Reviewed, UniProtKB/Swiss-Prot Q90733 (COT2_CHICK)

Names and origin

Protein names

Recommended name:
    COUP transcription factor 2
      Short name=COUP-TF2
Alternative name(s):
    COUP transcription factor II
      Short name=COUP-TF II
    Nuclear receptor subfamily 2 group F member 2

Gene names

Name:	NR2F2
Synonyms:	TFCOUP2

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in motor neuron development.
Subunit structure	Binds DNA as a homodimer.
Subcellular location	Nucleus.
Tissue specificity	Highly expressed in the developing spinal motor neurons.
Sequence similarities	Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	COUP transcription factor 2		PRO_0000053609
Regions
	DNA binding	72 – 147	76	Nuclear receptor
	Zinc finger	75 – 95	21	NR C4-type
	Zinc finger	111 – 135	25	NR C4-type
	Region	333 – 410	78	Important for dimerization
	Compositional bias	67 – 71	5	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q90733-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 760A996E29082E3D	FASTA	410	45,427
	10 20 30 40 50 60 MAMVVGAWRD PQDDVPGAQG TQPAPAPPVQ GPPAGTPHTP QTPGPGGPPS TPAQSNAASQ 70 80 90 100 110 120 QSQGDKQQQQ QHIECVVCGD KSSGKHYGQF TCEGCKSFFK RSVRRNLSYT CRANRNCPID 130 140 150 160 170 180 QHHRNQCQYC RLKKCLKVGM RREAVQRGRM PPTQPTHGQF ALTNGDPLNC HSYLSGYISL 190 200 210 220 230 240 LLRAEPYPTS RFGSQCMQPN NIMGIENICE LAARMLFSAV EWARNIPFFP DLQITDQVAL 250 260 270 280 290 300 LRLTWSELFV LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI FQEQVEKLKA 310 320 330 340 350 360 LHVDSAEYSC LKAIVLFTSD ACGLSDVAHV ESLQEKSQCA LEEYVRSQYP NQPTRFGKLL 370 380 390 400 410 LRLPSLRTVS SSVIEQLFFV RLVGKTPIET LIRDMLLSGS SFNWPYMSIQ

References

[1]	"Developmental regulation of the orphan receptor COUP-TF II gene in spinal motor neurons." Lutz B., Kuratani S., Cooney A.J., Wawersik W., Tsai S.Y., Eichele G., Tsai M. Development 120:25-36(1994) [PubMed: 8119130] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00697 mRNA. Translation: AAA17733.1.
IPI	IPI00598209.
PIR	I50689.
RefSeq	NP_989752.1.
UniGene	Gga.4445
3D structure databases
SMR	Q90733. Positions 73-153, 177-397.
ModBase	Search...
Protein-protein interaction databases
STRING	Q90733.
Genome annotation databases
Ensembl	ENSGALT00000023630; ENSGALP00000023584; ENSGALG00000007000; Gallus gallus. [Genome view]
GeneID	386585.
KEGG	gga:386585.
Organism-specific databases
CTD	386585.
Phylogenomic databases
eggNOG	veNOG08028.
HOGENOM	HBG713785.
HOVERGEN	Q90733.
InParanoid	Q90733.
Family and domain databases
InterPro	IPR003068. COUP_TF. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR013629. Znf_C4_C. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 1 hit. G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. PF08420. zf-C4_C. 1 hit. [Graphical view]
PRINTS	PR01282. COUPTNFACTOR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COT2_CHICK

Accession

Primary (citable) accession number: Q90733

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)