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Q90687

- PTN11_CHICK

UniProt

Q90687 - PTN11_CHICK

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Protein

Tyrosine-protein phosphatase non-receptor type 11

Gene

PTPN11

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation.By similarity1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarityPROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei425 – 4251SubstrateBy similarity
Active sitei459 – 4591Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei506 – 5061SubstrateBy similarity

GO - Molecular functioni

  1. non-membrane spanning protein tyrosine phosphatase activity Source: Ensembl

GO - Biological processi

  1. abortive mitotic cell cycle Source: Ensembl
  2. activation of MAPK activity Source: Ensembl
  3. atrioventricular canal development Source: Ensembl
  4. axonogenesis Source: Ensembl
  5. brain development Source: Ensembl
  6. DNA damage checkpoint Source: Ensembl
  7. ephrin receptor signaling pathway Source: Ensembl
  8. ERBB signaling pathway Source: Ensembl
  9. face morphogenesis Source: Ensembl
  10. genitalia development Source: Ensembl
  11. glucose homeostasis Source: Ensembl
  12. hormone-mediated signaling pathway Source: Ensembl
  13. hormone metabolic process Source: Ensembl
  14. inner ear development Source: Ensembl
  15. integrin-mediated signaling pathway Source: Ensembl
  16. megakaryocyte development Source: Ensembl
  17. multicellular organismal reproductive process Source: Ensembl
  18. negative regulation of cell adhesion mediated by integrin Source: Ensembl
  19. negative regulation of cortisol secretion Source: Ensembl
  20. negative regulation of growth hormone secretion Source: Ensembl
  21. negative regulation of insulin secretion Source: Ensembl
  22. neurotrophin TRK receptor signaling pathway Source: Ensembl
  23. organ growth Source: Ensembl
  24. platelet formation Source: Ensembl
  25. positive regulation of glucose import in response to insulin stimulus Source: Ensembl
  26. positive regulation of hormone secretion Source: Ensembl
  27. regulation of multicellular organism growth Source: Ensembl
  28. regulation of protein export from nucleus Source: Ensembl
  29. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_194391. Signaling by SCF-KIT.
REACT_194398. Signaling by Leptin.
REACT_197052. Prolactin receptor signaling.
REACT_197119. Interleukin-6 signaling.
REACT_197153. Negative regulation of FGFR signaling.
REACT_197530. Regulation of IFNA signaling.
REACT_197533. Interferon alpha/beta signaling.
REACT_197538. Regulation of IFNG signaling.
REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
REACT_204997. Netrin mediated repulsion signals.
REACT_207556. PI-3K cascade.
REACT_217737. GAB1 signalosome.
REACT_230783. CTLA4 inhibitory signaling.
REACT_231139. FRS2-mediated cascade.
REACT_235454. PD-1 signaling.
REACT_239556. Signal regulatory protein (SIRP) family interactions.
REACT_239808. Interleukin-3, 5 and GM-CSF signaling.
REACT_240004. Downstream signal transduction.
REACT_244511. PI3K Cascade.
REACT_244793. PIP3 activates AKT signaling.
REACT_251680. Tie2 Signaling.
REACT_258049. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_260156. ERK2 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 11 (EC:3.1.3.48)
Alternative name(s):
SH-PTP2
Short name:
cSH-PTP2
Gene namesi
Name:PTPN11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 15

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Tyrosine-protein phosphatase non-receptor type 11PRO_0000094770Add
BLAST

Post-translational modificationi

Phosphorylated by tyrosine-protein kinases.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ90687.
PRIDEiQ90687.

Expressioni

Tissue specificityi

Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033730.

Structurei

3D structure databases

ProteinModelPortaliQ90687.
SMRiQ90687. Positions 3-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 10297SH2 1CuratedPROSITE-ProRule annotationAdd
BLAST
Domaini112 – 216105SH2 2CuratedPROSITE-ProRule annotationAdd
BLAST
Domaini247 – 521275Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni459 – 4657Substrate bindingBy similarity

Sequence similaritiesi

Contains 2 SH2 domains.CuratedPROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000273907.
HOVERGENiHBG000223.
InParanoidiQ90687.
KOiK07293.
PhylomeDBiQ90687.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000980. SH2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTiSM00194. PTPc. 1 hit.
SM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90687-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRTGA
60 70 80 90 100
VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY
110 120 130 140 150
PLNCADPTSE RWFHGHLSGR EAEKLLTEKG KHGSFLVRES QSHPGDFVLS
160 170 180 190 200
VRTGDDKGES NDGKSKVTHV MIHCQDLKYD VGGGEKFDSL TDLVEHYKKN
210 220 230 240 250
PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE
260 270 280 290 300
FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP
310 320 330 340 350
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS
360 370 380 390 400
RVIVMTTKEV ERGKSKCVKY WPDEYSLKEY GVMRVRNVKE SAAHDYTLRE
410 420 430 440 450
LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIS
460 470 480 490 500
DAGPVVVHCS AGIGRTGTFI VIDILIDIIR EKGVDCDIDV PKTIQMVRSQ
510 520 530 540 550
RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH EYTNIKYSLS
560 570 580 590
DQTSGDQSPL PPCTPTPTCP EMREDSARVY ENVGLMQQQK SFR
Length:593
Mass (Da):67,983
Last modified:November 1, 1996 - v1
Checksum:i415231144BB43DDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38620 mRNA. Translation: AAC60049.1.
PIRiJC5167.
RefSeqiNP_990299.1. NM_204968.1.
UniGeneiGga.482.

Genome annotation databases

EnsembliENSGALT00000007704; ENSGALP00000007692; ENSGALG00000004821.
GeneIDi395815.
KEGGigga:395815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38620 mRNA. Translation: AAC60049.1 .
PIRi JC5167.
RefSeqi NP_990299.1. NM_204968.1.
UniGenei Gga.482.

3D structure databases

ProteinModelPortali Q90687.
SMRi Q90687. Positions 3-525.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000033730.

Proteomic databases

PaxDbi Q90687.
PRIDEi Q90687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000007704 ; ENSGALP00000007692 ; ENSGALG00000004821 .
GeneIDi 395815.
KEGGi gga:395815.

Organism-specific databases

CTDi 5781.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00770000120452.
HOGENOMi HOG000273907.
HOVERGENi HBG000223.
InParanoidi Q90687.
KOi K07293.
PhylomeDBi Q90687.

Enzyme and pathway databases

Reactomei REACT_194391. Signaling by SCF-KIT.
REACT_194398. Signaling by Leptin.
REACT_197052. Prolactin receptor signaling.
REACT_197119. Interleukin-6 signaling.
REACT_197153. Negative regulation of FGFR signaling.
REACT_197530. Regulation of IFNA signaling.
REACT_197533. Interferon alpha/beta signaling.
REACT_197538. Regulation of IFNG signaling.
REACT_198076. Constitutive PI3K/AKT Signaling in Cancer.
REACT_204997. Netrin mediated repulsion signals.
REACT_207556. PI-3K cascade.
REACT_217737. GAB1 signalosome.
REACT_230783. CTLA4 inhibitory signaling.
REACT_231139. FRS2-mediated cascade.
REACT_235454. PD-1 signaling.
REACT_239556. Signal regulatory protein (SIRP) family interactions.
REACT_239808. Interleukin-3, 5 and GM-CSF signaling.
REACT_240004. Downstream signal transduction.
REACT_244511. PI3K Cascade.
REACT_244793. PIP3 activates AKT signaling.
REACT_251680. Tie2 Signaling.
REACT_258049. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_260156. ERK2 activation.

Miscellaneous databases

NextBioi 20815883.
PROi Q90687.

Family and domain databases

Gene3Di 3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000980. SH2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSi PR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTi SM00194. PTPc. 1 hit.
SM00252. SH2. 2 hits.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEi PS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2."
    Park C.Y., LaMontagne K.R., Tonks N.K., Hayman M.J.
    Gene 177:93-97(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Erythroblast1 Publication.

Entry informationi

Entry nameiPTN11_CHICK
AccessioniPrimary (citable) accession number: Q90687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3