMAHSI VISWVPGFDA
310 320 330 340 350
FSALNSCSVQ VKEAVPQSNV SLLLFNTSVP PHVYRIQQLW PMADYNISVS
360 370 380 390 400
CKNEVGWSAF SPWITASTTE GAPTTQPLNV TVSLNESSSF LEIRWVKPPL
410 420 430 440 450
ERTHGELQGY HIWHTWQDSK GLQNISLEAQ PNATVAILPV VATNATCSVR
460 470 480 490 500
VAAVTKGGVG PFSSPVEVFV PASGLITSSP SSTPASGNTD SFIVALGFVC
510 520 530 540 550
GTVAVGLILC LSVVIQKRCM ETKYGNAFSR NDSELVVNYT AKKSYCRRAV
560 570 580 590 600
ELTLGSLGVS SELQQKLQDV VIDRNALSLG KVLGEGEFGS VMEGRLSQPE
610 620 630 640 650
GTPQKVAVKT MKLDNFSHRE IEEFLSEAAC MKDFDHPNVI KLLGVCIELS
660 670 680 690 700
SQQIPKPMVV LPFMKYGDLH SFLLRSRLEM APQFVPLQML LKFMVDIALG
710 720 730 740 750
MEYLSSRQFL HRDLAARNCM LRDDMTVCVA DFGLSKKIYS GDYYRQGRIA
760 770 780 790 800
KMPVKWIAIE SLADRVYTTK SDVWAFGVTM WEIATRGMTP YPGVQNHEIY
810 820 830 840 850
EYLFHGQRLK KPENCLDELY DIMSSCWRAE PADRPTFSQL KVHLEKLLES
860 870 880 890 900
LPAPRGSKDV IYVNTSLPEE SPDSTQDLGL DSVIPQADSD LDPGDIAEPC
910 920 930 940 950
CSHTKAALVA VDIHDGGSRY VLESEGSPTE DAYVPLLPHE GSAWTEASTL
960 970
PVGSSLAAQL PCADGCLEDS EALL
Length:974
Mass (Da):106,166
Last modified:November 1, 1996 - v1
Checksum:i9AAC5E408E5F705D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21719 mRNA. Translation: AAC38010.1.
PIRiA49714.
RefSeqiNP_990319.1. NM_204988.1.
UniGeneiGga.2893.

Genome annotation databases

GeneIDi395836.
KEGGigga:395836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21719 mRNA. Translation: AAC38010.1.
PIRiA49714.
RefSeqiNP_990319.1. NM_204988.1.
UniGeneiGga.2893.

3D structure databases

ProteinModelPortaliQ90777.
SMRiQ90777. Positions 356-474, 566-852.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013423.

Proteomic databases

PaxDbiQ90777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395836.
KEGGigga:395836.

Organism-specific databases

CTDi10461.

Phylogenomic databases

eggNOGiENOG410IG6I. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000231685.
HOVERGENiHBG006346.
KOiK05117.
PhylomeDBiQ90777.

Miscellaneous databases

NextBioi20815904.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The proto-oncogene of v-eyk (v-ryk) is a novel receptor-type protein tyrosine kinase with extracellular Ig/GN-III domains."
    Jia R., Hanafusa H.
    J. Biol. Chem. 269:1839-1844(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ90777_CHICK
AccessioniPrimary (citable) accession number: Q90777
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.