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Q90678

- PAFA_CHICK

UniProt

Q90678 - PAFA_CHICK

Protein

Platelet-activating factor acetylhydrolase

Gene

PLA2G7

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

    Catalytic activityi

    1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei266 – 2661NucleophileBy similarity
    Active sitei289 – 2891Charge relay systemPROSITE-ProRule annotation
    Active sitei345 – 3451Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet-activating factor acetylhydrolase (EC:3.1.1.47)
    Short name:
    PAF acetylhydrolase
    Alternative name(s):
    1-alkyl-2-acetylglycerophosphocholine esterase
    2-acetyl-1-alkylglycerophosphocholine esterase
    LDL-associated phospholipase A2
    Short name:
    LDL-PLA(2)
    PAF 2-acylhydrolase
    Gene namesi
    Name:PLA2G7
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 422401Platelet-activating factor acetylhydrolasePRO_0000017835Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ90678.

    Expressioni

    Tissue specificityi

    Plasma.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000026919.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90678.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4188.
    HOGENOMiHOG000008053.
    HOVERGENiHBG001322.
    InParanoidiQ90678.
    KOiK01062.
    PhylomeDBiQ90678.

    Family and domain databases

    Gene3Di3.40.50.1820. 3 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR005065. PAF_acetylhydro.
    IPR016715. PAF_acetylhydro_eukaryote.
    [Graphical view]
    PANTHERiPTHR10272. PTHR10272. 1 hit.
    PfamiPF03403. PAF-AH_p_II. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90678-1 [UniParc]FASTAAdd to Basket

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    MASLWVRARR VFMKSRASGF SAKAATEMGS GGAEKGYRIP AGKGPHAVGC    50
    TDLMTGDAAE GSFLRLYYLS CDDTDTEETP WIPDKEYYQG LSDFLNVYRA 100
    LGERLFQYYV GSVTCPAKSN AAFKPGEKYP LLVFSHGLGA FRTIYSAICI 150
    EMASQGFLVA AVEHRDESAS ATYFCKKKAD SEPEEDQTSG VEKEWIYYRK 200
    LRAGEEERCL RHKQVQQRAQ ECIKALNLIL KISSGEEVMN VLNSDFDWNH 250
    LKDSVDTSRI AVMGHSFGGA TVIESLSKEI RFRCGIALDA WMLPVGDDTY 300
    QSSVQQPLLF INSEKFQWAA NILKMKKLSS NDTNKKMITI KGSVHQSFPD 350
    FTFVSGEIIG KFFKLKGEID PNEAIDICNH ASLAFLQKHL SLKRDFDKWD 400
    SLVDGIGPNV ISGTNIDLSP TE 422
    Length:422
    Mass (Da):47,046
    Last modified:November 1, 1997 - v1
    Checksum:i15A5C794376E9141
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34278 mRNA. Translation: AAC59717.1.
    RefSeqiNP_990300.1. NM_204969.1.
    UniGeneiGga.1205.

    Genome annotation databases

    GeneIDi395816.
    KEGGigga:395816.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34278 mRNA. Translation: AAC59717.1 .
    RefSeqi NP_990300.1. NM_204969.1.
    UniGenei Gga.1205.

    3D structure databases

    ProteinModelPortali Q90678.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000026919.

    Proteomic databases

    PaxDbi Q90678.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395816.
    KEGGi gga:395816.

    Organism-specific databases

    CTDi 7941.

    Phylogenomic databases

    eggNOGi COG4188.
    HOGENOMi HOG000008053.
    HOVERGENi HBG001322.
    InParanoidi Q90678.
    KOi K01062.
    PhylomeDBi Q90678.

    Miscellaneous databases

    NextBioi 20815884.
    PROi Q90678.

    Family and domain databases

    Gene3Di 3.40.50.1820. 3 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR005065. PAF_acetylhydro.
    IPR016715. PAF_acetylhydro_eukaryote.
    [Graphical view ]
    PANTHERi PTHR10272. PTHR10272. 1 hit.
    Pfami PF03403. PAF-AH_p_II. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018169. PAF_acetylhydrolase. 1 hit.
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad."
      Tjoelker L.W., Eberhardt C., Unger J., le Trong H., Zimmerman G.A., McIntyre T.M., Stafforini D.M., Prescott S.M., Gray P.W.
      J. Biol. Chem. 270:25481-25487(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiPAFA_CHICK
    AccessioniPrimary (citable) accession number: Q90678
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3