Reviewed, UniProtKB/Swiss-Prot Q90669 (AVR2A_CHICK)

Names and origin

Protein names

Recommended name:
    Activin receptor type-2A
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IIA
      Short name=ACTR-IIA
      Short name=ACTRIIA

Gene names

Name:

ACVR2A

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane proteinBy similarity.
Tissue specificity	Expressed in hen anterior pituitary during the ovulatory cycle and in the ovarian follicle.
Developmental stage	Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG).
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 513	494	Activin receptor type-2A
Regions
	Topological domain	20 – 139	120	Extracellular Potential
	Transmembrane	140 – 160	21	Potential
	Topological domain	161 – 513	353	Cytoplasmic Potential
	Domain	192 – 485	294	Protein kinase
	Nucleotide binding	198 – 206	9	ATP By similarity
	Compositional bias	178 – 185	8	Poly-Pro
Sites
	Active site	322	1	Proton acceptor By similarity
	Binding site	219	1	ATP By similarity
Amino acid modifications
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	9	1	F → L in BAA06697. Ref.1
	Sequence conflict	43 – 45	3	NRS → IAV in BAA06697. Ref.1
	Sequence conflict	115	1	F → S in BAA06697. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q90669-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 03128AB7FF732552	FASTA	513	58,092
	10 20 30 40 50 60 MGAATKLAFA VFLISCSSGA ILGRSETQEC IYYNANWEKD KTNRSGIEPC YGDKDKRRHC 70 80 90 100 110 120 FATWKNISGS IEIVKQGCWL DDINCYDRND CIEKKDSPEV FFCCCEGNMC NERFFYFPEM 130 140 150 160 170 180 EVTQPTSNPV TPKPPLFNTL LYSLVPIMGI AVIVLFSFWM YRHHKLAYPP VLVPTQDPGP 190 200 210 220 230 240 PPPSPLMGLK PLQLLEIKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEIYSLPG 250 260 270 280 290 300 MKHDNILQFI GAEKRGTSID VDLWLITAFH EKGSLTDFLK ANVVSWNELC HIAQTMARGL 310 320 330 340 350 360 AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 370 380 390 400 410 420 GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTASDGPVDE YMLPFEEEIG 430 440 450 460 470 480 QHPSLEDMQE VVVHKKKRPV LRECWQKHSG MAMLCETIEE CWDHDAEARL SAGCVEERII 490 500 510 QMQKLTNIIT TEDIVTVVTM VTNVDFPPKE SSL

References

[1]	"Expression pattern of the activin receptor type IIA gene during differentiation of chick neural tissues, muscle and skin." Ohuchi H., Noji S., Koyama E., Myokai F., Nishikawa K., Nohno T., Tashiro K., Shiokawa K., Matsuo N., Taniguchi S. FEBS Lett. 303:185-189(1992) [PubMed: 1318847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE. Tissue: Embryo.
[2]	"Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo." Stern C.D., Yu R.T., Kakizuka A., Kintner C.R., Mathews L.S., Vale W.W., Evans R.M., Umesono K. Dev. Biol. 172:192-205(1995) [PubMed: 7589799] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, FUNCTION. Tissue: Embryo.
[3]	"Activin type II receptors in embryonic dorsal root ganglion neurons of the chicken." Kos K., Fine L., Coulombe J.N. J. Neurobiol. 47:93-108(2001) [PubMed: 11291100] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[4]	"The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube." Timmer J., Chesnutt C., Niswander L. Dev. Biol. 285:1-10(2005) [PubMed: 16039645] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[5]	"Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle." Lovell T.M., Knight P.G., Gladwell R.T. J. Endocrinol. 186:447-455(2005) [PubMed: 16135664] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary." Lovell T.M., Knight P.G., Gladwell R.T. J. Endocrinol. 188:241-249(2006) [PubMed: 16461550] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D31899 mRNA. Translation: BAA06697.1. U31222 mRNA. Translation: AAA87841.1.
PIR	S23089.
RefSeq	NP_990698.1.
UniGene	Gga.2852
3D structure databases
HSSP	HSSP built from PDB template 1BTE based on UniProtKB P27038.
SMR	Q90669. Positions 26-119.
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALG00000012444. Gallus gallus. [Contig view]
GeneID	396324.
KEGG	gga:396324.
Phylogenomic databases
HOVERGEN	Q90669.
Family and domain databases
InterPro	IPR000333. Activin_II_recpt. IPR015768. Activin_II_recpt_C. IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
PANTHER	PTHR23255:SF10. Activin_II_recpt_C. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

AVR2A_CHICK

Accession

Primary (citable) accession number: Q90669
Secondary accession number(s): Q90745

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 1, 1996
Last modified:	July 22, 2008
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)