Q90669 (AVR2A_CHICK) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 92.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Activin receptor type-2A EC=2.7.11.30 Alternative name(s): Activin receptor type IIA Short name=ACTR-IIA Short name=ACTRIIA | ||
| Gene names |
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| Organism | Gallus gallus (Chicken) [Reference proteome] | ||
| Taxonomic identifier | 9031 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 513 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. Ref.2 Ref.3 Ref.4 Ref.6 |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese By similarity. |
| Subcellular location | Membrane; Single-pass type I membrane protein By similarity. |
| Tissue specificity | Expressed in hen anterior pituitary during the ovulatory cycle and in the ovarian follicle. Ref.5 Ref.6 |
| Developmental stage | Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG). Ref.1 Ref.2 Ref.3 Ref.4 |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||
| Chain | 20 – 513 | 494 | Activin receptor type-2A | PRO_0000269545 | |||||
Regions | |||||||||
| Topological domain | 20 – 139 | 120 | Extracellular Potential | ||||||
| Transmembrane | 140 – 160 | 21 | Helical; Potential | ||||||
| Topological domain | 161 – 513 | 353 | Cytoplasmic Potential | ||||||
| Domain | 192 – 485 | 294 | Protein kinase | ||||||
| Nucleotide binding | 198 – 206 | 9 | ATP By similarity | ||||||
| Compositional bias | 178 – 185 | 8 | Poly-Pro | ||||||
Sites | |||||||||
| Active site | 322 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 219 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 43 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 66 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 9 | 1 | F → L in BAA06697. Ref.1 | ||||||
| Sequence conflict | 43 – 45 | 3 | NRS → IAV in BAA06697. Ref.1 | ||||||
| Sequence conflict | 115 | 1 | F → S in BAA06697. Ref.1 | ||||||
Sequences
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References
| [1] | "Expression pattern of the activin receptor type IIA gene during differentiation of chick neural tissues, muscle and skin." Ohuchi H., Noji S., Koyama E., Myokai F., Nishikawa K., Nohno T., Tashiro K., Shiokawa K., Matsuo N., Taniguchi S. FEBS Lett. 303:185-189(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE. Tissue: Embryo. |
| [2] | "Activin and its receptors during gastrulation and the later phases of mesoderm development in the chick embryo." Stern C.D., Yu R.T., Kakizuka A., Kintner C.R., Mathews L.S., Vale W.W., Evans R.M., Umesono K. Dev. Biol. 172:192-205(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, FUNCTION. Tissue: Embryo. |
| [3] | "Activin type II receptors in embryonic dorsal root ganglion neurons of the chicken." Kos K., Fine L., Coulombe J.N. J. Neurobiol. 47:93-108(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE. |
| [4] | "The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube." Timmer J., Chesnutt C., Niswander L. Dev. Biol. 285:1-10(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE. |
| [5] | "Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle." Lovell T.M., Knight P.G., Gladwell R.T. J. Endocrinol. 186:447-455(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [6] | "Differential expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and activin type-I and type-II receptors in preovulatory and prehierarchical follicles of the laying hen ovary." Lovell T.M., Knight P.G., Gladwell R.T. J. Endocrinol. 188:241-249(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D31899 mRNA. Translation: BAA06697.1. U31222 mRNA. Translation: AAA87841.1. |
| IPI | IPI00588623. |
| PIR | S23089. |
| RefSeq | NP_990698.1. NM_205367.1. |
| UniGene | Gga.2852. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BTE based on UniProtKB P27038. |
| ProteinModelPortal | Q90669. |
| SMR | Q90669. Positions 26-119, 192-479. |
| ModBase | Search... |
Proteomic databases | |
| PaxDb | Q90669. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSGALT00000020344; ENSGALP00000020317; ENSGALG00000012444. |
| GeneID | 396324. |
| KEGG | gga:396324. |
Organism-specific databases | |
| CTD | 92. |
Phylogenomic databases | |
| eggNOG | COG0515. |
| GeneTree | ENSGT00560000076906. |
| HOGENOM | HOG000231495. |
| HOVERGEN | HBG054502. |
| InParanoid | Q90669. |
| KO | K04670. |
| OMA | ERIIQMQ. |
| OrthoDB | EOG47WNNH. |
Gene expression databases | |
| ArrayExpress | Q90669. |
Family and domain databases | |
| InterPro | IPR000333. Activin_II/TGFBeta-II_recpt. IPR015768. Activin_II_recpt. IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view] |
| PANTHER | PTHR23255:SF10. PTHR23255:SF10. 1 hit. |
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view] |
| PRINTS | PR00653. ACTIVIN2R. |
| SUPFAM | SSF56112. Kinase_like. 1 hit. |
| PROSITE | PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 20816372. |
Entry information
| Entry name | AVR2A_CHICK | ||||||||
| Accession | Primary (citable) accession number: Q90669 Secondary accession number(s): Q90745 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |