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Q90687 (PTN11_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 11

EC=3.1.3.48
Alternative name(s):
SH-PTP2
Short name=cSH-PTP2
Gene names
Name:PTPN11
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates By similarity. May play a positive role during the stages of erythroid cell proliferation. Ref.1 UniProtKB Q06124

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. UniProtKB Q06124

Subcellular location

Cytoplasm By similarity UniProtKB Q06124.

Tissue specificity

Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells. Ref.1

Post-translational modification

Phosphorylated by tyrosine-protein kinases By similarity. UniProtKB Q06124

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.

Contains 2 SH2 domains.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
SH2 domain
   Molecular functionHydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA damage checkpoint

Inferred from electronic annotation. Source: Ensembl

ERBB signaling pathway

Inferred from electronic annotation. Source: Ensembl

activation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

atrioventricular canal development

Inferred from electronic annotation. Source: Ensembl

axonogenesis

Inferred from electronic annotation. Source: Ensembl

brain development

Inferred from electronic annotation. Source: Ensembl

ephrin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

face morphogenesis

Inferred from electronic annotation. Source: Ensembl

genitalia development

Inferred from electronic annotation. Source: Ensembl

glucose homeostasis

Inferred from electronic annotation. Source: Ensembl

hormone metabolic process

Inferred from electronic annotation. Source: Ensembl

hormone-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

inner ear development

Inferred from electronic annotation. Source: Ensembl

multicellular organismal reproductive process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cortisol secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of growth hormone secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

neurotrophin TRK receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

organ growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of glucose import in response to insulin stimulus

Inferred from electronic annotation. Source: Ensembl

positive regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

regulation of cell adhesion mediated by integrin

Inferred from electronic annotation. Source: Ensembl

regulation of multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

regulation of protein export from nucleus

Inferred from electronic annotation. Source: Ensembl

triglyceride metabolic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionnon-membrane spanning protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Tyrosine-protein phosphatase non-receptor type 11
PRO_0000094770

Regions

Domain6 – 10297SH2 1
Domain112 – 216105SH2 2
Domain247 – 521275Tyrosine-protein phosphatase
Region459 – 4657Substrate binding By similarity

Sites

Active site4591Phosphocysteine intermediate By similarity UniProtKB Q06124
Binding site4251Substrate By similarity
Binding site5061Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90687 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 415231144BB43DDA

FASTA59367,983
        10         20         30         40         50         60 
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRTGA VTHIKIQNTG 

        70         80         90        100        110        120 
DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGR 

       130        140        150        160        170        180 
EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIHCQDLKYD 

       190        200        210        220        230        240 
VGGGEKFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 

       250        260        270        280        290        300 
DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 

       310        320        330        340        350        360 
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 

       370        380        390        400        410        420 
ERGKSKCVKY WPDEYSLKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF 

       430        440        450        460        470        480 
RTWPDHGVPS DPGGVLDFLE EVHHKQESIS DAGPVVVHCS AGIGRTGTFI VIDILIDIIR 

       490        500        510        520        530        540 
EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH 

       550        560        570        580        590 
EYTNIKYSLS DQTSGDQSPL PPCTPTPTCP EMREDSARVY ENVGLMQQQK SFR 

« Hide

References

[1]"Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2."
Park C.Y., LaMontagne K.R., Tonks N.K., Hayman M.J.
Gene 177:93-97(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Erythroblast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U38620 mRNA. Translation: AAC60049.1.
PIRJC5167.
RefSeqNP_990299.1. NM_204968.1.
UniGeneGga.482.

3D structure databases

ProteinModelPortalQ90687.
SMRQ90687. Positions 3-525.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000033730.

Proteomic databases

PaxDbQ90687.
PRIDEQ90687.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000007704; ENSGALP00000007692; ENSGALG00000004821.
GeneID395815.
KEGGgga:395815.

Organism-specific databases

CTD5781.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00750000117233.
HOGENOMHOG000273907.
HOVERGENHBG000223.
KOK07293.
PhylomeDBQ90687.

Family and domain databases

Gene3D3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR000980. SH2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTSM00194. PTPc. 1 hit.
SM00252. SH2. 2 hits.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEPS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815883.
PROQ90687.

Entry information

Entry namePTN11_CHICK
AccessionPrimary (citable) accession number: Q90687
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families