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Q90660 (BIR_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inhibitor of apoptosis protein
Short name=IAP
Alternative name(s):
Inhibitor of T-cell apoptosis protein
Gene names
Name:ITA
Synonyms:IAP1
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length611 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Apoptotic suppressor.

Subcellular location

Nucleus. Cytoplasm. Note: Predominantly nuclear. According to Ref.2 it is cytoplasmic.

Tissue specificity

Cells of the T-lymphocyte lineage. Found in both cortical and medullary cells of the thymus. Expressed at relatively high levels also in spleen, bursa, intestine and lung and at very low levels in testis, brain and skeletal muscle.

Induction

High levels are induced within 4-8 hours of T-cell activation in spleen and thymus.

Domain

The ring finger is important for its antiapoptotic effect.

Sequence similarities

Belongs to the IAP family.

Contains 3 BIR repeats.

Contains 1 CARD domain.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processanti-apoptosis

Inferred from direct assay Ref.2. Source: AgBase

apoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 611611Inhibitor of apoptosis protein
PRO_0000122351

Regions

Repeat30 – 9768BIR 1
Repeat176 – 24267BIR 2
Repeat262 – 32968BIR 3
Domain446 – 53691CARD
Zinc finger564 – 59936RING-type

Sites

Metal binding2991Zinc By similarity
Metal binding3021Zinc By similarity
Metal binding3191Zinc By similarity
Metal binding3261Zinc By similarity

Experimental info

Sequence conflict271F → L in AAB88044. Ref.2
Sequence conflict1501R → Q in AAB88044. Ref.2
Sequence conflict1691Q → H in AAB88044. Ref.2
Sequence conflict1831S → F in AAB88044. Ref.2
Sequence conflict190 – 1923CLW → FLS in AAB88044. Ref.2
Sequence conflict1961V → L in AAB88044. Ref.2
Sequence conflict202 – 2032DD → YY in AAB88044. Ref.2
Sequence conflict213 – 2142VN → FT in AAB88044. Ref.2
Sequence conflict217 – 2182VK → GQ in AAB88044. Ref.2
Sequence conflict350 – 3556WNSSCT → EQLLS in AAB88044. Ref.2
Sequence conflict3591K → T in AAB88044. Ref.2
Sequence conflict4261E → D in AAB88044. Ref.2
Sequence conflict4921T → K in AAB88044. Ref.2
Sequence conflict4971S → L in AAB88044. Ref.2
Sequence conflict5241F → C in AAB88044. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q90660 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 53FC9136F34EBDDD

FASTA61169,010
        10         20         30         40         50         60 
MNIMDSSPLL ASVMKQNAHC GELKYDFSCE LYRMSTFSTF PVNVPVSERR LARAGFYYTG 

        70         80         90        100        110        120 
VQDKVKCFSC GLVLDNWQPG DNAMEKHKQV YPSCSFVQNM LSLNNLGLST HSAFSPLVAS 

       130        140        150        160        170        180 
NLSPSLRSMT LSPSFEQVGY FSGSFSSFPR DPVTTRAAED LSHLRSKLQN PSMSTEEARL 

       190        200        210        220        230        240 
RTSHAWPLMC LWPAEVAKAG LDDLGTADKV ACVNCGVKLS NWEPKDNAMS EHRRHFPNCP 

       250        260        270        280        290        300 
FVENLMRDQP SFNVSNVTMQ THEARVKTFI NWPTRIPVQP EQLADAGFYY VGRNDDVKCF 

       310        320        330        340        350        360 
CCDGGLRCWE SGDDPWIEHA KWFPRCEYLL RVKGGEFVSQ VQARFPHLLW NSSCTTSDKP 

       370        380        390        400        410        420 
VDENMDPIIH FEPGESPSED AIMMNTPVVK AALEMGFSRR LIKQTVQSKI LATEENYKTV 

       430        440        450        460        470        480 
NDLVSELLTA EDEKREEEKE RQFEEVASDD LSLIRKNRMA LFQRLTSVLP ILGSLLSAKV 

       490        500        510        520        530        540 
ITELEHDVIK QTTQTPSQAR ELIDTVLVKG NAAASIFRNC LKDFDPVLYK DLFVEKSMKY 

       550        560        570        580        590        600 
VPTEDVSGLP MEEQLRRLQE ERTCKVCMDK EVSIVFIPCG HLVVCKECAP SLRKCPICRG 

       610 
TIKGTVRTFL S

« Hide

References

[1]"ITA, a vertebrate homologue of IAP that is expressed in T lymphocytes."
Digby M.R., Kimpton W.G., York J.J., Connick T.E., Lowenthal J.W.
DNA Cell Biol. 15:981-988(1996) [PubMed: 8945639] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[2]"ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein."
You M., Ku P.-T., Hrdlickova R., Bose H.R. Jr.
Mol. Cell. Biol. 17:7328-7341(1997) [PubMed: 9372964] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: White leghorn.
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U27466 mRNA. Translation: AAB48118.1.
AF008592 mRNA. Translation: AAB88044.1.
IPIIPI00576596.
RefSeqNP_001007823.1. NM_001007822.1.
UniGeneGga.21826.

3D structure databases

ProteinModelPortalQ90660.
SMRQ90660. Positions 259-349, 549-611.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ90660.

Proteomic databases

PRIDEQ90660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000027772; ENSGALP00000027719; ENSGALG00000017186.
ENSGALT00000036426; ENSGALP00000035646; ENSGALG00000017186.
GeneID374012.
KEGGgga:374012.

Organism-specific databases

CTD329.

Phylogenomic databases

eggNOGveNOG08532.
HOGENOMHBG714776.
HOVERGENHBG004848.
InParanoidQ90660.
OrthoDBEOG4K3KVW.

Family and domain databases

InterProIPR001370. BIR.
IPR001315. CARD.
IPR011029. DEATH-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
Gene3DG3DSA:1.10.1170.10. BIR. 4 hits.
G3DSA:1.10.533.10. DEATH_like. 1 hit.
G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
KOK04725.
PfamPF00653. BIR. 3 hits.
PF00619. CARD. 1 hit.
[Graphical view]
SMARTSM00238. BIR. 3 hits.
SM00114. CARD. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF47986. DEATH_like. 1 hit.
PROSITEPS01282. BIR_REPEAT_1. 3 hits.
PS50143. BIR_REPEAT_2. 3 hits.
PS50209. CARD. 1 hit.
PS00518. ZF_RING_1. False negative.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBIR_CHICK
AccessionPrimary (citable) accession number: Q90660
Secondary accession number(s): O57319
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 16, 2011
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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