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Q90678 (PAFA_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Platelet-activating factor acetylhydrolase

Short name=PAF acetylhydrolase
EC=3.1.1.47
Alternative name(s):
1-alkyl-2-acetylglycerophosphocholine esterase
2-acetyl-1-alkylglycerophosphocholine esterase
LDL-associated phospholipase A2
Short name=LDL-PLA(2)
PAF 2-acylhydrolase
Gene names
Name:PLA2G7
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Catalytic activity

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Subcellular location

Secretedextracellular space.

Tissue specificity

Plasma.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 422401Platelet-activating factor acetylhydrolase
PRO_0000017835

Sites

Active site2661Nucleophile By similarity
Active site2891Charge relay system By similarity
Active site3451Charge relay system By similarity

Amino acid modifications

Glycosylation3311N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q90678 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 15A5C794376E9141

FASTA42247,046
        10         20         30         40         50         60 
MASLWVRARR VFMKSRASGF SAKAATEMGS GGAEKGYRIP AGKGPHAVGC TDLMTGDAAE 

        70         80         90        100        110        120 
GSFLRLYYLS CDDTDTEETP WIPDKEYYQG LSDFLNVYRA LGERLFQYYV GSVTCPAKSN 

       130        140        150        160        170        180 
AAFKPGEKYP LLVFSHGLGA FRTIYSAICI EMASQGFLVA AVEHRDESAS ATYFCKKKAD 

       190        200        210        220        230        240 
SEPEEDQTSG VEKEWIYYRK LRAGEEERCL RHKQVQQRAQ ECIKALNLIL KISSGEEVMN 

       250        260        270        280        290        300 
VLNSDFDWNH LKDSVDTSRI AVMGHSFGGA TVIESLSKEI RFRCGIALDA WMLPVGDDTY 

       310        320        330        340        350        360 
QSSVQQPLLF INSEKFQWAA NILKMKKLSS NDTNKKMITI KGSVHQSFPD FTFVSGEIIG 

       370        380        390        400        410        420 
KFFKLKGEID PNEAIDICNH ASLAFLQKHL SLKRDFDKWD SLVDGIGPNV ISGTNIDLSP 


TE 

« Hide

References

[1]"Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad."
Tjoelker L.W., Eberhardt C., Unger J., le Trong H., Zimmerman G.A., McIntyre T.M., Stafforini D.M., Prescott S.M., Gray P.W.
J. Biol. Chem. 270:25481-25487(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U34278 mRNA. Translation: AAC59717.1.
RefSeqNP_990300.1. NM_204969.1.
UniGeneGga.1205.

3D structure databases

ProteinModelPortalQ90678.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000026919.

Proteomic databases

PaxDbQ90678.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395816.
KEGGgga:395816.

Organism-specific databases

CTD7941.

Phylogenomic databases

eggNOGCOG4188.
HOGENOMHOG000008053.
HOVERGENHBG001322.
InParanoidQ90678.
KOK01062.
PhylomeDBQ90678.

Family and domain databases

InterProIPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERPTHR10272. PTHR10272. 1 hit.
PfamPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFPIRSF018169. PAF_acetylhydrolase. 1 hit.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815884.
PROQ90678.

Entry information

Entry namePAFA_CHICK
AccessionPrimary (citable) accession number: Q90678
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families