Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-7

Gene

CDH7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

  • cartilage condensation Source: AgBase
  • cell migration Source: AgBase
  • chondroblast differentiation Source: AgBase
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • limb development Source: AgBase
  • neural crest cell delamination Source: AgBase
  • neural tube formation Source: AgBase
  • wound healing Source: AgBase

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-7
Gene namesi
Name:CDH7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini48 – 607ExtracellularSequence analysisAdd BLAST560
Transmembranei608 – 628HelicalSequence analysisAdd BLAST21
Topological domaini629 – 785CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000000377128 – 47Sequence analysisAdd BLAST20
ChainiPRO_000000377248 – 785Cadherin-7Add BLAST738

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ90763
PRIDEiQ90763

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022341

Structurei

3D structure databases

ProteinModelPortaliQ90763
SMRiQ90763
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 153Cadherin 1PROSITE-ProRule annotationAdd BLAST105
Domaini154 – 262Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini263 – 377Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini378 – 482Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini482 – 599Cadherin 5PROSITE-ProRule annotationAdd BLAST118

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ90763
KOiK06799
PhylomeDBiQ90763

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGKVEFCH LLQIIALFLC LSGMNQAEPS RSRSKPYFQS GRTRTKRSWV
60 70 80 90 100
WNQFFVLEEY MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN
110 120 130 140 150
TGDIHATKRL DREEQAYYTL RAQAHDRLTN KPVEPESEFV IKIQDINDNE
160 170 180 190 200
PKFLDGPYTA GVPEMSPVGT SVVQVTATDA DDPTYGNSAR VVYSILQGQP
210 220 230 240 250
YFSVEPKTGI IKTALPNMDR EAKDQYLLVI QAKDMVGQNG GLSGTTSVTV
260 270 280 290 300
TLTDVNDNPP RFPRRSYQYN VPESLPLASV VARIKAADAD VGPNAEMEYK
310 320 330 340 350
IVDGDGLGVF KISVDKDTQE GIITIQKELD FEAKTSYTLR IEAANMHVDP
360 370 380 390 400
RFLSLGPFSD MTTVKIIVED VDEPPVFTSR LYSMVVSEAA KVGTIIGTVA
410 420 430 440 450
AHDPDASNSP VRYSIDRNTD LERYFNIDAN SGVITTAKSL DRETNAVHNI
460 470 480 490 500
TVLAMESQNP AQIGRGYVAI TILDINDNAP EFAMEYETTV CENAQPGQII
510 520 530 540 550
QKISAIDKDD PPNGHQFYFS LTAEAANNHN FTLQDNKDNT ATVLTRRNGF
560 570 580 590 600
RRQEQSVFYL PIFIVDSGSP SLSSTNTLTI RVCDCDADGI AQTCNAEAYI
610 620 630 640 650
LPAGLSTGAL IAILACVLTL LVLVLLIVTM RRRKKEPLIF DEERDIRENI
660 670 680 690 700
VRYDDEGGGE EDTEAFDMAA LRNLNIIRDT KTRRDVTPEI QFLSRPTFKS
710 720 730 740 750
IPDNVIFREF IWERLKEADV DPCAPPYDSL QTYAFEGNGS VAESLSSLDS
760 770 780
ISSNSDQNYD YLSDWGPRFK RLADMYGSGP DCLYS
Length:785
Mass (Da):87,172
Last modified:November 1, 1996 - v1
Checksum:i895B06D8141E34D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42150 mRNA Translation: BAA07721.1
PIRiI50180
RefSeqiNP_989518.2, NM_204187.2
UniGeneiGga.15

Genome annotation databases

GeneIDi374007
KEGGigga:374007

Similar proteinsi

Entry informationi

Entry nameiCADH7_CHICK
AccessioniPrimary (citable) accession number: Q90763
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health