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Protein

Tyrosine-protein kinase receptor

Gene

ctrkA

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:ctrkAImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500431864721 – 790Tyrosine-protein kinase receptorSequence analysisAdd BLAST770

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotation

Proteomic databases

PaxDbiQ90699.

Structurei

3D structure databases

ProteinModelPortaliQ90699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 273Ig-likeInterPro annotationAdd BLAST88
Domaini504 – 775Protein kinaseInterPro annotationAdd BLAST272

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG1026. Eukaryota.
ENOG410YGKQ. LUCA.
HOVERGENiHBG056735.
PhylomeDBiQ90699.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR031635. NTRK_C2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
PfamiView protein in Pfam
PF07679. I-set. 1 hit.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF16920. TPKR_C2. 1 hit.
PRINTSiPR01939. NTKRECEPTOR.
PR01940. NTKRECEPTOR1.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.

Sequencei

Sequence statusi: Complete.

Q90699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAWLRLCL AALLLPPGAA VPPACPAHCR CPASHTLRCR EPLTVSSLSA
60 70 80 90 100
LLLGAHRPTD VIIENQALLT SLTRDDTRML WDLRHLTISN SGLQYISDDA
110 120 130 140 150
FQDNHRLSHV NLSFNALTSL SWKTFQYLPL QELILEGNPF NCSCGIRWLQ
160 170 180 190 200
LWQNGSRAEL GNQSLLCWEG SMLVALDSHP LHDCEPPTAR IEHPDVVLRQ
210 220 230 240 250
GDSVNLTCHI WGEPSATGEW VLPHVGSEPS VTKLSEWELV LEINNISSSL
260 270 280 290 300
NHKDLTCRAE NAVGLAEDSV MLNVTFPPVI LLLSEAIPQH FWCIPFSVDS
310 320 330 340 350
NPTPRILWLF NGSMLPEGPY IHTRIVEYEP NSTVLHGCLQ LNRPTHVNNG
360 370 380 390 400
NYTLVVQNPL GRATRSIQGR FMDNPFSFSP EEPIPVSISP LGTRNSSLEG
410 420 430 440 450
PVETADEHTF GVSVAVALAV FASLFLSVML IALNKCGHRS KFGINRSAVL
460 470 480 490 500
AQEDDLAMSL HFMNLGSSPV SSTESKLDGL KSNFIENPQY FCNACVHHVQ
510 520 530 540 550
RRDIVLKWEL GEGAFGKVFL AECSHLLPEQ EKTLVAVKAL KEVTESARLD
560 570 580 590 600
FQREAELLTV LQHEHIVKFY GVCTEGEPLI MVFEYMKHGD LNRFLRSHGP
610 620 630 640 650
DAKILDQGQG QPCGQLTLSH MLQIATQIAS GMVYLASLHF VHRDLATRNC
660 670 680 690 700
LVGHDLVVKI GDFGMSRDIY STDYYRVGGR TMLPIRWMPP ESILYRKFTT
710 720 730 740 750
ESDIWSFGVV LWEIFTYGKQ PWYQLSNTEA IECITQGREL ERPRTCPSEV
760 770 780 790
YDIMQSCWQR EPQQRQRIQD IHSRLQALVK TPPIYLDILG
Length:790
Mass (Da):88,670
Last modified:November 1, 1996 - v1
Checksum:iAD2314608F30AD71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43396 mRNA. Translation: AAA85289.1.
RefSeqiNP_990709.1. NM_205378.1.
UniGeneiGga.579.

Genome annotation databases

GeneIDi396337.

Similar proteinsi

Entry informationi

Entry nameiQ90699_CHICK
AccessioniPrimary (citable) accession number: Q90699
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)