Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

COUP transcription factor 2

Gene

NR2F2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi72 – 14776Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri75 – 9521NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri111 – 13525NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
COUP transcription factor 2
Short name:
COUP-TF2
Alternative name(s):
COUP transcription factor II
Short name:
COUP-TF II
Nuclear receptor subfamily 2 group F member 2
Gene namesi
Name:NR2F2
Synonyms:TFCOUP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410COUP transcription factor 2PRO_0000053609Add
BLAST

Proteomic databases

PaxDbiQ90733.

Expressioni

Tissue specificityi

Highly expressed in the developing spinal motor neurons.

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023584.

Structurei

3D structure databases

ProteinModelPortaliQ90733.
SMRiQ90733. Positions 73-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni179 – 410232Ligand-bindingBy similarityAdd
BLAST
Regioni333 – 41078Important for dimerizationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 715Poly-Gln

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri75 – 9521NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri111 – 13525NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiQ90733.
KOiK08548.
OMAiSQAGDKQ.
PhylomeDBiQ90733.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVVGAWRD PQDDVPGAQG TQPAPAPPVQ GPPAGTPHTP QTPGPGGPPS
60 70 80 90 100
TPAQSNAASQ QSQGDKQQQQ QHIECVVCGD KSSGKHYGQF TCEGCKSFFK
110 120 130 140 150
RSVRRNLSYT CRANRNCPID QHHRNQCQYC RLKKCLKVGM RREAVQRGRM
160 170 180 190 200
PPTQPTHGQF ALTNGDPLNC HSYLSGYISL LLRAEPYPTS RFGSQCMQPN
210 220 230 240 250
NIMGIENICE LAARMLFSAV EWARNIPFFP DLQITDQVAL LRLTWSELFV
260 270 280 290 300
LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI FQEQVEKLKA
310 320 330 340 350
LHVDSAEYSC LKAIVLFTSD ACGLSDVAHV ESLQEKSQCA LEEYVRSQYP
360 370 380 390 400
NQPTRFGKLL LRLPSLRTVS SSVIEQLFFV RLVGKTPIET LIRDMLLSGS
410
SFNWPYMSIQ
Length:410
Mass (Da):45,427
Last modified:November 1, 1996 - v1
Checksum:i760A996E29082E3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00697 mRNA. Translation: AAA17733.1.
PIRiI50689.
RefSeqiNP_989752.1. NM_204421.1.
UniGeneiGga.4445.

Genome annotation databases

EnsembliENSGALT00000011332; ENSGALP00000011318; ENSGALG00000007000.
GeneIDi386585.
KEGGigga:386585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00697 mRNA. Translation: AAA17733.1.
PIRiI50689.
RefSeqiNP_989752.1. NM_204421.1.
UniGeneiGga.4445.

3D structure databases

ProteinModelPortaliQ90733.
SMRiQ90733. Positions 73-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023584.

Proteomic databases

PaxDbiQ90733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000011332; ENSGALP00000011318; ENSGALG00000007000.
GeneIDi386585.
KEGGigga:386585.

Organism-specific databases

CTDi7026.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiQ90733.
KOiK08548.
OMAiSQAGDKQ.
PhylomeDBiQ90733.

Miscellaneous databases

PROiQ90733.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Developmental regulation of the orphan receptor COUP-TF II gene in spinal motor neurons."
    Lutz B., Kuratani S., Cooney A.J., Wawersik W., Tsai S.Y., Eichele G., Tsai M.
    Development 120:25-36(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCOT2_CHICK
AccessioniPrimary (citable) accession number: Q90733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.