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Protein

Dihydropyrimidinase-related protein 2

Gene

DPYSL2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity).By similarity1 Publication

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-GGA-399956 CRMPs in Sema3A signaling

Protein family/group databases

MEROPSiM38.975

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 2
Short name:
DRP-2
Alternative name(s):
Collapsin response mediator protein CRMP-62
Gene namesi
Name:DPYSL2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 22

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659161 – 572Dihydropyrimidinase-related protein 2Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei509PhosphothreonineBy similarity1
Modified residuei518PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ90635

PTM databases

iPTMnetiQ90635

Expressioni

Tissue specificityi

Detected in the developing chick nervous system.1 Publication

Gene expression databases

BgeeiENSGALG00000000227
ExpressionAtlasiQ90635 baseline and differential

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ90635, 1 interactor
STRINGi9031.ENSGALP00000000304

Structurei

3D structure databases

ProteinModelPortaliQ90635
SMRiQ90635
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiQ90635

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030615 DRP2
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF56 PTHR11647:SF56, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit

Sequencei

Sequence statusi: Complete.

Q90635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI
60 70 80 90 100
VPGGVKTIEA HGRMVIPGGI DVHTRFQMPE QGMTSADDFF QGTKAALAGG
110 120 130 140 150
TTMIIDHVVP EPGTSLLTAF DQWREWADSK SCCDYSLHVD ITEWHKGVQE
160 170 180 190 200
EMEALVKDHG VNSFLVYMAF KDRFQLSDSQ IYEVLSVIRD IGATAQVHAE
210 220 230 240 250
NGDIIAEEQQ RILELGITGP EGHVLSRPEE VEAEAVNRAI TIANQTNCPL
260 270 280 290 300
YITKVMSKSA AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA
310 320 330 340 350
FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL
360 370 380 390 400
IPEGTNGTEE RMSIIWDKAV VTGKMDENQF VAVTSTNAAK IFNLYPRKGR
410 420 430 440 450
IAVGSDADLV IWDPDSVKTI SAKTHNISLE YNIFEGMECR GSPLVVISQG
460 470 480 490 500
KIVLEDGNLH VTEGSGRYIP RKPFPDFVYK RIKARSRLAE LRGVPRGLYD
510 520 530 540 550
GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS LSGAQIDDNI
560 570
PRRTTQRIVA PPGGRANITS LG
Length:572
Mass (Da):62,331
Last modified:November 1, 1996 - v1
Checksum:i85DB9E3DD5E54D8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17277 mRNA Translation: AAA93200.1
PIRiS58889
RefSeqiXP_015152784.1, XM_015297298.1
UniGeneiGga.3569
Gga.4756

Genome annotation databases

EnsembliENSGALT00000000305; ENSGALP00000000304; ENSGALG00000000227
GeneIDi395155

Similar proteinsi

Entry informationi

Entry nameiDPYL2_CHICK
AccessioniPrimary (citable) accession number: Q90635
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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