Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q90669

- AVR2A_CHICK

UniProt

Q90669 - AVR2A_CHICK

Protein

Activin receptor type-2A

Gene

ACVR2A

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.4 Publications

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei219 – 2191ATPPROSITE-ProRule annotation
    Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi198 – 2069ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. activin-activated receptor activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. coreceptor activity Source: Ensembl
    4. metal ion binding Source: UniProtKB-KW
    5. receptor signaling protein serine/threonine kinase activity Source: InterPro
    6. transforming growth factor beta-activated receptor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. BMP signaling pathway Source: Ensembl
    3. determination of left/right symmetry Source: Ensembl
    4. embryonic skeletal system development Source: Ensembl
    5. gastrulation with mouth forming second Source: Ensembl
    6. mesoderm development Source: Ensembl
    7. penile erection Source: Ensembl
    8. positive regulation of activin receptor signaling pathway Source: Ensembl
    9. positive regulation of bone mineralization Source: Ensembl
    10. positive regulation of erythrocyte differentiation Source: Ensembl
    11. positive regulation of osteoblast differentiation Source: Ensembl
    12. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    13. regulation of BMP signaling pathway Source: Ensembl
    14. regulation of nitric-oxide synthase activity Source: Ensembl
    15. Sertoli cell proliferation Source: Ensembl
    16. spermatogenesis Source: Ensembl
    17. sperm ejaculation Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_197099. Regulation of signaling by NODAL.
    REACT_197117. Signaling by Activin.
    REACT_197118. Signaling by NODAL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-2A (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type IIA
    Short name:
    ACTR-IIA
    Short name:
    ACTRIIA
    Gene namesi
    Name:ACVR2A
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 7

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. inhibin-betaglycan-ActRII complex Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 513494Activin receptor type-2APRO_0000269545Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ90669.

    Expressioni

    Tissue specificityi

    Expressed in hen anterior pituitary during the ovulatory cycle and in the ovarian follicle.2 Publications

    Developmental stagei

    Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG).4 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliQ90669.
    SMRiQ90669. Positions 26-119, 192-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 139120ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini161 – 513353CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini192 – 485294Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi178 – 1858Poly-Pro

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00560000076906.
    HOGENOMiHOG000231495.
    HOVERGENiHBG054502.
    InParanoidiQ90669.
    KOiK04670.
    OMAiEDPGNWI.
    PhylomeDBiQ90669.
    TreeFamiTF352876.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90669-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAATKLAFA VFLISCSSGA ILGRSETQEC IYYNANWEKD KTNRSGIEPC    50
    YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRND CIEKKDSPEV 100
    FFCCCEGNMC NERFFYFPEM EVTQPTSNPV TPKPPLFNTL LYSLVPIMGI 150
    AVIVLFSFWM YRHHKLAYPP VLVPTQDPGP PPPSPLMGLK PLQLLEIKAR 200
    GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEIYSLPG MKHDNILQFI 250
    GAEKRGTSID VDLWLITAFH EKGSLTDFLK ANVVSWNELC HIAQTMARGL 300
    AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG 350
    KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR 400
    CTASDGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRECWQKHSG 450
    MAMLCETIEE CWDHDAEARL SAGCVEERII QMQKLTNIIT TEDIVTVVTM 500
    VTNVDFPPKE SSL 513
    Length:513
    Mass (Da):58,092
    Last modified:November 1, 1996 - v1
    Checksum:i03128AB7FF732552
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91F → L in BAA06697. (PubMed:1318847)Curated
    Sequence conflicti43 – 453NRS → IAV in BAA06697. (PubMed:1318847)Curated
    Sequence conflicti115 – 1151F → S in BAA06697. (PubMed:1318847)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31899 mRNA. Translation: BAA06697.1.
    U31222 mRNA. Translation: AAA87841.1.
    PIRiS23089.
    RefSeqiNP_990698.1. NM_205367.1.
    UniGeneiGga.2852.

    Genome annotation databases

    EnsembliENSGALT00000037806; ENSGALP00000037012; ENSGALG00000012444.
    GeneIDi396324.
    KEGGigga:396324.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D31899 mRNA. Translation: BAA06697.1 .
    U31222 mRNA. Translation: AAA87841.1 .
    PIRi S23089.
    RefSeqi NP_990698.1. NM_205367.1.
    UniGenei Gga.2852.

    3D structure databases

    ProteinModelPortali Q90669.
    SMRi Q90669. Positions 26-119, 192-479.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q90669.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000037806 ; ENSGALP00000037012 ; ENSGALG00000012444 .
    GeneIDi 396324.
    KEGGi gga:396324.

    Organism-specific databases

    CTDi 92.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00560000076906.
    HOGENOMi HOG000231495.
    HOVERGENi HBG054502.
    InParanoidi Q90669.
    KOi K04670.
    OMAi EDPGNWI.
    PhylomeDBi Q90669.
    TreeFami TF352876.

    Enzyme and pathway databases

    Reactomei REACT_197099. Regulation of signaling by NODAL.
    REACT_197117. Signaling by Activin.
    REACT_197118. Signaling by NODAL.

    Miscellaneous databases

    NextBioi 20816372.
    PROi Q90669.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression pattern of the activin receptor type IIA gene during differentiation of chick neural tissues, muscle and skin."
      Ohuchi H., Noji S., Koyama E., Myokai F., Nishikawa K., Nohno T., Tashiro K., Shiokawa K., Matsuo N., Taniguchi S.
      FEBS Lett. 303:185-189(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Tissue: Embryo.
    2. "Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo."
      Stern C.D., Yu R.T., Kakizuka A., Kintner C.R., Mathews L.S., Vale W.W., Evans R.M., Umesono K.
      Dev. Biol. 172:192-205(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, FUNCTION.
      Tissue: Embryo.
    3. "Activin type II receptors in embryonic dorsal root ganglion neurons of the chicken."
      Kos K., Fine L., Coulombe J.N.
      J. Neurobiol. 47:93-108(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    4. "The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube."
      Timmer J., Chesnutt C., Niswander L.
      Dev. Biol. 285:1-10(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    5. "Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle."
      Lovell T.M., Knight P.G., Gladwell R.T.
      J. Endocrinol. 186:447-455(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary."
      Lovell T.M., Knight P.G., Gladwell R.T.
      J. Endocrinol. 188:241-249(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiAVR2A_CHICK
    AccessioniPrimary (citable) accession number: Q90669
    Secondary accession number(s): Q90745
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3