Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein phosphatase non-receptor type 11

Gene

PTPN11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation.1 PublicationBy similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotationBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei425 – 4251SubstrateBy similarity
Active sitei459 – 4591Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei506 – 5061SubstrateBy similarity

GO - Molecular functioni

  1. non-membrane spanning protein tyrosine phosphatase activity Source: Ensembl

GO - Biological processi

  1. abortive mitotic cell cycle Source: Ensembl
  2. activation of MAPK activity Source: Ensembl
  3. atrioventricular canal development Source: Ensembl
  4. axonogenesis Source: Ensembl
  5. brain development Source: Ensembl
  6. DNA damage checkpoint Source: Ensembl
  7. ephrin receptor signaling pathway Source: Ensembl
  8. epidermal growth factor receptor signaling pathway Source: Ensembl
  9. face morphogenesis Source: Ensembl
  10. genitalia development Source: Ensembl
  11. glucose homeostasis Source: Ensembl
  12. hormone-mediated signaling pathway Source: Ensembl
  13. hormone metabolic process Source: Ensembl
  14. inner ear development Source: Ensembl
  15. integrin-mediated signaling pathway Source: Ensembl
  16. megakaryocyte development Source: Ensembl
  17. multicellular organismal reproductive process Source: Ensembl
  18. negative regulation of cell adhesion mediated by integrin Source: Ensembl
  19. negative regulation of cortisol secretion Source: Ensembl
  20. negative regulation of growth hormone secretion Source: Ensembl
  21. negative regulation of insulin secretion Source: Ensembl
  22. neurotrophin TRK receptor signaling pathway Source: Ensembl
  23. organ growth Source: Ensembl
  24. platelet-derived growth factor receptor signaling pathway Source: Ensembl
  25. platelet formation Source: Ensembl
  26. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  27. positive regulation of glucose import in response to insulin stimulus Source: Ensembl
  28. positive regulation of hormone secretion Source: Ensembl
  29. positive regulation of mitotic cell cycle Source: Ensembl
  30. regulation of multicellular organism growth Source: Ensembl
  31. regulation of protein export from nucleus Source: Ensembl
  32. triglyceride metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_275881. Tie2 Signaling.
REACT_284939. PIP3 activates AKT signaling.
REACT_285062. ERK2 activation.
REACT_288933. Signaling by SCF-KIT.
REACT_291383. Interferon alpha/beta signaling.
REACT_297795. FRS2-mediated cascade.
REACT_303663. Prolactin receptor signaling.
REACT_304572. Netrin mediated repulsion signals.
REACT_306408. Signaling by Leptin.
REACT_312706. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_317212. Negative regulation of FGFR signaling.
REACT_322031. GAB1 signalosome.
REACT_324881. Interleukin-3, 5 and GM-CSF signaling.
REACT_328321. PD-1 signaling.
REACT_332748. CTLA4 inhibitory signaling.
REACT_333012. Downstream signal transduction.
REACT_334987. Signal regulatory protein (SIRP) family interactions.
REACT_335624. Regulation of IFNA signaling.
REACT_340124. Regulation of IFNG signaling.
REACT_343900. Constitutive PI3K/AKT Signaling in Cancer.
REACT_344129. PI3K Cascade.
REACT_344336. Interleukin-6 signaling.
REACT_344411. PI-3K cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 11 (EC:3.1.3.48)
Alternative name(s):
SH-PTP2
Short name:
cSH-PTP2
Gene namesi
Name:PTPN11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 15

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Tyrosine-protein phosphatase non-receptor type 11PRO_0000094770Add
BLAST

Post-translational modificationi

Phosphorylated by tyrosine-protein kinases.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ90687.
PRIDEiQ90687.

Expressioni

Tissue specificityi

Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033730.

Structurei

3D structure databases

ProteinModelPortaliQ90687.
SMRiQ90687. Positions 3-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 10297SH2 1PROSITE-ProRule annotationCuratedAdd
BLAST
Domaini112 – 216105SH2 2PROSITE-ProRule annotationCuratedAdd
BLAST
Domaini247 – 521275Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni459 – 4657Substrate bindingBy similarity

Sequence similaritiesi

Contains 2 SH2 domains.PROSITE-ProRule annotationCurated
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000273907.
HOVERGENiHBG000223.
InParanoidiQ90687.
KOiK07293.
OMAiIVIDILM.
PhylomeDBiQ90687.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000980. SH2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTiSM00194. PTPc. 1 hit.
SM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRTGA
60 70 80 90 100
VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY
110 120 130 140 150
PLNCADPTSE RWFHGHLSGR EAEKLLTEKG KHGSFLVRES QSHPGDFVLS
160 170 180 190 200
VRTGDDKGES NDGKSKVTHV MIHCQDLKYD VGGGEKFDSL TDLVEHYKKN
210 220 230 240 250
PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE
260 270 280 290 300
FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP
310 320 330 340 350
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS
360 370 380 390 400
RVIVMTTKEV ERGKSKCVKY WPDEYSLKEY GVMRVRNVKE SAAHDYTLRE
410 420 430 440 450
LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIS
460 470 480 490 500
DAGPVVVHCS AGIGRTGTFI VIDILIDIIR EKGVDCDIDV PKTIQMVRSQ
510 520 530 540 550
RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH EYTNIKYSLS
560 570 580 590
DQTSGDQSPL PPCTPTPTCP EMREDSARVY ENVGLMQQQK SFR
Length:593
Mass (Da):67,983
Last modified:November 1, 1996 - v1
Checksum:i415231144BB43DDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38620 mRNA. Translation: AAC60049.1.
PIRiJC5167.
RefSeqiNP_990299.1. NM_204968.1.
UniGeneiGga.482.

Genome annotation databases

EnsembliENSGALT00000007704; ENSGALP00000007692; ENSGALG00000004821.
GeneIDi395815.
KEGGigga:395815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38620 mRNA. Translation: AAC60049.1.
PIRiJC5167.
RefSeqiNP_990299.1. NM_204968.1.
UniGeneiGga.482.

3D structure databases

ProteinModelPortaliQ90687.
SMRiQ90687. Positions 3-525.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033730.

Proteomic databases

PaxDbiQ90687.
PRIDEiQ90687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000007704; ENSGALP00000007692; ENSGALG00000004821.
GeneIDi395815.
KEGGigga:395815.

Organism-specific databases

CTDi5781.

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000273907.
HOVERGENiHBG000223.
InParanoidiQ90687.
KOiK07293.
OMAiIVIDILM.
PhylomeDBiQ90687.

Enzyme and pathway databases

ReactomeiREACT_275881. Tie2 Signaling.
REACT_284939. PIP3 activates AKT signaling.
REACT_285062. ERK2 activation.
REACT_288933. Signaling by SCF-KIT.
REACT_291383. Interferon alpha/beta signaling.
REACT_297795. FRS2-mediated cascade.
REACT_303663. Prolactin receptor signaling.
REACT_304572. Netrin mediated repulsion signals.
REACT_306408. Signaling by Leptin.
REACT_312706. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_317212. Negative regulation of FGFR signaling.
REACT_322031. GAB1 signalosome.
REACT_324881. Interleukin-3, 5 and GM-CSF signaling.
REACT_328321. PD-1 signaling.
REACT_332748. CTLA4 inhibitory signaling.
REACT_333012. Downstream signal transduction.
REACT_334987. Signal regulatory protein (SIRP) family interactions.
REACT_335624. Regulation of IFNA signaling.
REACT_340124. Regulation of IFNG signaling.
REACT_343900. Constitutive PI3K/AKT Signaling in Cancer.
REACT_344129. PI3K Cascade.
REACT_344336. Interleukin-6 signaling.
REACT_344411. PI-3K cascade.

Miscellaneous databases

NextBioi20815883.
PROiQ90687.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000980. SH2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00017. SH2. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTiSM00194. PTPc. 1 hit.
SM00252. SH2. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2."
    Park C.Y., LaMontagne K.R., Tonks N.K., Hayman M.J.
    Gene 177:93-97(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Erythroblast1 Publication.

Entry informationi

Entry nameiPTN11_CHICK
AccessioniPrimary (citable) accession number: Q90687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.