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Protein

Inhibitor of apoptosis protein

Gene

ITA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Apoptotic suppressor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi299 – 2991ZincPROSITE-ProRule annotation
Metal bindingi302 – 3021ZincPROSITE-ProRule annotation
Metal bindingi319 – 3191ZincPROSITE-ProRule annotation
Metal bindingi326 – 3261ZincPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri564 – 59936RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-111465. Apoptotic cleavage of cellular proteins.
R-GGA-5357905. Regulation of TNFR1 signaling.
R-GGA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-GGA-5668541. TNFR2 non-canonical NF-kB pathway.
R-GGA-5675482. Regulation of necroptotic cell death.
R-GGA-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Protein family/group databases

MEROPSiI32.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of apoptosis protein
Short name:
IAP
Alternative name(s):
Inhibitor of T-cell apoptosis protein
Gene namesi
Name:ITA
Synonyms:IAP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 611611Inhibitor of apoptosis proteinPRO_0000122351Add
BLAST

Proteomic databases

PaxDbiQ90660.
PRIDEiQ90660.

Expressioni

Tissue specificityi

Cells of the T-lymphocyte lineage. Found in both cortical and medullary cells of the thymus. Expressed at relatively high levels also in spleen, bursa, intestine and lung and at very low levels in testis, brain and skeletal muscle.

Inductioni

High levels are induced within 4-8 hours of T-cell activation in spleen and thymus.

Gene expression databases

BgeeiENSGALG00000017186.
ExpressionAtlasiQ90660. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035646.

Structurei

3D structure databases

ProteinModelPortaliQ90660.
SMRiQ90660. Positions 259-349, 549-611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati30 – 9768BIR 1Add
BLAST
Repeati176 – 24267BIR 2Add
BLAST
Repeati262 – 32968BIR 3Add
BLAST
Domaini446 – 53691CARDPROSITE-ProRule annotationAdd
BLAST

Domaini

The ring finger is important for its antiapoptotic effect.

Sequence similaritiesi

Belongs to the IAP family.Curated
Contains 3 BIR repeats.PROSITE-ProRule annotation
Contains 1 CARD domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri564 – 59936RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
HOGENOMiHOG000232059.
HOVERGENiHBG004848.
InParanoidiQ90660.
KOiK16060.
OrthoDBiEOG091G0CXH.
PhylomeDBiQ90660.
TreeFamiTF105356.

Family and domain databases

Gene3Di1.10.1170.10. 4 hits.
1.10.533.10. 1 hit.
InterProiIPR001370. BIR_rpt.
IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF00653. BIR. 3 hits.
PF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 3 hits.
SM00114. CARD. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS01282. BIR_REPEAT_1. 3 hits.
PS50143. BIR_REPEAT_2. 3 hits.
PS50209. CARD. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIMDSSPLL ASVMKQNAHC GELKYDFSCE LYRMSTFSTF PVNVPVSERR
60 70 80 90 100
LARAGFYYTG VQDKVKCFSC GLVLDNWQPG DNAMEKHKQV YPSCSFVQNM
110 120 130 140 150
LSLNNLGLST HSAFSPLVAS NLSPSLRSMT LSPSFEQVGY FSGSFSSFPR
160 170 180 190 200
DPVTTRAAED LSHLRSKLQN PSMSTEEARL RTSHAWPLMC LWPAEVAKAG
210 220 230 240 250
LDDLGTADKV ACVNCGVKLS NWEPKDNAMS EHRRHFPNCP FVENLMRDQP
260 270 280 290 300
SFNVSNVTMQ THEARVKTFI NWPTRIPVQP EQLADAGFYY VGRNDDVKCF
310 320 330 340 350
CCDGGLRCWE SGDDPWIEHA KWFPRCEYLL RVKGGEFVSQ VQARFPHLLW
360 370 380 390 400
NSSCTTSDKP VDENMDPIIH FEPGESPSED AIMMNTPVVK AALEMGFSRR
410 420 430 440 450
LIKQTVQSKI LATEENYKTV NDLVSELLTA EDEKREEEKE RQFEEVASDD
460 470 480 490 500
LSLIRKNRMA LFQRLTSVLP ILGSLLSAKV ITELEHDVIK QTTQTPSQAR
510 520 530 540 550
ELIDTVLVKG NAAASIFRNC LKDFDPVLYK DLFVEKSMKY VPTEDVSGLP
560 570 580 590 600
MEEQLRRLQE ERTCKVCMDK EVSIVFIPCG HLVVCKECAP SLRKCPICRG
610
TIKGTVRTFL S
Length:611
Mass (Da):69,010
Last modified:November 1, 1996 - v1
Checksum:i53FC9136F34EBDDD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271F → L in AAB88044 (PubMed:9372964).Curated
Sequence conflicti150 – 1501R → Q in AAB88044 (PubMed:9372964).Curated
Sequence conflicti169 – 1691Q → H in AAB88044 (PubMed:9372964).Curated
Sequence conflicti183 – 1831S → F in AAB88044 (PubMed:9372964).Curated
Sequence conflicti190 – 1923CLW → FLS in AAB88044 (PubMed:9372964).Curated
Sequence conflicti196 – 1961V → L in AAB88044 (PubMed:9372964).Curated
Sequence conflicti202 – 2032DD → YY in AAB88044 (PubMed:9372964).Curated
Sequence conflicti213 – 2142VN → FT in AAB88044 (PubMed:9372964).Curated
Sequence conflicti217 – 2182VK → GQ in AAB88044 (PubMed:9372964).Curated
Sequence conflicti350 – 3556WNSSCT → EQLLS in AAB88044 (PubMed:9372964).Curated
Sequence conflicti359 – 3591K → T in AAB88044 (PubMed:9372964).Curated
Sequence conflicti426 – 4261E → D in AAB88044 (PubMed:9372964).Curated
Sequence conflicti492 – 4921T → K in AAB88044 (PubMed:9372964).Curated
Sequence conflicti497 – 4971S → L in AAB88044 (PubMed:9372964).Curated
Sequence conflicti524 – 5241F → C in AAB88044 (PubMed:9372964).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27466 mRNA. Translation: AAB48118.1.
AF008592 mRNA. Translation: AAB88044.1.
RefSeqiNP_001007823.1. NM_001007822.1.
UniGeneiGga.21826.

Genome annotation databases

GeneIDi374012.
KEGGigga:374012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27466 mRNA. Translation: AAB48118.1.
AF008592 mRNA. Translation: AAB88044.1.
RefSeqiNP_001007823.1. NM_001007822.1.
UniGeneiGga.21826.

3D structure databases

ProteinModelPortaliQ90660.
SMRiQ90660. Positions 259-349, 549-611.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035646.

Protein family/group databases

MEROPSiI32.002.

Proteomic databases

PaxDbiQ90660.
PRIDEiQ90660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374012.
KEGGigga:374012.

Organism-specific databases

CTDi329.

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
HOGENOMiHOG000232059.
HOVERGENiHBG004848.
InParanoidiQ90660.
KOiK16060.
OrthoDBiEOG091G0CXH.
PhylomeDBiQ90660.
TreeFamiTF105356.

Enzyme and pathway databases

ReactomeiR-GGA-111465. Apoptotic cleavage of cellular proteins.
R-GGA-5357905. Regulation of TNFR1 signaling.
R-GGA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-GGA-5668541. TNFR2 non-canonical NF-kB pathway.
R-GGA-5675482. Regulation of necroptotic cell death.
R-GGA-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Miscellaneous databases

PROiQ90660.

Gene expression databases

BgeeiENSGALG00000017186.
ExpressionAtlasiQ90660. baseline and differential.

Family and domain databases

Gene3Di1.10.1170.10. 4 hits.
1.10.533.10. 1 hit.
InterProiIPR001370. BIR_rpt.
IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF00653. BIR. 3 hits.
PF00619. CARD. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 3 hits.
SM00114. CARD. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS01282. BIR_REPEAT_1. 3 hits.
PS50143. BIR_REPEAT_2. 3 hits.
PS50209. CARD. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIR_CHICK
AccessioniPrimary (citable) accession number: Q90660
Secondary accession number(s): O57319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.