Activin receptor type-2A precursor - Gallus gallus (Chicken)

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Q90669 (AVR2A_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 84. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Activin receptor type-2A
EC=2.7.11.30

Alternative name(s):
Activin receptor type IIA
Short name=ACTR-IIA
Short name=ACTRIIA

Gene names

Name:

ACVR2A

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. Ref.2 Ref.3 Ref.4 Ref.6
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Expressed in hen anterior pituitary during the ovulatory cycle and in the ovarian follicle. Ref.5 Ref.6
Developmental stage	Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG). Ref.1 Ref.2 Ref.3 Ref.4
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activin receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW receptor signaling protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro transforming growth factor beta-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

Potential

Chain

20 – 513

494

Activin receptor type-2A

PRO_0000269545

Regions

Topological domain

20 – 139

120

Extracellular Potential

Transmembrane

140 – 160

Helical; Potential

Topological domain

161 – 513

353

Cytoplasmic Potential

Domain

192 – 485

294

Protein kinase

Nucleotide binding

198 – 206

ATP By similarity

Compositional bias

178 – 185

Poly-Pro

Sites

Active site

322

Proton acceptor By similarity

Binding site

219

ATP By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

F → L in BAA06697. Ref.1

Sequence conflict

43 – 45

NRS → IAV in BAA06697. Ref.1

Sequence conflict

115

F → S in BAA06697. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q90669 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 03128AB7FF732552
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FASTA

513

58,092

        10         20         30         40         50         60 
MGAATKLAFA VFLISCSSGA ILGRSETQEC IYYNANWEKD KTNRSGIEPC YGDKDKRRHC 

        70         80         90        100        110        120 
FATWKNISGS IEIVKQGCWL DDINCYDRND CIEKKDSPEV FFCCCEGNMC NERFFYFPEM 

       130        140        150        160        170        180 
EVTQPTSNPV TPKPPLFNTL LYSLVPIMGI AVIVLFSFWM YRHHKLAYPP VLVPTQDPGP 

       190        200        210        220        230        240 
PPPSPLMGLK PLQLLEIKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEIYSLPG 

       250        260        270        280        290        300 
MKHDNILQFI GAEKRGTSID VDLWLITAFH EKGSLTDFLK ANVVSWNELC HIAQTMARGL 

       310        320        330        340        350        360 
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 

       370        380        390        400        410        420 
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTASDGPVDE YMLPFEEEIG 

       430        440        450        460        470        480 
QHPSLEDMQE VVVHKKKRPV LRECWQKHSG MAMLCETIEE CWDHDAEARL SAGCVEERII 

       490        500        510 
QMQKLTNIIT TEDIVTVVTM VTNVDFPPKE SSL

« Hide

References

[1]	"Expression pattern of the activin receptor type IIA gene during differentiation of chick neural tissues, muscle and skin." Ohuchi H., Noji S., Koyama E., Myokai F., Nishikawa K., Nohno T., Tashiro K., Shiokawa K., Matsuo N., Taniguchi S. FEBS Lett. 303:185-189(1992) [PubMed: 1318847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE. Tissue: Embryo.
[2]	"Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo." Stern C.D., Yu R.T., Kakizuka A., Kintner C.R., Mathews L.S., Vale W.W., Evans R.M., Umesono K. Dev. Biol. 172:192-205(1995) [PubMed: 7589799] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, FUNCTION. Tissue: Embryo.
[3]	"Activin type II receptors in embryonic dorsal root ganglion neurons of the chicken." Kos K., Fine L., Coulombe J.N. J. Neurobiol. 47:93-108(2001) [PubMed: 11291100] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[4]	"The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube." Timmer J., Chesnutt C., Niswander L. Dev. Biol. 285:1-10(2005) [PubMed: 16039645] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[5]	"Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle." Lovell T.M., Knight P.G., Gladwell R.T. J. Endocrinol. 186:447-455(2005) [PubMed: 16135664] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary." Lovell T.M., Knight P.G., Gladwell R.T. J. Endocrinol. 188:241-249(2006) [PubMed: 16461550] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D31899 mRNA. Translation: BAA06697.1. U31222 mRNA. Translation: AAA87841.1.
IPI	IPI00588623.
PIR	S23089.
RefSeq	NP_990698.1. NM_205367.1.
UniGene	Gga.2852.
3D structure databases
HSSP	HSSP built from PDB template 1BTE based on UniProtKB P27038.
ProteinModelPortal	Q90669.
SMR	Q90669. Positions 26-119, 192-479.
ModBase	Search...
Protein-protein interaction databases
STRING	Q90669.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000020344; ENSGALP00000020317; ENSGALG00000012444.
GeneID	396324.
KEGG	gga:396324.
Organism-specific databases
CTD	92.
Phylogenomic databases
eggNOG	veNOG05750.
HOGENOM	HBG403003.
HOVERGEN	HBG054502.
InParanoid	Q90669.
OMA	FWMYRHH.
OrthoDB	EOG47WNNH.
Family and domain databases
InterPro	IPR000333. Activin_II/TGFBeta-II_recpt. IPR015768. Activin_II_recpt. IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
KO	K04670.
PANTHER	PTHR23255:SF10. Activin_II_recpt_C. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AVR2A_CHICK

Accession

Primary (citable) accession number: Q90669
Secondary accession number(s): Q90745

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents