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Protein

Activin receptor type-2A

Gene

ACVR2A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.4 Publications

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei219ATPPROSITE-ProRule annotation1
Active sitei322Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 206ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-1502540 Signaling by Activin
R-GGA-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2A (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIA
Short name:
ACTR-IIA
Short name:
ACTRIIA
Gene namesi
Name:ACVR2A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 139ExtracellularSequence analysisAdd BLAST120
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 513CytoplasmicSequence analysisAdd BLAST353

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000026954520 – 513Activin receptor type-2AAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 60By similarity
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi50 ↔ 78By similarity
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 104By similarity
Disulfide bondi91 ↔ 103By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90669

Expressioni

Tissue specificityi

Expressed in hen anterior pituitary during the ovulatory cycle and in the ovarian follicle.2 Publications

Developmental stagei

Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG).4 Publications

Gene expression databases

BgeeiENSGALG00000012444

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020317

Structurei

3D structure databases

ProteinModelPortaliQ90669
SMRiQ90669
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 485Protein kinasePROSITE-ProRule annotationAdd BLAST294

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi178 – 185Poly-Pro8

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653 Eukaryota
ENOG410XS2Z LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000231495
HOVERGENiHBG054502
InParanoidiQ90669
KOiK04670
OMAiRIIQMQR
OrthoDBiEOG091G03YO
PhylomeDBiQ90669
TreeFamiTF352876

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit
PRINTSiPR00653 ACTIVIN2R
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAATKLAFA VFLISCSSGA ILGRSETQEC IYYNANWEKD KTNRSGIEPC
60 70 80 90 100
YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRND CIEKKDSPEV
110 120 130 140 150
FFCCCEGNMC NERFFYFPEM EVTQPTSNPV TPKPPLFNTL LYSLVPIMGI
160 170 180 190 200
AVIVLFSFWM YRHHKLAYPP VLVPTQDPGP PPPSPLMGLK PLQLLEIKAR
210 220 230 240 250
GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEIYSLPG MKHDNILQFI
260 270 280 290 300
GAEKRGTSID VDLWLITAFH EKGSLTDFLK ANVVSWNELC HIAQTMARGL
310 320 330 340 350
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG
360 370 380 390 400
KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR
410 420 430 440 450
CTASDGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRECWQKHSG
460 470 480 490 500
MAMLCETIEE CWDHDAEARL SAGCVEERII QMQKLTNIIT TEDIVTVVTM
510
VTNVDFPPKE SSL
Length:513
Mass (Da):58,092
Last modified:November 1, 1996 - v1
Checksum:i03128AB7FF732552
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9F → L in BAA06697 (PubMed:1318847).Curated1
Sequence conflicti43 – 45NRS → IAV in BAA06697 (PubMed:1318847).Curated3
Sequence conflicti115F → S in BAA06697 (PubMed:1318847).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31899 mRNA Translation: BAA06697.1
U31222 mRNA Translation: AAA87841.1
PIRiS23089
RefSeqiNP_990698.1, NM_205367.1
UniGeneiGga.2852

Genome annotation databases

EnsembliENSGALT00000037806; ENSGALP00000037012; ENSGALG00000012444
GeneIDi396324
KEGGigga:396324

Similar proteinsi

Entry informationi

Entry nameiAVR2A_CHICK
AccessioniPrimary (citable) accession number: Q90669
Secondary accession number(s): Q90745
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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