Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q90699

- Q90699_CHICK

UniProt

Q90699 - Q90699_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tyrosine-protein kinase receptor

Gene

ctrkA

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. neurotrophin receptor activity Source: InterPro
  3. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:ctrkAImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021606.

Structurei

3D structure databases

ProteinModelPortaliQ90699.
SMRiQ90699. Positions 276-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation
Contains LRRCT domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG056735.
KOiK03176.
PhylomeDBiQ90699.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01939. NTKRECEPTOR.
PR01940. NTKRECEPTOR1.
PR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90699 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPAWLRLCL AALLLPPGAA VPPACPAHCR CPASHTLRCR EPLTVSSLSA
60 70 80 90 100
LLLGAHRPTD VIIENQALLT SLTRDDTRML WDLRHLTISN SGLQYISDDA
110 120 130 140 150
FQDNHRLSHV NLSFNALTSL SWKTFQYLPL QELILEGNPF NCSCGIRWLQ
160 170 180 190 200
LWQNGSRAEL GNQSLLCWEG SMLVALDSHP LHDCEPPTAR IEHPDVVLRQ
210 220 230 240 250
GDSVNLTCHI WGEPSATGEW VLPHVGSEPS VTKLSEWELV LEINNISSSL
260 270 280 290 300
NHKDLTCRAE NAVGLAEDSV MLNVTFPPVI LLLSEAIPQH FWCIPFSVDS
310 320 330 340 350
NPTPRILWLF NGSMLPEGPY IHTRIVEYEP NSTVLHGCLQ LNRPTHVNNG
360 370 380 390 400
NYTLVVQNPL GRATRSIQGR FMDNPFSFSP EEPIPVSISP LGTRNSSLEG
410 420 430 440 450
PVETADEHTF GVSVAVALAV FASLFLSVML IALNKCGHRS KFGINRSAVL
460 470 480 490 500
AQEDDLAMSL HFMNLGSSPV SSTESKLDGL KSNFIENPQY FCNACVHHVQ
510 520 530 540 550
RRDIVLKWEL GEGAFGKVFL AECSHLLPEQ EKTLVAVKAL KEVTESARLD
560 570 580 590 600
FQREAELLTV LQHEHIVKFY GVCTEGEPLI MVFEYMKHGD LNRFLRSHGP
610 620 630 640 650
DAKILDQGQG QPCGQLTLSH MLQIATQIAS GMVYLASLHF VHRDLATRNC
660 670 680 690 700
LVGHDLVVKI GDFGMSRDIY STDYYRVGGR TMLPIRWMPP ESILYRKFTT
710 720 730 740 750
ESDIWSFGVV LWEIFTYGKQ PWYQLSNTEA IECITQGREL ERPRTCPSEV
760 770 780 790
YDIMQSCWQR EPQQRQRIQD IHSRLQALVK TPPIYLDILG
Length:790
Mass (Da):88,670
Last modified:November 1, 1996 - v1
Checksum:iAD2314608F30AD71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43396 mRNA. Translation: AAA85289.1.
RefSeqiNP_990709.1. NM_205378.1.
UniGeneiGga.579.

Genome annotation databases

GeneIDi396337.
KEGGigga:396337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43396 mRNA. Translation: AAA85289.1 .
RefSeqi NP_990709.1. NM_205378.1.
UniGenei Gga.579.

3D structure databases

ProteinModelPortali Q90699.
SMRi Q90699. Positions 276-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000021606.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396337.
KEGGi gga:396337.

Organism-specific databases

CTDi 4914.

Phylogenomic databases

HOVERGENi HBG056735.
KOi K03176.
PhylomeDBi Q90699.

Miscellaneous databases

NextBioi 20816385.
PROi Q90699.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view ]
Pfami PF07679. I-set. 1 hit.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR01939. NTKRECEPTOR.
PR01940. NTKRECEPTOR1.
PR00109. TYRKINASE.
SMARTi SM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Schroepel A., Dechant G., Barde Y.A.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Early expression of the nerve growth factor ctrkA in chicken sympathetic and sensory ganglia."
    Schroepel A., v Schack D., Dechant G., Barde Y.A.
    Mol. Cell. Neurosci. 6:0-0(0)
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ90699_CHICK
AccessioniPrimary (citable) accession number: Q90699
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)