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Protein

Tyrosine-protein phosphatase non-receptor type 11

Gene

PTPN11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation.1 PublicationBy similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei425SubstrateBy similarity1
Active sitei459Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei506SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-GGA-1059683. Interleukin-6 signaling.
R-GGA-109704. PI3K Cascade.
R-GGA-112411. MAPK1 (ERK2) activation.
R-GGA-1257604. PIP3 activates AKT signaling.
R-GGA-1433557. Signaling by SCF-KIT.
R-GGA-180292. GAB1 signalosome.
R-GGA-186763. Downstream signal transduction.
R-GGA-210993. Tie2 Signaling.
R-GGA-389513. CTLA4 inhibitory signaling.
R-GGA-389948. PD-1 signaling.
R-GGA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-GGA-5654689. PI-3K cascade:FGFR1.
R-GGA-5654693. FRS-mediated FGFR1 signaling.
R-GGA-5654695. PI-3K cascade:FGFR2.
R-GGA-5654699. SHC-mediated cascade:FGFR2.
R-GGA-5654700. FRS-mediated FGFR2 signaling.
R-GGA-5654706. FRS-mediated FGFR3 signaling.
R-GGA-5654710. PI-3K cascade:FGFR3.
R-GGA-5654712. FRS-mediated FGFR4 signaling.
R-GGA-5654719. SHC-mediated cascade:FGFR4.
R-GGA-5654720. PI-3K cascade:FGFR4.
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5654732. Negative regulation of FGFR3 signaling.
R-GGA-5654733. Negative regulation of FGFR4 signaling.
R-GGA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-GGA-8853659. RET signaling.
R-GGA-8865999. MET activates PTPN11.
R-GGA-909733. Interferon alpha/beta signaling.
R-GGA-912694. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 11 (EC:3.1.3.48)
Alternative name(s):
SH-PTP2
Short name:
cSH-PTP2
Gene namesi
Name:PTPN11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947701 – 593Tyrosine-protein phosphatase non-receptor type 11Add BLAST593

Post-translational modificationi

Phosphorylated by tyrosine-protein kinases.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ90687.
PRIDEiQ90687.

Expressioni

Tissue specificityi

Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells.1 Publication

Gene expression databases

BgeeiENSGALG00000004821.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033730.

Structurei

3D structure databases

ProteinModelPortaliQ90687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 102SH2 1PROSITE-ProRule annotationCuratedAdd BLAST97
Domaini112 – 216SH2 2PROSITE-ProRule annotationCuratedAdd BLAST105
Domaini247 – 521Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni459 – 465Substrate bindingBy similarity7

Sequence similaritiesi

Contains 2 SH2 domains.PROSITE-ProRule annotationCurated
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000273907.
HOVERGENiHBG000223.
InParanoidiQ90687.
KOiK07293.
OMAiKEYGAMR.
OrthoDBiEOG091G0VZ3.
PhylomeDBiQ90687.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR000980. SH2.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRTGA
60 70 80 90 100
VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY
110 120 130 140 150
PLNCADPTSE RWFHGHLSGR EAEKLLTEKG KHGSFLVRES QSHPGDFVLS
160 170 180 190 200
VRTGDDKGES NDGKSKVTHV MIHCQDLKYD VGGGEKFDSL TDLVEHYKKN
210 220 230 240 250
PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE
260 270 280 290 300
FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP
310 320 330 340 350
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS
360 370 380 390 400
RVIVMTTKEV ERGKSKCVKY WPDEYSLKEY GVMRVRNVKE SAAHDYTLRE
410 420 430 440 450
LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIS
460 470 480 490 500
DAGPVVVHCS AGIGRTGTFI VIDILIDIIR EKGVDCDIDV PKTIQMVRSQ
510 520 530 540 550
RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH EYTNIKYSLS
560 570 580 590
DQTSGDQSPL PPCTPTPTCP EMREDSARVY ENVGLMQQQK SFR
Length:593
Mass (Da):67,983
Last modified:November 1, 1996 - v1
Checksum:i415231144BB43DDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38620 mRNA. Translation: AAC60049.1.
PIRiJC5167.
RefSeqiNP_990299.1. NM_204968.1.
UniGeneiGga.482.

Genome annotation databases

EnsembliENSGALT00000007704; ENSGALP00000007692; ENSGALG00000004821.
GeneIDi395815.
KEGGigga:395815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38620 mRNA. Translation: AAC60049.1.
PIRiJC5167.
RefSeqiNP_990299.1. NM_204968.1.
UniGeneiGga.482.

3D structure databases

ProteinModelPortaliQ90687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033730.

Proteomic databases

PaxDbiQ90687.
PRIDEiQ90687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000007704; ENSGALP00000007692; ENSGALG00000004821.
GeneIDi395815.
KEGGigga:395815.

Organism-specific databases

CTDi5781.

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000273907.
HOVERGENiHBG000223.
InParanoidiQ90687.
KOiK07293.
OMAiKEYGAMR.
OrthoDBiEOG091G0VZ3.
PhylomeDBiQ90687.

Enzyme and pathway databases

ReactomeiR-GGA-1059683. Interleukin-6 signaling.
R-GGA-109704. PI3K Cascade.
R-GGA-112411. MAPK1 (ERK2) activation.
R-GGA-1257604. PIP3 activates AKT signaling.
R-GGA-1433557. Signaling by SCF-KIT.
R-GGA-180292. GAB1 signalosome.
R-GGA-186763. Downstream signal transduction.
R-GGA-210993. Tie2 Signaling.
R-GGA-389513. CTLA4 inhibitory signaling.
R-GGA-389948. PD-1 signaling.
R-GGA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-GGA-5654689. PI-3K cascade:FGFR1.
R-GGA-5654693. FRS-mediated FGFR1 signaling.
R-GGA-5654695. PI-3K cascade:FGFR2.
R-GGA-5654699. SHC-mediated cascade:FGFR2.
R-GGA-5654700. FRS-mediated FGFR2 signaling.
R-GGA-5654706. FRS-mediated FGFR3 signaling.
R-GGA-5654710. PI-3K cascade:FGFR3.
R-GGA-5654712. FRS-mediated FGFR4 signaling.
R-GGA-5654719. SHC-mediated cascade:FGFR4.
R-GGA-5654720. PI-3K cascade:FGFR4.
R-GGA-5654726. Negative regulation of FGFR1 signaling.
R-GGA-5654727. Negative regulation of FGFR2 signaling.
R-GGA-5654732. Negative regulation of FGFR3 signaling.
R-GGA-5654733. Negative regulation of FGFR4 signaling.
R-GGA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-GGA-8853659. RET signaling.
R-GGA-8865999. MET activates PTPN11.
R-GGA-909733. Interferon alpha/beta signaling.
R-GGA-912694. Regulation of IFNA signaling.

Miscellaneous databases

PROiQ90687.

Gene expression databases

BgeeiENSGALG00000004821.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR000980. SH2.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTN11_CHICK
AccessioniPrimary (citable) accession number: Q90687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.