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Q90678

- PAFA_CHICK

UniProt

Q90678 - PAFA_CHICK

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Protein
Platelet-activating factor acetylhydrolase
Gene
PLA2G7
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661Nucleophile By similarity
Active sitei289 – 2891Charge relay system By similarity
Active sitei345 – 3451Charge relay system By similarity

GO - Molecular functioni

  1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase (EC:3.1.1.47)
Short name:
PAF acetylhydrolase
Alternative name(s):
1-alkyl-2-acetylglycerophosphocholine esterase
2-acetyl-1-alkylglycerophosphocholine esterase
LDL-associated phospholipase A2
Short name:
LDL-PLA(2)
PAF 2-acylhydrolase
Gene namesi
Name:PLA2G7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 By similarity
Add
BLAST
Chaini22 – 422401Platelet-activating factor acetylhydrolase
PRO_0000017835Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90678.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026919.

Structurei

3D structure databases

ProteinModelPortaliQ90678.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4188.
HOGENOMiHOG000008053.
HOVERGENiHBG001322.
InParanoidiQ90678.
KOiK01062.
PhylomeDBiQ90678.

Family and domain databases

Gene3Di3.40.50.1820. 3 hits.
InterProiIPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90678-1 [UniParc]FASTAAdd to Basket

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MASLWVRARR VFMKSRASGF SAKAATEMGS GGAEKGYRIP AGKGPHAVGC    50
TDLMTGDAAE GSFLRLYYLS CDDTDTEETP WIPDKEYYQG LSDFLNVYRA 100
LGERLFQYYV GSVTCPAKSN AAFKPGEKYP LLVFSHGLGA FRTIYSAICI 150
EMASQGFLVA AVEHRDESAS ATYFCKKKAD SEPEEDQTSG VEKEWIYYRK 200
LRAGEEERCL RHKQVQQRAQ ECIKALNLIL KISSGEEVMN VLNSDFDWNH 250
LKDSVDTSRI AVMGHSFGGA TVIESLSKEI RFRCGIALDA WMLPVGDDTY 300
QSSVQQPLLF INSEKFQWAA NILKMKKLSS NDTNKKMITI KGSVHQSFPD 350
FTFVSGEIIG KFFKLKGEID PNEAIDICNH ASLAFLQKHL SLKRDFDKWD 400
SLVDGIGPNV ISGTNIDLSP TE 422
Length:422
Mass (Da):47,046
Last modified:November 1, 1997 - v1
Checksum:i15A5C794376E9141
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34278 mRNA. Translation: AAC59717.1.
RefSeqiNP_990300.1. NM_204969.1.
UniGeneiGga.1205.

Genome annotation databases

GeneIDi395816.
KEGGigga:395816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34278 mRNA. Translation: AAC59717.1 .
RefSeqi NP_990300.1. NM_204969.1.
UniGenei Gga.1205.

3D structure databases

ProteinModelPortali Q90678.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000026919.

Proteomic databases

PaxDbi Q90678.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395816.
KEGGi gga:395816.

Organism-specific databases

CTDi 7941.

Phylogenomic databases

eggNOGi COG4188.
HOGENOMi HOG000008053.
HOVERGENi HBG001322.
InParanoidi Q90678.
KOi K01062.
PhylomeDBi Q90678.

Miscellaneous databases

NextBioi 20815884.
PROi Q90678.

Family and domain databases

Gene3Di 3.40.50.1820. 3 hits.
InterProi IPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view ]
PANTHERi PTHR10272. PTHR10272. 1 hit.
Pfami PF03403. PAF-AH_p_II. 1 hit.
[Graphical view ]
PIRSFi PIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00120. LIPASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad."
    Tjoelker L.W., Eberhardt C., Unger J., le Trong H., Zimmerman G.A., McIntyre T.M., Stafforini D.M., Prescott S.M., Gray P.W.
    J. Biol. Chem. 270:25481-25487(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiPAFA_CHICK
AccessioniPrimary (citable) accession number: Q90678
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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