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Q90670

- AVR2B_CHICK

UniProt

Q90670 - AVR2B_CHICK

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Protein
Activin receptor type-2B
Gene
ACVR2B
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.4 Publications

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei217 – 2171ATP By similarity
Active sitei321 – 3211Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi196 – 2049ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transforming growth factor beta-activated receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-2B (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type IIB
    Short name:
    ACTR-IIB
    Gene namesi
    Name:ACVR2B
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 137113Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei138 – 15821Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini159 – 512354Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424 Reviewed prediction
    Add
    BLAST
    Chaini25 – 512488Activin receptor type-2B
    PRO_0000269546Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 59 By similarity
    Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi49 ↔ 77 By similarity
    Glycosylationi65 – 651N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi84 ↔ 103 By similarity
    Disulfide bondi90 ↔ 102 By similarity
    Disulfide bondi104 ↔ 109 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ90670.

    Expressioni

    Tissue specificityi

    Not expressed in hen anterior pituitary during the ovulatory cycle but expressed in the ovarian follicle.2 Publications

    Developmental stagei

    Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG).3 Publications

    Inductioni

    By activin.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000030643.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90670.
    SMRiQ90670. Positions 24-117, 190-484.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini190 – 478289Protein kinase
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi128 – 1336Poly-Pro
    Compositional biasi176 – 1838Poly-Pro

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000231495.
    HOVERGENiHBG054502.
    InParanoidiQ90670.
    KOiK13596.
    PhylomeDBiQ90670.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90670-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASWLTLAV LCATLGAGPG HGEAETRECI YYNANWELEK TNQSGVERCE    50
    GEKDKRLHCY ASWRNNSGSI ELVKKGCWLD DFNCYDRQEC VATEENPQVF 100
    FCCCEGNYCN EKFTHLPEVT GPEVIYEPPP PTPSLLNILV YSLLPIAVLS 150
    VAILLAFWMY RHRKPPYGHV DINEDPGPPP PSPLVGLKPL QLLEIKARGR 200
    FGCVWKAQLM NDYVAVKIFP IQDKQSWQSE REIFNTPGMK HENLLQFIAA 250
    EKRGTNLETE LWLITAFHDK GSLTDYLKGN IISWNELCHV AETMARGLSY 300
    LHEDVPWCKG EGHKPAIAHR DFKSKNVLLK NDLTAVLADF GLAVRFEPGK 350
    PPGDTHGQVG TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC 400
    RAVDGPVDEY MLPFEEEIGQ HPSLEDLQEV VVHKKMRPVF KDHWLKHPGL 450
    AQLCVTIEEC WDHDAEARLS AGCVEERIAQ IRKSVNGTTS DCLVSIVTSV 500
    TNVDLPPKES SI 512
    Length:512
    Mass (Da):57,776
    Last modified:November 1, 1996 - v1
    Checksum:i6051F0CBE94AE060
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31223 mRNA. Translation: AAA87842.1.
    RefSeqiNP_989648.1. NM_204317.1.
    UniGeneiGga.764.

    Genome annotation databases

    GeneIDi374213.
    KEGGigga:374213.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31223 mRNA. Translation: AAA87842.1 .
    RefSeqi NP_989648.1. NM_204317.1.
    UniGenei Gga.764.

    3D structure databases

    ProteinModelPortali Q90670.
    SMRi Q90670. Positions 24-117, 190-484.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000030643.

    Proteomic databases

    PaxDbi Q90670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 374213.
    KEGGi gga:374213.

    Organism-specific databases

    CTDi 93.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000231495.
    HOVERGENi HBG054502.
    InParanoidi Q90670.
    KOi K13596.
    PhylomeDBi Q90670.

    Miscellaneous databases

    NextBioi 20813717.
    PROi Q90670.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo."
      Stern C.D., Yu R.T., Kakizuka A., Kintner C.R., Mathews L.S., Vale W.W., Evans R.M., Umesono K.
      Dev. Biol. 172:192-205(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, FUNCTION, INDUCTION.
    2. "Activin type II receptors in embryonic dorsal root ganglion neurons of the chicken."
      Kos K., Fine L., Coulombe J.N.
      J. Neurobiol. 47:93-108(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    3. "The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube."
      Timmer J., Chesnutt C., Niswander L.
      Dev. Biol. 285:1-10(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    4. "Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle."
      Lovell T.M., Knight P.G., Gladwell R.T.
      J. Endocrinol. 186:447-455(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary."
      Lovell T.M., Knight P.G., Gladwell R.T.
      J. Endocrinol. 188:241-249(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiAVR2B_CHICK
    AccessioniPrimary (citable) accession number: Q90670
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: November 1, 1996
    Last modified: June 11, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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