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Protein

Chromosome-associated kinesin KIF4

Gene

KIF4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for mitotic chromosomal positioning and bipolar spindle stabilization.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi88 – 95ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome-associated kinesin KIF4
Alternative name(s):
Chromokinesin
Gene namesi
Name:KIF4
Synonyms:KIF4A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosome 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: Associated with mitotic chromosomes.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254391 – 1225Chromosome-associated kinesin KIF4Add BLAST1225

Proteomic databases

PaxDbiQ90640.
PRIDEiQ90640.

Expressioni

Tissue specificityi

Expressed in proliferating cells; neuroepithelium of embryos.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006656.

Structurei

3D structure databases

ProteinModelPortaliQ90640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 338Kinesin motorPROSITE-ProRule annotationAdd BLAST330

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1004 – 1225GlobularAdd BLAST222

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili352 – 1003Sequence analysisAdd BLAST652

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0244. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000048108.
HOVERGENiHBG052256.
InParanoidiQ90640.
KOiK10395.
PhylomeDBiQ90640.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM01114. CXC. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVREEEKGIP VRVVRCRPLV PKETSEGCQM CLSFVPGEPQ VIVGSDKAFT
60 70 80 90 100
YDYVFDPSVE QEEVFNTAVA PLIRGIFKGY NATVLAYGQT GSGKTYSMGG
110 120 130 140 150
TYTASQEHDP SMGVIPRVIK LLFKEKEQRQ DWEFVLKVSY LEIYNEDILD
160 170 180 190 200
LLCSSRERSS QISIREDPKE GIKIVGLTER NVASARDTVS CLEQGNNCRT
210 220 230 240 250
VASTAMNSQS SRSHAIFTIC IDQKKKNDKN SSFHSKLHLV DLAGSERQKK
260 270 280 290 300
TKAEGDRLKE GININRGLLC LGNVISALGE ENKKGGFVPY RDSKLTRLLQ
310 320 330 340 350
DSLGGNSHTL MIACVSPADS NLEETLNTLR YADRARKIKN KPIVNVDPQA
360 370 380 390 400
AELNHLKQQV QQLQVLLLQA HGGTLPVSIN SMAPSENLQS LMEKNQSLME
410 420 430 440 450
ENEKLSRGLS EAAGQTAQML ERIIVTEQEN EKMNAKLEQL QQHAVCKLDL
460 470 480 490 500
QKLLETVEDE ELKENVEVIR NLQQVLAQFQ SESAAAAEAA TEMANAEQDA
510 520 530 540 550
AGEAETGQVT KRSSDDFTTQ HALRQAQMSK ELVELNKALA LKEALAKKMI
560 570 580 590 600
QNDSQLEPIQ SQYQTNIKDL ELEVSNLQKE KEELILALSM AKKDVNQAKL
610 620 630 640 650
SERRRKRLQE LEGQINELKK KLNEQAKLLK LKESTERTVS KLNQEIREMK
660 670 680 690 700
NQRVQLMRQM KEDAEKFRQW KQQKDKEVIQ LKERDRKRQY ELLKLERDFQ
710 720 730 740 750
KQASVLRRKT EEAAAANKRL KDALQKQREA ADKRKESQNR GMEGVAARVK
760 770 780 790 800
SWLANEVEVL VSTEEARRHL ADLLEDRKIL AQELLQLKEK KESGENPPSK
810 820 830 840 850
LRRRTYSITD LQASEMDLSL SKQIESLETE MELRSAQIAD LQQKLLDADN
860 870 880 890 900
GDRVKQRWDN IATILEAKCA LKYLLGELVS SKVQESKLES SLQQSKTNCS
910 920 930 940 950
DIQKMLIEER NHATEMEAEF QNQLLLQEQQ HQQEVLYLLS QFQQKEAPGK
960 970 980 990 1000
GVEDSLSEQE KQMQERLKFQ EKELEKMREI CEKNQELLQE NDVLKQKMLL
1010 1020 1030 1040 1050
VQVASGQKLR RDQQVSPESP DSPFDYIPPK PKTRRQTVAK PRAPTPEMNV
1060 1070 1080 1090 1100
EELFSDSEES GEEEDAEWVP VKAAKGTKKS ATGCFCKGRC GNRQCGCRKQ
1110 1120 1130 1140 1150
KVGCTAGCSC DSTKCRNRDP GFQDATVCED QTKDSEGSFK LEDLRDVTAG
1160 1170 1180 1190 1200
ETFFQPVYSP PTMKVLKDIT DQGVFMKKPS TAASLLVRDE ESQENQLPFV
1210 1220
KKKKRMLSSN TSFFSGCTPI KEEID
Length:1,225
Mass (Da):138,924
Last modified:November 1, 1996 - v1
Checksum:iFA01ED83425F5875
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1087 – 1088KG → RI (PubMed:8108415).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18309 mRNA. Translation: AAC59666.1.
U04821 mRNA. Translation: AAA18960.1.
PIRiA56514.
RefSeqiNP_990306.1. NM_204975.1.
UniGeneiGga.4358.

Genome annotation databases

GeneIDi395823.
KEGGigga:395823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18309 mRNA. Translation: AAC59666.1.
U04821 mRNA. Translation: AAA18960.1.
PIRiA56514.
RefSeqiNP_990306.1. NM_204975.1.
UniGeneiGga.4358.

3D structure databases

ProteinModelPortaliQ90640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006656.

Proteomic databases

PaxDbiQ90640.
PRIDEiQ90640.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395823.
KEGGigga:395823.

Organism-specific databases

CTDi24137.

Phylogenomic databases

eggNOGiKOG0244. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000048108.
HOVERGENiHBG052256.
InParanoidiQ90640.
KOiK10395.
PhylomeDBiQ90640.

Miscellaneous databases

PROiQ90640.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR033467. Tesmin/TSO1-like_CXC.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM01114. CXC. 1 hit.
SM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF4_CHICK
AccessioniPrimary (citable) accession number: Q90640
Secondary accession number(s): Q90608
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.