Q90655 (AKR_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Homeobox protein AKR Alternative name(s): Avian knotted-related protein
Organism	Gallus gallus (Chicken) [Reference proteome]
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to the F' element of the APOVLDLII gene and represses its transcription.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the TALE/TGIF homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	determination of left/right symmetry Inferred from electronic annotation. Source: Compara dorsal/ventral pattern formation Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of retinoic acid receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from direct assay Ref.1. Source: Roslin neural tube closure Inferred from electronic annotation. Source: Compara nodal signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of fibroblast proliferation Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara regulation of gastrulation Inferred from electronic annotation. Source: Compara retina development in camera-type eye Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred by curator Ref.1. Source: Roslin
Molecular_function	DNA binding Inferred from direct assay Ref.1. Source: Roslin chromatin binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Homeobox protein AKR		PRO_0000048810
Regions
	DNA binding	35 – 97	63	Homeobox; TALE-type

Sequences

	Sequence		Length	Mass (Da)
	Q90655 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 1074355DCC0C2253	FASTA	269	29,442
	10 20 30 40 50 60 MKSKKGVVAI SGSETEDDDT MDVPLDLSSS AGSGKRRRRG NLPKESVQIL RDWLYEHRYN 70 80 90 100 110 120 AYPSEQEKVL LSRQTHLSTL QVCNWFINAR RRLLPDMLRK DGKDPNQFTI SRRGTKLPEG 130 140 150 160 170 180 SMVESSMGTK NFLPLLEESP FLPASATLSK TVSSSKPVSP GSVLARPSVI CHTTVTALKD 190 200 210 220 230 240 APFHFCQPGD VGQTTDLQQP PANAFTDSSL SYHEDASKLG PGANAQSGLF NTPPPTPPDL 250 260 NQDFSGFQLL VDVALKRAAE MELQAKLMA

References

[1]	"Isolation and characterization of the chicken homeodomain protein AKR." Ryan A.K., Tejada M.L., May D.L., Dubaova M., Deeley R.G. Nucleic Acids Res. 23:3252-3259(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U25353 mRNA. Translation: AAA83567.1.
IPI	IPI00603757.
PIR	S58439.
RefSeq	NP_990710.1. NM_205379.1.
UniGene	Gga.768.
3D structure databases
ProteinModelPortal	Q90655.
SMR	Q90655. Positions 30-106.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000023838.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000023884; ENSGALP00000023838; ENSGALG00000014795.
GeneID	396339.
KEGG	gga:396339.
Organism-specific databases
CTD	7050.
Phylogenomic databases
eggNOG	NOG308174.
GeneTree	ENSGT00680000099964.
HOGENOM	HOG000232039.
HOVERGEN	HBG001143.
InParanoid	Q90655.
OMA	IAANNFT.
OrthoDB	EOG4JQ3ZS.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR008422. Homeobox_KN_domain. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF05920. Homeobox_KN. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. False negative. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816387.

Entry information

Entry name

AKR_CHICK

Accession

Primary (citable) accession number: Q90655

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program