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Protein

Tyrosine-protein kinase receptor

Gene

ctrkA

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. neurotrophin receptor activity Source: InterPro
  3. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:ctrkAImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021606.

Structurei

3D structure databases

ProteinModelPortaliQ90699.
SMRiQ90699. Positions 276-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation
Contains LRRCT domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG056735.
KOiK03176.
PhylomeDBiQ90699.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01939. NTKRECEPTOR.
PR01940. NTKRECEPTOR1.
PR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAWLRLCL AALLLPPGAA VPPACPAHCR CPASHTLRCR EPLTVSSLSA
60 70 80 90 100
LLLGAHRPTD VIIENQALLT SLTRDDTRML WDLRHLTISN SGLQYISDDA
110 120 130 140 150
FQDNHRLSHV NLSFNALTSL SWKTFQYLPL QELILEGNPF NCSCGIRWLQ
160 170 180 190 200
LWQNGSRAEL GNQSLLCWEG SMLVALDSHP LHDCEPPTAR IEHPDVVLRQ
210 220 230 240 250
GDSVNLTCHI WGEPSATGEW VLPHVGSEPS VTKLSEWELV LEINNISSSL
260 270 280 290 300
NHKDLTCRAE NAVGLAEDSV MLNVTFPPVI LLLSEAIPQH FWCIPFSVDS
310 320 330 340 350
NPTPRILWLF NGSMLPEGPY IHTRIVEYEP NSTVLHGCLQ LNRPTHVNNG
360 370 380 390 400
NYTLVVQNPL GRATRSIQGR FMDNPFSFSP EEPIPVSISP LGTRNSSLEG
410 420 430 440 450
PVETADEHTF GVSVAVALAV FASLFLSVML IALNKCGHRS KFGINRSAVL
460 470 480 490 500
AQEDDLAMSL HFMNLGSSPV SSTESKLDGL KSNFIENPQY FCNACVHHVQ
510 520 530 540 550
RRDIVLKWEL GEGAFGKVFL AECSHLLPEQ EKTLVAVKAL KEVTESARLD
560 570 580 590 600
FQREAELLTV LQHEHIVKFY GVCTEGEPLI MVFEYMKHGD LNRFLRSHGP
610 620 630 640 650
DAKILDQGQG QPCGQLTLSH MLQIATQIAS GMVYLASLHF VHRDLATRNC
660 670 680 690 700
LVGHDLVVKI GDFGMSRDIY STDYYRVGGR TMLPIRWMPP ESILYRKFTT
710 720 730 740 750
ESDIWSFGVV LWEIFTYGKQ PWYQLSNTEA IECITQGREL ERPRTCPSEV
760 770 780 790
YDIMQSCWQR EPQQRQRIQD IHSRLQALVK TPPIYLDILG
Length:790
Mass (Da):88,670
Last modified:November 1, 1996 - v1
Checksum:iAD2314608F30AD71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43396 mRNA. Translation: AAA85289.1.
RefSeqiNP_990709.1. NM_205378.1.
UniGeneiGga.579.

Genome annotation databases

GeneIDi396337.
KEGGigga:396337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43396 mRNA. Translation: AAA85289.1.
RefSeqiNP_990709.1. NM_205378.1.
UniGeneiGga.579.

3D structure databases

ProteinModelPortaliQ90699.
SMRiQ90699. Positions 276-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396337.
KEGGigga:396337.

Organism-specific databases

CTDi4914.

Phylogenomic databases

HOVERGENiHBG056735.
KOiK03176.
PhylomeDBiQ90699.

Miscellaneous databases

NextBioi20816385.
PROiQ90699.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR011009. Kinase-like_dom.
IPR001611. Leu-rich_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR020461. Tyr_kinase_neurotrophic_rcpt_1.
IPR020777. Tyr_kinase_NGF_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01939. NTKRECEPTOR.
PR01940. NTKRECEPTOR1.
PR00109. TYRKINASE.
SMARTiSM00409. IG. 1 hit.
SM00082. LRRCT. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Schroepel A., Dechant G., Barde Y.A.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Early expression of the nerve growth factor ctrkA in chicken sympathetic and sensory ganglia."
    Schroepel A., v Schack D., Dechant G., Barde Y.A.
    Mol. Cell. Neurosci. 6:0-0(0)
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ90699_CHICK
AccessioniPrimary (citable) accession number: Q90699
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.