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Protein

Cadherin-7

Gene

CDH7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

  • cartilage condensation Source: AgBase
  • cell migration Source: AgBase
  • chondroblast differentiation Source: AgBase
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • limb development Source: AgBase
  • wound healing Source: AgBase
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-7
Gene namesi
Name:CDH7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini48 – 607560ExtracellularSequence analysisAdd
BLAST
Transmembranei608 – 62821HelicalSequence analysisAdd
BLAST
Topological domaini629 – 785157CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Propeptidei28 – 4720Sequence analysisPRO_0000003771Add
BLAST
Chaini48 – 785738Cadherin-7PRO_0000003772Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence analysis
Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ90763.
PRIDEiQ90763.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022341.

Structurei

3D structure databases

ProteinModelPortaliQ90763.
SMRiQ90763. Positions 48-369, 715-776.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 153105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini154 – 262109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini263 – 377115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 482105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini482 – 599118Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ90763.
KOiK06799.
PhylomeDBiQ90763.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGKVEFCH LLQIIALFLC LSGMNQAEPS RSRSKPYFQS GRTRTKRSWV
60 70 80 90 100
WNQFFVLEEY MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN
110 120 130 140 150
TGDIHATKRL DREEQAYYTL RAQAHDRLTN KPVEPESEFV IKIQDINDNE
160 170 180 190 200
PKFLDGPYTA GVPEMSPVGT SVVQVTATDA DDPTYGNSAR VVYSILQGQP
210 220 230 240 250
YFSVEPKTGI IKTALPNMDR EAKDQYLLVI QAKDMVGQNG GLSGTTSVTV
260 270 280 290 300
TLTDVNDNPP RFPRRSYQYN VPESLPLASV VARIKAADAD VGPNAEMEYK
310 320 330 340 350
IVDGDGLGVF KISVDKDTQE GIITIQKELD FEAKTSYTLR IEAANMHVDP
360 370 380 390 400
RFLSLGPFSD MTTVKIIVED VDEPPVFTSR LYSMVVSEAA KVGTIIGTVA
410 420 430 440 450
AHDPDASNSP VRYSIDRNTD LERYFNIDAN SGVITTAKSL DRETNAVHNI
460 470 480 490 500
TVLAMESQNP AQIGRGYVAI TILDINDNAP EFAMEYETTV CENAQPGQII
510 520 530 540 550
QKISAIDKDD PPNGHQFYFS LTAEAANNHN FTLQDNKDNT ATVLTRRNGF
560 570 580 590 600
RRQEQSVFYL PIFIVDSGSP SLSSTNTLTI RVCDCDADGI AQTCNAEAYI
610 620 630 640 650
LPAGLSTGAL IAILACVLTL LVLVLLIVTM RRRKKEPLIF DEERDIRENI
660 670 680 690 700
VRYDDEGGGE EDTEAFDMAA LRNLNIIRDT KTRRDVTPEI QFLSRPTFKS
710 720 730 740 750
IPDNVIFREF IWERLKEADV DPCAPPYDSL QTYAFEGNGS VAESLSSLDS
760 770 780
ISSNSDQNYD YLSDWGPRFK RLADMYGSGP DCLYS
Length:785
Mass (Da):87,172
Last modified:November 1, 1996 - v1
Checksum:i895B06D8141E34D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42150 mRNA. Translation: BAA07721.1.
PIRiI50180.
RefSeqiNP_989518.2. NM_204187.2.
UniGeneiGga.15.

Genome annotation databases

GeneIDi374007.
KEGGigga:374007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42150 mRNA. Translation: BAA07721.1.
PIRiI50180.
RefSeqiNP_989518.2. NM_204187.2.
UniGeneiGga.15.

3D structure databases

ProteinModelPortaliQ90763.
SMRiQ90763. Positions 48-369, 715-776.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022341.

Proteomic databases

PaxDbiQ90763.
PRIDEiQ90763.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374007.
KEGGigga:374007.

Organism-specific databases

CTDi1005.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ90763.
KOiK06799.
PhylomeDBiQ90763.

Miscellaneous databases

NextBioi20813535.
PROiQ90763.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins."
    Nakagawa S., Takeichi M.
    Development 121:1321-1332(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: White leghorn.
    Tissue: Brain.

Entry informationi

Entry nameiCADH7_CHICK
AccessioniPrimary (citable) accession number: Q90763
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.