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Protein

Platelet-activating factor acetylhydrolase

Gene

PLA2G7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei266NucleophileBy similarity1
Active sitei289Charge relay systemPROSITE-ProRule annotation1
Active sitei345Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Protein family/group databases

ESTHERichick-pafa. PAF-Acetylhydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase (EC:3.1.1.47)
Short name:
PAF acetylhydrolase
Alternative name(s):
1-alkyl-2-acetylglycerophosphocholine esterase
2-acetyl-1-alkylglycerophosphocholine esterase
LDL-associated phospholipase A2
Short name:
LDL-PLA(2)
PAF 2-acylhydrolase
Gene namesi
Name:PLA2G7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001783522 – 422Platelet-activating factor acetylhydrolaseAdd BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90678.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026919.

Structurei

3D structure databases

ProteinModelPortaliQ90678.
SMRiQ90678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3847. Eukaryota.
ENOG4111FH0. LUCA.
HOGENOMiHOG000008053.
HOVERGENiHBG001322.
InParanoidiQ90678.
KOiK01062.
PhylomeDBiQ90678.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro-like.
IPR016715. PAF_acetylhydro_eukaryote.
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiView protein in Pfam
PF03403. PAF-AH_p_II. 1 hit.
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiView protein in PROSITE
PS00120. LIPASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLWVRARR VFMKSRASGF SAKAATEMGS GGAEKGYRIP AGKGPHAVGC
60 70 80 90 100
TDLMTGDAAE GSFLRLYYLS CDDTDTEETP WIPDKEYYQG LSDFLNVYRA
110 120 130 140 150
LGERLFQYYV GSVTCPAKSN AAFKPGEKYP LLVFSHGLGA FRTIYSAICI
160 170 180 190 200
EMASQGFLVA AVEHRDESAS ATYFCKKKAD SEPEEDQTSG VEKEWIYYRK
210 220 230 240 250
LRAGEEERCL RHKQVQQRAQ ECIKALNLIL KISSGEEVMN VLNSDFDWNH
260 270 280 290 300
LKDSVDTSRI AVMGHSFGGA TVIESLSKEI RFRCGIALDA WMLPVGDDTY
310 320 330 340 350
QSSVQQPLLF INSEKFQWAA NILKMKKLSS NDTNKKMITI KGSVHQSFPD
360 370 380 390 400
FTFVSGEIIG KFFKLKGEID PNEAIDICNH ASLAFLQKHL SLKRDFDKWD
410 420
SLVDGIGPNV ISGTNIDLSP TE
Length:422
Mass (Da):47,046
Last modified:November 1, 1997 - v1
Checksum:i15A5C794376E9141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34278 mRNA. Translation: AAC59717.1.
RefSeqiNP_990300.1. NM_204969.1.
UniGeneiGga.1205.

Genome annotation databases

GeneIDi395816.
KEGGigga:395816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34278 mRNA. Translation: AAC59717.1.
RefSeqiNP_990300.1. NM_204969.1.
UniGeneiGga.1205.

3D structure databases

ProteinModelPortaliQ90678.
SMRiQ90678.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026919.

Protein family/group databases

ESTHERichick-pafa. PAF-Acetylhydrolase.

Proteomic databases

PaxDbiQ90678.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395816.
KEGGigga:395816.

Organism-specific databases

CTDi7941.

Phylogenomic databases

eggNOGiKOG3847. Eukaryota.
ENOG4111FH0. LUCA.
HOGENOMiHOG000008053.
HOVERGENiHBG001322.
InParanoidiQ90678.
KOiK01062.
PhylomeDBiQ90678.

Miscellaneous databases

PROiPR:Q90678.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro-like.
IPR016715. PAF_acetylhydro_eukaryote.
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiView protein in Pfam
PF03403. PAF-AH_p_II. 1 hit.
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiView protein in PROSITE
PS00120. LIPASE_SER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPAFA_CHICK
AccessioniPrimary (citable) accession number: Q90678
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 10, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.