Q90686 (CATK_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin K
EC=3.4.22.38

Alternative name(s):
JTAP-1

Gene names

Name:

CTSK

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity. UniProtKB P43235
Catalytic activity	Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg. UniProtKB P43235
Induction	Up-regulated in response to V-Jun induced cell transformation. Ref.1
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 119	100	Activation peptide UniProtKB P43235		PRO_0000026309
	Chain	120 – 334	215	Cathepsin K UniProtKB P43235		PRO_0000026310
Sites
	Active site	144	1	By similarity UniProtKB P07688
	Active site	281	1	By similarity UniProtKB P07688
	Active site	301	1	By similarity UniProtKB P07688
Amino acid modifications
	Glycosylation	108	1	N-linked (GlcNAc...) Potential
	Disulfide bond	141 ↔ 182		By similarity UniProtKB P43235
	Disulfide bond	175 ↔ 215		By similarity UniProtKB P43235
	Disulfide bond	274 ↔ 323		By similarity UniProtKB P43235

Sequences

	Sequence		Length	Mass (Da)
	Q90686 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: DB3E23FBC21BF3B9	FASTA	334	37,219
	10 20 30 40 50 60 MLRLHWLALL VLLLPMAAAQ LRPEPELDAQ WDLWKRTIQK AVQRQGGRNV PEVDLGEEPE 70 80 90 100 110 120 VHRCPQRGAR LGKHSFQLAM NYLGDMTSEE VVRTMTGLRV PRSRPRPNGT LYVPDWSSRA 130 140 150 160 170 180 PAAVDWRRKG YVTPVKDQGQ CGSCWAFSSV GALEGQLKRR TGKLLSLSPQ NLVYCVSNNN 190 200 210 220 230 240 GCGGGYMTNA FEYVRLNRGI DSEDAYPYIG QDESCMYSPT GKAAKCRGYR EIPEDNEKAL 250 260 270 280 290 300 KRAVARIGPV SVGIDASLPS FQFYSRGVYY DTGCNPENIN HAVLAVGYGA QKGTKHWIIK 310 320 330 NSWGTEWGNK GYVLLARNMK QTCGIANLAS FPKM

References

[1]	"Isolation and cloning of JTAP-1: a cathepsin like gene upregulated in response to V-Jun induced cell transformation." Hadman M., Gabos L., Loo M., Sehgal A., Bos T.J. Oncogene 12:135-142(1996) [PubMed: 8552384] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U37691 mRNA. Translation: AAC59739.1.
IPI	IPI00575213.
RefSeq	NP_990302.1. NM_204971.1.
UniGene	Gga.483.
3D structure databases
ProteinModelPortal	Q90686.
SMR	Q90686. Positions 21-334.
ModBase	Search...
Protein family/group databases
MEROPS	C01.036.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395818.
KEGG	gga:395818.
Organism-specific databases
CTD	1513.
Phylogenomic databases
HOVERGEN	HBG011513.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR015644. Peptidase_C1A_cathepsin-K. [Graphical view]
KO	K01371.
PANTHER	PTHR12411:SF55. CathpsnK_like. 1 hit. PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATK_CHICK

Accession

Primary (citable) accession number: Q90686

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program