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Q90670 (AVR2B_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Activin receptor type-2B

EC=2.7.11.30
Alternative name(s):
Activin receptor type IIB
Short name=ACTR-IIB
Gene names
Name:ACVR2B
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. Ref.1 Ref.2 Ref.3 Ref.5

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Not expressed in hen anterior pituitary during the ovulatory cycle but expressed in the ovarian follicle. Ref.4 Ref.5

Developmental stage

Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG). Ref.1 Ref.2 Ref.3

Induction

By activin. Ref.1

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 512488Activin receptor type-2B
PRO_0000269546

Regions

Topological domain25 – 137113Extracellular Potential
Transmembrane138 – 15821Helical; Potential
Topological domain159 – 512354Cytoplasmic Potential
Domain190 – 478289Protein kinase
Nucleotide binding196 – 2049ATP By similarity
Compositional bias128 – 1336Poly-Pro
Compositional bias176 – 1838Poly-Pro

Sites

Active site3211Proton acceptor By similarity
Binding site2171ATP By similarity

Amino acid modifications

Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation651N-linked (GlcNAc...) Potential
Disulfide bond29 ↔ 59 By similarity
Disulfide bond49 ↔ 77 By similarity
Disulfide bond84 ↔ 103 By similarity
Disulfide bond90 ↔ 102 By similarity
Disulfide bond104 ↔ 109 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90670 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6051F0CBE94AE060

FASTA51257,776
        10         20         30         40         50         60 
MSASWLTLAV LCATLGAGPG HGEAETRECI YYNANWELEK TNQSGVERCE GEKDKRLHCY 

        70         80         90        100        110        120 
ASWRNNSGSI ELVKKGCWLD DFNCYDRQEC VATEENPQVF FCCCEGNYCN EKFTHLPEVT 

       130        140        150        160        170        180 
GPEVIYEPPP PTPSLLNILV YSLLPIAVLS VAILLAFWMY RHRKPPYGHV DINEDPGPPP 

       190        200        210        220        230        240 
PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDYVAVKIFP IQDKQSWQSE REIFNTPGMK 

       250        260        270        280        290        300 
HENLLQFIAA EKRGTNLETE LWLITAFHDK GSLTDYLKGN IISWNELCHV AETMARGLSY 

       310        320        330        340        350        360 
LHEDVPWCKG EGHKPAIAHR DFKSKNVLLK NDLTAVLADF GLAVRFEPGK PPGDTHGQVG 

       370        380        390        400        410        420 
TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC RAVDGPVDEY MLPFEEEIGQ 

       430        440        450        460        470        480 
HPSLEDLQEV VVHKKMRPVF KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERIAQ 

       490        500        510 
IRKSVNGTTS DCLVSIVTSV TNVDLPPKES SI 

« Hide

References

[1]"Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo."
Stern C.D., Yu R.T., Kakizuka A., Kintner C.R., Mathews L.S., Vale W.W., Evans R.M., Umesono K.
Dev. Biol. 172:192-205(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, FUNCTION, INDUCTION.
[2]"Activin type II receptors in embryonic dorsal root ganglion neurons of the chicken."
Kos K., Fine L., Coulombe J.N.
J. Neurobiol. 47:93-108(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[3]"The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube."
Timmer J., Chesnutt C., Niswander L.
Dev. Biol. 285:1-10(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[4]"Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle."
Lovell T.M., Knight P.G., Gladwell R.T.
J. Endocrinol. 186:447-455(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary."
Lovell T.M., Knight P.G., Gladwell R.T.
J. Endocrinol. 188:241-249(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31223 mRNA. Translation: AAA87842.1.
RefSeqNP_989648.1. NM_204317.1.
UniGeneGga.764.

3D structure databases

ProteinModelPortalQ90670.
SMRQ90670. Positions 24-117, 190-484.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000030643.

Proteomic databases

PaxDbQ90670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID374213.
KEGGgga:374213.

Organism-specific databases

CTD93.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000231495.
HOVERGENHBG054502.
InParanoidQ90670.
KOK13596.
PhylomeDBQ90670.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255:SF10. PTHR23255:SF10. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR00653. ACTIVIN2R.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20813717.
PROQ90670.

Entry information

Entry nameAVR2B_CHICK
AccessionPrimary (citable) accession number: Q90670
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families