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Q90687

- PTN11_CHICK

UniProt

Q90687 - PTN11_CHICK

Protein

Tyrosine-protein phosphatase non-receptor type 11

Gene

PTPN11

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates By similarity. May play a positive role during the stages of erythroid cell proliferation.By similarity1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarityPROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei425 – 4251SubstrateBy similarity
    Active sitei459 – 4591Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei506 – 5061SubstrateBy similarity

    GO - Molecular functioni

    1. non-membrane spanning protein tyrosine phosphatase activity Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. atrioventricular canal development Source: Ensembl
    3. axonogenesis Source: Ensembl
    4. brain development Source: Ensembl
    5. DNA damage checkpoint Source: Ensembl
    6. ephrin receptor signaling pathway Source: Ensembl
    7. ERBB signaling pathway Source: Ensembl
    8. face morphogenesis Source: Ensembl
    9. genitalia development Source: Ensembl
    10. glucose homeostasis Source: Ensembl
    11. hormone-mediated signaling pathway Source: Ensembl
    12. hormone metabolic process Source: Ensembl
    13. inner ear development Source: Ensembl
    14. multicellular organismal reproductive process Source: Ensembl
    15. negative regulation of cortisol secretion Source: Ensembl
    16. negative regulation of growth hormone secretion Source: Ensembl
    17. negative regulation of insulin secretion Source: Ensembl
    18. neurotrophin TRK receptor signaling pathway Source: Ensembl
    19. organ growth Source: Ensembl
    20. positive regulation of glucose import in response to insulin stimulus Source: Ensembl
    21. positive regulation of hormone secretion Source: Ensembl
    22. regulation of cell adhesion mediated by integrin Source: Ensembl
    23. regulation of multicellular organism growth Source: Ensembl
    24. regulation of protein export from nucleus Source: Ensembl
    25. triglyceride metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    ReactomeiREACT_194391. Signaling by SCF-KIT.
    REACT_194398. Signaling by Leptin.
    REACT_197052. Prolactin receptor signaling.
    REACT_197119. Interleukin-6 signaling.
    REACT_197153. Negative regulation of FGFR signaling.
    REACT_197530. Regulation of IFNA signaling.
    REACT_197533. Interferon alpha/beta signaling.
    REACT_197538. Regulation of IFNG signaling.
    REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_204997. Netrin mediated repulsion signals.
    REACT_207556. PI-3K cascade.
    REACT_217737. GAB1 signalosome.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 11 (EC:3.1.3.48)
    Alternative name(s):
    SH-PTP2
    Short name:
    cSH-PTP2
    Gene namesi
    Name:PTPN11
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 15

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593Tyrosine-protein phosphatase non-receptor type 11PRO_0000094770Add
    BLAST

    Post-translational modificationi

    Phosphorylated by tyrosine-protein kinases.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ90687.
    PRIDEiQ90687.

    Expressioni

    Tissue specificityi

    Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000033730.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90687.
    SMRiQ90687. Positions 3-525.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 10297SH2 1CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini112 – 216105SH2 2CuratedPROSITE-ProRule annotationAdd
    BLAST
    Domaini247 – 521275Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni459 – 4657Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 2 SH2 domains.CuratedPROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117233.
    HOGENOMiHOG000273907.
    HOVERGENiHBG000223.
    KOiK07293.
    PhylomeDBiQ90687.

    Family and domain databases

    Gene3Di3.30.505.10. 2 hits.
    3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000980. SH2.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00017. SH2. 2 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
    PRINTSiPR00700. PRTYPHPHTASE.
    PR00401. SH2DOMAIN.
    SMARTiSM00194. PTPc. 1 hit.
    SM00252. SH2. 2 hits.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEiPS50001. SH2. 2 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90687-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRTGA    50
    VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY 100
    PLNCADPTSE RWFHGHLSGR EAEKLLTEKG KHGSFLVRES QSHPGDFVLS 150
    VRTGDDKGES NDGKSKVTHV MIHCQDLKYD VGGGEKFDSL TDLVEHYKKN 200
    PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE 250
    FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300
    VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS 350
    RVIVMTTKEV ERGKSKCVKY WPDEYSLKEY GVMRVRNVKE SAAHDYTLRE 400
    LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIS 450
    DAGPVVVHCS AGIGRTGTFI VIDILIDIIR EKGVDCDIDV PKTIQMVRSQ 500
    RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH EYTNIKYSLS 550
    DQTSGDQSPL PPCTPTPTCP EMREDSARVY ENVGLMQQQK SFR 593
    Length:593
    Mass (Da):67,983
    Last modified:November 1, 1996 - v1
    Checksum:i415231144BB43DDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38620 mRNA. Translation: AAC60049.1.
    PIRiJC5167.
    RefSeqiNP_990299.1. NM_204968.1.
    UniGeneiGga.482.

    Genome annotation databases

    EnsembliENSGALT00000007704; ENSGALP00000007692; ENSGALG00000004821.
    GeneIDi395815.
    KEGGigga:395815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38620 mRNA. Translation: AAC60049.1 .
    PIRi JC5167.
    RefSeqi NP_990299.1. NM_204968.1.
    UniGenei Gga.482.

    3D structure databases

    ProteinModelPortali Q90687.
    SMRi Q90687. Positions 3-525.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000033730.

    Proteomic databases

    PaxDbi Q90687.
    PRIDEi Q90687.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000007704 ; ENSGALP00000007692 ; ENSGALG00000004821 .
    GeneIDi 395815.
    KEGGi gga:395815.

    Organism-specific databases

    CTDi 5781.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117233.
    HOGENOMi HOG000273907.
    HOVERGENi HBG000223.
    KOi K07293.
    PhylomeDBi Q90687.

    Enzyme and pathway databases

    Reactomei REACT_194391. Signaling by SCF-KIT.
    REACT_194398. Signaling by Leptin.
    REACT_197052. Prolactin receptor signaling.
    REACT_197119. Interleukin-6 signaling.
    REACT_197153. Negative regulation of FGFR signaling.
    REACT_197530. Regulation of IFNA signaling.
    REACT_197533. Interferon alpha/beta signaling.
    REACT_197538. Regulation of IFNG signaling.
    REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_204997. Netrin mediated repulsion signals.
    REACT_207556. PI-3K cascade.
    REACT_217737. GAB1 signalosome.

    Miscellaneous databases

    NextBioi 20815883.
    PROi Q90687.

    Family and domain databases

    Gene3Di 3.30.505.10. 2 hits.
    3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000980. SH2.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00017. SH2. 2 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000929. Tyr-Ptase_nr_6. 1 hit.
    PRINTSi PR00700. PRTYPHPHTASE.
    PR00401. SH2DOMAIN.
    SMARTi SM00194. PTPc. 1 hit.
    SM00252. SH2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEi PS50001. SH2. 2 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2."
      Park C.Y., LaMontagne K.R., Tonks N.K., Hayman M.J.
      Gene 177:93-97(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Erythroblast1 Publication.

    Entry informationi

    Entry nameiPTN11_CHICK
    AccessioniPrimary (citable) accession number: Q90687
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3