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Protein

Anion exchange protein

Gene

AE2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
Gene namesi
Name:AE2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei701 – 722HelicalUniRule annotationAdd BLAST22
Transmembranei743 – 766HelicalUniRule annotationAdd BLAST24
Transmembranei786 – 811HelicalUniRule annotationAdd BLAST26
Transmembranei818 – 836HelicalUniRule annotationAdd BLAST19
Transmembranei880 – 897HelicalUniRule annotationAdd BLAST18
Transmembranei913 – 933HelicalUniRule annotationAdd BLAST21
Transmembranei970 – 989HelicalUniRule annotationAdd BLAST20
Transmembranei1010 – 1034HelicalUniRule annotationAdd BLAST25
Transmembranei1070 – 1089HelicalUniRule annotationAdd BLAST20
Transmembranei1096 – 1115HelicalUniRule annotationAdd BLAST20
Transmembranei1147 – 1175HelicalUniRule annotationAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ90710.

Structurei

3D structure databases

ProteinModelPortaliQ90710.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini343 – 616Band_3_cytoInterPro annotationAdd BLAST274
Domaini667 – 1145HCO3_cotranspInterPro annotationAdd BLAST479

Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOVERGENiHBG004326.
KOiK13855.
PhylomeDBiQ90710.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF14. PTHR11453:SF14. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSPVSSEL HHIVSSAIES PEPPAPGPAS PPLAEEEEKD LNKALGVERF
60 70 80 90 100
EEILSDAHPR SVEEPGRIYG EEDFEYHRQS SLHIHHPLSA HLPPDARRKK
110 120 130 140 150
GVPKKGRKKR GRAAAPGENP PIEEGEEDEE EACDTETERS AEELRGGPAE
160 170 180 190 200
GVQFFLQEDE VTERRAEEPP APPAPPGPTA EPHGATAPAA ASPGAEEGRA
210 220 230 240 250
ADGGAVPEDG GSPGRPAARA TEHRSYNLHE RRRIGSMTGA DEAQYQKVPT
260 270 280 290 300
DESEAQTLAS ADLDYMKSHR FEDVPGVRRH LVRKSAKAQV VHVGKEHREQ
310 320 330 340 350
SARPRRSDRQ PHEVFVELNE LVLDKNQELQ WKETARWIKF EEDVEEETDR
360 370 380 390 400
WGKPHVASLS FRSLLELRKT LSHGAVLLDL DQKTLPGVAH QVVEQMVITD
410 420 430 440 450
QIRAEDRANV LRALLLKHSH PSDEKEFSFP RNISAGSLGS LLVHHHSTNH
460 470 480 490 500
VGEGGEPAVT EPLIAGHGAE HDARVDVERE REVPTPAPPA GITRSKSKHE
510 520 530 540 550
LKLLEKIPDN AEATVVLVGC VEFLDQPTMA FVRLQEAVEL DSVLEVPVPV
560 570 580 590 600
RFLFLLLGPS STHMDYHEIG RSISTLMSDK QFHEAAYLAD DRHDLLTAIN
610 620 630 640 650
EFLDCSVVVP PSEVQGEELR SVAHFQREML KKREEQEKRM LLEPKSPEEK
660 670 680 690 700
ALLKLKVAED EDEDDPLRRT GRPFGGLIRD VRRRYPHYLS DFRDALNPQC
710 720 730 740 750
IAAVIFIYFA ALSPAITFGG LLGEKTQDLI GVSELIISTS LQGVLFCLLG
760 770 780 790 800
AQPLLVIGFS GPLLVFEEAF FTFCTSNGLE YLVGRVWIGF WLILIVLLMV
810 820 830 840 850
ACEGSFLVRF VSRFTQEIFA FLISLIFIYE TFSKLGKIFQ EHPLHGCAQP
860 870 880 890 900
NGTAWSNGTA APNGTAQRGA AKVTGQPNTA LLSLVLMAGT FFIAFFLRKF
910 920 930 940 950
KNSRFFPGRI RRLIGDFGVP IAILVMVLVD YSIRDTYTQK LSVPSGFSVT
960 970 980 990 1000
APDKRGWVIN PLGERSDFPV WMMVASGLPA VLVFILIFME TQITTLIISK
1010 1020 1030 1040 1050
KERMLQKGSG FHLDLLLIVA MGGFFALFGL PWLAAATVRS VTHANALTVM
1060 1070 1080 1090 1100
SKAVAPGDKP KIQEVKEQRV TGLLVAVLVG LSIVIGELLR QIPLAVLFGI
1110 1120 1130 1140 1150
FLYMGVTSLN GIQFYERLQL LLMPPKHHPD VPYVKKVRTR MHLFTGLQLA
1160 1170 1180 1190 1200
CLAVLWAVMS TVASLAFPFI LILTVPVRMC LLSRIFTDRE MKCLDADEAE
1210
PILDEREGVD EYNEMPMPV
Length:1,219
Mass (Da):135,289
Last modified:November 1, 1996 - v1
Checksum:i25F42A73C3483B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48889 mRNA. Translation: AAC59881.1.
RefSeqiNP_990294.1. NM_204963.1.
UniGeneiGga.1335.

Genome annotation databases

GeneIDi395809.
KEGGigga:395809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48889 mRNA. Translation: AAC59881.1.
RefSeqiNP_990294.1. NM_204963.1.
UniGeneiGga.1335.

3D structure databases

ProteinModelPortaliQ90710.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ90710.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395809.
KEGGigga:395809.

Organism-specific databases

CTDi6522.

Phylogenomic databases

HOVERGENiHBG004326.
KOiK13855.
PhylomeDBiQ90710.

Family and domain databases

Gene3Di3.40.1100.10. 2 hits.
InterProiIPR001717. Anion_exchange.
IPR002978. Anion_exchange_2.
IPR018241. Anion_exchange_CS.
IPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PTHR11453:SF14. PTHR11453:SF14. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR00165. ANIONEXCHNGR.
PR01188. ANIONEXHNGR2.
PR01231. HCO3TRNSPORT.
SUPFAMiSSF55804. SSF55804. 2 hits.
TIGRFAMsiTIGR00834. ae. 1 hit.
PROSITEiPS00219. ANION_EXCHANGER_1. 1 hit.
PS00220. ANION_EXCHANGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ90710_CHICK
AccessioniPrimary (citable) accession number: Q90710
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.