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Protein

COUP transcription factor 2

Gene

NR2F2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi72 – 147Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri75 – 95NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri111 – 135NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
COUP transcription factor 2
Short name:
COUP-TF2
Alternative name(s):
COUP transcription factor II
Short name:
COUP-TF II
Nuclear receptor subfamily 2 group F member 2
Gene namesi
Name:NR2F2
Synonyms:TFCOUP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536091 – 410COUP transcription factor 2Add BLAST410

Proteomic databases

PaxDbiQ90733

Expressioni

Tissue specificityi

Highly expressed in the developing spinal motor neurons.

Gene expression databases

BgeeiENSGALG00000007000

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023584

Structurei

3D structure databases

ProteinModelPortaliQ90733
SMRiQ90733
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 399NR LBDPROSITE-ProRule annotationAdd BLAST227

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni333 – 410Important for dimerizationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 71Poly-Gln5

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri75 – 95NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri111 – 135NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000260820
HOVERGENiHBG005606
InParanoidiQ90733
KOiK08548
OMAiGNQGTQP
OrthoDBiEOG091G0YX6
PhylomeDBiQ90733

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003068 COUP_TF
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01282 COUPTNFACTOR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q90733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVVGAWRD PQDDVPGAQG TQPAPAPPVQ GPPAGTPHTP QTPGPGGPPS
60 70 80 90 100
TPAQSNAASQ QSQGDKQQQQ QHIECVVCGD KSSGKHYGQF TCEGCKSFFK
110 120 130 140 150
RSVRRNLSYT CRANRNCPID QHHRNQCQYC RLKKCLKVGM RREAVQRGRM
160 170 180 190 200
PPTQPTHGQF ALTNGDPLNC HSYLSGYISL LLRAEPYPTS RFGSQCMQPN
210 220 230 240 250
NIMGIENICE LAARMLFSAV EWARNIPFFP DLQITDQVAL LRLTWSELFV
260 270 280 290 300
LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI FQEQVEKLKA
310 320 330 340 350
LHVDSAEYSC LKAIVLFTSD ACGLSDVAHV ESLQEKSQCA LEEYVRSQYP
360 370 380 390 400
NQPTRFGKLL LRLPSLRTVS SSVIEQLFFV RLVGKTPIET LIRDMLLSGS
410
SFNWPYMSIQ
Length:410
Mass (Da):45,427
Last modified:November 1, 1996 - v1
Checksum:i760A996E29082E3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00697 mRNA Translation: AAA17733.1
PIRiI50689
RefSeqiNP_989752.1, NM_204421.1
UniGeneiGga.4445

Genome annotation databases

GeneIDi386585
KEGGigga:386585

Similar proteinsi

Entry informationi

Entry nameiCOT2_CHICK
AccessioniPrimary (citable) accession number: Q90733
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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