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Protein

Cathepsin K

Gene

CTSK

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity).By similarity

Catalytic activityi

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei144 – 1441By similarity
Active sitei281 – 2811By similarity
Active sitei301 – 3011By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.036.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin K (EC:3.4.22.38)
Alternative name(s):
JTAP-1
Gene namesi
Name:CTSK
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 119100Activation peptidePRO_0000026309Add
BLAST
Chaini120 – 334215Cathepsin KPRO_0000026310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Disulfide bondi141 ↔ 182By similarity
Disulfide bondi175 ↔ 215By similarity
Disulfide bondi274 ↔ 323By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Inductioni

Up-regulated in response to V-Jun induced cell transformation.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ90686.
SMRiQ90686. Positions 21-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG011513.
InParanoidiQ90686.
PhylomeDBiQ90686.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015644. Peptidase_C1A_cathepsin-K.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF55. PTHR12411:SF55. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLHWLALL VLLLPMAAAQ LRPEPELDAQ WDLWKRTIQK AVQRQGGRNV
60 70 80 90 100
PEVDLGEEPE VHRCPQRGAR LGKHSFQLAM NYLGDMTSEE VVRTMTGLRV
110 120 130 140 150
PRSRPRPNGT LYVPDWSSRA PAAVDWRRKG YVTPVKDQGQ CGSCWAFSSV
160 170 180 190 200
GALEGQLKRR TGKLLSLSPQ NLVYCVSNNN GCGGGYMTNA FEYVRLNRGI
210 220 230 240 250
DSEDAYPYIG QDESCMYSPT GKAAKCRGYR EIPEDNEKAL KRAVARIGPV
260 270 280 290 300
SVGIDASLPS FQFYSRGVYY DTGCNPENIN HAVLAVGYGA QKGTKHWIIK
310 320 330
NSWGTEWGNK GYVLLARNMK QTCGIANLAS FPKM
Length:334
Mass (Da):37,219
Last modified:November 1, 1996 - v1
Checksum:iDB3E23FBC21BF3B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37691 mRNA. Translation: AAC59739.1.
UniGeneiGga.51509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37691 mRNA. Translation: AAC59739.1.
UniGeneiGga.51509.

3D structure databases

ProteinModelPortaliQ90686.
SMRiQ90686. Positions 21-334.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC01.036.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG011513.
InParanoidiQ90686.
PhylomeDBiQ90686.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015644. Peptidase_C1A_cathepsin-K.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF55. PTHR12411:SF55. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and cloning of JTAP-1: a cathepsin like gene upregulated in response to V-Jun induced cell transformation."
    Hadman M., Gabos L., Loo M., Sehgal A., Bos T.J.
    Oncogene 12:135-142(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.

Entry informationi

Entry nameiCATK_CHICK
AccessioniPrimary (citable) accession number: Q90686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.