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Protein

Cell division control protein 42 homolog

Gene

CDC42

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (By similarity).By similarity

Enzyme regulationi

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTPBy similarity
Nucleotide bindingi57 – 615GTPBy similarity
Nucleotide bindingi115 – 1184GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-182971. EGFR downregulation.
R-GGA-194840. Rho GTPase cycle.
R-GGA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-GGA-375170. CDO in myogenesis.
R-GGA-389359. CD28 dependent Vav1 pathway.
R-GGA-3928662. EPHB-mediated forward signaling.
R-GGA-4420097. VEGFA-VEGFR2 Pathway.
R-GGA-5625970. RHO GTPases activate KTN1.
R-GGA-5626467. RHO GTPases activate IQGAPs.
R-GGA-5627123. RHO GTPases activate PAKs.
R-GGA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-GGA-5663220. RHO GTPases Activate Formins.
R-GGA-5687128. MAPK6/MAPK4 signaling.
R-GGA-68877. Mitotic Prometaphase.
R-GGA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 42 homolog
Alternative name(s):
G25K GTP-binding protein
Gene namesi
Name:CDC42
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 21

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Cell division control protein 42 homologPRO_0000198956Add
BLAST
Propeptidei189 – 1913Removed in mature formBy similarityPRO_0000281286

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei188 – 1881Cysteine methyl esterBy similarity
Lipidationi188 – 1881S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ90694.
PRIDEiQ90694.

Expressioni

Gene expression databases

BgeeiENSGALG00000004796.

Interactioni

Protein-protein interaction databases

MINTiMINT-126406.
STRINGi9031.ENSGALP00000007641.

Structurei

3D structure databases

ProteinModelPortaliQ90694.
SMRiQ90694. Positions 1-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 409Effector regionSequence analysis

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ90694.
KOiK04393.
OMAiVITIDQG.
OrthoDBiEOG091G0KCM.
PhylomeDBiQ90694.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90694-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP
60 70 80 90 100
YTLGLFDTAG QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE
110 120 130 140 150
ITHHCPKTPF LLVGTQIDLR DDPSTIEKLA KNKQKPITPE TAEKLARDLK
160 170 180 190
AVKYVECSAL TQKGLKNVFD EAILAALEPP EPKKTRRCVL L
Length:191
Mass (Da):21,273
Last modified:November 1, 1997 - v1
Checksum:i51A437E22A4D8BEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40848 mRNA. Translation: AAC00027.1.
RefSeqiNP_990379.1. NM_205048.1.
XP_015152311.1. XM_015296825.1.
XP_015152312.1. XM_015296826.1.
UniGeneiGga.4438.

Genome annotation databases

EnsembliENSGALT00000034897; ENSGALP00000034254; ENSGALG00000004796.
GeneIDi395917.
KEGGigga:395917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40848 mRNA. Translation: AAC00027.1.
RefSeqiNP_990379.1. NM_205048.1.
XP_015152311.1. XM_015296825.1.
XP_015152312.1. XM_015296826.1.
UniGeneiGga.4438.

3D structure databases

ProteinModelPortaliQ90694.
SMRiQ90694. Positions 1-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-126406.
STRINGi9031.ENSGALP00000007641.

Proteomic databases

PaxDbiQ90694.
PRIDEiQ90694.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000034897; ENSGALP00000034254; ENSGALG00000004796.
GeneIDi395917.
KEGGigga:395917.

Organism-specific databases

CTDi998.

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118978.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ90694.
KOiK04393.
OMAiVITIDQG.
OrthoDBiEOG091G0KCM.
PhylomeDBiQ90694.

Enzyme and pathway databases

ReactomeiR-GGA-182971. EGFR downregulation.
R-GGA-194840. Rho GTPase cycle.
R-GGA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-GGA-375170. CDO in myogenesis.
R-GGA-389359. CD28 dependent Vav1 pathway.
R-GGA-3928662. EPHB-mediated forward signaling.
R-GGA-4420097. VEGFA-VEGFR2 Pathway.
R-GGA-5625970. RHO GTPases activate KTN1.
R-GGA-5626467. RHO GTPases activate IQGAPs.
R-GGA-5627123. RHO GTPases activate PAKs.
R-GGA-5663213. RHO GTPases Activate WASPs and WAVEs.
R-GGA-5663220. RHO GTPases Activate Formins.
R-GGA-5687128. MAPK6/MAPK4 signaling.
R-GGA-68877. Mitotic Prometaphase.
R-GGA-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiQ90694.

Gene expression databases

BgeeiENSGALG00000004796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC42_CHICK
AccessioniPrimary (citable) accession number: Q90694
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.