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Protein

Tyrosine-protein phosphatase non-receptor type 11

Gene

PTPN11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation (PubMed:8921851).1 PublicationBy similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei425SubstrateBy similarity1
Active sitei459Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei506SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-GGA-1059683 Interleukin-6 signaling
R-GGA-109704 PI3K Cascade
R-GGA-112411 MAPK1 (ERK2) activation
R-GGA-1257604 PIP3 activates AKT signaling
R-GGA-1295596 Spry regulation of FGF signaling
R-GGA-1433557 Signaling by SCF-KIT
R-GGA-180292 GAB1 signalosome
R-GGA-186763 Downstream signal transduction
R-GGA-210993 Tie2 Signaling
R-GGA-389513 CTLA4 inhibitory signaling
R-GGA-389948 PD-1 signaling
R-GGA-512988 Interleukin-3, 5 and GM-CSF signaling
R-GGA-5654689 PI-3K cascade:FGFR1
R-GGA-5654693 FRS-mediated FGFR1 signaling
R-GGA-5654695 PI-3K cascade:FGFR2
R-GGA-5654700 FRS-mediated FGFR2 signaling
R-GGA-5654706 FRS-mediated FGFR3 signaling
R-GGA-5654710 PI-3K cascade:FGFR3
R-GGA-5654712 FRS-mediated FGFR4 signaling
R-GGA-5654720 PI-3K cascade:FGFR4
R-GGA-5654726 Negative regulation of FGFR1 signaling
R-GGA-5654727 Negative regulation of FGFR2 signaling
R-GGA-5654732 Negative regulation of FGFR3 signaling
R-GGA-5654733 Negative regulation of FGFR4 signaling
R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-GGA-8853659 RET signaling
R-GGA-8854691 Interleukin-20 family signaling
R-GGA-8865999 MET activates PTPN11
R-GGA-8934593 Regulation of RUNX1 Expression and Activity
R-GGA-909733 Interferon alpha/beta signaling
R-GGA-912694 Regulation of IFNA signaling
R-GGA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 11 (EC:3.1.3.48By similarity)
Alternative name(s):
SH-PTP2
Short name:
cSH-PTP2
Gene namesi
Name:PTPN11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947701 – 593Tyrosine-protein phosphatase non-receptor type 11Add BLAST593

Post-translational modificationi

Phosphorylated by tyrosine-protein kinases.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ90687
PRIDEiQ90687

Expressioni

Tissue specificityi

Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells.1 Publication

Gene expression databases

BgeeiENSGALG00000004821

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033730

Structurei

3D structure databases

ProteinModelPortaliQ90687
SMRiQ90687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 102SH2 1PROSITE-ProRule annotationCuratedAdd BLAST97
Domaini112 – 216SH2 2PROSITE-ProRule annotationCuratedAdd BLAST105
Domaini247 – 521Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni459 – 465Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Repeat, SH2 domain

Phylogenomic databases

eggNOGiKOG0790 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00910000144001
HOGENOMiHOG000273907
HOVERGENiHBG000223
InParanoidiQ90687
KOiK07293
OMAiKEYGAMR
OrthoDBiEOG091G0VZ3
PhylomeDBiQ90687

Family and domain databases

Gene3Di3.30.505.10, 2 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012152 Tyr_Pase_non-rcpt_typ-6/11
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00017 SH2, 2 hits
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000929 Tyr-Ptase_nr_6, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
PR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 2 hits
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001 SH2, 2 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q90687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRTGA
60 70 80 90 100
VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY
110 120 130 140 150
PLNCADPTSE RWFHGHLSGR EAEKLLTEKG KHGSFLVRES QSHPGDFVLS
160 170 180 190 200
VRTGDDKGES NDGKSKVTHV MIHCQDLKYD VGGGEKFDSL TDLVEHYKKN
210 220 230 240 250
PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE
260 270 280 290 300
FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP
310 320 330 340 350
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS
360 370 380 390 400
RVIVMTTKEV ERGKSKCVKY WPDEYSLKEY GVMRVRNVKE SAAHDYTLRE
410 420 430 440 450
LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIS
460 470 480 490 500
DAGPVVVHCS AGIGRTGTFI VIDILIDIIR EKGVDCDIDV PKTIQMVRSQ
510 520 530 540 550
RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH EYTNIKYSLS
560 570 580 590
DQTSGDQSPL PPCTPTPTCP EMREDSARVY ENVGLMQQQK SFR
Length:593
Mass (Da):67,983
Last modified:November 1, 1996 - v1
Checksum:i415231144BB43DDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38620 mRNA Translation: AAC60049.1
PIRiJC5167
RefSeqiNP_990299.1, NM_204968.1
UniGeneiGga.482

Genome annotation databases

EnsembliENSGALT00000007704; ENSGALP00000007692; ENSGALG00000004821
GeneIDi395815
KEGGigga:395815

Similar proteinsi

Entry informationi

Entry nameiPTN11_CHICK
AccessioniPrimary (citable) accession number: Q90687
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health