ID   Q90699_CHICK            Unreviewed;       790 AA.
AC   Q90699;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 164.
DE   RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE            EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN   Name=ctrkA {ECO:0000313|EMBL:AAA85289.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|EMBL:AAA85289.1};
RN   [1] {ECO:0000313|EMBL:AAA85289.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Schroepel A., Dechant G., Barde Y.A.;
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAA85289.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Schroepel A., v Schack D., Dechant G., Barde Y.A.;
RT   "Early expression of the nerve growth factor ctrkA in chicken sympathetic
RT   and sensory ganglia.";
RL   Mol. Cell. Neurosci. 6:0-0(0).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001171,
CC         ECO:0000256|RuleBase:RU000312};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Insulin receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000312}.
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DR   EMBL; U43396; AAA85289.1; -; mRNA.
DR   RefSeq; NP_990709.1; NM_205378.1.
DR   AlphaFoldDB; Q90699; -.
DR   GeneID; 396337; -.
DR   KEGG; gga:396337; -.
DR   CTD; 4914; -.
DR   VEuPathDB; HostDB:geneid_396337; -.
DR   PhylomeDB; Q90699; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005030; F:neurotrophin receptor activity; IEA:InterPro.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd05092; PTKc_TrkA; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR020777; NTRK.
DR   InterPro; IPR020461; NTRK1.
DR   InterPro; IPR031635; NTRK_LRRCT.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR040665; TrkA_TMD.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR   PANTHER; PTHR24416:SF370; HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF16920; LRRCT_2; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF18613; TrkA_TMD; 1.
DR   PRINTS; PR01939; NTKRECEPTOR.
DR   PRINTS; PR01940; NTKRECEPTOR1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR620777-
KW   51}; Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Kinase {ECO:0000313|EMBL:AAA85289.1};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR620777-51, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000312};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00023137};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000312};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..790
FT                   /note="Tyrosine-protein kinase receptor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004318647"
FT   DOMAIN          186..273
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          504..775
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   ACT_SITE        644
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620777-50"
FT   BINDING         510..518
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620777-51"
FT   BINDING         538
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620777-51,
FT                   ECO:0000256|PROSITE-ProRule:PRU10141"
FT   SITE            490
FT                   /note="Interaction with SHC1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620777-52"
FT   SITE            785
FT                   /note="Interaction with PLCG1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR620777-52"
SQ   SEQUENCE   790 AA;  88670 MW;  AD2314608F30AD71 CRC64;
     MLPAWLRLCL AALLLPPGAA VPPACPAHCR CPASHTLRCR EPLTVSSLSA LLLGAHRPTD
     VIIENQALLT SLTRDDTRML WDLRHLTISN SGLQYISDDA FQDNHRLSHV NLSFNALTSL
     SWKTFQYLPL QELILEGNPF NCSCGIRWLQ LWQNGSRAEL GNQSLLCWEG SMLVALDSHP
     LHDCEPPTAR IEHPDVVLRQ GDSVNLTCHI WGEPSATGEW VLPHVGSEPS VTKLSEWELV
     LEINNISSSL NHKDLTCRAE NAVGLAEDSV MLNVTFPPVI LLLSEAIPQH FWCIPFSVDS
     NPTPRILWLF NGSMLPEGPY IHTRIVEYEP NSTVLHGCLQ LNRPTHVNNG NYTLVVQNPL
     GRATRSIQGR FMDNPFSFSP EEPIPVSISP LGTRNSSLEG PVETADEHTF GVSVAVALAV
     FASLFLSVML IALNKCGHRS KFGINRSAVL AQEDDLAMSL HFMNLGSSPV SSTESKLDGL
     KSNFIENPQY FCNACVHHVQ RRDIVLKWEL GEGAFGKVFL AECSHLLPEQ EKTLVAVKAL
     KEVTESARLD FQREAELLTV LQHEHIVKFY GVCTEGEPLI MVFEYMKHGD LNRFLRSHGP
     DAKILDQGQG QPCGQLTLSH MLQIATQIAS GMVYLASLHF VHRDLATRNC LVGHDLVVKI
     GDFGMSRDIY STDYYRVGGR TMLPIRWMPP ESILYRKFTT ESDIWSFGVV LWEIFTYGKQ
     PWYQLSNTEA IECITQGREL ERPRTCPSEV YDIMQSCWQR EPQQRQRIQD IHSRLQALVK
     TPPIYLDILG
//