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Protein

Inhibitor of apoptosis protein

Gene

ITA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Apoptotic suppressor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi299ZincPROSITE-ProRule annotation1
Metal bindingi302ZincPROSITE-ProRule annotation1
Metal bindingi319ZincPROSITE-ProRule annotation1
Metal bindingi326ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri564 – 599RING-typePROSITE-ProRule annotationAdd BLAST36

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiI32.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of apoptosis protein
Short name:
IAP
Alternative name(s):
Inhibitor of T-cell apoptosis protein
Gene namesi
Name:ITA
Synonyms:IAP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001223511 – 611Inhibitor of apoptosis proteinAdd BLAST611

Proteomic databases

PaxDbiQ90660.
PRIDEiQ90660.

Expressioni

Tissue specificityi

Cells of the T-lymphocyte lineage. Found in both cortical and medullary cells of the thymus. Expressed at relatively high levels also in spleen, bursa, intestine and lung and at very low levels in testis, brain and skeletal muscle.

Inductioni

High levels are induced within 4-8 hours of T-cell activation in spleen and thymus.

Gene expression databases

BgeeiENSGALG00000017186.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035646.

Structurei

3D structure databases

ProteinModelPortaliQ90660.
SMRiQ90660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati30 – 97BIR 1Add BLAST68
Repeati176 – 242BIR 2Add BLAST67
Repeati262 – 329BIR 3Add BLAST68
Domaini446 – 536CARDPROSITE-ProRule annotationAdd BLAST91

Domaini

The ring finger is important for its antiapoptotic effect.

Sequence similaritiesi

Belongs to the IAP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri564 – 599RING-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1101. Eukaryota.
ENOG410YPNM. LUCA.
HOGENOMiHOG000232059.
HOVERGENiHBG004848.
InParanoidiQ90660.
KOiK16060.
OrthoDBiEOG091G0CXH.
PhylomeDBiQ90660.
TreeFamiTF105356.

Family and domain databases

CDDicd00022. BIR. 3 hits.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001370. BIR_rpt.
IPR001315. CARD.
IPR011029. DEATH-like_dom_sf.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF00653. BIR. 3 hits.
PF00619. CARD. 1 hit.
SMARTiView protein in SMART
SM00238. BIR. 3 hits.
SM00114. CARD. 1 hit.
SM00184. RING. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS01282. BIR_REPEAT_1. 3 hits.
PS50143. BIR_REPEAT_2. 3 hits.
PS50209. CARD. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q90660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIMDSSPLL ASVMKQNAHC GELKYDFSCE LYRMSTFSTF PVNVPVSERR
60 70 80 90 100
LARAGFYYTG VQDKVKCFSC GLVLDNWQPG DNAMEKHKQV YPSCSFVQNM
110 120 130 140 150
LSLNNLGLST HSAFSPLVAS NLSPSLRSMT LSPSFEQVGY FSGSFSSFPR
160 170 180 190 200
DPVTTRAAED LSHLRSKLQN PSMSTEEARL RTSHAWPLMC LWPAEVAKAG
210 220 230 240 250
LDDLGTADKV ACVNCGVKLS NWEPKDNAMS EHRRHFPNCP FVENLMRDQP
260 270 280 290 300
SFNVSNVTMQ THEARVKTFI NWPTRIPVQP EQLADAGFYY VGRNDDVKCF
310 320 330 340 350
CCDGGLRCWE SGDDPWIEHA KWFPRCEYLL RVKGGEFVSQ VQARFPHLLW
360 370 380 390 400
NSSCTTSDKP VDENMDPIIH FEPGESPSED AIMMNTPVVK AALEMGFSRR
410 420 430 440 450
LIKQTVQSKI LATEENYKTV NDLVSELLTA EDEKREEEKE RQFEEVASDD
460 470 480 490 500
LSLIRKNRMA LFQRLTSVLP ILGSLLSAKV ITELEHDVIK QTTQTPSQAR
510 520 530 540 550
ELIDTVLVKG NAAASIFRNC LKDFDPVLYK DLFVEKSMKY VPTEDVSGLP
560 570 580 590 600
MEEQLRRLQE ERTCKVCMDK EVSIVFIPCG HLVVCKECAP SLRKCPICRG
610
TIKGTVRTFL S
Length:611
Mass (Da):69,010
Last modified:November 1, 1996 - v1
Checksum:i53FC9136F34EBDDD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27F → L in AAB88044 (PubMed:9372964).Curated1
Sequence conflicti150R → Q in AAB88044 (PubMed:9372964).Curated1
Sequence conflicti169Q → H in AAB88044 (PubMed:9372964).Curated1
Sequence conflicti183S → F in AAB88044 (PubMed:9372964).Curated1
Sequence conflicti190 – 192CLW → FLS in AAB88044 (PubMed:9372964).Curated3
Sequence conflicti196V → L in AAB88044 (PubMed:9372964).Curated1
Sequence conflicti202 – 203DD → YY in AAB88044 (PubMed:9372964).Curated2
Sequence conflicti213 – 214VN → FT in AAB88044 (PubMed:9372964).Curated2
Sequence conflicti217 – 218VK → GQ in AAB88044 (PubMed:9372964).Curated2
Sequence conflicti350 – 355WNSSCT → EQLLS in AAB88044 (PubMed:9372964).Curated6
Sequence conflicti359K → T in AAB88044 (PubMed:9372964).Curated1
Sequence conflicti426E → D in AAB88044 (PubMed:9372964).Curated1
Sequence conflicti492T → K in AAB88044 (PubMed:9372964).Curated1
Sequence conflicti497S → L in AAB88044 (PubMed:9372964).Curated1
Sequence conflicti524F → C in AAB88044 (PubMed:9372964).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27466 mRNA. Translation: AAB48118.1.
AF008592 mRNA. Translation: AAB88044.1.
RefSeqiNP_001007823.1. NM_001007822.1.
UniGeneiGga.21826.

Genome annotation databases

GeneIDi374012.
KEGGigga:374012.

Similar proteinsi

Entry informationi

Entry nameiBIR_CHICK
AccessioniPrimary (citable) accession number: Q90660
Secondary accession number(s): O57319
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families