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Protein

Platelet-activating factor acetylhydrolase

Gene

PLA2G7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei266NucleophileBy similarity1
Active sitei289Charge relay systemPROSITE-ProRule annotation1
Active sitei345Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Protein family/group databases

ESTHERichick-pafa PAF-Acetylhydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase (EC:3.1.1.47)
Short name:
PAF acetylhydrolase
Alternative name(s):
1-alkyl-2-acetylglycerophosphocholine esterase
2-acetyl-1-alkylglycerophosphocholine esterase
LDL-associated phospholipase A2
Short name:
LDL-PLA(2)
PAF 2-acylhydrolase
Gene namesi
Name:PLA2G7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001783522 – 422Platelet-activating factor acetylhydrolaseAdd BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90678
PRIDEiQ90678

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026919

Structurei

3D structure databases

ProteinModelPortaliQ90678
SMRiQ90678
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3847 Eukaryota
ENOG4111FH0 LUCA
HOGENOMiHOG000008053
HOVERGENiHBG001322
InParanoidiQ90678
KOiK01062
PhylomeDBiQ90678

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR005065 PAF_acetylhydro-like
IPR016715 PAF_acetylhydro_eukaryote
PANTHERiPTHR10272 PTHR10272, 1 hit
PfamiView protein in Pfam
PF03403 PAF-AH_p_II, 1 hit
PIRSFiPIRSF018169 PAF_acetylhydrolase, 1 hit
SUPFAMiSSF53474 SSF53474, 2 hits
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90678-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLWVRARR VFMKSRASGF SAKAATEMGS GGAEKGYRIP AGKGPHAVGC
60 70 80 90 100
TDLMTGDAAE GSFLRLYYLS CDDTDTEETP WIPDKEYYQG LSDFLNVYRA
110 120 130 140 150
LGERLFQYYV GSVTCPAKSN AAFKPGEKYP LLVFSHGLGA FRTIYSAICI
160 170 180 190 200
EMASQGFLVA AVEHRDESAS ATYFCKKKAD SEPEEDQTSG VEKEWIYYRK
210 220 230 240 250
LRAGEEERCL RHKQVQQRAQ ECIKALNLIL KISSGEEVMN VLNSDFDWNH
260 270 280 290 300
LKDSVDTSRI AVMGHSFGGA TVIESLSKEI RFRCGIALDA WMLPVGDDTY
310 320 330 340 350
QSSVQQPLLF INSEKFQWAA NILKMKKLSS NDTNKKMITI KGSVHQSFPD
360 370 380 390 400
FTFVSGEIIG KFFKLKGEID PNEAIDICNH ASLAFLQKHL SLKRDFDKWD
410 420
SLVDGIGPNV ISGTNIDLSP TE
Length:422
Mass (Da):47,046
Last modified:November 1, 1997 - v1
Checksum:i15A5C794376E9141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34278 mRNA Translation: AAC59717.1
RefSeqiNP_990300.1, NM_204969.1
UniGeneiGga.1205

Genome annotation databases

GeneIDi395816
KEGGigga:395816

Similar proteinsi

Entry informationi

Entry nameiPAFA_CHICK
AccessioniPrimary (citable) accession number: Q90678
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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