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Q90687

- PTN11_CHICK

UniProt

Q90687 - PTN11_CHICK

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Protein

Tyrosine-protein phosphatase non-receptor type 11

Gene
PTPN11
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates By similarity. May play a positive role during the stages of erythroid cell proliferation.By similarity1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei425 – 4251Substrate By similarity
Active sitei459 – 4591Phosphocysteine intermediate By similarityBy similarity
Binding sitei506 – 5061Substrate By similarity

GO - Molecular functioni

  1. non-membrane spanning protein tyrosine phosphatase activity Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. atrioventricular canal development Source: Ensembl
  3. axonogenesis Source: Ensembl
  4. brain development Source: Ensembl
  5. DNA damage checkpoint Source: Ensembl
  6. ephrin receptor signaling pathway Source: Ensembl
  7. ERBB signaling pathway Source: Ensembl
  8. face morphogenesis Source: Ensembl
  9. genitalia development Source: Ensembl
  10. glucose homeostasis Source: Ensembl
  11. hormone-mediated signaling pathway Source: Ensembl
  12. hormone metabolic process Source: Ensembl
  13. inner ear development Source: Ensembl
  14. multicellular organismal reproductive process Source: Ensembl
  15. negative regulation of cortisol secretion Source: Ensembl
  16. negative regulation of growth hormone secretion Source: Ensembl
  17. negative regulation of insulin secretion Source: Ensembl
  18. neurotrophin TRK receptor signaling pathway Source: Ensembl
  19. organ growth Source: Ensembl
  20. positive regulation of glucose import in response to insulin stimulus Source: Ensembl
  21. positive regulation of hormone secretion Source: Ensembl
  22. regulation of cell adhesion mediated by integrin Source: Ensembl
  23. regulation of multicellular organism growth Source: Ensembl
  24. regulation of protein export from nucleus Source: Ensembl
  25. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_194391. Signaling by SCF-KIT.
REACT_194398. Signaling by Leptin.
REACT_197052. Prolactin receptor signaling.
REACT_197119. Interleukin-6 signaling.
REACT_197153. Negative regulation of FGFR signaling.
REACT_197530. Regulation of IFNA signaling.
REACT_197533. Interferon alpha/beta signaling.
REACT_197538. Regulation of IFNG signaling.
REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
REACT_204997. Netrin mediated repulsion signals.
REACT_207556. PI-3K cascade.
REACT_217737. GAB1 signalosome.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 11 (EC:3.1.3.48)
Alternative name(s):
SH-PTP2
Short name:
cSH-PTP2
Gene namesi
Name:PTPN11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 15

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Tyrosine-protein phosphatase non-receptor type 11PRO_0000094770Add
BLAST

Post-translational modificationi

Phosphorylated by tyrosine-protein kinases By similarity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ90687.
PRIDEiQ90687.

Expressioni

Tissue specificityi

Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033730.

Structurei

3D structure databases

ProteinModelPortaliQ90687.
SMRiQ90687. Positions 3-525.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 10297SH2 1Add
BLAST
Domaini112 – 216105SH2 2Add
BLAST
Domaini247 – 521275Tyrosine-protein phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni459 – 4657Substrate binding By similarity

Sequence similaritiesi

Contains 2 SH2 domains.

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117233.
HOGENOMiHOG000273907.
HOVERGENiHBG000223.
KOiK07293.
PhylomeDBiQ90687.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000980. SH2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTiSM00194. PTPc. 1 hit.
SM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90687-1 [UniParc]FASTAAdd to Basket

« Hide

MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRTGA    50
VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY 100
PLNCADPTSE RWFHGHLSGR EAEKLLTEKG KHGSFLVRES QSHPGDFVLS 150
VRTGDDKGES NDGKSKVTHV MIHCQDLKYD VGGGEKFDSL TDLVEHYKKN 200
PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE 250
FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS 350
RVIVMTTKEV ERGKSKCVKY WPDEYSLKEY GVMRVRNVKE SAAHDYTLRE 400
LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIS 450
DAGPVVVHCS AGIGRTGTFI VIDILIDIIR EKGVDCDIDV PKTIQMVRSQ 500
RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH EYTNIKYSLS 550
DQTSGDQSPL PPCTPTPTCP EMREDSARVY ENVGLMQQQK SFR 593
Length:593
Mass (Da):67,983
Last modified:November 1, 1996 - v1
Checksum:i415231144BB43DDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38620 mRNA. Translation: AAC60049.1.
PIRiJC5167.
RefSeqiNP_990299.1. NM_204968.1.
UniGeneiGga.482.

Genome annotation databases

EnsembliENSGALT00000007704; ENSGALP00000007692; ENSGALG00000004821.
GeneIDi395815.
KEGGigga:395815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38620 mRNA. Translation: AAC60049.1 .
PIRi JC5167.
RefSeqi NP_990299.1. NM_204968.1.
UniGenei Gga.482.

3D structure databases

ProteinModelPortali Q90687.
SMRi Q90687. Positions 3-525.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000033730.

Proteomic databases

PaxDbi Q90687.
PRIDEi Q90687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000007704 ; ENSGALP00000007692 ; ENSGALG00000004821 .
GeneIDi 395815.
KEGGi gga:395815.

Organism-specific databases

CTDi 5781.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117233.
HOGENOMi HOG000273907.
HOVERGENi HBG000223.
KOi K07293.
PhylomeDBi Q90687.

Enzyme and pathway databases

Reactomei REACT_194391. Signaling by SCF-KIT.
REACT_194398. Signaling by Leptin.
REACT_197052. Prolactin receptor signaling.
REACT_197119. Interleukin-6 signaling.
REACT_197153. Negative regulation of FGFR signaling.
REACT_197530. Regulation of IFNA signaling.
REACT_197533. Interferon alpha/beta signaling.
REACT_197538. Regulation of IFNG signaling.
REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
REACT_204997. Netrin mediated repulsion signals.
REACT_207556. PI-3K cascade.
REACT_217737. GAB1 signalosome.

Miscellaneous databases

NextBioi 20815883.
PROi Q90687.

Family and domain databases

Gene3Di 3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000980. SH2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSi PR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTi SM00194. PTPc. 1 hit.
SM00252. SH2. 2 hits.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEi PS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2."
    Park C.Y., LaMontagne K.R., Tonks N.K., Hayman M.J.
    Gene 177:93-97(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Erythroblast.

Entry informationi

Entry nameiPTN11_CHICK
AccessioniPrimary (citable) accession number: Q90687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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