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Protein
Submitted name:

Amyloid protein

Gene

IAPP

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-418555 G alpha (s) signalling events
R-GGA-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Submitted name:
Amyloid proteinImported
Submitted name:
Islet amyloid polypeptideImported
Gene namesi
Name:IAPPImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501431241723 – 135Sequence analysisAdd BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 86UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGALG00000013168

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021476

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 120CALCITONINInterPro annotationAdd BLAST43

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J0NB Eukaryota
ENOG410Z7V7 LUCA
GeneTreeiENSGT00510000048671
HOGENOMiHOG000038203
HOVERGENiHBG096065
KOiK08039
OMAiSHQMEKR
OrthoDBiEOG091G15QG
TreeFamiTF330783

Family and domain databases

InterProiView protein in InterPro
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR001693 Calcitonin_peptide-like
IPR000443 Pro-islet_amyloid_polypep
PANTHERiPTHR10505 PTHR10505, 1 hit
PTHR10505:SF4 PTHR10505:SF4, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00818 ISLETAMYLOID
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q90743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNLKLSAFF IVLSVTLNCL EATSIEKLLS VTDDLSDGTS KRQEWILPIM
60 70 80 90 100
SQNTLSGLSE EMPEQPAAKT KSSHQLEKRK CNTATCVTQR LADFLVRSSS
110 120 130
NIGAIYSPTN VGSNTYGKRD TAGLSSRKSQ NNTKL
Length:135
Mass (Da):14,762
Last modified:November 1, 1996 - v1
Checksum:i83DE3223AC735159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000045 Genomic DNA No translation available.
L16955 mRNA Translation: AAA67704.1
PIRiA56855
RefSeqiNP_990728.1, NM_205397.1
UniGeneiGga.780

Genome annotation databases

EnsembliENSGALT00000021509; ENSGALP00000021476; ENSGALG00000013168
GeneIDi396362
KEGGigga:396362

Similar proteinsi

Entry informationi

Entry nameiQ90743_CHICK
AccessioniPrimary (citable) accession number: Q90743
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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