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Q90669

- AVR2A_CHICK

UniProt

Q90669 - AVR2A_CHICK

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Protein

Activin receptor type-2A

Gene

ACVR2A

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.4 Publications

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei219 – 2191ATPPROSITE-ProRule annotation
Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi198 – 2069ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. activin-activated receptor activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. coreceptor activity Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW
  5. receptor signaling protein serine/threonine kinase activity Source: InterPro
  6. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. BMP signaling pathway Source: Ensembl
  3. cellular response to BMP stimulus Source: Ensembl
  4. determination of left/right symmetry Source: Ensembl
  5. embryonic skeletal system development Source: Ensembl
  6. gastrulation with mouth forming second Source: Ensembl
  7. mesoderm development Source: Ensembl
  8. penile erection Source: Ensembl
  9. positive regulation of activin receptor signaling pathway Source: Ensembl
  10. positive regulation of bone mineralization Source: Ensembl
  11. positive regulation of erythrocyte differentiation Source: Ensembl
  12. positive regulation of osteoblast differentiation Source: Ensembl
  13. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  14. regulation of BMP signaling pathway Source: Ensembl
  15. regulation of nitric-oxide synthase activity Source: Ensembl
  16. Sertoli cell proliferation Source: Ensembl
  17. spermatogenesis Source: Ensembl
  18. sperm ejaculation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197099. Regulation of signaling by NODAL.
REACT_197117. Signaling by Activin.
REACT_197118. Signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2A (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIA
Short name:
ACTR-IIA
Short name:
ACTRIIA
Gene namesi
Name:ACVR2A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 7

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. inhibin-betaglycan-ActRII complex Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 513494Activin receptor type-2APRO_0000269545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90669.

Expressioni

Tissue specificityi

Expressed in hen anterior pituitary during the ovulatory cycle and in the ovarian follicle.2 Publications

Developmental stagei

Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG).4 Publications

Gene expression databases

ExpressionAtlasiQ90669. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ90669.
SMRiQ90669. Positions 26-119, 192-479.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 139120ExtracellularSequence AnalysisAdd
BLAST
Topological domaini161 – 513353CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 485294Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi178 – 1858Poly-Pro

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG054502.
InParanoidiQ90669.
KOiK04670.
OMAiEDPGNWI.
PhylomeDBiQ90669.
TreeFamiTF352876.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90669-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAATKLAFA VFLISCSSGA ILGRSETQEC IYYNANWEKD KTNRSGIEPC
60 70 80 90 100
YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRND CIEKKDSPEV
110 120 130 140 150
FFCCCEGNMC NERFFYFPEM EVTQPTSNPV TPKPPLFNTL LYSLVPIMGI
160 170 180 190 200
AVIVLFSFWM YRHHKLAYPP VLVPTQDPGP PPPSPLMGLK PLQLLEIKAR
210 220 230 240 250
GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEIYSLPG MKHDNILQFI
260 270 280 290 300
GAEKRGTSID VDLWLITAFH EKGSLTDFLK ANVVSWNELC HIAQTMARGL
310 320 330 340 350
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG
360 370 380 390 400
KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR
410 420 430 440 450
CTASDGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRECWQKHSG
460 470 480 490 500
MAMLCETIEE CWDHDAEARL SAGCVEERII QMQKLTNIIT TEDIVTVVTM
510
VTNVDFPPKE SSL
Length:513
Mass (Da):58,092
Last modified:November 1, 1996 - v1
Checksum:i03128AB7FF732552
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91F → L in BAA06697. (PubMed:1318847)Curated
Sequence conflicti43 – 453NRS → IAV in BAA06697. (PubMed:1318847)Curated
Sequence conflicti115 – 1151F → S in BAA06697. (PubMed:1318847)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31899 mRNA. Translation: BAA06697.1.
U31222 mRNA. Translation: AAA87841.1.
PIRiS23089.
RefSeqiNP_990698.1. NM_205367.1.
UniGeneiGga.2852.

Genome annotation databases

EnsembliENSGALT00000037806; ENSGALP00000037012; ENSGALG00000012444.
GeneIDi396324.
KEGGigga:396324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D31899 mRNA. Translation: BAA06697.1 .
U31222 mRNA. Translation: AAA87841.1 .
PIRi S23089.
RefSeqi NP_990698.1. NM_205367.1.
UniGenei Gga.2852.

3D structure databases

ProteinModelPortali Q90669.
SMRi Q90669. Positions 26-119, 192-479.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q90669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000037806 ; ENSGALP00000037012 ; ENSGALG00000012444 .
GeneIDi 396324.
KEGGi gga:396324.

Organism-specific databases

CTDi 92.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118876.
HOGENOMi HOG000231495.
HOVERGENi HBG054502.
InParanoidi Q90669.
KOi K04670.
OMAi EDPGNWI.
PhylomeDBi Q90669.
TreeFami TF352876.

Enzyme and pathway databases

Reactomei REACT_197099. Regulation of signaling by NODAL.
REACT_197117. Signaling by Activin.
REACT_197118. Signaling by NODAL.

Miscellaneous databases

NextBioi 20816372.
PROi Q90669.

Gene expression databases

ExpressionAtlasi Q90669. baseline.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression pattern of the activin receptor type IIA gene during differentiation of chick neural tissues, muscle and skin."
    Ohuchi H., Noji S., Koyama E., Myokai F., Nishikawa K., Nohno T., Tashiro K., Shiokawa K., Matsuo N., Taniguchi S.
    FEBS Lett. 303:185-189(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  2. "Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo."
    Stern C.D., Yu R.T., Kakizuka A., Kintner C.R., Mathews L.S., Vale W.W., Evans R.M., Umesono K.
    Dev. Biol. 172:192-205(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, FUNCTION.
    Tissue: Embryo.
  3. "Activin type II receptors in embryonic dorsal root ganglion neurons of the chicken."
    Kos K., Fine L., Coulombe J.N.
    J. Neurobiol. 47:93-108(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  4. "The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube."
    Timmer J., Chesnutt C., Niswander L.
    Dev. Biol. 285:1-10(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  5. "Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle."
    Lovell T.M., Knight P.G., Gladwell R.T.
    J. Endocrinol. 186:447-455(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary."
    Lovell T.M., Knight P.G., Gladwell R.T.
    J. Endocrinol. 188:241-249(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiAVR2A_CHICK
AccessioniPrimary (citable) accession number: Q90669
Secondary accession number(s): Q90745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3