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Protein
Submitted name:

CD3 glycoprotein

Gene

CD3D

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • T cell receptor binding Source: AgBase
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CD3 glycoproteinImported
Submitted name:
CD3D antigen deltaImported
Submitted name:
CD3g/d proteinImported
Gene namesi
Name:CD3DImported
Synonyms:cd3gImported, dImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei109 – 13022HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • alpha-beta T cell receptor complex Source: AgBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 175150Sequence analysisPRO_5006751047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 81Combined sources

Interactioni

GO - Molecular functioni

  • T cell receptor binding Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011984.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MIMNMR-A18-97[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 10874Ig_4InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IWAX. Eukaryota.
ENOG410Y2TD. LUCA.
HOVERGENiHBG005278.
KOiK06450.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR015485. CD3D.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR032052. Ig_4.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PTHR10570:SF5. PTHR10570:SF5. 1 hit.
PfamiPF16680. Ig_4. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKGRALGTW LLLACVAVAK LGVHGLSMSV KEVSGKVFLQ CQESKDLNTN
60 70 80 90 100
YLWKKGKEEL GNMRQLDLGA IYDDPRGTYT CQRDENVNST LHVHYRMCQN
110 120 130 140 150
CIEVDAPTIS GIVVADVVAT VLLAIAVYCI TGQDKGLMSR ASDRQNLIAN
160 170
DQLYQPLGER NDGQYSQLAT AKARK
Length:175
Mass (Da):19,366
Last modified:November 1, 1996 - v1
Checksum:i7429EBB88320C2E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59925 mRNA. Translation: AAA48660.1.
EU477524 mRNA. Translation: ACA48578.1.
AJ250458 Genomic DNA. Translation: CAB62062.1.
PIRiA39171.
RefSeqiNP_990843.1. NM_205512.1.
UniGeneiGga.998.

Genome annotation databases

GeneIDi396518.
KEGGigga:396518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59925 mRNA. Translation: AAA48660.1.
EU477524 mRNA. Translation: ACA48578.1.
AJ250458 Genomic DNA. Translation: CAB62062.1.
PIRiA39171.
RefSeqiNP_990843.1. NM_205512.1.
UniGeneiGga.998.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MIMNMR-A18-97[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396518.
KEGGigga:396518.

Organism-specific databases

CTDi915.

Phylogenomic databases

eggNOGiENOG410IWAX. Eukaryota.
ENOG410Y2TD. LUCA.
HOVERGENiHBG005278.
KOiK06450.

Miscellaneous databases

NextBioi20816555.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR015485. CD3D.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR032052. Ig_4.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PTHR10570:SF5. PTHR10570:SF5. 1 hit.
PfamiPF16680. Ig_4. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure and ontogeny of an avian CD3 transcript."
    Bernot A., Auffray C.
    Proc. Natl. Acad. Sci. U.S.A. 88:2550-2554(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: T-lymphoblastoidImported.
  2. "Evidence for a stepwise evolution of the CD3 family."
    Goebel T.W., Dangy J.P.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Carattoli A.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Structure of the chicken CD3epsilondelta/gamma heterodimer and its assembly with the alphabetaT cell receptor."
    Berry R., Headey S.J., Call M.J., McCluskey J., Tregaskes C.A., Kaufman J., Koh R., Scanlon M.J., Call M.E., Rossjohn J.
    J. Biol. Chem. 289:8240-8251(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 18-97, DISULFIDE BONDS.

Entry informationi

Entry nameiQ90768_CHICK
AccessioniPrimary (citable) accession number: Q90768
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.