Q90687 (PTN11_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase non-receptor type 11
EC=3.1.3.48

Alternative name(s):
SH-PTP2
Short name=cSH-PTP2

Gene names

Name:

PTPN11

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	593 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates By similarity. May play a positive role during the stages of erythroid cell proliferation. Ref.1 UniProtKB Q06124
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. UniProtKB Q06124
Subcellular location	Cytoplasm By similarity UniProtKB Q06124.
Tissue specificity	Expressed in embryonic fibroblast, hematopoietic, erythroid, myeloid and lymphoid cells. Ref.1
Post-translational modification	Phosphorylated by tyrosine-protein kinases By similarity. UniProtKB Q06124
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Contains 2 SH2 domains. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat SH2 domain
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 593	593	Tyrosine-protein phosphatase non-receptor type 11		PRO_0000094770
Regions
	Domain	6 – 102	97	SH2 1
	Domain	112 – 216	105	SH2 2
	Domain	247 – 521	275	Tyrosine-protein phosphatase
	Region	459 – 465	7	Substrate binding By similarity
Sites
	Active site	459	1	Phosphocysteine intermediate By similarity UniProtKB Q06124
	Binding site	425	1	Substrate By similarity
	Binding site	506	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q90687 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 415231144BB43DDA	FASTA	593	67,983
	10 20 30 40 50 60 MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRTGA VTHIKIQNTG 70 80 90 100 110 120 DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGR 130 140 150 160 170 180 EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIHCQDLKYD 190 200 210 220 230 240 VGGGEKFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 250 260 270 280 290 300 DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 310 320 330 340 350 360 VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 370 380 390 400 410 420 ERGKSKCVKY WPDEYSLKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF 430 440 450 460 470 480 RTWPDHGVPS DPGGVLDFLE EVHHKQESIS DAGPVVVHCS AGIGRTGTFI VIDILIDIIR 490 500 510 520 530 540 EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH 550 560 570 580 590 EYTNIKYSLS DQTSGDQSPL PPCTPTPTCP EMREDSARVY ENVGLMQQQK SFR

References

[1]	"Cloning and expression of the chicken protein tyrosine phosphatase SH-PTP2." Park C.Y., LaMontagne K.R., Tonks N.K., Hayman M.J. Gene 177:93-97(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Erythroblast.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U38620 mRNA. Translation: AAC60049.1.
IPI	IPI00598624.
PIR	JC5167.
RefSeq	NP_990299.1. NM_204968.1.
UniGene	Gga.482.
3D structure databases
ProteinModelPortal	Q90687.
SMR	Q90687. Positions 3-525.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000033730.
Proteomic databases
PaxDb	Q90687.
PRIDE	Q90687.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395815.
KEGG	gga:395815.
Organism-specific databases
CTD	5781.
Phylogenomic databases
eggNOG	COG5599.
HOGENOM	HOG000273907.
HOVERGEN	HBG000223.
KO	K07293.
Family and domain databases
Gene3D	3.30.505.10. 2 hits.
InterPro	IPR000980. SH2. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR012152. Tyr_Pase_non-rcpt_typ-6/11. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00017. SH2. 2 hits. PF00102. Y_phosphatase. 1 hit. [Graphical view]
PIRSF	PIRSF000929. Tyr-Ptase_nr_6. 1 hit.
PRINTS	PR00700. PRTYPHPHTASE. PR00401. SH2DOMAIN.
SMART	SM00194. PTPc. 1 hit. SM00252. SH2. 2 hits. [Graphical view]
PROSITE	PS50001. SH2. 2 hits. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815883.

Entry information

Entry name

PTN11_CHICK

Accession

Primary (citable) accession number: Q90687

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program