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Q90699

- Q90699_CHICK

UniProt

Q90699 - Q90699_CHICK

Protein

Tyrosine-protein kinase receptor

Gene

ctrkA

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. neurotrophin receptor activity Source: InterPro
    3. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
    Gene namesi
    Name:ctrkAImported
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation, PhosphoproteinUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000021606.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90699.
    SMRiQ90699. Positions 276-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation
    Contains LRRCT domain.SAAS annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG056735.
    KOiK03176.
    PhylomeDBiQ90699.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
    IPR020777. Tyr_kinase_NGF_rcpt.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view]
    PfamiPF07679. I-set. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR01939. NTKRECEPTOR.
    PR01940. NTKRECEPTOR1.
    PR00109. TYRKINASE.
    SMARTiSM00409. IG. 1 hit.
    SM00082. LRRCT. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90699-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPAWLRLCL AALLLPPGAA VPPACPAHCR CPASHTLRCR EPLTVSSLSA    50
    LLLGAHRPTD VIIENQALLT SLTRDDTRML WDLRHLTISN SGLQYISDDA 100
    FQDNHRLSHV NLSFNALTSL SWKTFQYLPL QELILEGNPF NCSCGIRWLQ 150
    LWQNGSRAEL GNQSLLCWEG SMLVALDSHP LHDCEPPTAR IEHPDVVLRQ 200
    GDSVNLTCHI WGEPSATGEW VLPHVGSEPS VTKLSEWELV LEINNISSSL 250
    NHKDLTCRAE NAVGLAEDSV MLNVTFPPVI LLLSEAIPQH FWCIPFSVDS 300
    NPTPRILWLF NGSMLPEGPY IHTRIVEYEP NSTVLHGCLQ LNRPTHVNNG 350
    NYTLVVQNPL GRATRSIQGR FMDNPFSFSP EEPIPVSISP LGTRNSSLEG 400
    PVETADEHTF GVSVAVALAV FASLFLSVML IALNKCGHRS KFGINRSAVL 450
    AQEDDLAMSL HFMNLGSSPV SSTESKLDGL KSNFIENPQY FCNACVHHVQ 500
    RRDIVLKWEL GEGAFGKVFL AECSHLLPEQ EKTLVAVKAL KEVTESARLD 550
    FQREAELLTV LQHEHIVKFY GVCTEGEPLI MVFEYMKHGD LNRFLRSHGP 600
    DAKILDQGQG QPCGQLTLSH MLQIATQIAS GMVYLASLHF VHRDLATRNC 650
    LVGHDLVVKI GDFGMSRDIY STDYYRVGGR TMLPIRWMPP ESILYRKFTT 700
    ESDIWSFGVV LWEIFTYGKQ PWYQLSNTEA IECITQGREL ERPRTCPSEV 750
    YDIMQSCWQR EPQQRQRIQD IHSRLQALVK TPPIYLDILG 790
    Length:790
    Mass (Da):88,670
    Last modified:November 1, 1996 - v1
    Checksum:iAD2314608F30AD71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43396 mRNA. Translation: AAA85289.1.
    RefSeqiNP_990709.1. NM_205378.1.
    UniGeneiGga.579.

    Genome annotation databases

    GeneIDi396337.
    KEGGigga:396337.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43396 mRNA. Translation: AAA85289.1 .
    RefSeqi NP_990709.1. NM_205378.1.
    UniGenei Gga.579.

    3D structure databases

    ProteinModelPortali Q90699.
    SMRi Q90699. Positions 276-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000021606.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396337.
    KEGGi gga:396337.

    Organism-specific databases

    CTDi 4914.

    Phylogenomic databases

    HOVERGENi HBG056735.
    KOi K03176.
    PhylomeDBi Q90699.

    Miscellaneous databases

    NextBioi 20816385.
    PROi Q90699.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR011009. Kinase-like_dom.
    IPR001611. Leu-rich_rpt.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
    IPR020777. Tyr_kinase_NGF_rcpt.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view ]
    Pfami PF07679. I-set. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR01939. NTKRECEPTOR.
    PR01940. NTKRECEPTOR1.
    PR00109. TYRKINASE.
    SMARTi SM00409. IG. 1 hit.
    SM00082. LRRCT. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Schroepel A., Dechant G., Barde Y.A.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Early expression of the nerve growth factor ctrkA in chicken sympathetic and sensory ganglia."
      Schroepel A., v Schack D., Dechant G., Barde Y.A.
      Mol. Cell. Neurosci. 6:0-0(0)
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ90699_CHICK
    AccessioniPrimary (citable) accession number: Q90699
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)