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Protein

Cell division control protein 42 homolog

Gene

CDC42

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.By similarity

Enzyme regulationi

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, Neurogenesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-114604 GPVI-mediated activation cascade
R-GGA-182971 EGFR downregulation
R-GGA-194840 Rho GTPase cycle
R-GGA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-GGA-375170 CDO in myogenesis
R-GGA-389359 CD28 dependent Vav1 pathway
R-GGA-3928662 EPHB-mediated forward signaling
R-GGA-416482 G alpha (12/13) signalling events
R-GGA-4420097 VEGFA-VEGFR2 Pathway
R-GGA-5625970 RHO GTPases activate KTN1
R-GGA-5626467 RHO GTPases activate IQGAPs
R-GGA-5627123 RHO GTPases activate PAKs
R-GGA-5663213 RHO GTPases Activate WASPs and WAVEs
R-GGA-5663220 RHO GTPases Activate Formins
R-GGA-5687128 MAPK6/MAPK4 signaling
R-GGA-68877 Mitotic Prometaphase
R-GGA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 42 homolog
Alternative name(s):
G25K GTP-binding protein
Gene namesi
Name:CDC42
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989561 – 188Cell division control protein 42 homologAdd BLAST188
PropeptideiPRO_0000281286189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188Cysteine methyl esterBy similarity1
Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ90694
PRIDEiQ90694

Expressioni

Gene expression databases

BgeeiENSGALG00000004796

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ90694, 1 interactor
MINTiQ90694
STRINGi9031.ENSGALP00000007641

Structurei

3D structure databases

ProteinModelPortaliQ90694
SMRiQ90694
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ90694
KOiK04393
OMAiMQTLKCV
OrthoDBiEOG091G0KCM
PhylomeDBiQ90694

Family and domain databases

CDDicd01874 Cdc42, 1 hit
InterProiView protein in InterPro
IPR037874 Cdc42
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90694-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP
60 70 80 90 100
YTLGLFDTAG QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE
110 120 130 140 150
ITHHCPKTPF LLVGTQIDLR DDPSTIEKLA KNKQKPITPE TAEKLARDLK
160 170 180 190
AVKYVECSAL TQKGLKNVFD EAILAALEPP EPKKTRRCVL L
Length:191
Mass (Da):21,273
Last modified:November 1, 1997 - v1
Checksum:i51A437E22A4D8BEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40848 mRNA Translation: AAC00027.1
RefSeqiNP_990379.1, NM_205048.1
XP_015152311.1, XM_015296825.1
XP_015152312.1, XM_015296826.1
UniGeneiGga.4438

Genome annotation databases

EnsembliENSGALT00000034897; ENSGALP00000034254; ENSGALG00000004796
ENSGALT00000049495; ENSGALP00000050376; ENSGALG00000004796
GeneIDi395917
KEGGigga:395917

Similar proteinsi

Entry informationi

Entry nameiCDC42_CHICK
AccessioniPrimary (citable) accession number: Q90694
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health